MersV1, PubMed, Curation, bibRecord, 001615

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein.

Identifieur interne : 001615 ( PubMed/Curation ); précédent : 001614; suivant : 001616

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein.

Auteurs : Asisa Volz [Allemagne] ; Alexandra Kupke [Allemagne] ; Fei Song [Allemagne] ; Sylvia Jany [Allemagne] ; Robert Fux [Allemagne] ; Hosam Shams-Eldin [Allemagne] ; Jörg Schmidt [Allemagne] ; Christin Becker [Allemagne] ; Markus Eickmann [Allemagne] ; Stephan Becker [Allemagne] ; Gerd Sutter [Allemagne]

Source :

Journal of virology [ 1098-5514 ] ; 2015.

RBID : pubmed:26018172

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies, Neutralizing (immunology), CD8-Positive T-Lymphocytes (immunology), Coronavirus Infections (prevention & control), Drug Evaluation, Preclinical (methods), Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (immunology), Spike Glycoprotein, Coronavirus (metabolism), Vaccinia virus (genetics), Viral Vaccines (genetics), Viral Vaccines (immunology).
MESH :
- chemical , genetics : Viral Vaccines.
- chemical , immunology : Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- genetics : Vaccinia virus.
- immunology : CD8-Positive T-Lymphocytes, Middle East Respiratory Syndrome Coronavirus.
- chemical , metabolism : Spike Glycoprotein, Coronavirus.
- methods : Drug Evaluation, Preclinical.
- prevention & control : Coronavirus Infections.
- Animals, Mice, Mice, Inbred BALB C.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine expressing full-length MERS-CoV spike (S) glycoprotein by immunizing BALB/c mice with either intramuscular or subcutaneous regimens. In all cases, MVA-MERS-S induced MERS-CoV-specific CD8(+) T cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine.

DOI: 10.1128/JVI.00614-15
PubMed: 26018172

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine expressing full-length MERS-CoV spike (S) glycoprotein by immunizing BALB/c mice with either intramuscular or subcutaneous regimens. In all cases, MVA-MERS-S induced MERS-CoV-specific CD8(+) T cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine. </div>
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<Month>01</Month>
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<DateRevised><Year>2018</Year>
<Month>11</Month>
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<Title>Journal of virology</Title>
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<Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine expressing full-length MERS-CoV spike (S) glycoprotein by immunizing BALB/c mice with either intramuscular or subcutaneous regimens. In all cases, MVA-MERS-S induced MERS-CoV-specific CD8(+) T cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine. </AbstractText>
<CopyrightInformation>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Volz</LastName>
<ForeName>Asisa</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich, Germany.</Affiliation>
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<Initials>A</Initials>
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<ForeName>Fei</ForeName>
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<ForeName>Sylvia</ForeName>
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<ForeName>Jörg</ForeName>
<Initials>J</Initials>
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<Author ValidYN="Y"><LastName>Becker</LastName>
<ForeName>Christin</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of Giessen Lung Center, Department of Internal Medicine II, Section of Infectious Diseases, Giessen, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Eickmann</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Becker</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Gerd</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich, Germany gerd.sutter@lmu.de.</Affiliation>
</AffiliationInfo>
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<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>05</Month>
<Day>27</Day>
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<MedlineTA>J Virol</MedlineTA>
<NlmUniqueID>0113724</NlmUniqueID>
<ISSNLinking>0022-538X</ISSNLinking>
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Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein.

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein.

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