MersV1, PubMed, Checkpoint, bibRecord, 000864

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

Identifieur interne : 000864 ( PubMed/Checkpoint ); précédent : 000863; suivant : 000865

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2018.

RBID : pubmed:29507189

Descripteurs français

KwdFr :
- Afrique, Animaux, Chameaux (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Femelle, Humains, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (virologie), Phylogénie, Poumon (virologie), Réplication virale, Souris de lignée C57BL, Variation génétique, Zoonoses (virologie).
MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Infections à coronavirus.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Chameaux, Infections à coronavirus, Poumon, Zoonoses.
- Afrique, Animaux, Femelle, Humains, Phylogénie, Réplication virale, Souris de lignée C57BL, Variation génétique.

English descriptors

KwdEn :
- Africa, Animals, Camelus (virology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Female, Genetic Variation, Humans, Lung (virology), Mice, Inbred C57BL, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Phylogeny, Virus Replication, Zoonoses (virology).
MESH :
- genetics : Middle East Respiratory Syndrome Coronavirus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Camelus, Coronavirus Infections, Lung, Zoonoses.
- Africa, Animals, Female, Genetic Variation, Humans, Mice, Inbred C57BL, Phylogeny, Virus Replication.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene ORF4b Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking ORF4b elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, ORF4b deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface.

DOI: 10.1073/pnas.1718769115
PubMed: 29507189

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000982
to stream PubMed, to step Curation: 000982

Links to Exploration step

pubmed:29507189

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.</title>
<author><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hui, Kenrie P Y" sort="Hui, Kenrie P Y" uniqKey="Hui K" first="Kenrie P Y" last="Hui">Kenrie P Y. Hui</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miguel, Eve" sort="Miguel, Eve" uniqKey="Miguel E" first="Eve" last="Miguel">Eve Miguel</name>
<affiliation wicri:level="3"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Niemeyer, Daniela" sort="Niemeyer, Daniela" uniqKey="Niemeyer D" first="Daniela" last="Niemeyer">Daniela Niemeyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Oladipo, Jamiu O" sort="Oladipo, Jamiu O" uniqKey="Oladipo J" first="Jamiu O" last="Oladipo">Jamiu O. Oladipo</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Traore, Amadou" sort="Traore, Amadou" uniqKey="Traore A" first="Amadou" last="Traoré">Amadou Traoré</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04, Burkina Faso.</nlm:affiliation>
<country xml:lang="fr">Burkina Faso</country>
<wicri:regionArea>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04</wicri:regionArea>
<wicri:noRegion>04 BP 8645 Ouagadougou 04</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fassi Fihri, Ouafaa" sort="Fassi Fihri, Ouafaa" uniqKey="Fassi Fihri O" first="Ouafaa" last="Fassi-Fihri">Ouafaa Fassi-Fihri</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat, Morocco.</nlm:affiliation>
<country xml:lang="fr">Maroc</country>
<wicri:regionArea>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat</wicri:regionArea>
<placeName><settlement type="city">Rabat</settlement>
<region nuts="2">Rabat-Salé-Kénitra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ali, Abraham" sort="Ali, Abraham" uniqKey="Ali A" first="Abraham" last="Ali">Abraham Ali</name>
<affiliation wicri:level="1"><nlm:affiliation>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa</wicri:regionArea>
<wicri:noRegion>Addis Ababa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demissie, Getnet F" sort="Demissie, Getnet F" uniqKey="Demissie G" first="Getnet F" last="Demissié">Getnet F. Demissié</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>College of Veterinary Medecine, Haramaya University, Dire Dawa</wicri:regionArea>
<wicri:noRegion>Dire Dawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kuranga, Sulyman A" sort="Kuranga, Sulyman A" uniqKey="Kuranga S" first="Sulyman A" last="Kuranga">Sulyman A. Kuranga</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria.</nlm:affiliation>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin</wicri:regionArea>
<wicri:noRegion>Ilorin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mamo, Gezahegne" sort="Mamo, Gezahegne" uniqKey="Mamo G" first="Gezahegne" last="Mamo">Gezahegne Mamo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu</wicri:regionArea>
<wicri:noRegion>Bishoftu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T Y" last="So">Ray T Y. So</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa</wicri:regionArea>
<wicri:noRegion>Al-Hasa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roger, Francois" sort="Roger, Francois" uniqKey="Roger F" first="Francois" last="Roger">Francois Roger</name>
<affiliation wicri:level="3"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chevalier, Veronique" sort="Chevalier, Veronique" uniqKey="Chevalier V" first="Veronique" last="Chevalier">Veronique Chevalier</name>
<affiliation wicri:level="3"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China; malik@hku.hk.</nlm:affiliation>
<country wicri:rule="url">Hong Kong</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29507189</idno>
<idno type="pmid">29507189</idno>
<idno type="doi">10.1073/pnas.1718769115</idno>
<idno type="wicri:Area/PubMed/Corpus">000982</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000982</idno>
<idno type="wicri:Area/PubMed/Curation">000982</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000982</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000864</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000864</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.</title>
<author><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hui, Kenrie P Y" sort="Hui, Kenrie P Y" uniqKey="Hui K" first="Kenrie P Y" last="Hui">Kenrie P Y. Hui</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miguel, Eve" sort="Miguel, Eve" uniqKey="Miguel E" first="Eve" last="Miguel">Eve Miguel</name>
<affiliation wicri:level="3"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Niemeyer, Daniela" sort="Niemeyer, Daniela" uniqKey="Niemeyer D" first="Daniela" last="Niemeyer">Daniela Niemeyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Oladipo, Jamiu O" sort="Oladipo, Jamiu O" uniqKey="Oladipo J" first="Jamiu O" last="Oladipo">Jamiu O. Oladipo</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Traore, Amadou" sort="Traore, Amadou" uniqKey="Traore A" first="Amadou" last="Traoré">Amadou Traoré</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04, Burkina Faso.</nlm:affiliation>
<country xml:lang="fr">Burkina Faso</country>
<wicri:regionArea>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04</wicri:regionArea>
<wicri:noRegion>04 BP 8645 Ouagadougou 04</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fassi Fihri, Ouafaa" sort="Fassi Fihri, Ouafaa" uniqKey="Fassi Fihri O" first="Ouafaa" last="Fassi-Fihri">Ouafaa Fassi-Fihri</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat, Morocco.</nlm:affiliation>
<country xml:lang="fr">Maroc</country>
<wicri:regionArea>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat</wicri:regionArea>
<placeName><settlement type="city">Rabat</settlement>
<region nuts="2">Rabat-Salé-Kénitra</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ali, Abraham" sort="Ali, Abraham" uniqKey="Ali A" first="Abraham" last="Ali">Abraham Ali</name>
<affiliation wicri:level="1"><nlm:affiliation>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa</wicri:regionArea>
<wicri:noRegion>Addis Ababa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demissie, Getnet F" sort="Demissie, Getnet F" uniqKey="Demissie G" first="Getnet F" last="Demissié">Getnet F. Demissié</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>College of Veterinary Medecine, Haramaya University, Dire Dawa</wicri:regionArea>
<wicri:noRegion>Dire Dawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kuranga, Sulyman A" sort="Kuranga, Sulyman A" uniqKey="Kuranga S" first="Sulyman A" last="Kuranga">Sulyman A. Kuranga</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria.</nlm:affiliation>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin</wicri:regionArea>
<wicri:noRegion>Ilorin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mamo, Gezahegne" sort="Mamo, Gezahegne" uniqKey="Mamo G" first="Gezahegne" last="Mamo">Gezahegne Mamo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu</wicri:regionArea>
<wicri:noRegion>Bishoftu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T Y" last="So">Ray T Y. So</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa</wicri:regionArea>
<wicri:noRegion>Al-Hasa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roger, Francois" sort="Roger, Francois" uniqKey="Roger F" first="Francois" last="Roger">Francois Roger</name>
<affiliation wicri:level="3"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chevalier, Veronique" sort="Chevalier, Veronique" uniqKey="Chevalier V" first="Veronique" last="Chevalier">Veronique Chevalier</name>
<affiliation wicri:level="3"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
<settlement type="city">Montpellier</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China; malik@hku.hk.</nlm:affiliation>
<country wicri:rule="url">Hong Kong</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
<wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa</term>
<term>Animals</term>
<term>Camelus (virology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Lung (virology)</term>
<term>Mice, Inbred C57BL</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Phylogeny</term>
<term>Virus Replication</term>
<term>Zoonoses (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afrique</term>
<term>Animaux</term>
<term>Chameaux (virologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Phylogénie</term>
<term>Poumon (virologie)</term>
<term>Réplication virale</term>
<term>Souris de lignée C57BL</term>
<term>Variation génétique</term>
<term>Zoonoses (virologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term>
<term>Infections à coronavirus</term>
<term>Poumon</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term>
<term>Coronavirus Infections</term>
<term>Lung</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Africa</term>
<term>Animals</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
<term>Phylogeny</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Afrique</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Réplication virale</term>
<term>Souris de lignée C57BL</term>
<term>Variation génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene <i>ORF4b</i>
 Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking <i>ORF4b</i>
 elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, <i>ORF4b</i>
 deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29507189</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>115</Volume>
<Issue>12</Issue>
<PubDate><Year>2018</Year>
<Month>03</Month>
<Day>20</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
</Journal>
<ArticleTitle>MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.</ArticleTitle>
<Pagination><MedlinePgn>3144-3149</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1718769115</ELocationID>
<Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene <i>ORF4b</i>
 Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking <i>ORF4b</i>
 elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, <i>ORF4b</i>
 deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface.</AbstractText>
<CopyrightInformation>Copyright © 2018 the Author(s). Published by PNAS.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chu</LastName>
<ForeName>Daniel K W</ForeName>
<Initials>DKW</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hui</LastName>
<ForeName>Kenrie P Y</ForeName>
<Initials>KPY</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perera</LastName>
<ForeName>Ranawaka A P M</ForeName>
<Initials>RAPM</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Miguel</LastName>
<ForeName>Eve</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, L'Institut de Recherche pour le Développement, CNRS, Universitè de Montpellier, F-34398 Montpellier, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niemeyer</LastName>
<ForeName>Daniela</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Jincun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, Republic of China 510000.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Channappanavar</LastName>
<ForeName>Rudragouda</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dudas</LastName>
<ForeName>Gytis</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oladipo</LastName>
<ForeName>Jamiu O</ForeName>
<Initials>JO</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Traoré</LastName>
<ForeName>Amadou</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04, Burkina Faso.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fassi-Fihri</LastName>
<ForeName>Ouafaa</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat, Morocco.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ali</LastName>
<ForeName>Abraham</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demissié</LastName>
<ForeName>Getnet F</ForeName>
<Initials>GF</Initials>
<AffiliationInfo><Affiliation>College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muth</LastName>
<ForeName>Doreen</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Michael C W</ForeName>
<Initials>MCW</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nicholls</LastName>
<ForeName>John M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meyerholz</LastName>
<ForeName>David K</ForeName>
<Initials>DK</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kuranga</LastName>
<ForeName>Sulyman A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mamo</LastName>
<ForeName>Gezahegne</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Ziqi</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>So</LastName>
<ForeName>Ray T Y</ForeName>
<Initials>RTY</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hemida</LastName>
<ForeName>Maged G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Webby</LastName>
<ForeName>Richard J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roger</LastName>
<ForeName>Francois</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Kasetsart University, 10900 Bangkok, Thailand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rambaut</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh, United Kingdom.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Fogarty International Center, National Institutes of Health, Bethesda, MD 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Poon</LastName>
<ForeName>Leo L M</ForeName>
<Initials>LLM</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perlman</LastName>
<ForeName>Stanley</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0003-4213-2354</Identifier>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drosten</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chevalier</LastName>
<ForeName>Veronique</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institut Pasteur du Cambodge, Phnom Penh, Cambodia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peiris</LastName>
<ForeName>Malik</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China; malik@hku.hk.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName>
<AccessionNumberList><AccessionNumber>MG923465</AccessionNumber>
<AccessionNumber>MG923481</AccessionNumber>
<AccessionNumber>KC869678</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>HHSN272201400006C</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 AI060699</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI129269</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>206298</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>03</Month>
<Day>05</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Proc Natl Acad Sci U S A</MedlineTA>
<NlmUniqueID>7505876</NlmUniqueID>
<ISSNLinking>0027-8424</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000349" MajorTopicYN="N">Africa</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002162" MajorTopicYN="N">Camelus</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015047" MajorTopicYN="N">Zoonoses</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Africa</Keyword>
<Keyword MajorTopicYN="Y">MERS</Keyword>
<Keyword MajorTopicYN="Y">coronavirus</Keyword>
<Keyword MajorTopicYN="Y">evolution</Keyword>
<Keyword MajorTopicYN="Y">zoonosis</Keyword>
</KeywordList>
<CoiStatement>The authors declare no conflict of interest.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>3</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>3</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29507189</ArticleId>
<ArticleId IdType="pii">1718769115</ArticleId>
<ArticleId IdType="doi">10.1073/pnas.1718769115</ArticleId>
<ArticleId IdType="pmc">PMC5866576</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Sci Rep. 2015 Dec 03;5:17554</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26631542</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Jul;20(7):1231-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24964193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2016 Mar;22(3):555-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26889787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Microbiol. 2016 Nov 28;2:16226</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27892925</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2013 Oct;19(10):1697-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24050621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2016 Apr;22(4):716-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26981770</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2017 Aug 22;8(4):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28830941</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Virol. 2016 Feb;16:55-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26826951</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24043791</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2014 Apr;95(Pt 4):874-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24443473</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Infect Dis. 2015 Aug;28(4):392-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26103552</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2016 Mar 29;7(2):e00258</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27025250</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Jun;20(6):1049-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24856660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Infect Dis. 2014 Feb;14 (2):140-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Respir Med. 2014 Oct;2(10 ):813-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25174549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3119-E3128</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28348219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2016 Jan 1;351(6268):77-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26678878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24599590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 May;87(9):5300-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23449793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Syst Biol. 2010 May;59(3):307-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20525638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 May;88(9):4866-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24522921</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2017 Mar 30;22(13):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28382915</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Arabie saoudite</li>
<li>Burkina Faso</li>
<li>France</li>
<li>Hong Kong</li>
<li>Maroc</li>
<li>Nigeria</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
<li>Éthiopie</li>
</country>
<region><li>Berlin</li>
<li>Iowa</li>
<li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
<li>Rabat-Salé-Kénitra</li>
<li>Tennessee</li>
<li>Washington (État)</li>
<li>Écosse</li>
</region>
<settlement><li>Berlin</li>
<li>Montpellier</li>
<li>Rabat</li>
<li>Édimbourg</li>
</settlement>
<orgName><li>Université d'Édimbourg</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name>
</noRegion>
<name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name>
<name sortKey="Hui, Kenrie P Y" sort="Hui, Kenrie P Y" uniqKey="Hui K" first="Kenrie P Y" last="Hui">Kenrie P Y. Hui</name>
<name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name>
<name sortKey="Oladipo, Jamiu O" sort="Oladipo, Jamiu O" uniqKey="Oladipo J" first="Jamiu O" last="Oladipo">Jamiu O. Oladipo</name>
<name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name>
<name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
<name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T Y" last="So">Ray T Y. So</name>
<name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Miguel, Eve" sort="Miguel, Eve" uniqKey="Miguel E" first="Eve" last="Miguel">Eve Miguel</name>
</region>
<name sortKey="Chevalier, Veronique" sort="Chevalier, Veronique" uniqKey="Chevalier V" first="Veronique" last="Chevalier">Veronique Chevalier</name>
<name sortKey="Roger, Francois" sort="Roger, Francois" uniqKey="Roger F" first="Francois" last="Roger">Francois Roger</name>
</country>
<country name="Allemagne"><region name="Berlin"><name sortKey="Niemeyer, Daniela" sort="Niemeyer, Daniela" uniqKey="Niemeyer D" first="Daniela" last="Niemeyer">Daniela Niemeyer</name>
</region>
<name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
</country>
<country name="États-Unis"><region name="Iowa"><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name>
</region>
<name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name>
<name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name>
<name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
<name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name>
</country>
<country name="Burkina Faso"><noRegion><name sortKey="Traore, Amadou" sort="Traore, Amadou" uniqKey="Traore A" first="Amadou" last="Traoré">Amadou Traoré</name>
</noRegion>
</country>
<country name="Maroc"><region name="Rabat-Salé-Kénitra"><name sortKey="Fassi Fihri, Ouafaa" sort="Fassi Fihri, Ouafaa" uniqKey="Fassi Fihri O" first="Ouafaa" last="Fassi-Fihri">Ouafaa Fassi-Fihri</name>
</region>
</country>
<country name="Éthiopie"><noRegion><name sortKey="Ali, Abraham" sort="Ali, Abraham" uniqKey="Ali A" first="Abraham" last="Ali">Abraham Ali</name>
</noRegion>
<name sortKey="Demissie, Getnet F" sort="Demissie, Getnet F" uniqKey="Demissie G" first="Getnet F" last="Demissié">Getnet F. Demissié</name>
<name sortKey="Mamo, Gezahegne" sort="Mamo, Gezahegne" uniqKey="Mamo G" first="Gezahegne" last="Mamo">Gezahegne Mamo</name>
</country>
<country name="Nigeria"><noRegion><name sortKey="Kuranga, Sulyman A" sort="Kuranga, Sulyman A" uniqKey="Kuranga S" first="Sulyman A" last="Kuranga">Sulyman A. Kuranga</name>
</noRegion>
</country>
<country name="Arabie saoudite"><noRegion><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Écosse"><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
</region>
</country>
<country name="Hong Kong"><noRegion><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000864 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000864 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:29507189
   |texte=   MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:29507189" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki