MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.
Identifieur interne : 000982 ( PubMed/Curation ); précédent : 000981; suivant : 000983MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.
Auteurs : Daniel K W. Chu [République populaire de Chine] ; Kenrie P Y. Hui [République populaire de Chine] ; Ranawaka A P M. Perera [République populaire de Chine] ; Eve Miguel [France] ; Daniela Niemeyer [Allemagne] ; Jincun Zhao [États-Unis] ; Rudragouda Channappanavar [États-Unis] ; Gytis Dudas [États-Unis] ; Jamiu O. Oladipo [République populaire de Chine] ; Amadou Traoré [Burkina Faso] ; Ouafaa Fassi-Fihri [Maroc] ; Abraham Ali [Éthiopie] ; Getnet F. Demissié [Éthiopie] ; Doreen Muth [Allemagne] ; Michael C W. Chan [République populaire de Chine] ; John M. Nicholls [République populaire de Chine] ; David K. Meyerholz [États-Unis] ; Sulyman A. Kuranga [Nigeria] ; Gezahegne Mamo [Éthiopie] ; Ziqi Zhou [République populaire de Chine] ; Ray T Y. So [République populaire de Chine] ; Maged G. Hemida [Arabie saoudite] ; Richard J. Webby [États-Unis] ; Francois Roger [France] ; Andrew Rambaut [Royaume-Uni] ; Leo L M. Poon [République populaire de Chine] ; Stanley Perlman [États-Unis] ; Christian Drosten [Allemagne] ; Veronique Chevalier [France] ; Malik Peiris [Hong Kong]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2018.
Descripteurs français
- KwdFr :
- Afrique, Animaux, Chameaux (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Femelle, Humains, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (virologie), Phylogénie, Poumon (virologie), Réplication virale, Souris de lignée C57BL, Variation génétique, Zoonoses (virologie).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Infections à coronavirus.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Chameaux, Infections à coronavirus, Poumon, Zoonoses.
- Afrique, Animaux, Femelle, Humains, Phylogénie, Réplication virale, Souris de lignée C57BL, Variation génétique.
English descriptors
- KwdEn :
- Africa, Animals, Camelus (virology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Female, Genetic Variation, Humans, Lung (virology), Mice, Inbred C57BL, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Phylogeny, Virus Replication, Zoonoses (virology).
- MESH :
- genetics : Middle East Respiratory Syndrome Coronavirus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Camelus, Coronavirus Infections, Lung, Zoonoses.
- Africa, Animals, Female, Genetic Variation, Humans, Mice, Inbred C57BL, Phylogeny, Virus Replication.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene ORF4b Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking ORF4b elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, ORF4b deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface.
DOI: 10.1073/pnas.1718769115
PubMed: 29507189
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<author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name>
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<author><name sortKey="Traore, Amadou" sort="Traore, Amadou" uniqKey="Traore A" first="Amadou" last="Traoré">Amadou Traoré</name>
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<author><name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
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<author><name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T Y" last="So">Ray T Y. So</name>
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<author><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name>
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<author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name>
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<placeName><region type="state">Tennessee</region>
</placeName>
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<author><name sortKey="Roger, Francois" sort="Roger, Francois" uniqKey="Roger F" first="Francois" last="Roger">Francois Roger</name>
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<wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh</wicri:regionArea>
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<author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
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<author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
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<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
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<author><name sortKey="Chevalier, Veronique" sort="Chevalier, Veronique" uniqKey="Chevalier V" first="Veronique" last="Chevalier">Veronique Chevalier</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
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<country wicri:rule="url">Hong Kong</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.</title>
<author><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Hui, Kenrie P Y" sort="Hui, Kenrie P Y" uniqKey="Hui K" first="Kenrie P Y" last="Hui">Kenrie P Y. Hui</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
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<author><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
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</author>
<author><name sortKey="Miguel, Eve" sort="Miguel, Eve" uniqKey="Miguel E" first="Eve" last="Miguel">Eve Miguel</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niemeyer, Daniela" sort="Niemeyer, Daniela" uniqKey="Niemeyer D" first="Daniela" last="Niemeyer">Daniela Niemeyer</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dudas, Gytis" sort="Dudas, Gytis" uniqKey="Dudas G" first="Gytis" last="Dudas">Gytis Dudas</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Oladipo, Jamiu O" sort="Oladipo, Jamiu O" uniqKey="Oladipo J" first="Jamiu O" last="Oladipo">Jamiu O. Oladipo</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Traore, Amadou" sort="Traore, Amadou" uniqKey="Traore A" first="Amadou" last="Traoré">Amadou Traoré</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04, Burkina Faso.</nlm:affiliation>
<country xml:lang="fr">Burkina Faso</country>
<wicri:regionArea>Laboratoire de Biologie et Santé Animals, L'Institut de l'Environnement et de Recherches Agricoles du Burkina Faso/Centre National de la Recherche Scientifique et Technologique, 04 BP 8645 Ouagadougou 04</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fassi Fihri, Ouafaa" sort="Fassi Fihri, Ouafaa" uniqKey="Fassi Fihri O" first="Ouafaa" last="Fassi-Fihri">Ouafaa Fassi-Fihri</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat, Morocco.</nlm:affiliation>
<country xml:lang="fr">Maroc</country>
<wicri:regionArea>Institut Agronomique et Vétérinaire, Hassan II Université, B.P. 6202 Rabat-Instituts, Rabat</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ali, Abraham" sort="Ali, Abraham" uniqKey="Ali A" first="Abraham" last="Ali">Abraham Ali</name>
<affiliation wicri:level="1"><nlm:affiliation>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Bacterial, Parasitic and Zoonotic Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Demissie, Getnet F" sort="Demissie, Getnet F" uniqKey="Demissie G" first="Getnet F" last="Demissié">Getnet F. Demissié</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medecine, Haramaya University, Dire Dawa, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>College of Veterinary Medecine, Haramaya University, Dire Dawa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kuranga, Sulyman A" sort="Kuranga, Sulyman A" uniqKey="Kuranga S" first="Sulyman A" last="Kuranga">Sulyman A. Kuranga</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria.</nlm:affiliation>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mamo, Gezahegne" sort="Mamo, Gezahegne" uniqKey="Mamo G" first="Gezahegne" last="Mamo">Gezahegne Mamo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Ethiopia.</nlm:affiliation>
<country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Department of Veterinary Microbiology, Immunology and Public Health, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhou, Ziqi" sort="Zhou, Ziqi" uniqKey="Zhou Z" first="Ziqi" last="Zhou">Ziqi Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T Y" last="So">Ray T Y. So</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Hasa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roger, Francois" sort="Roger, Francois" uniqKey="Roger F" first="Francois" last="Roger">Francois Roger</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Evolutionary Biology, University of Edinburgh, EH9 2FL Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Iowa, Iowa City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Campus Charite Mitte, Charite-Universitätsmedizin Berlin, 10117 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chevalier, Veronique" sort="Chevalier, Veronique" uniqKey="Chevalier V" first="Veronique" last="Chevalier">Veronique Chevalier</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China; malik@hku.hk.</nlm:affiliation>
<country wicri:rule="url">Hong Kong</country>
<wicri:regionArea>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa</term>
<term>Animals</term>
<term>Camelus (virology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Lung (virology)</term>
<term>Mice, Inbred C57BL</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Phylogeny</term>
<term>Virus Replication</term>
<term>Zoonoses (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afrique</term>
<term>Animaux</term>
<term>Chameaux (virologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Phylogénie</term>
<term>Poumon (virologie)</term>
<term>Réplication virale</term>
<term>Souris de lignée C57BL</term>
<term>Variation génétique</term>
<term>Zoonoses (virologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term>
<term>Infections à coronavirus</term>
<term>Poumon</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term>
<term>Coronavirus Infections</term>
<term>Lung</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Africa</term>
<term>Animals</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
<term>Phylogeny</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Afrique</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Phylogénie</term>
<term>Réplication virale</term>
<term>Souris de lignée C57BL</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene <i>ORF4b</i>
Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking <i>ORF4b</i>
elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, <i>ORF4b</i>
deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29507189</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>115</Volume>
<Issue>12</Issue>
<PubDate><Year>2018</Year>
<Month>03</Month>
<Day>20</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
</Journal>
<ArticleTitle>MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.</ArticleTitle>
<Pagination><MedlinePgn>3144-3149</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1718769115</ELocationID>
<Abstract><AbstractText>Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene <i>ORF4b</i>
Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking <i>ORF4b</i>
elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, <i>ORF4b</i>
deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface.</AbstractText>
<CopyrightInformation>Copyright © 2018 the Author(s). Published by PNAS.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chu</LastName>
<ForeName>Daniel K W</ForeName>
<Initials>DKW</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hui</LastName>
<ForeName>Kenrie P Y</ForeName>
<Initials>KPY</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perera</LastName>
<ForeName>Ranawaka A P M</ForeName>
<Initials>RAPM</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Miguel</LastName>
<ForeName>Eve</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, F-34398 Montpellier, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, L'Institut de Recherche pour le Développement, CNRS, Universitè de Montpellier, F-34398 Montpellier, France.</Affiliation>
</AffiliationInfo>
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