Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus
Identifieur interne : 001428 ( Pmc/Curation ); précédent : 001427; suivant : 001429Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus
Auteurs : Troy C. Sutton ; Kanta SubbaraoSource :
- Virology [ 0042-6822 ] ; 2015.
Abstract
Two novel coronaviruses have emerged to cause severe disease in humans. While bats may be the primary reservoir for both viruses, SARS coronavirus (SARS-CoV) likely crossed into humans from civets in China, and MERS coronavirus (MERS-CoV) has been transmitted from camels in the Middle East. Unlike SARS-CoV that resolved within a year, continued introductions of MERS-CoV present an on-going public health threat. Animal models are needed to evaluate countermeasures against emerging viruses. With SARS-CoV, several animal species were permissive to infection. In contrast, most laboratory animals are refractory or only semi-permissive to infection with MERS-CoV. This host-range restriction is largely determined by sequence heterogeneity in the MERS-CoV receptor. We describe animal models developed to study coronaviruses, with a focus on host-range restriction at the level of the viral receptor and discuss approaches to consider in developing a model to evaluate countermeasures against MERS-CoV.
Url:
DOI: 10.1016/j.virol.2015.02.030
PubMed: 25791336
PubMed Central: 4793273
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<front><div type="abstract" xml:lang="en"><p>Two novel coronaviruses have emerged to cause severe disease in humans. While bats may be the primary reservoir for both viruses, SARS coronavirus (SARS-CoV) likely crossed into humans from civets in China, and MERS coronavirus (MERS-CoV) has been transmitted from camels in the Middle East. Unlike SARS-CoV that resolved within a year, continued introductions of MERS-CoV present an on-going public health threat. Animal models are needed to evaluate countermeasures against emerging viruses. With SARS-CoV, several animal species were permissive to infection. In contrast, most laboratory animals are refractory or only semi-permissive to infection with MERS-CoV. This host-range restriction is largely determined by sequence heterogeneity in the MERS-CoV receptor. We describe animal models developed to study coronaviruses, with a focus on host-range restriction at the level of the viral receptor and discuss approaches to consider in developing a model to evaluate countermeasures against MERS-CoV.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group><journal-title>Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0042-6822</issn>
<issn pub-type="epub">1096-0341</issn>
<publisher><publisher-name>Published by Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25791336</article-id>
<article-id pub-id-type="pmc">4793273</article-id>
<article-id pub-id-type="publisher-id">S0042-6822(15)00076-8</article-id>
<article-id pub-id-type="doi">10.1016/j.virol.2015.02.030</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Sutton</surname>
<given-names>Troy C.</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="au0010"><name><surname>Subbarao</surname>
<given-names>Kanta</given-names>
</name>
<email>ksubbarao@niaid.nih.gov</email>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="aff0005">Laboratory of Infectious Disease, NIAID, NIH, United States</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author. Tel.: +1 301 451 3839. <email>ksubbarao@niaid.nih.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>16</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>3</month>
<year>2015</year>
</pub-date>
<volume>479</volume>
<fpage>247</fpage>
<lpage>258</lpage>
<history><date date-type="received"><day>22</day>
<month>12</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>30</day>
<month>1</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>16</day>
<month>2</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 Published by Elsevier Inc.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder></copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="ab0005"><p>Two novel coronaviruses have emerged to cause severe disease in humans. While bats may be the primary reservoir for both viruses, SARS coronavirus (SARS-CoV) likely crossed into humans from civets in China, and MERS coronavirus (MERS-CoV) has been transmitted from camels in the Middle East. Unlike SARS-CoV that resolved within a year, continued introductions of MERS-CoV present an on-going public health threat. Animal models are needed to evaluate countermeasures against emerging viruses. With SARS-CoV, several animal species were permissive to infection. In contrast, most laboratory animals are refractory or only semi-permissive to infection with MERS-CoV. This host-range restriction is largely determined by sequence heterogeneity in the MERS-CoV receptor. We describe animal models developed to study coronaviruses, with a focus on host-range restriction at the level of the viral receptor and discuss approaches to consider in developing a model to evaluate countermeasures against MERS-CoV.</p>
</abstract>
<abstract abstract-type="author-highlights" id="ab0010"><title>Highlights</title>
<p><list list-type="simple" id="li0005"><list-item id="u0005"><label>•</label>
<p id="p0005">We discuss the development of animal models for SARS and MERS-CoV.</p>
</list-item>
<list-item id="u0010"><label>•</label>
<p id="p0010">Strategies to develop models for the FDA “Animal Rule” are illustrated.</p>
</list-item>
<list-item id="u0015"><label>•</label>
<p id="p0015">Host range is discussed in the context of viral receptor heterogeneity.</p>
</list-item>
</list>
</p>
</abstract>
<kwd-group id="keys0005"><title>Keywords</title>
<kwd>Coronaviruses</kwd>
<kwd>SARS-CoV</kwd>
<kwd>MERS-CoV</kwd>
<kwd>Animal models</kwd>
<kwd>Receptor</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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