Serveur d'exploration MERS

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Middle East respiratory syndrome (MERS) coronavirus and dromedaries

Identifieur interne : 001427 ( Pmc/Curation ); précédent : 001426; suivant : 001428

Middle East respiratory syndrome (MERS) coronavirus and dromedaries

Auteurs : Ulrich Wernery [Émirats arabes unis] ; Susanna K. P. Lau [République populaire de Chine] ; Patrick C. Y. Woo [République populaire de Chine]

Source :

RBID : PMC:7110516

Abstract

Highlights

Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease transmissible from dromedaries to human beings.

MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic but mild respiratory signs may occur.

No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries.

Dromedaries acquire MERS-CoV at less than 1 year of age and 100% of adult dromedaries are seropositive for the virus.

MERS-CoV in dromedaries is detected by virus isolation, quantitative reverse transcriptase-PCR or antigen detection.


Url:
DOI: 10.1016/j.tvjl.2016.12.020
PubMed: 28190501
PubMed Central: 7110516

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Links to Exploration step

PMC:7110516

Le document en format XML

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<p id="p0010">Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease transmissible from dromedaries to human beings.</p>
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<p id="p0015">MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic but mild respiratory signs may occur.</p>
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<p id="p0020">No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries.</p>
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<p id="p0025">Dromedaries acquire MERS-CoV at less than 1 year of age and 100% of adult dromedaries are seropositive for the virus.</p>
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</TEI>
<pmc article-type="review-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
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<journal-id journal-id-type="nlm-ta">Vet J</journal-id>
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<journal-title>Veterinary Journal (London, England : 1997)</journal-title>
</journal-title-group>
<issn pub-type="ppub">1090-0233</issn>
<issn pub-type="epub">1532-2971</issn>
<publisher>
<publisher-name>Published by Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">28190501</article-id>
<article-id pub-id-type="pmc">7110516</article-id>
<article-id pub-id-type="publisher-id">S1090-0233(17)30005-9</article-id>
<article-id pub-id-type="doi">10.1016/j.tvjl.2016.12.020</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Middle East respiratory syndrome (MERS) coronavirus and dromedaries</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" id="au0010">
<name>
<surname>Wernery</surname>
<given-names>Ulrich</given-names>
</name>
<email>cvrl@cvrl.ae</email>
<xref rid="af0010" ref-type="aff">a</xref>
<xref rid="co0010" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author" id="au0015">
<name>
<surname>Lau</surname>
<given-names>Susanna K.P.</given-names>
</name>
<xref rid="af0015" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au0020">
<name>
<surname>Woo</surname>
<given-names>Patrick C.Y.</given-names>
</name>
<xref rid="af0015" ref-type="aff">b</xref>
</contrib>
</contrib-group>
<aff id="af0010">
<label>a</label>
Central Veterinary Research Laboratory, Dubai, United Arab Emirates</aff>
<aff id="af0015">
<label>b</label>
Department of Microbiology, University of Hong Kong, Hong Kong, China</aff>
<author-notes>
<corresp id="co0010">
<label>*</label>
Corresponding author.
<email>cvrl@cvrl.ae</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release">
<day>9</day>
<month>1</month>
<year>2017</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub">
<month>2</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>9</day>
<month>1</month>
<year>2017</year>
</pub-date>
<volume>220</volume>
<fpage>75</fpage>
<lpage>79</lpage>
<history>
<date date-type="accepted">
<day>28</day>
<month>12</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>© 2017 Published by Elsevier Ltd.</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder></copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract abstract-type="author-highlights" id="ab0010">
<title>Highlights</title>
<p>
<list list-type="simple" id="ulist0010">
<list-item id="u0010">
<label></label>
<p id="p0010">Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease transmissible from dromedaries to human beings.</p>
</list-item>
<list-item id="u0015">
<label></label>
<p id="p0015">MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic but mild respiratory signs may occur.</p>
</list-item>
<list-item id="u0020">
<label></label>
<p id="p0020">No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries.</p>
</list-item>
<list-item id="u0025">
<label></label>
<p id="p0025">Dromedaries acquire MERS-CoV at less than 1 year of age and 100% of adult dromedaries are seropositive for the virus.</p>
</list-item>
<list-item id="u0030">
<label></label>
<p id="p0030">MERS-CoV in dromedaries is detected by virus isolation, quantitative reverse transcriptase-PCR or antigen detection.</p>
</list-item>
</list>
</p>
</abstract>
<abstract id="ab0015">
<p>Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease that can be transmitted from dromedaries to human beings. More than 1500 cases of MERS have been reported in human beings to date. Although MERS has been associated with 30% case fatality in human beings, MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic. In rare cases, dromedaries may develop mild respiratory signs. No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries. MERS-CoV is mainly acquired in dromedaries when they are less than 1 year of age, and the proportion of seropositivity increases with age to a seroprevalence of 100% in adult dromedaries. Laboratory diagnosis of MERS-CoV infection in dromedaries can be achieved through virus isolation using Vero cells, RNA detection by real-time quantitative reverse transcriptase-PCR and antigen detection using respiratory specimens or serum. Rapid nucleocapsid antigen detection using a lateral flow platform allows efficient screening of dromedaries carrying MERS-CoV. In addition to MERS-CoV, which is a lineage C virus in the
<italic>Betacoronavirus</italic>
(betaCoV) genus, a lineage B betaCoV and a virus in the
<italic>Alphacoronavirus</italic>
(alphaCoV) genus have been detected in dromedaries. Dromedary CoV UAE-HKU23 is closely related to human CoV OC43, whereas the alphaCoV has not been detected in human beings to date.</p>
</abstract>
<kwd-group id="kwd0010">
<title>Keywords</title>
<kwd>Middle East respiratory syndrome (MERS)</kwd>
<kwd>Coronavirus</kwd>
<kwd>Dromedary</kwd>
<kwd>Diagnosis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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