The prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) antibodies in dromedary camels in Israel
Identifieur interne : 000753 ( Pmc/Curation ); précédent : 000752; suivant : 000754The prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) antibodies in dromedary camels in Israel
Auteurs : Jennifer L. Harcourt ; Nir Rudoler ; Azaibi Tamin ; Eyal Leshem ; Michal Rasis ; Michael Giladi ; Lia M. HaynesSource :
- Zoonoses and Public Health [ 1863-1959 ] ; 2018.
Abstract
Middle East respiratory syndrome coronavirus, MERS‐CoV, was identified in Saudi Arabia in 2012, and as of January 29, 2018, there were 2,123 laboratory‐confirmed MERS‐CoV cases reported to WHO (WHO, 2018,
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DOI: 10.1111/zph.12482
PubMed: 29855166
PubMed Central: 6274617
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Middle East respiratory syndrome coronavirus, MERS‐CoV, was identified in Saudi Arabia in 2012, and as of January 29, 2018, there were 2,123 laboratory‐confirmed MERS‐CoV cases reported to WHO (WHO, 2018, <ext-link ext-link-type="uri" xlink:href="https://www.who.int/emergencies/mers-cov/en/">https://www.who.int/emergencies/mers-cov/en/</ext-link>
). Multiple studies suggest that dromedary camels are a source for human MERS‐CoV infection. MERS‐CoV‐specific antibodies have been detected in the serum of dromedary camels across Northern Africa and across the Arabian Peninsula. Israel's geographic location places Israel at risk for MERS‐CoV infection. To date, MERS‐CoV‐related illness has not been reported and the burden of MERS‐CoV infection in the Israeli population is unknown. The seroprevalence of MERS‐CoV‐specific antibodies in Israeli dromedary camels is unknown. The objective of this study was to determine the prevalence of MERS‐CoV seropositivity in dromedary camels in Israel. The prevalence of MERS‐CoV antibodies in Israeli camels was examined in 71 camel sera collected from four farms across Israel by MERS‐CoV‐specific microneutralization (Mnt) assay and confirmed by MERS‐CoV‐specific immunofluorescence assay (IFA). Although this study cannot rule out potential antibody cross‐reactivity by IFA, the presence of bovine coronavirus‐specific antibodies do not appear to impact detection of MERS‐CoV antibodies by Mnt. MERS‐CoV neutralizing antibodies were detectable in 51 (71.8%) camel sera, and no association was observed between the presence of neutralizing antibodies and camel age or gender. These findings extend the known range of MERS‐CoV circulation in Middle Eastern camels. The high rate of MERS‐CoV‐specific antibody seropositivity in dromedary camels in the absence of any reported human MERS cases suggests that there is still much to be learned about the dynamics of camel‐to‐human transmission of MERS‐CoV.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Zoonoses Public Health</journal-id>
<journal-id journal-id-type="iso-abbrev">Zoonoses Public Health</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1863-2378</journal-id>
<journal-id journal-id-type="publisher-id">ZPH</journal-id>
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<issn pub-type="ppub">1863-1959</issn>
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<title-group><article-title>The prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) antibodies in dromedary camels in Israel</article-title>
<alt-title alt-title-type="left-running-head">HARCOURT et al.</alt-title>
</title-group>
<contrib-group><contrib id="zph12482-cr-0001" contrib-type="author" corresp="yes"><name><surname>Harcourt</surname>
<given-names>Jennifer L.</given-names>
</name>
<contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-3271-4174</contrib-id>
<xref ref-type="aff" rid="zph12482-aff-0001"><sup>1</sup>
</xref>
<address><email>zaq6@cdc.gov</email>
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<contrib id="zph12482-cr-0002" contrib-type="author"><name><surname>Rudoler</surname>
<given-names>Nir</given-names>
</name>
<xref ref-type="aff" rid="zph12482-aff-0002"><sup>2</sup>
</xref>
</contrib>
<contrib id="zph12482-cr-0003" contrib-type="author"><name><surname>Tamin</surname>
<given-names>Azaibi</given-names>
</name>
<xref ref-type="aff" rid="zph12482-aff-0001"><sup>1</sup>
</xref>
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<contrib id="zph12482-cr-0004" contrib-type="author"><name><surname>Leshem</surname>
<given-names>Eyal</given-names>
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<xref ref-type="aff" rid="zph12482-aff-0003"><sup>3</sup>
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<contrib id="zph12482-cr-0005" contrib-type="author"><name><surname>Rasis</surname>
<given-names>Michal</given-names>
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<xref ref-type="aff" rid="zph12482-aff-0004"><sup>4</sup>
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<contrib id="zph12482-cr-0006" contrib-type="author"><name><surname>Giladi</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="zph12482-aff-0004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="zph12482-aff-0005"><sup>5</sup>
</xref>
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<contrib id="zph12482-cr-0007" contrib-type="author"><name><surname>Haynes</surname>
<given-names>Lia M.</given-names>
</name>
<xref ref-type="aff" rid="zph12482-aff-0006"><sup>6</sup>
</xref>
</contrib>
</contrib-group>
<aff id="zph12482-aff-0001"><label><sup>1</sup>
</label>
<named-content content-type="organisation-division">National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Gastroenteritis and Respiratory Viruses Laboratory Branch</named-content>
<institution>Centers for Disease Control and Prevention (CDC)</institution>
<city>Atlanta</city>
<named-content content-type="country-part">Georgia</named-content>
</aff>
<aff id="zph12482-aff-0002"><label><sup>2</sup>
</label>
<named-content content-type="organisation-division">Koret School of Veterinary Medicine, Faculty of Agriculture</named-content>
<institution>Hebrew University</institution>
<city>Rehovot</city>
<country country="IL">Israel</country>
</aff>
<aff id="zph12482-aff-0003"><label><sup>3</sup>
</label>
<named-content content-type="organisation-division">National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Epidemiology Branch</named-content>
<institution>Centers for Disease Control and Prevention (CDC)</institution>
<city>Atlanta</city>
<named-content content-type="country-part">Georgia</named-content>
</aff>
<aff id="zph12482-aff-0004"><label><sup>4</sup>
</label>
<named-content content-type="organisation-division">Bernard Pridan Laboratory for Molecular Biology of Infectious Diseases</named-content>
<institution>Tel Aviv Sourasky Medical Center</institution>
<city>Tel Aviv</city>
<country country="IL">Israel</country>
</aff>
<aff id="zph12482-aff-0005"><label><sup>5</sup>
</label>
<named-content content-type="organisation-division">Sackler Faculty of Medicine</named-content>
<institution>Tel Aviv University</institution>
<city>Tel Aviv</city>
<country country="IL">Israel</country>
</aff>
<aff id="zph12482-aff-0006"><label><sup>6</sup>
</label>
<named-content content-type="organisation-division">National Center for Immunization and Respiratory Diseases, Division of Viral Diseases</named-content>
<institution>Centers for Disease Control and Prevention (CDC)</institution>
<city>Atlanta</city>
<named-content content-type="country-part">Georgia</named-content>
</aff>
<author-notes><corresp id="correspondenceTo"><label>*</label>
<bold>Correspondence</bold>
<break></break>
Jennifer L. Harcourt, Division of Viral Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G‐18, Atlanta, 30333, GA.<break></break>
Email: <email>zaq6@cdc.gov</email>
<break></break>
</corresp>
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<pub-date pub-type="epub"><day>31</day>
<month>5</month>
<year>2018</year>
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<pub-date pub-type="ppub"><month>9</month>
<year>2018</year>
</pub-date>
<volume>65</volume>
<issue>6</issue>
<issue-id pub-id-type="doi">10.1111/zph.2018.65.issue-6</issue-id>
<fpage>749</fpage>
<lpage>754</lpage>
<history><date date-type="received"><day>29</day>
<month>1</month>
<year>2018</year>
</date>
<date date-type="rev-recd"><day>24</day>
<month>4</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>28</day>
<month>4</month>
<year>2018</year>
</date>
</history>
<permissions><pmc-comment> Copyright © 2018 Blackwell Verlag GmbH </pmc-comment>
<copyright-statement content-type="article-copyright">© 2018 Blackwell Verlag GmbH</copyright-statement>
<license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p>
</license>
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<self-uri content-type="pdf" xlink:href="file:ZPH-65-749.pdf"></self-uri>
<abstract id="zph12482-abs-0001"><title>Abstract</title>
<p>Middle East respiratory syndrome coronavirus, MERS‐CoV, was identified in Saudi Arabia in 2012, and as of January 29, 2018, there were 2,123 laboratory‐confirmed MERS‐CoV cases reported to WHO (WHO, 2018, <ext-link ext-link-type="uri" xlink:href="https://www.who.int/emergencies/mers-cov/en/">https://www.who.int/emergencies/mers-cov/en/</ext-link>
). Multiple studies suggest that dromedary camels are a source for human MERS‐CoV infection. MERS‐CoV‐specific antibodies have been detected in the serum of dromedary camels across Northern Africa and across the Arabian Peninsula. Israel's geographic location places Israel at risk for MERS‐CoV infection. To date, MERS‐CoV‐related illness has not been reported and the burden of MERS‐CoV infection in the Israeli population is unknown. The seroprevalence of MERS‐CoV‐specific antibodies in Israeli dromedary camels is unknown. The objective of this study was to determine the prevalence of MERS‐CoV seropositivity in dromedary camels in Israel. The prevalence of MERS‐CoV antibodies in Israeli camels was examined in 71 camel sera collected from four farms across Israel by MERS‐CoV‐specific microneutralization (Mnt) assay and confirmed by MERS‐CoV‐specific immunofluorescence assay (IFA). Although this study cannot rule out potential antibody cross‐reactivity by IFA, the presence of bovine coronavirus‐specific antibodies do not appear to impact detection of MERS‐CoV antibodies by Mnt. MERS‐CoV neutralizing antibodies were detectable in 51 (71.8%) camel sera, and no association was observed between the presence of neutralizing antibodies and camel age or gender. These findings extend the known range of MERS‐CoV circulation in Middle Eastern camels. The high rate of MERS‐CoV‐specific antibody seropositivity in dromedary camels in the absence of any reported human MERS cases suggests that there is still much to be learned about the dynamics of camel‐to‐human transmission of MERS‐CoV.</p>
</abstract>
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<notes><p content-type="self-citation"><mixed-citation publication-type="journal" id="zph12482-cit-1001"><string-name><surname>Harcourt</surname>
<given-names>JL</given-names>
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, <string-name><surname>Tamin</surname>
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, et al. <article-title>The prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) antibodies in dromedary camels in Israel</article-title>
. <source xml:lang="en">Zoonoses Public Health</source>
. <year>2018</year>
;<volume>65</volume>
:<fpage>749</fpage>
–<lpage>754</lpage>
. <pub-id pub-id-type="doi">10.1111/zph.12482</pub-id>
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<fn-group id="zph12482-ntgp-0001"><fn fn-type="equal" id="zph12482-note-0001"><p>The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention.</p>
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