Human monoclonal antibodies as candidate therapeutics against emerging viruses
Identifieur interne : 000516 ( Pmc/Curation ); précédent : 000515; suivant : 000517Human monoclonal antibodies as candidate therapeutics against emerging viruses
Auteurs : Yujia Jin [République populaire de Chine] ; Cheng Lei [République populaire de Chine] ; Dan Hu [République populaire de Chine] ; Dimiter S. Dimitrov [États-Unis] ; Tianlei Ying [République populaire de Chine]Source :
- Frontiers of Medicine [ 2095-0217 ] ; 2017.
Abstract
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses
Url:
DOI: 10.1007/s11684-017-0596-6
PubMed: 29159596
PubMed Central: 7088856
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<series><title level="j">Frontiers of Medicine</title>
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<front><div type="abstract" xml:lang="en"><p>The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses <italic>in vitro</italic>
and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.</p>
</div>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Med</journal-id>
<journal-title-group><journal-title>Frontiers of Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">2095-0217</issn>
<issn pub-type="epub">2095-0225</issn>
<publisher><publisher-name>Higher Education Press</publisher-name>
<publisher-loc>Beijing</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29159596</article-id>
<article-id pub-id-type="pmc">7088856</article-id>
<article-id pub-id-type="publisher-id">596</article-id>
<article-id pub-id-type="doi">10.1007/s11684-017-0596-6</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Human monoclonal antibodies as candidate therapeutics against emerging viruses</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jin</surname>
<given-names>Yujia</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lei</surname>
<given-names>Cheng</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hu</surname>
<given-names>Dan</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Dimitrov</surname>
<given-names>Dimiter S.</given-names>
</name>
<address><email>dimitrdi@mail.nih.gov</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Ying</surname>
<given-names>Tianlei</given-names>
</name>
<address><email>tlying@fudan.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id>
<institution-id institution-id-type="GRID">grid.8547.e</institution-id>
<institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution>
<institution>Fudan University,</institution>
</institution-wrap>
Shanghai, 200032 China</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2297 5165</institution-id>
<institution-id institution-id-type="GRID">grid.94365.3d</institution-id>
<institution>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute,</institution>
<institution>National Institutes of Health,</institution>
</institution-wrap>
Frederick, MD 21702 USA</aff>
</contrib-group>
<pub-date pub-type="epub"><day>20</day>
<month>11</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="ppub"><year>2017</year>
</pub-date>
<volume>11</volume>
<issue>4</issue>
<fpage>462</fpage>
<lpage>470</lpage>
<history><date date-type="received"><day>26</day>
<month>8</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>10</day>
<month>10</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© Higher Education Press and Springer-Verlag GmbH Germany 2017</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses <italic>in vitro</italic>
and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>human monoclonal antibodies</kwd>
<kwd>emerging infectious diseases</kwd>
<kwd>SARS-CoV</kwd>
<kwd>MERS-CoV</kwd>
<kwd>Ebola virus</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Higher Education Press and Springer-Verlag GmbH Germany 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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