Human monoclonal antibodies as candidate therapeutics against emerging viruses
Identifieur interne : 000516 ( Pmc/Corpus ); précédent : 000515; suivant : 000517Human monoclonal antibodies as candidate therapeutics against emerging viruses
Auteurs : Yujia Jin ; Cheng Lei ; Dan Hu ; Dimiter S. Dimitrov ; Tianlei YingSource :
- Frontiers of Medicine [ 2095-0217 ] ; 2017.
Abstract
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses
Url:
DOI: 10.1007/s11684-017-0596-6
PubMed: 29159596
PubMed Central: 7088856
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human monoclonal antibodies as candidate therapeutics against emerging viruses</title><author><name sortKey="Jin, Yujia" sort="Jin, Yujia" uniqKey="Jin Y" first="Yujia" last="Jin">Yujia Jin</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author><author><name sortKey="Lei, Cheng" sort="Lei, Cheng" uniqKey="Lei C" first="Cheng" last="Lei">Cheng Lei</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author><author><name sortKey="Hu, Dan" sort="Hu, Dan" uniqKey="Hu D" first="Dan" last="Hu">Dan Hu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author><author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S." last="Dimitrov">Dimiter S. Dimitrov</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2297 5165</institution-id><institution-id institution-id-type="GRID">grid.94365.3d</institution-id><institution>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute,</institution><institution>National Institutes of Health,</institution></institution-wrap>Frederick, MD 21702 USA</nlm:aff></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29159596</idno><idno type="pmc">7088856</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088856</idno><idno type="RBID">PMC:7088856</idno><idno type="doi">10.1007/s11684-017-0596-6</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000516</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000516</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human monoclonal antibodies as candidate therapeutics against emerging viruses</title><author><name sortKey="Jin, Yujia" sort="Jin, Yujia" uniqKey="Jin Y" first="Yujia" last="Jin">Yujia Jin</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author><author><name sortKey="Lei, Cheng" sort="Lei, Cheng" uniqKey="Lei C" first="Cheng" last="Lei">Cheng Lei</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author><author><name sortKey="Hu, Dan" sort="Hu, Dan" uniqKey="Hu D" first="Dan" last="Hu">Dan Hu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author><author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S." last="Dimitrov">Dimiter S. Dimitrov</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2297 5165</institution-id><institution-id institution-id-type="GRID">grid.94365.3d</institution-id><institution>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute,</institution><institution>National Institutes of Health,</institution></institution-wrap>Frederick, MD 21702 USA</nlm:aff></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers of Medicine</title><idno type="ISSN">2095-0217</idno><idno type="eISSN">2095-0225</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses <italic>in vitro</italic> and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Günther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name></author><author><name sortKey="Burguiere, Am" uniqKey="Burguiere A">AM Burguière</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S Kramme</name></author><author><name sortKey="Manuguerra, Jc" uniqKey="Manuguerra J">JC Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S Müller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M Stürmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S Vieth</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H Schmitz</name></author><author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name></author><author><name sortKey="Comer, Ja" uniqKey="Comer J">JA Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name></author><author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name></author><author><name sortKey="Humphrey, Cd" uniqKey="Humphrey C">CD Humphrey</name></author><author><name sortKey="Shieh, Wj" uniqKey="Shieh W">WJ Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name></author><author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B Fields</name></author><author><name sortKey="De Risi, J" uniqKey="De Risi J">J De Risi</name></author><author><name sortKey="Yang, Jy" uniqKey="Yang J">JY Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name></author><author><name sortKey="Hughes, Jm" uniqKey="Hughes J">JM Hughes</name></author><author><name sortKey="Le Duc, Jw" uniqKey="Le Duc J">JW Le Duc</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yam, Ly" uniqKey="Yam L">LY Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name></author><author><name sortKey="Yee, Wk" uniqKey="Yee W">WK Yee</name></author><author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name></author><author><name sortKey="Cheung, Mt" uniqKey="Cheung M">MT Cheung</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Tsang, Dn" uniqKey="Tsang D">DN Tsang</name></author><author><name sortKey="Yung, Rw" uniqKey="Yung R">RW Yung</name></author><author><name sortKey="Ng, Tk" uniqKey="Ng T">TK Ng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name></author><author><name sortKey="Van Doornum, Gj" uniqKey="Van Doornum G">GJ van Doornum</name></author><author><name sortKey="Van Den Hoogen, Bg" uniqKey="Van Den Hoogen B">BG van den Hoogen</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stöhr</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name></author><author><name sortKey="Rimmelzwaan, G V" uniqKey="Rimmelzwaan G">G v Rimmelzwaan</name></author><author><name sortKey="Amerongen, G" uniqKey="Amerongen G">G Amerongen</name></author><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name></author><author><name sortKey="Laman, Jd" uniqKey="Laman J">JD Laman</name></author><author><name sortKey="De Jong, T" uniqKey="De Jong T">T de Jong</name></author><author><name sortKey="Van Doornum, G" uniqKey="Van Doornum G">G van Doornum</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name></author><author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N Escriou</name></author><author><name sortKey="Manuguerra, Jc" uniqKey="Manuguerra J">JC Manuguerra</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stöhr</name></author><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Geisbert, Tw" uniqKey="Geisbert T">TW Geisbert</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lyon, Gm" uniqKey="Lyon G">GM Lyon</name></author><author><name sortKey="Mehta, Ak" uniqKey="Mehta A">AK Mehta</name></author><author><name sortKey="Varkey, Jb" uniqKey="Varkey J">JB Varkey</name></author><author><name sortKey="Brantly, K" uniqKey="Brantly K">K Brantly</name></author><author><name sortKey="Plyler, L" uniqKey="Plyler L">L Plyler</name></author><author><name sortKey="Mcelroy, Ak" uniqKey="Mcelroy A">AK McElroy</name></author><author><name sortKey="Kraft, Cs" uniqKey="Kraft C">CS Kraft</name></author><author><name sortKey="Towner, Js" uniqKey="Towner J">JS Towner</name></author><author><name sortKey="Spiropoulou, C" uniqKey="Spiropoulou C">C Spiropoulou</name></author><author><name sortKey="Stroher, U" uniqKey="Stroher U">U Ströher</name></author><author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name></author><author><name sortKey="Ribner, Bs" uniqKey="Ribner B">BS Ribner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winau, F" uniqKey="Winau F">F Winau</name></author><author><name sortKey="Winau, R" uniqKey="Winau R">R Winau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berry, Jd" uniqKey="Berry J">JD Berry</name></author><author><name sortKey="Gaudet, Rg" uniqKey="Gaudet R">RG Gaudet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casadevall, A" uniqKey="Casadevall A">A Casadevall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author><author><name sortKey="Marks, Jd" uniqKey="Marks J">JD Marks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Dimitrov, As" uniqKey="Dimitrov A">AS Dimitrov</name></author><author><name sortKey="Chakraborti, S" uniqKey="Chakraborti S">S Chakraborti</name></author><author><name sortKey="Dimitrova, D" uniqKey="Dimitrova D">D Dimitrova</name></author><author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name></author><author><name sortKey="Broder, Cc" uniqKey="Broder C">CC Broder</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulman, M" uniqKey="Shulman M">M Shulman</name></author><author><name sortKey="Wilde, Cd" uniqKey="Wilde C">CD Wilde</name></author><author><name sortKey="Kohler, G" uniqKey="Kohler G">G Köhler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gp" uniqKey="Smith G">GP Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gp" uniqKey="Smith G">GP Smith</name></author><author><name sortKey="Petrenko, Va" uniqKey="Petrenko V">VA Petrenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, C" uniqKey="Gao C">C Gao</name></author><author><name sortKey="Mao, S" uniqKey="Mao S">S Mao</name></author><author><name sortKey="Kaufmann, G" uniqKey="Kaufmann G">G Kaufmann</name></author><author><name sortKey="Wirsching, P" uniqKey="Wirsching P">P Wirsching</name></author><author><name sortKey="Lerner, Ra" uniqKey="Lerner R">RA Lerner</name></author><author><name sortKey="Janda, Kd" uniqKey="Janda K">KD Janda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccafferty, J" uniqKey="Mccafferty J">J McCafferty</name></author><author><name sortKey="Fitzgerald, Kj" uniqKey="Fitzgerald K">KJ Fitzgerald</name></author><author><name sortKey="Earnshaw, J" uniqKey="Earnshaw J">J Earnshaw</name></author><author><name sortKey="Chiswell, Dj" uniqKey="Chiswell D">DJ Chiswell</name></author><author><name sortKey="Link, J" uniqKey="Link J">J Link</name></author><author><name sortKey="Smith, R" uniqKey="Smith R">R Smith</name></author><author><name sortKey="Kenten, J" uniqKey="Kenten J">J Kenten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davies, El" uniqKey="Davies E">EL Davies</name></author><author><name sortKey="Smith, Js" uniqKey="Smith J">JS Smith</name></author><author><name sortKey="Birkett, Cr" uniqKey="Birkett C">CR Birkett</name></author><author><name sortKey="Manser, Jm" uniqKey="Manser J">JM Manser</name></author><author><name sortKey="Anderson Dear, Dv" uniqKey="Anderson Dear D">DV Anderson-Dear</name></author><author><name sortKey="Young, Jr" uniqKey="Young J">JR Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sok, D" uniqKey="Sok D">D Sok</name></author><author><name sortKey="Briney, B" uniqKey="Briney B">B Briney</name></author><author><name sortKey="Jardine, Jg" uniqKey="Jardine J">JG Jardine</name></author><author><name sortKey="Kulp, Dw" uniqKey="Kulp D">DW Kulp</name></author><author><name sortKey="Menis, S" uniqKey="Menis S">S Menis</name></author><author><name sortKey="Pauthner, M" uniqKey="Pauthner M">M Pauthner</name></author><author><name sortKey="Wood, A" uniqKey="Wood A">A Wood</name></author><author><name sortKey="Lee, Ec" uniqKey="Lee E">EC Lee</name></author><author><name sortKey="Le, Km" uniqKey="Le K">KM Le</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name></author><author><name sortKey="Ramos, A" uniqKey="Ramos A">A Ramos</name></author><author><name sortKey="Kalyuzhniy, O" uniqKey="Kalyuzhniy O">O Kalyuzhniy</name></author><author><name sortKey="Adachi, Y" uniqKey="Adachi Y">Y Adachi</name></author><author><name sortKey="Kubitz, M" uniqKey="Kubitz M">M Kubitz</name></author><author><name sortKey="Macpherson, S" uniqKey="Macpherson S">S MacPherson</name></author><author><name sortKey="Bradley, A" uniqKey="Bradley A">A Bradley</name></author><author><name sortKey="Friedrich, Ga" uniqKey="Friedrich G">GA Friedrich</name></author><author><name sortKey="Schief, Wr" uniqKey="Schief W">WR Schief</name></author><author><name sortKey="Burton, Dr" uniqKey="Burton D">DR Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Aj" uniqKey="Murphy A">AJ Murphy</name></author><author><name sortKey="Macdonald, Le" uniqKey="Macdonald L">LE Macdonald</name></author><author><name sortKey="Stevens, S" uniqKey="Stevens S">S Stevens</name></author><author><name sortKey="Karow, M" uniqKey="Karow M">M Karow</name></author><author><name sortKey="Dore, At" uniqKey="Dore A">AT Dore</name></author><author><name sortKey="Pobursky, K" uniqKey="Pobursky K">K Pobursky</name></author><author><name sortKey="Huang, Tt" uniqKey="Huang T">TT Huang</name></author><author><name sortKey="Poueymirou, Wt" uniqKey="Poueymirou W">WT Poueymirou</name></author><author><name sortKey="Esau, L" uniqKey="Esau L">L Esau</name></author><author><name sortKey="Meola, M" uniqKey="Meola M">M Meola</name></author><author><name sortKey="Mikulka, W" uniqKey="Mikulka W">W Mikulka</name></author><author><name sortKey="Krueger, P" uniqKey="Krueger P">P Krueger</name></author><author><name sortKey="Fairhurst, J" uniqKey="Fairhurst J">J Fairhurst</name></author><author><name sortKey="Valenzuela, Dm" uniqKey="Valenzuela D">DM Valenzuela</name></author><author><name sortKey="Papadopoulos, N" uniqKey="Papadopoulos N">N Papadopoulos</name></author><author><name sortKey="Yancopoulos, Gd" uniqKey="Yancopoulos G">GD Yancopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipke, Pn" uniqKey="Lipke P">PN Lipke</name></author><author><name sortKey="Kurjan, J" uniqKey="Kurjan J">J Kurjan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boder, Et" uniqKey="Boder E">ET Boder</name></author><author><name sortKey="Wittrup, Kd" uniqKey="Wittrup K">KD Wittrup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boder, Et" uniqKey="Boder E">ET Boder</name></author><author><name sortKey="Wittrup, Kd" uniqKey="Wittrup K">KD Wittrup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kieke, Mc" uniqKey="Kieke M">MC Kieke</name></author><author><name sortKey="Cho, Bk" uniqKey="Cho B">BK Cho</name></author><author><name sortKey="Boder, Et" uniqKey="Boder E">ET Boder</name></author><author><name sortKey="Kranz, Dm" uniqKey="Kranz D">DM Kranz</name></author><author><name sortKey="Wittrup, Kd" uniqKey="Wittrup K">KD Wittrup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wardemann, H" uniqKey="Wardemann H">H Wardemann</name></author><author><name sortKey="Yurasov, S" uniqKey="Yurasov S">S Yurasov</name></author><author><name sortKey="Schaefer, A" uniqKey="Schaefer A">A Schaefer</name></author><author><name sortKey="Young, Jw" uniqKey="Young J">JW Young</name></author><author><name sortKey="Meffre, E" uniqKey="Meffre E">E Meffre</name></author><author><name sortKey="Nussenzweig, Mc" uniqKey="Nussenzweig M">MC Nussenzweig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, Lm" uniqKey="Walker L">LM Walker</name></author><author><name sortKey="Phogat, Sk" uniqKey="Phogat S">SK Phogat</name></author><author><name sortKey="Chan Hui, Py" uniqKey="Chan Hui P">PY Chan-Hui</name></author><author><name sortKey="Wagner, D" uniqKey="Wagner D">D Wagner</name></author><author><name sortKey="Phung, P" uniqKey="Phung P">P Phung</name></author><author><name sortKey="Goss, Jl" uniqKey="Goss J">JL Goss</name></author><author><name sortKey="Wrin, T" uniqKey="Wrin T">T Wrin</name></author><author><name sortKey="Simek, Md" uniqKey="Simek M">MD Simek</name></author><author><name sortKey="Fling, S" uniqKey="Fling S">S Fling</name></author><author><name sortKey="Mitcham, Jl" uniqKey="Mitcham J">JL Mitcham</name></author><author><name sortKey="Lehrman, Jk" uniqKey="Lehrman J">JK Lehrman</name></author><author><name sortKey="Priddy, Fh" uniqKey="Priddy F">FH Priddy</name></author><author><name sortKey="Olsen, Oa" uniqKey="Olsen O">OA Olsen</name></author><author><name sortKey="Frey, Sm" uniqKey="Frey S">SM Frey</name></author><author><name sortKey="Hammond, Pw" uniqKey="Hammond P">PW Hammond</name></author><author><name sortKey="Protocol, G P I" uniqKey="Protocol G">G P I Protocol</name></author><author><name sortKey="Kaminsky, S" uniqKey="Kaminsky S">S Kaminsky</name></author><author><name sortKey="Zamb, T" uniqKey="Zamb T">T Zamb</name></author><author><name sortKey="Moyle, M" uniqKey="Moyle M">M Moyle</name></author><author><name sortKey="Koff, Wc" uniqKey="Koff W">WC Koff</name></author><author><name sortKey="Poignard, P" uniqKey="Poignard P">P Poignard</name></author><author><name sortKey="Burton, Dr" uniqKey="Burton D">DR Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, Lm" uniqKey="Walker L">LM Walker</name></author><author><name sortKey="Huber, M" uniqKey="Huber M">M Huber</name></author><author><name sortKey="Doores, Kj" uniqKey="Doores K">KJ Doores</name></author><author><name sortKey="Falkowska, E" uniqKey="Falkowska E">E Falkowska</name></author><author><name sortKey="Pejchal, R" uniqKey="Pejchal R">R Pejchal</name></author><author><name sortKey="Julien, Jp" uniqKey="Julien J">JP Julien</name></author><author><name sortKey="Wang, Sk" uniqKey="Wang S">SK Wang</name></author><author><name sortKey="Ramos, A" uniqKey="Ramos A">A Ramos</name></author><author><name sortKey="Chan Hui, Py" uniqKey="Chan Hui P">PY Chan-Hui</name></author><author><name sortKey="Moyle, M" uniqKey="Moyle M">M Moyle</name></author><author><name sortKey="Mitcham, Jl" uniqKey="Mitcham J">JL Mitcham</name></author><author><name sortKey="Hammond, Pw" uniqKey="Hammond P">PW Hammond</name></author><author><name sortKey="Olsen, Oa" uniqKey="Olsen O">OA Olsen</name></author><author><name sortKey="Phung, P" uniqKey="Phung P">P Phung</name></author><author><name sortKey="Fling, S" uniqKey="Fling S">S Fling</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author><author><name sortKey="Phogat, S" uniqKey="Phogat S">S Phogat</name></author><author><name sortKey="Wrin, T" uniqKey="Wrin T">T Wrin</name></author><author><name sortKey="Simek, Md" uniqKey="Simek M">MD Simek</name></author><author><name sortKey="Protocol, G P I" uniqKey="Protocol G">G P I Protocol</name></author><author><name sortKey="Koff, Wc" uniqKey="Koff W">WC Koff</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author><author><name sortKey="Burton, Dr" uniqKey="Burton D">DR Burton</name></author><author><name sortKey="Poignard, P" uniqKey="Poignard P">P Poignard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traggiai, E" uniqKey="Traggiai E">E Traggiai</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name></author><author><name sortKey="Uematsu, Y" uniqKey="Uematsu Y">Y Uematsu</name></author><author><name sortKey="Gismondo, Mr" uniqKey="Gismondo M">MR Gismondo</name></author><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R Rappuoli</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aman, P" uniqKey="Aman P">P Aman</name></author><author><name sortKey="Ehlin Henriksson, B" uniqKey="Ehlin Henriksson B">B Ehlin-Henriksson</name></author><author><name sortKey="Klein, G" uniqKey="Klein G">G Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bres, P" uniqKey="Bres P">P Brès</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ka, D" uniqKey="Ka D">D Ka</name></author><author><name sortKey="Fall, G" uniqKey="Fall G">G Fall</name></author><author><name sortKey="Diallo, Vc" uniqKey="Diallo V">VC Diallo</name></author><author><name sortKey="Faye, O" uniqKey="Faye O">O Faye</name></author><author><name sortKey="Fortes, Ld" uniqKey="Fortes L">LD Fortes</name></author><author><name sortKey="Faye, O" uniqKey="Faye O">O Faye</name></author><author><name sortKey="Bah, Ei" uniqKey="Bah E">EI Bah</name></author><author><name sortKey="Diallo, Km" uniqKey="Diallo K">KM Diallo</name></author><author><name sortKey="Balique, F" uniqKey="Balique F">F Balique</name></author><author><name sortKey="Ndour, Ct" uniqKey="Ndour C">CT Ndour</name></author><author><name sortKey="Seydi, M" uniqKey="Seydi M">M Seydi</name></author><author><name sortKey="Sall, Aa" uniqKey="Sall A">AA Sall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Yh" uniqKey="Li Y">YH Li</name></author><author><name sortKey="Chen, Sp" uniqKey="Chen S">SP Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geisbert, Tw" uniqKey="Geisbert T">TW Geisbert</name></author><author><name sortKey="Jahrling, Pb" uniqKey="Jahrling P">PB Jahrling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name></author><author><name sortKey="Fusco, Ml" uniqKey="Fusco M">ML Fusco</name></author><author><name sortKey="Hessell, Aj" uniqKey="Hessell A">AJ Hessell</name></author><author><name sortKey="Oswald, Wb" uniqKey="Oswald W">WB Oswald</name></author><author><name sortKey="Burton, Dr" uniqKey="Burton D">DR Burton</name></author><author><name sortKey="Saphire, Eo" uniqKey="Saphire E">EO Saphire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hood, Cl" uniqKey="Hood C">CL Hood</name></author><author><name sortKey="Abraham, J" uniqKey="Abraham J">J Abraham</name></author><author><name sortKey="Boyington, Jc" uniqKey="Boyington J">JC Boyington</name></author><author><name sortKey="Leung, K" uniqKey="Leung K">K Leung</name></author><author><name sortKey="Kwong, Pd" uniqKey="Kwong P">PD Kwong</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richardson, Js" uniqKey="Richardson J">JS Richardson</name></author><author><name sortKey="Yao, Mk" uniqKey="Yao M">MK Yao</name></author><author><name sortKey="Tran, Kn" uniqKey="Tran K">KN Tran</name></author><author><name sortKey="Croyle, Ma" uniqKey="Croyle M">MA Croyle</name></author><author><name sortKey="Strong, Je" uniqKey="Strong J">JE Strong</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Kobinger, Gp" uniqKey="Kobinger G">GP Kobinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Sm" uniqKey="Jones S">SM Jones</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Stroher, U" uniqKey="Stroher U">U Ströher</name></author><author><name sortKey="Geisbert, Jb" uniqKey="Geisbert J">JB Geisbert</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name></author><author><name sortKey="Grolla, A" uniqKey="Grolla A">A Grolla</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author><author><name sortKey="Sullivan, Nj" uniqKey="Sullivan N">NJ Sullivan</name></author><author><name sortKey="Volchkov, Ve" uniqKey="Volchkov V">VE Volchkov</name></author><author><name sortKey="Fritz, Ea" uniqKey="Fritz E">EA Fritz</name></author><author><name sortKey="Daddario, Km" uniqKey="Daddario K">KM Daddario</name></author><author><name sortKey="Hensley, Le" uniqKey="Hensley L">LE Hensley</name></author><author><name sortKey="Jahrling, Pb" uniqKey="Jahrling P">PB Jahrling</name></author><author><name sortKey="Geisbert, Tw" uniqKey="Geisbert T">TW Geisbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warfield, Kl" uniqKey="Warfield K">KL Warfield</name></author><author><name sortKey="Swenson, Dl" uniqKey="Swenson D">DL Swenson</name></author><author><name sortKey="Olinger, Gg" uniqKey="Olinger G">GG Olinger</name></author><author><name sortKey="Kalina, Wv" uniqKey="Kalina W">WV Kalina</name></author><author><name sortKey="Aman, Mj" uniqKey="Aman M">MJ Aman</name></author><author><name sortKey="Bavari, S" uniqKey="Bavari S">S Bavari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowling, W" uniqKey="Dowling W">W Dowling</name></author><author><name sortKey="Thompson, E" uniqKey="Thompson E">E Thompson</name></author><author><name sortKey="Badger, C" uniqKey="Badger C">C Badger</name></author><author><name sortKey="Mellquist, Jl" uniqKey="Mellquist J">JL Mellquist</name></author><author><name sortKey="Garrison, Ar" uniqKey="Garrison A">AR Garrison</name></author><author><name sortKey="Smith, Jm" uniqKey="Smith J">JM Smith</name></author><author><name sortKey="Paragas, J" uniqKey="Paragas J">J Paragas</name></author><author><name sortKey="Hogan, Rj" uniqKey="Hogan R">RJ Hogan</name></author><author><name sortKey="Schmaljohn, C" uniqKey="Schmaljohn C">C Schmaljohn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name></author><author><name sortKey="Alimonti, Jb" uniqKey="Alimonti J">JB Alimonti</name></author><author><name sortKey="Melito, Pl" uniqKey="Melito P">PL Melito</name></author><author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name></author><author><name sortKey="Dick, D" uniqKey="Dick D">D Dick</name></author><author><name sortKey="Stroher, U" uniqKey="Stroher U">U Ströher</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Jones, Sm" uniqKey="Jones S">SM Jones</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Olinger, Gg" uniqKey="Olinger G">GG Olinger</name></author><author><name sortKey="Pettitt, J" uniqKey="Pettitt J">J Pettitt</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D Kim</name></author><author><name sortKey="Working, C" uniqKey="Working C">C Working</name></author><author><name sortKey="Bohorov, O" uniqKey="Bohorov O">O Bohorov</name></author><author><name sortKey="Bratcher, B" uniqKey="Bratcher B">B Bratcher</name></author><author><name sortKey="Hiatt, E" uniqKey="Hiatt E">E Hiatt</name></author><author><name sortKey="Hume, Sd" uniqKey="Hume S">SD Hume</name></author><author><name sortKey="Johnson, Ak" uniqKey="Johnson A">AK Johnson</name></author><author><name sortKey="Morton, J" uniqKey="Morton J">J Morton</name></author><author><name sortKey="Pauly, M" uniqKey="Pauly M">M Pauly</name></author><author><name sortKey="Whaley, Kj" uniqKey="Whaley K">KJ Whaley</name></author><author><name sortKey="Lear, Cm" uniqKey="Lear C">CM Lear</name></author><author><name sortKey="Biggins, Je" uniqKey="Biggins J">JE Biggins</name></author><author><name sortKey="Scully, C" uniqKey="Scully C">C Scully</name></author><author><name sortKey="Hensley, L" uniqKey="Hensley L">L Hensley</name></author><author><name sortKey="Zeitlin, L" uniqKey="Zeitlin L">L Zeitlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kugelman, Jr" uniqKey="Kugelman J">JR Kugelman</name></author><author><name sortKey="Kugelman Tonos, J" uniqKey="Kugelman Tonos J">J Kugelman-Tonos</name></author><author><name sortKey="Ladner, Jt" uniqKey="Ladner J">JT Ladner</name></author><author><name sortKey="Pettit, J" uniqKey="Pettit J">J Pettit</name></author><author><name sortKey="Keeton, Cm" uniqKey="Keeton C">CM Keeton</name></author><author><name sortKey="Nagle, Er" uniqKey="Nagle E">ER Nagle</name></author><author><name sortKey="Garcia, Ky" uniqKey="Garcia K">KY Garcia</name></author><author><name sortKey="Froude, Jw" uniqKey="Froude J">JW Froude</name></author><author><name sortKey="Kuehne, Ai" uniqKey="Kuehne A">AI Kuehne</name></author><author><name sortKey="Kuhn, Jh" uniqKey="Kuhn J">JH Kuhn</name></author><author><name sortKey="Bavari, S" uniqKey="Bavari S">S Bavari</name></author><author><name sortKey="Zeitlin, L" uniqKey="Zeitlin L">L Zeitlin</name></author><author><name sortKey="Dye, Jm" uniqKey="Dye J">JM Dye</name></author><author><name sortKey="Olinger, Gg" uniqKey="Olinger G">GG Olinger</name></author><author><name sortKey="Sanchez Lockhart, M" uniqKey="Sanchez Lockhart M">M Sanchez-Lockhart</name></author><author><name sortKey="Palacios, Gf" uniqKey="Palacios G">GF Palacios</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Audet, J" uniqKey="Audet J">J Audet</name></author><author><name sortKey="Bello, A" uniqKey="Bello A">A Bello</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name></author><author><name sortKey="Alimonti, J F B H" uniqKey="Alimonti J">J F-B H Alimonti</name></author><author><name sortKey="Wei, H" uniqKey="Wei H">H Wei</name></author><author><name sortKey="Aviles, J" uniqKey="Aviles J">J Aviles</name></author><author><name sortKey="Hiatt, E" uniqKey="Hiatt E">E Hiatt</name></author><author><name sortKey="Johnson, A" uniqKey="Johnson A">A Johnson</name></author><author><name sortKey="Morton, J" uniqKey="Morton J">J Morton</name></author><author><name sortKey="Swope, K" uniqKey="Swope K">K Swope</name></author><author><name sortKey="Bohorov, O" uniqKey="Bohorov O">O Bohorov</name></author><author><name sortKey="Bohorova, N" uniqKey="Bohorova N">N Bohorova</name></author><author><name sortKey="Goodman, C" uniqKey="Goodman C">C Goodman</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D Kim</name></author><author><name sortKey="Pauly, Mh" uniqKey="Pauly M">MH Pauly</name></author><author><name sortKey="Velasco, J" uniqKey="Velasco J">J Velasco</name></author><author><name sortKey="Pettitt, J" uniqKey="Pettitt J">J Pettitt</name></author><author><name sortKey="Olinger, Gg" uniqKey="Olinger G">GG Olinger</name></author><author><name sortKey="Whaley, K" uniqKey="Whaley K">K Whaley</name></author><author><name sortKey="Xu, B" uniqKey="Xu B">B Xu</name></author><author><name sortKey="Strong, Je" uniqKey="Strong J">JE Strong</name></author><author><name sortKey="Zeitlin, L" uniqKey="Zeitlin L">L Zeitlin</name></author><author><name sortKey="Kobinger, Gp" uniqKey="Kobinger G">GP Kobinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Misasi, J" uniqKey="Misasi J">J Misasi</name></author><author><name sortKey="Mulangu, S" uniqKey="Mulangu S">S Mulangu</name></author><author><name sortKey="Stanley, Da" uniqKey="Stanley D">DA Stanley</name></author><author><name sortKey="Kanekiyo, M" uniqKey="Kanekiyo M">M Kanekiyo</name></author><author><name sortKey="Wollen, S" uniqKey="Wollen S">S Wollen</name></author><author><name sortKey="Ploquin, A" uniqKey="Ploquin A">A Ploquin</name></author><author><name sortKey="Doria Rose, Na" uniqKey="Doria Rose N">NA Doria-Rose</name></author><author><name sortKey="Staupe, Rp" uniqKey="Staupe R">RP Staupe</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Choe, M" uniqKey="Choe M">M Choe</name></author><author><name sortKey="Marcus, H" uniqKey="Marcus H">H Marcus</name></author><author><name sortKey="Thompson, Ea" uniqKey="Thompson E">EA Thompson</name></author><author><name sortKey="Cagigi, A" uniqKey="Cagigi A">A Cagigi</name></author><author><name sortKey="Silacci, C" uniqKey="Silacci C">C Silacci</name></author><author><name sortKey="Fernandez Rodriguez, B" uniqKey="Fernandez Rodriguez B">B Fernandez-Rodriguez</name></author><author><name sortKey="Perez, L" uniqKey="Perez L">L Perez</name></author><author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F Sallusto</name></author><author><name sortKey="Vanzetta, F" uniqKey="Vanzetta F">F Vanzetta</name></author><author><name sortKey="Agatic, G" uniqKey="Agatic G">G Agatic</name></author><author><name sortKey="Cameroni, E" uniqKey="Cameroni E">E Cameroni</name></author><author><name sortKey="Kisalu, N" uniqKey="Kisalu N">N Kisalu</name></author><author><name sortKey="Gordon, I" uniqKey="Gordon I">I Gordon</name></author><author><name sortKey="Ledgerwood, Je" uniqKey="Ledgerwood J">JE Ledgerwood</name></author><author><name sortKey="Mascola, Jr" uniqKey="Mascola J">JR Mascola</name></author><author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name></author><author><name sortKey="Muyembe Tamfun, Jj" uniqKey="Muyembe Tamfun J">JJ Muyembe-Tamfun</name></author><author><name sortKey="Trefry, Jc" uniqKey="Trefry J">JC Trefry</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Sullivan, Nj" uniqKey="Sullivan N">NJ Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misasi, J" uniqKey="Misasi J">J Misasi</name></author><author><name sortKey="Gilman, Ms" uniqKey="Gilman M">MS Gilman</name></author><author><name sortKey="Kanekiyo, M" uniqKey="Kanekiyo M">M Kanekiyo</name></author><author><name sortKey="Gui, M" uniqKey="Gui M">M Gui</name></author><author><name sortKey="Cagigi, A" uniqKey="Cagigi A">A Cagigi</name></author><author><name sortKey="Mulangu, S" uniqKey="Mulangu S">S Mulangu</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Ledgerwood, Je" uniqKey="Ledgerwood J">JE Ledgerwood</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Cunningham, J" uniqKey="Cunningham J">J Cunningham</name></author><author><name sortKey="Muyembe Tamfun, Jj" uniqKey="Muyembe Tamfun J">JJ Muyembe-Tamfun</name></author><author><name sortKey="Baxa, U" uniqKey="Baxa U">U Baxa</name></author><author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name></author><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y Xiang</name></author><author><name sortKey="Sullivan, Nj" uniqKey="Sullivan N">NJ Sullivan</name></author><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowall, Sd" uniqKey="Dowall S">SD Dowall</name></author><author><name sortKey="Callan, J" uniqKey="Callan J">J Callan</name></author><author><name sortKey="Zeltina, A" uniqKey="Zeltina A">A Zeltina</name></author><author><name sortKey="Al Abdulla, I" uniqKey="Al Abdulla I">I Al-Abdulla</name></author><author><name sortKey="Strecker, T" uniqKey="Strecker T">T Strecker</name></author><author><name sortKey="Fehling, S K V" uniqKey="Fehling S">S K V Fehling</name></author><author><name sortKey="Bosworth, A" uniqKey="Bosworth A">A Bosworth</name></author><author><name sortKey="Rayner, E" uniqKey="Rayner E">E Rayner</name></author><author><name sortKey="Taylor, I" uniqKey="Taylor I">I Taylor</name></author><author><name sortKey="Charlton, S" uniqKey="Charlton S">S Charlton</name></author><author><name sortKey="Landon, J" uniqKey="Landon J">J Landon</name></author><author><name sortKey="Cameron, I" uniqKey="Cameron I">I Cameron</name></author><author><name sortKey="Hewson, R" uniqKey="Hewson R">R Hewson</name></author><author><name sortKey="Nasidi, A" uniqKey="Nasidi A">A Nasidi</name></author><author><name sortKey="Bowden, Ta" uniqKey="Bowden T">TA Bowden</name></author><author><name sortKey="Carroll, Mw" uniqKey="Carroll M">MW Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N Vasilieva</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Berne, Ma" uniqKey="Berne M">MA Berne</name></author><author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M Somasundaran</name></author><author><name sortKey="Sullivan, Jl" uniqKey="Sullivan J">JL Sullivan</name></author><author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K Luzuriaga</name></author><author><name sortKey="Greenough, Tc" uniqKey="Greenough T">TC Greenough</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name></author><author><name sortKey="Low, De" uniqKey="Low D">DE Low</name></author><author><name sortKey="Henry, B" uniqKey="Henry B">B Henry</name></author><author><name sortKey="Finkelstein, S" uniqKey="Finkelstein S">S Finkelstein</name></author><author><name sortKey="Rose, D" uniqKey="Rose D">D Rose</name></author><author><name sortKey="Green, K" uniqKey="Green K">K Green</name></author><author><name sortKey="Tellier, R" uniqKey="Tellier R">R Tellier</name></author><author><name sortKey="Draker, R" uniqKey="Draker R">R Draker</name></author><author><name sortKey="Adachi, D" uniqKey="Adachi D">D Adachi</name></author><author><name sortKey="Ayers, M" uniqKey="Ayers M">M Ayers</name></author><author><name sortKey="Chan, Ak" uniqKey="Chan A">AK Chan</name></author><author><name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name></author><author><name sortKey="Salit, I" uniqKey="Salit I">I Salit</name></author><author><name sortKey="Simor, Ae" uniqKey="Simor A">AE Simor</name></author><author><name sortKey="Slutsky, As" uniqKey="Slutsky A">AS Slutsky</name></author><author><name sortKey="Doyle, Pw" uniqKey="Doyle P">PW Doyle</name></author><author><name sortKey="Krajden, M" uniqKey="Krajden M">M Krajden</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M Petric</name></author><author><name sortKey="Brunham, Rc" uniqKey="Brunham R">RC Brunham</name></author><author><name sortKey="Mcgeer, Aj" uniqKey="Mcgeer A">AJ McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, E" uniqKey="Qin E">E Qin</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author><author><name sortKey="Fan, B" uniqKey="Fan B">B Fan</name></author><author><name sortKey="Chang, G" uniqKey="Chang G">G Chang</name></author><author><name sortKey="Si, B" uniqKey="Si B">B Si</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Peng, W" uniqKey="Peng W">W Peng</name></author><author><name sortKey="Jiang, T" uniqKey="Jiang T">T Jiang</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Gan, Y" uniqKey="Gan Y">Y Gan</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Lu, F" uniqKey="Lu F">F Lü</name></author><author><name sortKey="Tan, G" uniqKey="Tan G">G Tan</name></author><author><name sortKey="Cao, W" uniqKey="Cao W">W Cao</name></author><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Xu, Z L Y" uniqKey="Xu Z">Z L Y Xu</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Lin, W" uniqKey="Lin W">W Lin</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L Tang</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Lei, M" uniqKey="Lei M">M Lei</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lü</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Tong, Z" uniqKey="Tong Z">Z Tong</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Dong, W" uniqKey="Dong W">W Dong</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Wong, Gks" uniqKey="Wong G">GKS Wong</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Km" uniqKey="Moore K">KM Moore</name></author><author><name sortKey="Jackwood, Mw" uniqKey="Jackwood M">MW Jackwood</name></author><author><name sortKey="Hilt, Da" uniqKey="Hilt D">DA Hilt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Murakami, A" uniqKey="Murakami A">A Murakami</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A Tamin</name></author><author><name sortKey="Matthews, Lj" uniqKey="Matthews L">LJ Matthews</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Tallarico, Asc" uniqKey="Tallarico A">ASC Tallarico</name></author><author><name sortKey="Olurinde, M" uniqKey="Olurinde M">M Olurinde</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Matthews, Lj" uniqKey="Matthews L">LJ Matthews</name></author><author><name sortKey="Murakami, A" uniqKey="Murakami A">A Murakami</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author><author><name sortKey="Werner, Hc" uniqKey="Werner H">HC Werner</name></author><author><name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name></author><author><name sortKey="Leung, K" uniqKey="Leung K">K Leung</name></author><author><name sortKey="Traggiai, E" uniqKey="Traggiai E">E Traggiai</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Chakraborti, S" uniqKey="Chakraborti S">S Chakraborti</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author><author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name></author><author><name sortKey="Hensley, Le" uniqKey="Hensley L">LE Hensley</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author><author><name sortKey="Sidorov, Ia" uniqKey="Sidorov I">IA Sidorov</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Kim, Jo" uniqKey="Kim J">JO Kim</name></author><author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Curtis, Km" uniqKey="Curtis K">KM Curtis</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Butler, D" uniqKey="Butler D">D Butler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J Bao</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorrell, Md" uniqKey="Gorrell M">MD Gorrell</name></author><author><name sortKey="Gysbers, V" uniqKey="Gysbers V">V Gysbers</name></author><author><name sortKey="Mccaughan, Gw" uniqKey="Mccaughan G">GW McCaughan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ju, Tw" uniqKey="Ju T">TW Ju</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Lau, Cc" uniqKey="Lau C">CC Lau</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Xc" uniqKey="Tang X">XC Tang</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Stanhope, J" uniqKey="Stanhope J">J Stanhope</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Peterson, Ec" uniqKey="Peterson E">EC Peterson</name></author><author><name sortKey="Avnir, Y" uniqKey="Avnir Y">Y Avnir</name></author><author><name sortKey="Tallarico, As" uniqKey="Tallarico A">AS Tallarico</name></author><author><name sortKey="Sheehan, J" uniqKey="Sheehan J">J Sheehan</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author><author><name sortKey="Zhou, T" uniqKey="Zhou T">T Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Passini, N" uniqKey="Passini N">N Passini</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name></author><author><name sortKey="Kamat, V" uniqKey="Kamat V">V Kamat</name></author><author><name sortKey="Badithe, A" uniqKey="Badithe A">A Badithe</name></author><author><name sortKey="Fairhurst, J" uniqKey="Fairhurst J">J Fairhurst</name></author><author><name sortKey="Hunt, C" uniqKey="Hunt C">C Hunt</name></author><author><name sortKey="Strein, J" uniqKey="Strein J">J Strein</name></author><author><name sortKey="Berrebi, A" uniqKey="Berrebi A">A Berrebi</name></author><author><name sortKey="Sisk, Jm" uniqKey="Sisk J">JM Sisk</name></author><author><name sortKey="Matthews, Kl" uniqKey="Matthews K">KL Matthews</name></author><author><name sortKey="Babb, R" uniqKey="Babb R">R Babb</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Lai, Km" uniqKey="Lai K">KM Lai</name></author><author><name sortKey="Huang, Tt" uniqKey="Huang T">TT Huang</name></author><author><name sortKey="Olson, W" uniqKey="Olson W">W Olson</name></author><author><name sortKey="Yancopoulos, Gd" uniqKey="Yancopoulos G">GD Yancopoulos</name></author><author><name sortKey="Stahl, N" uniqKey="Stahl N">N Stahl</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author><author><name sortKey="Kyratsous, Ca" uniqKey="Kyratsous C">CA Kyratsous</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Roopenian, Dc" uniqKey="Roopenian D">DC Roopenian</name></author><author><name sortKey="Akilesh, S" uniqKey="Akilesh S">S Akilesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Med</journal-id><journal-id journal-id-type="iso-abbrev">Front Med</journal-id><journal-title-group><journal-title>Frontiers of Medicine</journal-title></journal-title-group><issn pub-type="ppub">2095-0217</issn><issn pub-type="epub">2095-0225</issn><publisher><publisher-name>Higher Education Press</publisher-name><publisher-loc>Beijing</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29159596</article-id><article-id pub-id-type="pmc">7088856</article-id><article-id pub-id-type="publisher-id">596</article-id><article-id pub-id-type="doi">10.1007/s11684-017-0596-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Human monoclonal antibodies as candidate therapeutics against emerging viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Yujia</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lei</surname><given-names>Cheng</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Dan</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Dimitrov</surname><given-names>Dimiter S.</given-names></name><address><email>dimitrdi@mail.nih.gov</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Ying</surname><given-names>Tianlei</given-names></name><address><email>tlying@fudan.edu.cn</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0125 2443</institution-id><institution-id institution-id-type="GRID">grid.8547.e</institution-id><institution>Key Laboratory of Medical Molecular Virology of the Ministries of Education and Health, School of Basic Medical Sciences,</institution><institution>Fudan University,</institution></institution-wrap>Shanghai, 200032 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2297 5165</institution-id><institution-id institution-id-type="GRID">grid.94365.3d</institution-id><institution>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute,</institution><institution>National Institutes of Health,</institution></institution-wrap>Frederick, MD 21702 USA</aff></contrib-group><pub-date pub-type="epub"><day>20</day><month>11</month><year>2017</year></pub-date><pub-date pub-type="ppub"><year>2017</year></pub-date><volume>11</volume><issue>4</issue><fpage>462</fpage><lpage>470</lpage><history><date date-type="received"><day>26</day><month>8</month><year>2017</year></date><date date-type="accepted"><day>10</day><month>10</month><year>2017</year></date></history><permissions><copyright-statement>© Higher Education Press and Springer-Verlag GmbH Germany 2017</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses <italic>in vitro</italic> and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>human monoclonal antibodies</kwd><kwd>emerging infectious diseases</kwd><kwd>SARS-CoV</kwd><kwd>MERS-CoV</kwd><kwd>Ebola virus</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Higher Education Press and Springer-Verlag GmbH Germany 2017</meta-value></custom-meta></custom-meta-group></article-meta></front><back><ack><title>Acknowledgements</title><p>This work was supported by the National Natural Science Foundation of China (Nos. 31570936, 81501735, and 81561128006), the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research, and the Technology Service Platform for detecting high-level biological safety pathogenic microorganisms supported by the Shanghai Science and Technology Commission (No. 15DZ2290200).</p></ack><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Drosten</surname><given-names>C</given-names></name><name><surname>Günther</surname><given-names>S</given-names></name><name><surname>Preiser</surname><given-names>W</given-names></name><name><surname>van der Werf</surname><given-names>S</given-names></name><name><surname>Brodt</surname><given-names>HR</given-names></name><name><surname>Becker</surname><given-names>S</given-names></name><name><surname>Rabenau</surname><given-names>H</given-names></name><name><surname>Panning</surname><given-names>M</given-names></name><name><surname>Kolesnikova</surname><given-names>L</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Berger</surname><given-names>A</given-names></name><name><surname>Burguière</surname><given-names>AM</given-names></name><name><surname>Cinatl</surname><given-names>J</given-names></name><name><surname>Eickmann</surname><given-names>M</given-names></name><name><surname>Escriou</surname><given-names>N</given-names></name><name><surname>Grywna</surname><given-names>K</given-names></name><name><surname>Kramme</surname><given-names>S</given-names></name><name><surname>Manuguerra</surname><given-names>JC</given-names></name><name><surname>Müller</surname><given-names>S</given-names></name><name><surname>Rickerts</surname><given-names>V</given-names></name><name><surname>Stürmer</surname><given-names>M</given-names></name><name><surname>Vieth</surname><given-names>S</given-names></name><name><surname>Klenk</surname><given-names>HD</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Schmitz</surname><given-names>H</given-names></name><name><surname>Doerr</surname><given-names>HW</given-names></name></person-group><article-title>Identification of a novel coronavirus in patients with severe acute respiratory syndrome</article-title><source>N Engl J Med</source><year>2003</year><volume>348</volume><issue>20</issue><fpage>1967</fpage><lpage>1976</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa030747</pub-id><pub-id pub-id-type="pmid">12690091</pub-id></element-citation></ref><ref id="CR2"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ksiazek</surname><given-names>TG</given-names></name><name><surname>Erdman</surname><given-names>D</given-names></name><name><surname>Goldsmith</surname><given-names>CS</given-names></name><name><surname>Zaki</surname><given-names>SR</given-names></name><name><surname>Peret</surname><given-names>T</given-names></name><name><surname>Emery</surname><given-names>S</given-names></name><name><surname>Tong</surname><given-names>S</given-names></name><name><surname>Urbani</surname><given-names>C</given-names></name><name><surname>Comer</surname><given-names>JA</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Rollin</surname><given-names>PE</given-names></name><name><surname>Dowell</surname><given-names>SF</given-names></name><name><surname>Ling</surname><given-names>AE</given-names></name><name><surname>Humphrey</surname><given-names>CD</given-names></name><name><surname>Shieh</surname><given-names>WJ</given-names></name><name><surname>Guarner</surname><given-names>J</given-names></name><name><surname>Paddock</surname><given-names>CD</given-names></name><name><surname>Rota</surname><given-names>P</given-names></name><name><surname>Fields</surname><given-names>B</given-names></name><name><surname>De Risi</surname><given-names>J</given-names></name><name><surname>Yang</surname><given-names>JY</given-names></name><name><surname>Cox</surname><given-names>N</given-names></name><name><surname>Hughes</surname><given-names>JM</given-names></name><name><surname>Le Duc</surname><given-names>JW</given-names></name><name><surname>Bellini</surname><given-names>WJ</given-names></name><name><surname>Anderson</surname><given-names>LJ</given-names></name><collab>SARS Working Group</collab></person-group><article-title>A novel coronavirus associated with severe acute respiratory syndrome</article-title><source>N Engl J Med</source><year>2003</year><volume>348</volume><issue>20</issue><fpage>1953</fpage><lpage>1966</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa030781</pub-id><pub-id pub-id-type="pmid">12690092</pub-id></element-citation></ref><ref id="CR3"><label>3.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peiris</surname><given-names>JS</given-names></name><name><surname>Lai</surname><given-names>ST</given-names></name><name><surname>Poon</surname><given-names>LL</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><name><surname>Yam</surname><given-names>LY</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Nicholls</surname><given-names>J</given-names></name><name><surname>Yee</surname><given-names>WK</given-names></name><name><surname>Yan</surname><given-names>WW</given-names></name><name><surname>Cheung</surname><given-names>MT</given-names></name><name><surname>Cheng</surname><given-names>VC</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Tsang</surname><given-names>DN</given-names></name><name><surname>Yung</surname><given-names>RW</given-names></name><name><surname>Ng</surname><given-names>TK</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><collab>SARS study group</collab></person-group><article-title>Coronavirus as a possible cause of severe acute respiratory syndrome</article-title><source>Lancet</source><year>2003</year><volume>361</volume><issue>9366</issue><fpage>1319</fpage><lpage>1325</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(03)13077-2</pub-id><pub-id pub-id-type="pmid">12711465</pub-id></element-citation></ref><ref id="CR4"><label>4.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>Schutten</surname><given-names>M</given-names></name><name><surname>van Amerongen</surname><given-names>G</given-names></name><name><surname>van Doornum</surname><given-names>GJ</given-names></name><name><surname>van den Hoogen</surname><given-names>BG</given-names></name><name><surname>Peiris</surname><given-names>M</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Stöhr</surname><given-names>K</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name></person-group><article-title>Aetiology: Koch’s postulates fulfilled for SARS virus</article-title><source>Nature</source><year>2003</year><volume>423</volume><issue>6937</issue><fpage>240</fpage><pub-id pub-id-type="doi">10.1038/423240a</pub-id><pub-id pub-id-type="pmid">12748632</pub-id></element-citation></ref><ref id="CR5"><label>5.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Schutten</surname><given-names>M</given-names></name><name><surname>Rimmelzwaan</surname><given-names>G v</given-names></name><name><surname>Amerongen</surname><given-names>G</given-names></name><name><surname>van Riel</surname><given-names>D</given-names></name><name><surname>Laman</surname><given-names>JD</given-names></name><name><surname>de Jong</surname><given-names>T</given-names></name><name><surname>van Doornum</surname><given-names>G</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Ling</surname><given-names>AE</given-names></name><name><surname>Chan</surname><given-names>PK</given-names></name><name><surname>Tam</surname><given-names>JS</given-names></name><name><surname>Zambon</surname><given-names>MC</given-names></name><name><surname>Gopal</surname><given-names>R</given-names></name><name><surname>Drosten</surname><given-names>C</given-names></name><name><surname>van der Werf</surname><given-names>S</given-names></name><name><surname>Escriou</surname><given-names>N</given-names></name><name><surname>Manuguerra</surname><given-names>JC</given-names></name><name><surname>Stöhr</surname><given-names>K</given-names></name><name><surname>Peiris</surname><given-names>JS</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name></person-group><article-title>Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome</article-title><source>Lancet</source><year>2003</year><volume>362</volume><issue>9380</issue><fpage>263</fpage><lpage>270</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(03)13967-0</pub-id><pub-id pub-id-type="pmid">12892955</pub-id></element-citation></ref><ref id="CR6"><label>6.</label><element-citation publication-type="book"><person-group person-group-type="author"><collab>World Health Organization.</collab></person-group><source>WHO SARS Risk Assessment and Preparedness Framework</source><year>2014</year></element-citation></ref><ref id="CR7"><label>7.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Feldmann</surname><given-names>H</given-names></name><name><surname>Geisbert</surname><given-names>TW</given-names></name></person-group><article-title>Ebola haemorrhagic fever</article-title><source>Lancet</source><year>2011</year><volume>377</volume><issue>9768</issue><fpage>849</fpage><lpage>862</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(10)60667-8</pub-id><pub-id pub-id-type="pmid">21084112</pub-id></element-citation></ref><ref id="CR8"><label>8.</label><element-citation publication-type="book"><person-group person-group-type="author"><collab>World Health Organization.</collab></person-group><source>Ebola Situation Report — 30 March 2016</source><year>2016</year></element-citation></ref><ref id="CR9"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lyon</surname><given-names>GM</given-names></name><name><surname>Mehta</surname><given-names>AK</given-names></name><name><surname>Varkey</surname><given-names>JB</given-names></name><name><surname>Brantly</surname><given-names>K</given-names></name><name><surname>Plyler</surname><given-names>L</given-names></name><name><surname>McElroy</surname><given-names>AK</given-names></name><name><surname>Kraft</surname><given-names>CS</given-names></name><name><surname>Towner</surname><given-names>JS</given-names></name><name><surname>Spiropoulou</surname><given-names>C</given-names></name><name><surname>Ströher</surname><given-names>U</given-names></name><name><surname>Uyeki</surname><given-names>TM</given-names></name><name><surname>Ribner</surname><given-names>BS</given-names></name><collab>Emory Serious Communicable Diseases Unit</collab></person-group><article-title>Clinical care of two patients with Ebola virus disease in the United States</article-title><source>N Engl J Med</source><year>2014</year><volume>371</volume><issue>25</issue><fpage>2402</fpage><lpage>2409</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa1409838</pub-id><pub-id pub-id-type="pmid">25390460</pub-id></element-citation></ref><ref id="CR10"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Winau</surname><given-names>F</given-names></name><name><surname>Winau</surname><given-names>R</given-names></name></person-group><article-title>Emil von Behring and serum therapy</article-title><source>Microbes Infect</source><year>2002</year><volume>4</volume><issue>2</issue><fpage>185</fpage><lpage>188</lpage><pub-id pub-id-type="doi">10.1016/S1286-4579(01)01526-X</pub-id><pub-id pub-id-type="pmid">11880051</pub-id></element-citation></ref><ref id="CR11"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Berry</surname><given-names>JD</given-names></name><name><surname>Gaudet</surname><given-names>RG</given-names></name></person-group><article-title>Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology</article-title><source>N Biotechnol</source><year>2011</year><volume>28</volume><issue>5</issue><fpage>489</fpage><lpage>501</lpage><pub-id pub-id-type="doi">10.1016/j.nbt.2011.03.018</pub-id><pub-id pub-id-type="pmid">21473942</pub-id></element-citation></ref><ref id="CR12"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Casadevall</surname><given-names>A</given-names></name></person-group><article-title>Passive antibody therapies: progress and continuing challenges</article-title><source>Clin Immunol</source><year>1999</year><volume>93</volume><issue>1</issue><fpage>5</fpage><lpage>15</lpage><pub-id pub-id-type="doi">10.1006/clim.1999.4768</pub-id><pub-id pub-id-type="pmid">10497006</pub-id></element-citation></ref><ref id="CR13"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dimitrov</surname><given-names>DS</given-names></name><name><surname>Marks</surname><given-names>JD</given-names></name></person-group><article-title>Therapeutic antibodies: current state and future trends— is a paradigm change coming soon</article-title><source>Methods Mol Biol</source><year>2009</year><volume>525</volume><fpage>1</fpage><lpage>27</lpage><pub-id pub-id-type="doi">10.1007/978-1-59745-554-1_1</pub-id><pub-id pub-id-type="pmid">19252861</pub-id></element-citation></ref><ref id="CR14"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhu</surname><given-names>Z</given-names></name><name><surname>Dimitrov</surname><given-names>AS</given-names></name><name><surname>Chakraborti</surname><given-names>S</given-names></name><name><surname>Dimitrova</surname><given-names>D</given-names></name><name><surname>Xiao</surname><given-names>X</given-names></name><name><surname>Broder</surname><given-names>CC</given-names></name><name><surname>Dimitrov</surname><given-names>DS</given-names></name></person-group><article-title>Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses</article-title><source>Expert Rev Anti Infect Ther</source><year>2006</year><volume>4</volume><issue>1</issue><fpage>57</fpage><lpage>66</lpage><pub-id pub-id-type="doi">10.1586/14787210.4.1.57</pub-id><pub-id pub-id-type="pmid">16441209</pub-id></element-citation></ref><ref id="CR15"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shulman</surname><given-names>M</given-names></name><name><surname>Wilde</surname><given-names>CD</given-names></name><name><surname>Köhler</surname><given-names>G</given-names></name></person-group><article-title>A better cell line for making hybridomas secreting specific antibodies</article-title><source>Nature</source><year>1978</year><volume>276</volume><issue>5685</issue><fpage>269</fpage><lpage>270</lpage><pub-id pub-id-type="doi">10.1038/276269a0</pub-id><pub-id pub-id-type="pmid">714156</pub-id></element-citation></ref><ref id="CR16"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>GP</given-names></name></person-group><article-title>Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface</article-title><source>Science</source><year>1985</year><volume>228</volume><issue>4705</issue><fpage>1315</fpage><lpage>1317</lpage><pub-id pub-id-type="doi">10.1126/science.4001944</pub-id><pub-id pub-id-type="pmid">4001944</pub-id></element-citation></ref><ref id="CR17"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>GP</given-names></name><name><surname>Petrenko</surname><given-names>VA</given-names></name></person-group><article-title>Phage Display</article-title><source>Chem Rev</source><year>1997</year><volume>97</volume><issue>2</issue><fpage>391</fpage><lpage>410</lpage><pub-id pub-id-type="doi">10.1021/cr960065d</pub-id><pub-id pub-id-type="pmid">11848876</pub-id></element-citation></ref><ref id="CR18"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gao</surname><given-names>C</given-names></name><name><surname>Mao</surname><given-names>S</given-names></name><name><surname>Kaufmann</surname><given-names>G</given-names></name><name><surname>Wirsching</surname><given-names>P</given-names></name><name><surname>Lerner</surname><given-names>RA</given-names></name><name><surname>Janda</surname><given-names>KD</given-names></name></person-group><article-title>A method for the generation of combinatorial antibody libraries using pIX phage display</article-title><source>Proc Natl Acad Sci USA</source><year>2002</year><volume>99</volume><issue>20</issue><fpage>12612</fpage><lpage>12616</lpage><pub-id pub-id-type="doi">10.1073/pnas.192467999</pub-id><pub-id pub-id-type="pmid">12239343</pub-id></element-citation></ref><ref id="CR19"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>McCafferty</surname><given-names>J</given-names></name><name><surname>Fitzgerald</surname><given-names>KJ</given-names></name><name><surname>Earnshaw</surname><given-names>J</given-names></name><name><surname>Chiswell</surname><given-names>DJ</given-names></name><name><surname>Link</surname><given-names>J</given-names></name><name><surname>Smith</surname><given-names>R</given-names></name><name><surname>Kenten</surname><given-names>J</given-names></name></person-group><article-title>Selection and rapid purification of murine antibody fragments that bind a transition-state analog by phage display</article-title><source>Appl Biochem Biotechnol</source><year>1994</year><volume>47</volume><issue>2-3</issue><fpage>157</fpage><lpage>173</lpage><pub-id pub-id-type="doi">10.1007/BF02787932</pub-id><pub-id pub-id-type="pmid">7944335</pub-id></element-citation></ref><ref id="CR20"><label>20.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Davies</surname><given-names>EL</given-names></name><name><surname>Smith</surname><given-names>JS</given-names></name><name><surname>Birkett</surname><given-names>CR</given-names></name><name><surname>Manser</surname><given-names>JM</given-names></name><name><surname>Anderson-Dear</surname><given-names>DV</given-names></name><name><surname>Young</surname><given-names>JR</given-names></name></person-group><article-title>Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes</article-title><source>J Immunol Methods</source><year>1995</year><volume>186</volume><issue>1</issue><fpage>125</fpage><lpage>135</lpage><pub-id pub-id-type="doi">10.1016/0022-1759(95)00143-X</pub-id><pub-id pub-id-type="pmid">7561141</pub-id></element-citation></ref><ref id="CR21"><label>21.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sok</surname><given-names>D</given-names></name><name><surname>Briney</surname><given-names>B</given-names></name><name><surname>Jardine</surname><given-names>JG</given-names></name><name><surname>Kulp</surname><given-names>DW</given-names></name><name><surname>Menis</surname><given-names>S</given-names></name><name><surname>Pauthner</surname><given-names>M</given-names></name><name><surname>Wood</surname><given-names>A</given-names></name><name><surname>Lee</surname><given-names>EC</given-names></name><name><surname>Le</surname><given-names>KM</given-names></name><name><surname>Jones</surname><given-names>M</given-names></name><name><surname>Ramos</surname><given-names>A</given-names></name><name><surname>Kalyuzhniy</surname><given-names>O</given-names></name><name><surname>Adachi</surname><given-names>Y</given-names></name><name><surname>Kubitz</surname><given-names>M</given-names></name><name><surname>MacPherson</surname><given-names>S</given-names></name><name><surname>Bradley</surname><given-names>A</given-names></name><name><surname>Friedrich</surname><given-names>GA</given-names></name><name><surname>Schief</surname><given-names>WR</given-names></name><name><surname>Burton</surname><given-names>DR</given-names></name></person-group><article-title>Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice</article-title><source>Science</source><year>2016</year><volume>353</volume><issue>6307</issue><fpage>1557</fpage><lpage>1560</lpage><pub-id pub-id-type="doi">10.1126/science.aah3945</pub-id><pub-id pub-id-type="pmid">27608668</pub-id></element-citation></ref><ref id="CR22"><label>22.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murphy</surname><given-names>AJ</given-names></name><name><surname>Macdonald</surname><given-names>LE</given-names></name><name><surname>Stevens</surname><given-names>S</given-names></name><name><surname>Karow</surname><given-names>M</given-names></name><name><surname>Dore</surname><given-names>AT</given-names></name><name><surname>Pobursky</surname><given-names>K</given-names></name><name><surname>Huang</surname><given-names>TT</given-names></name><name><surname>Poueymirou</surname><given-names>WT</given-names></name><name><surname>Esau</surname><given-names>L</given-names></name><name><surname>Meola</surname><given-names>M</given-names></name><name><surname>Mikulka</surname><given-names>W</given-names></name><name><surname>Krueger</surname><given-names>P</given-names></name><name><surname>Fairhurst</surname><given-names>J</given-names></name><name><surname>Valenzuela</surname><given-names>DM</given-names></name><name><surname>Papadopoulos</surname><given-names>N</given-names></name><name><surname>Yancopoulos</surname><given-names>GD</given-names></name></person-group><article-title>Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice</article-title><source>Proc Natl Acad Sci USA</source><year>2014</year><volume>111</volume><issue>14</issue><fpage>5153</fpage><lpage>5158</lpage><pub-id pub-id-type="doi">10.1073/pnas.1324022111</pub-id><pub-id pub-id-type="pmid">24706856</pub-id></element-citation></ref><ref id="CR23"><label>23.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lipke</surname><given-names>PN</given-names></name><name><surname>Kurjan</surname><given-names>J</given-names></name></person-group><article-title>Sexual agglutination in budding yeasts: structure, function, and regulation of adhesion glycoproteins</article-title><source>Microbiol Rev</source><year>1992</year><volume>56</volume><issue>1</issue><fpage>180</fpage><lpage>194</lpage><pub-id pub-id-type="pmid">1579109</pub-id></element-citation></ref><ref id="CR24"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boder</surname><given-names>ET</given-names></name><name><surname>Wittrup</surname><given-names>KD</given-names></name></person-group><article-title>Yeast surface display for directed evolution of protein expression, affinity, and stability</article-title><source>Methods Enzymol</source><year>2000</year><volume>328</volume><fpage>430</fpage><lpage>444</lpage><pub-id pub-id-type="doi">10.1016/S0076-6879(00)28410-3</pub-id><pub-id pub-id-type="pmid">11075358</pub-id></element-citation></ref><ref id="CR25"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boder</surname><given-names>ET</given-names></name><name><surname>Wittrup</surname><given-names>KD</given-names></name></person-group><article-title>Yeast surface display for screening combinatorial polypeptide libraries</article-title><source>Nat Biotechnol</source><year>1997</year><volume>15</volume><issue>6</issue><fpage>553</fpage><lpage>557</lpage><pub-id pub-id-type="doi">10.1038/nbt0697-553</pub-id><pub-id pub-id-type="pmid">9181578</pub-id></element-citation></ref><ref id="CR26"><label>26.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kieke</surname><given-names>MC</given-names></name><name><surname>Cho</surname><given-names>BK</given-names></name><name><surname>Boder</surname><given-names>ET</given-names></name><name><surname>Kranz</surname><given-names>DM</given-names></name><name><surname>Wittrup</surname><given-names>KD</given-names></name></person-group><article-title>Isolation of anti-T cell receptor scFv mutants by yeast surface display</article-title><source>Protein Eng</source><year>1997</year><volume>10</volume><issue>11</issue><fpage>1303</fpage><lpage>1310</lpage><pub-id pub-id-type="doi">10.1093/protein/10.11.1303</pub-id><pub-id pub-id-type="pmid">9514119</pub-id></element-citation></ref><ref id="CR27"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wardemann</surname><given-names>H</given-names></name><name><surname>Yurasov</surname><given-names>S</given-names></name><name><surname>Schaefer</surname><given-names>A</given-names></name><name><surname>Young</surname><given-names>JW</given-names></name><name><surname>Meffre</surname><given-names>E</given-names></name><name><surname>Nussenzweig</surname><given-names>MC</given-names></name></person-group><article-title>Predominant autoantibody production by early human B cell precursors</article-title><source>Science</source><year>2003</year><volume>301</volume><issue>5638</issue><fpage>1374</fpage><lpage>1377</lpage><pub-id pub-id-type="doi">10.1126/science.1086907</pub-id><pub-id pub-id-type="pmid">12920303</pub-id></element-citation></ref><ref id="CR28"><label>28.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walker</surname><given-names>LM</given-names></name><name><surname>Phogat</surname><given-names>SK</given-names></name><name><surname>Chan-Hui</surname><given-names>PY</given-names></name><name><surname>Wagner</surname><given-names>D</given-names></name><name><surname>Phung</surname><given-names>P</given-names></name><name><surname>Goss</surname><given-names>JL</given-names></name><name><surname>Wrin</surname><given-names>T</given-names></name><name><surname>Simek</surname><given-names>MD</given-names></name><name><surname>Fling</surname><given-names>S</given-names></name><name><surname>Mitcham</surname><given-names>JL</given-names></name><name><surname>Lehrman</surname><given-names>JK</given-names></name><name><surname>Priddy</surname><given-names>FH</given-names></name><name><surname>Olsen</surname><given-names>OA</given-names></name><name><surname>Frey</surname><given-names>SM</given-names></name><name><surname>Hammond</surname><given-names>PW</given-names></name><name><surname>Protocol</surname><given-names>G P I</given-names></name><name><surname>Kaminsky</surname><given-names>S</given-names></name><name><surname>Zamb</surname><given-names>T</given-names></name><name><surname>Moyle</surname><given-names>M</given-names></name><name><surname>Koff</surname><given-names>WC</given-names></name><name><surname>Poignard</surname><given-names>P</given-names></name><name><surname>Burton</surname><given-names>DR</given-names></name></person-group><article-title>Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target</article-title><source>Science</source><year>2009</year><volume>326</volume><issue>5950</issue><fpage>285</fpage><lpage>289</lpage><pub-id pub-id-type="doi">10.1126/science.1178746</pub-id><pub-id pub-id-type="pmid">19729618</pub-id></element-citation></ref><ref id="CR29"><label>29.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walker</surname><given-names>LM</given-names></name><name><surname>Huber</surname><given-names>M</given-names></name><name><surname>Doores</surname><given-names>KJ</given-names></name><name><surname>Falkowska</surname><given-names>E</given-names></name><name><surname>Pejchal</surname><given-names>R</given-names></name><name><surname>Julien</surname><given-names>JP</given-names></name><name><surname>Wang</surname><given-names>SK</given-names></name><name><surname>Ramos</surname><given-names>A</given-names></name><name><surname>Chan-Hui</surname><given-names>PY</given-names></name><name><surname>Moyle</surname><given-names>M</given-names></name><name><surname>Mitcham</surname><given-names>JL</given-names></name><name><surname>Hammond</surname><given-names>PW</given-names></name><name><surname>Olsen</surname><given-names>OA</given-names></name><name><surname>Phung</surname><given-names>P</given-names></name><name><surname>Fling</surname><given-names>S</given-names></name><name><surname>Wong</surname><given-names>CH</given-names></name><name><surname>Phogat</surname><given-names>S</given-names></name><name><surname>Wrin</surname><given-names>T</given-names></name><name><surname>Simek</surname><given-names>MD</given-names></name><name><surname>Protocol</surname><given-names>G P I</given-names></name><name><surname>Koff</surname><given-names>WC</given-names></name><name><surname>Wilson</surname><given-names>IA</given-names></name><name><surname>Burton</surname><given-names>DR</given-names></name><name><surname>Poignard</surname><given-names>P</given-names></name></person-group><article-title>Broad neutralization coverage of HIV by multiple highly potent antibodies</article-title><source>Nature</source><year>2011</year><volume>477</volume><issue>7365</issue><fpage>466</fpage><lpage>470</lpage><pub-id pub-id-type="doi">10.1038/nature10373</pub-id><pub-id pub-id-type="pmid">21849977</pub-id></element-citation></ref><ref id="CR30"><label>30.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Traggiai</surname><given-names>E</given-names></name><name><surname>Becker</surname><given-names>S</given-names></name><name><surname>Subbarao</surname><given-names>K</given-names></name><name><surname>Kolesnikova</surname><given-names>L</given-names></name><name><surname>Uematsu</surname><given-names>Y</given-names></name><name><surname>Gismondo</surname><given-names>MR</given-names></name><name><surname>Murphy</surname><given-names>BR</given-names></name><name><surname>Rappuoli</surname><given-names>R</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name></person-group><article-title>An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus</article-title><source>Nat Med</source><year>2004</year><volume>10</volume><issue>8</issue><fpage>871</fpage><lpage>875</lpage><pub-id pub-id-type="doi">10.1038/nm1080</pub-id><pub-id pub-id-type="pmid">15247913</pub-id></element-citation></ref><ref id="CR31"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aman</surname><given-names>P</given-names></name><name><surname>Ehlin-Henriksson</surname><given-names>B</given-names></name><name><surname>Klein</surname><given-names>G</given-names></name></person-group><article-title>Epstein-Barr virus susceptibility of normal human B lymphocyte populations</article-title><source>J Exp Med</source><year>1984</year><volume>159</volume><issue>1</issue><fpage>208</fpage><lpage>220</lpage><pub-id pub-id-type="doi">10.1084/jem.159.1.208</pub-id><pub-id pub-id-type="pmid">6319530</pub-id></element-citation></ref><ref id="CR32"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brès</surname><given-names>P</given-names></name></person-group><article-title>The epidemic of Ebola haemorrhagic fever in Sudan and Zaire, 1976: introductory note</article-title><source>Bull World Health Organ</source><year>1978</year><volume>56</volume><issue>2</issue><fpage>245</fpage><pub-id pub-id-type="pmid">307454</pub-id></element-citation></ref><ref id="CR33"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>H</given-names></name><name><surname>Ying</surname><given-names>T</given-names></name><name><surname>Yu</surname><given-names>F</given-names></name><name><surname>Lu</surname><given-names>L</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name></person-group><article-title>Development of therapeutics for treatment of Ebola virus infection</article-title><source>Microbes Infect</source><year>2015</year><volume>17</volume><issue>2</issue><fpage>109</fpage><lpage>117</lpage><pub-id pub-id-type="doi">10.1016/j.micinf.2014.11.012</pub-id><pub-id pub-id-type="pmid">25498866</pub-id></element-citation></ref><ref id="CR34"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ka</surname><given-names>D</given-names></name><name><surname>Fall</surname><given-names>G</given-names></name><name><surname>Diallo</surname><given-names>VC</given-names></name><name><surname>Faye</surname><given-names>O</given-names></name><name><surname>Fortes</surname><given-names>LD</given-names></name><name><surname>Faye</surname><given-names>O</given-names></name><name><surname>Bah</surname><given-names>EI</given-names></name><name><surname>Diallo</surname><given-names>KM</given-names></name><name><surname>Balique</surname><given-names>F</given-names></name><name><surname>Ndour</surname><given-names>CT</given-names></name><name><surname>Seydi</surname><given-names>M</given-names></name><name><surname>Sall</surname><given-names>AA</given-names></name></person-group><article-title>Ebola virus imported from Guinea to Senegal, 2014</article-title><source>Emerg Infect Dis</source><year>2017</year><volume>23</volume><issue>6</issue><fpage>1026</fpage><lpage>1028</lpage><pub-id pub-id-type="doi">10.3201/eid2306.161092</pub-id><pub-id pub-id-type="pmid">28518019</pub-id></element-citation></ref><ref id="CR35"><label>35.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>YH</given-names></name><name><surname>Chen</surname><given-names>SP</given-names></name></person-group><article-title>Evolutionary history of Ebola virus</article-title><source>Epidemiol Infect</source><year>2014</year><volume>142</volume><issue>6</issue><fpage>1138</fpage><lpage>1145</lpage><pub-id pub-id-type="doi">10.1017/S0950268813002215</pub-id><pub-id pub-id-type="pmid">24040779</pub-id></element-citation></ref><ref id="CR36"><label>36.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>Y</given-names></name><name><surname>Xu</surname><given-names>L</given-names></name><name><surname>Sun</surname><given-names>Y</given-names></name><name><surname>Nabel</surname><given-names>GJ</given-names></name></person-group><article-title>The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein</article-title><source>Mol Cell</source><year>2002</year><volume>10</volume><issue>2</issue><fpage>307</fpage><lpage>316</lpage><pub-id pub-id-type="doi">10.1016/S1097-2765(02)00588-9</pub-id><pub-id pub-id-type="pmid">12191476</pub-id></element-citation></ref><ref id="CR37"><label>37.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Geisbert</surname><given-names>TW</given-names></name><name><surname>Jahrling</surname><given-names>PB</given-names></name></person-group><article-title>Differentiation of filoviruses by electron microscopy</article-title><source>Virus Res</source><year>1995</year><volume>39</volume><issue>2-3</issue><fpage>129</fpage><lpage>150</lpage><pub-id pub-id-type="doi">10.1016/0168-1702(95)00080-1</pub-id><pub-id pub-id-type="pmid">8837880</pub-id></element-citation></ref><ref id="CR38"><label>38.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>JE</given-names></name><name><surname>Fusco</surname><given-names>ML</given-names></name><name><surname>Hessell</surname><given-names>AJ</given-names></name><name><surname>Oswald</surname><given-names>WB</given-names></name><name><surname>Burton</surname><given-names>DR</given-names></name><name><surname>Saphire</surname><given-names>EO</given-names></name></person-group><article-title>Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor</article-title><source>Nature</source><year>2008</year><volume>454</volume><issue>7201</issue><fpage>177</fpage><lpage>182</lpage><pub-id pub-id-type="doi">10.1038/nature07082</pub-id><pub-id pub-id-type="pmid">18615077</pub-id></element-citation></ref><ref id="CR39"><label>39.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hood</surname><given-names>CL</given-names></name><name><surname>Abraham</surname><given-names>J</given-names></name><name><surname>Boyington</surname><given-names>JC</given-names></name><name><surname>Leung</surname><given-names>K</given-names></name><name><surname>Kwong</surname><given-names>PD</given-names></name><name><surname>Nabel</surname><given-names>GJ</given-names></name></person-group><article-title>Biochemical and structural characterization of cathepsin Lprocessed Ebola virus glycoprotein: implications for viral entry and immunogenicity</article-title><source>J Virol</source><year>2010</year><volume>84</volume><issue>6</issue><fpage>2972</fpage><lpage>2982</lpage><pub-id pub-id-type="doi">10.1128/JVI.02151-09</pub-id><pub-id pub-id-type="pmid">20053739</pub-id></element-citation></ref><ref id="CR40"><label>40.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Richardson</surname><given-names>JS</given-names></name><name><surname>Yao</surname><given-names>MK</given-names></name><name><surname>Tran</surname><given-names>KN</given-names></name><name><surname>Croyle</surname><given-names>MA</given-names></name><name><surname>Strong</surname><given-names>JE</given-names></name><name><surname>Feldmann</surname><given-names>H</given-names></name><name><surname>Kobinger</surname><given-names>GP</given-names></name></person-group><article-title>Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine</article-title><source>PLoS One</source><year>2009</year><volume>4</volume><issue>4</issue><fpage>e5308</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0005308</pub-id><pub-id pub-id-type="pmid">19390586</pub-id></element-citation></ref><ref id="CR41"><label>41.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jones</surname><given-names>SM</given-names></name><name><surname>Feldmann</surname><given-names>H</given-names></name><name><surname>Ströher</surname><given-names>U</given-names></name><name><surname>Geisbert</surname><given-names>JB</given-names></name><name><surname>Fernando</surname><given-names>L</given-names></name><name><surname>Grolla</surname><given-names>A</given-names></name><name><surname>Klenk</surname><given-names>HD</given-names></name><name><surname>Sullivan</surname><given-names>NJ</given-names></name><name><surname>Volchkov</surname><given-names>VE</given-names></name><name><surname>Fritz</surname><given-names>EA</given-names></name><name><surname>Daddario</surname><given-names>KM</given-names></name><name><surname>Hensley</surname><given-names>LE</given-names></name><name><surname>Jahrling</surname><given-names>PB</given-names></name><name><surname>Geisbert</surname><given-names>TW</given-names></name></person-group><article-title>Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses</article-title><source>Nat Med</source><year>2005</year><volume>11</volume><issue>7</issue><fpage>786</fpage><lpage>790</lpage><pub-id pub-id-type="doi">10.1038/nm1258</pub-id><pub-id pub-id-type="pmid">15937495</pub-id></element-citation></ref><ref id="CR42"><label>42.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Warfield</surname><given-names>KL</given-names></name><name><surname>Swenson</surname><given-names>DL</given-names></name><name><surname>Olinger</surname><given-names>GG</given-names></name><name><surname>Kalina</surname><given-names>WV</given-names></name><name><surname>Aman</surname><given-names>MJ</given-names></name><name><surname>Bavari</surname><given-names>S</given-names></name></person-group><article-title>Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge</article-title><source>J Infect Dis</source><year>2007</year><volume>196</volume><fpage>S430</fpage><lpage>S437</lpage><pub-id pub-id-type="doi">10.1086/520583</pub-id><pub-id pub-id-type="pmid">17940980</pub-id></element-citation></ref><ref id="CR43"><label>43.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dowling</surname><given-names>W</given-names></name><name><surname>Thompson</surname><given-names>E</given-names></name><name><surname>Badger</surname><given-names>C</given-names></name><name><surname>Mellquist</surname><given-names>JL</given-names></name><name><surname>Garrison</surname><given-names>AR</given-names></name><name><surname>Smith</surname><given-names>JM</given-names></name><name><surname>Paragas</surname><given-names>J</given-names></name><name><surname>Hogan</surname><given-names>RJ</given-names></name><name><surname>Schmaljohn</surname><given-names>C</given-names></name></person-group><article-title>Influences of glycosylation on antigenicity, immunogenicity, and protective efficacy of Ebola virus GP DNA vaccines</article-title><source>J Virol</source><year>2007</year><volume>81</volume><issue>4</issue><fpage>1821</fpage><lpage>1837</lpage><pub-id pub-id-type="doi">10.1128/JVI.02098-06</pub-id><pub-id pub-id-type="pmid">17151111</pub-id></element-citation></ref><ref id="CR44"><label>44.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qiu</surname><given-names>X</given-names></name><name><surname>Fernando</surname><given-names>L</given-names></name><name><surname>Alimonti</surname><given-names>JB</given-names></name><name><surname>Melito</surname><given-names>PL</given-names></name><name><surname>Feldmann</surname><given-names>F</given-names></name><name><surname>Dick</surname><given-names>D</given-names></name><name><surname>Ströher</surname><given-names>U</given-names></name><name><surname>Feldmann</surname><given-names>H</given-names></name><name><surname>Jones</surname><given-names>SM</given-names></name></person-group><article-title>Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses</article-title><source>PLoS One</source><year>2009</year><volume>4</volume><issue>5</issue><fpage>e5547</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0005547</pub-id><pub-id pub-id-type="pmid">19440245</pub-id></element-citation></ref><ref id="CR45"><label>45.</label><element-citation publication-type="other"><source>Sci Transl Med</source><year>2012</year><volume>4</volume><issue>138</issue></element-citation></ref><ref id="CR46"><label>46.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Olinger</surname><given-names>GG</given-names><suffix>Jr</suffix></name><name><surname>Pettitt</surname><given-names>J</given-names></name><name><surname>Kim</surname><given-names>D</given-names></name><name><surname>Working</surname><given-names>C</given-names></name><name><surname>Bohorov</surname><given-names>O</given-names></name><name><surname>Bratcher</surname><given-names>B</given-names></name><name><surname>Hiatt</surname><given-names>E</given-names></name><name><surname>Hume</surname><given-names>SD</given-names></name><name><surname>Johnson</surname><given-names>AK</given-names></name><name><surname>Morton</surname><given-names>J</given-names></name><name><surname>Pauly</surname><given-names>M</given-names></name><name><surname>Whaley</surname><given-names>KJ</given-names></name><name><surname>Lear</surname><given-names>CM</given-names></name><name><surname>Biggins</surname><given-names>JE</given-names></name><name><surname>Scully</surname><given-names>C</given-names></name><name><surname>Hensley</surname><given-names>L</given-names></name><name><surname>Zeitlin</surname><given-names>L</given-names></name></person-group><article-title>Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques</article-title><source>Proc Natl Acad Sci USA</source><year>2012</year><volume>109</volume><issue>44</issue><fpage>18030</fpage><lpage>18035</lpage><pub-id pub-id-type="doi">10.1073/pnas.1213709109</pub-id><pub-id pub-id-type="pmid">23071322</pub-id></element-citation></ref><ref id="CR47"><label>47.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kugelman</surname><given-names>JR</given-names></name><name><surname>Kugelman-Tonos</surname><given-names>J</given-names></name><name><surname>Ladner</surname><given-names>JT</given-names></name><name><surname>Pettit</surname><given-names>J</given-names></name><name><surname>Keeton</surname><given-names>CM</given-names></name><name><surname>Nagle</surname><given-names>ER</given-names></name><name><surname>Garcia</surname><given-names>KY</given-names></name><name><surname>Froude</surname><given-names>JW</given-names></name><name><surname>Kuehne</surname><given-names>AI</given-names></name><name><surname>Kuhn</surname><given-names>JH</given-names></name><name><surname>Bavari</surname><given-names>S</given-names></name><name><surname>Zeitlin</surname><given-names>L</given-names></name><name><surname>Dye</surname><given-names>JM</given-names></name><name><surname>Olinger</surname><given-names>GG</given-names></name><name><surname>Sanchez-Lockhart</surname><given-names>M</given-names></name><name><surname>Palacios</surname><given-names>GF</given-names></name></person-group><article-title>Emergence of Ebola virus escape variants in infected nonhuman primates treated with the MB-003 antibody cocktail</article-title><source>Cell Reports</source><year>2015</year><volume>12</volume><issue>12</issue><fpage>2111</fpage><lpage>2120</lpage><pub-id pub-id-type="doi">10.1016/j.celrep.2015.08.038</pub-id><pub-id pub-id-type="pmid">26365189</pub-id></element-citation></ref><ref id="CR48"><label>48.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qiu</surname><given-names>X</given-names></name><name><surname>Wong</surname><given-names>G</given-names></name><name><surname>Audet</surname><given-names>J</given-names></name><name><surname>Bello</surname><given-names>A</given-names></name><name><surname>Fernando</surname><given-names>L</given-names></name><name><surname>Alimonti</surname><given-names>J F-B H</given-names></name><name><surname>Wei</surname><given-names>H</given-names></name><name><surname>Aviles</surname><given-names>J</given-names></name><name><surname>Hiatt</surname><given-names>E</given-names></name><name><surname>Johnson</surname><given-names>A</given-names></name><name><surname>Morton</surname><given-names>J</given-names></name><name><surname>Swope</surname><given-names>K</given-names></name><name><surname>Bohorov</surname><given-names>O</given-names></name><name><surname>Bohorova</surname><given-names>N</given-names></name><name><surname>Goodman</surname><given-names>C</given-names></name><name><surname>Kim</surname><given-names>D</given-names></name><name><surname>Pauly</surname><given-names>MH</given-names></name><name><surname>Velasco</surname><given-names>J</given-names></name><name><surname>Pettitt</surname><given-names>J</given-names></name><name><surname>Olinger</surname><given-names>GG</given-names></name><name><surname>Whaley</surname><given-names>K</given-names></name><name><surname>Xu</surname><given-names>B</given-names></name><name><surname>Strong</surname><given-names>JE</given-names></name><name><surname>Zeitlin</surname><given-names>L</given-names></name><name><surname>Kobinger</surname><given-names>GP</given-names></name></person-group><article-title>Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp</article-title><source>Nature</source><year>2014</year><volume>514</volume><issue>7520</issue><fpage>47</fpage><lpage>53</lpage><pub-id pub-id-type="doi">10.1038/nature13777</pub-id><pub-id pub-id-type="pmid">25171469</pub-id></element-citation></ref><ref id="CR49"><label>49.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Corti</surname><given-names>D</given-names></name><name><surname>Misasi</surname><given-names>J</given-names></name><name><surname>Mulangu</surname><given-names>S</given-names></name><name><surname>Stanley</surname><given-names>DA</given-names></name><name><surname>Kanekiyo</surname><given-names>M</given-names></name><name><surname>Wollen</surname><given-names>S</given-names></name><name><surname>Ploquin</surname><given-names>A</given-names></name><name><surname>Doria-Rose</surname><given-names>NA</given-names></name><name><surname>Staupe</surname><given-names>RP</given-names></name><name><surname>Bailey</surname><given-names>M</given-names></name><name><surname>Shi</surname><given-names>W</given-names></name><name><surname>Choe</surname><given-names>M</given-names></name><name><surname>Marcus</surname><given-names>H</given-names></name><name><surname>Thompson</surname><given-names>EA</given-names></name><name><surname>Cagigi</surname><given-names>A</given-names></name><name><surname>Silacci</surname><given-names>C</given-names></name><name><surname>Fernandez-Rodriguez</surname><given-names>B</given-names></name><name><surname>Perez</surname><given-names>L</given-names></name><name><surname>Sallusto</surname><given-names>F</given-names></name><name><surname>Vanzetta</surname><given-names>F</given-names></name><name><surname>Agatic</surname><given-names>G</given-names></name><name><surname>Cameroni</surname><given-names>E</given-names></name><name><surname>Kisalu</surname><given-names>N</given-names></name><name><surname>Gordon</surname><given-names>I</given-names></name><name><surname>Ledgerwood</surname><given-names>JE</given-names></name><name><surname>Mascola</surname><given-names>JR</given-names></name><name><surname>Graham</surname><given-names>BS</given-names></name><name><surname>Muyembe-Tamfun</surname><given-names>JJ</given-names></name><name><surname>Trefry</surname><given-names>JC</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name><name><surname>Sullivan</surname><given-names>NJ</given-names></name></person-group><article-title>Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody</article-title><source>Science</source><year>2016</year><volume>351</volume><issue>6279</issue><fpage>1339</fpage><lpage>1342</lpage><pub-id pub-id-type="doi">10.1126/science.aad5224</pub-id><pub-id pub-id-type="pmid">26917593</pub-id></element-citation></ref><ref id="CR50"><label>50.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Misasi</surname><given-names>J</given-names></name><name><surname>Gilman</surname><given-names>MS</given-names></name><name><surname>Kanekiyo</surname><given-names>M</given-names></name><name><surname>Gui</surname><given-names>M</given-names></name><name><surname>Cagigi</surname><given-names>A</given-names></name><name><surname>Mulangu</surname><given-names>S</given-names></name><name><surname>Corti</surname><given-names>D</given-names></name><name><surname>Ledgerwood</surname><given-names>JE</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name><name><surname>Cunningham</surname><given-names>J</given-names></name><name><surname>Muyembe-Tamfun</surname><given-names>JJ</given-names></name><name><surname>Baxa</surname><given-names>U</given-names></name><name><surname>Graham</surname><given-names>BS</given-names></name><name><surname>Xiang</surname><given-names>Y</given-names></name><name><surname>Sullivan</surname><given-names>NJ</given-names></name><name><surname>McLellan</surname><given-names>JS</given-names></name></person-group><article-title>Structural and molecular basis for Ebola virus neutralization by protective human antibodies</article-title><source>Science</source><year>2016</year><volume>351</volume><issue>6279</issue><fpage>1343</fpage><lpage>1346</lpage><pub-id pub-id-type="doi">10.1126/science.aad6117</pub-id><pub-id pub-id-type="pmid">26917592</pub-id></element-citation></ref><ref id="CR51"><label>51.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dowall</surname><given-names>SD</given-names></name><name><surname>Callan</surname><given-names>J</given-names></name><name><surname>Zeltina</surname><given-names>A</given-names></name><name><surname>Al-Abdulla</surname><given-names>I</given-names></name><name><surname>Strecker</surname><given-names>T</given-names></name><name><surname>Fehling</surname><given-names>S K V</given-names></name><name><surname>Bosworth</surname><given-names>A</given-names></name><name><surname>Rayner</surname><given-names>E</given-names></name><name><surname>Taylor</surname><given-names>I</given-names></name><name><surname>Charlton</surname><given-names>S</given-names></name><name><surname>Landon</surname><given-names>J</given-names></name><name><surname>Cameron</surname><given-names>I</given-names></name><name><surname>Hewson</surname><given-names>R</given-names></name><name><surname>Nasidi</surname><given-names>A</given-names></name><name><surname>Bowden</surname><given-names>TA</given-names></name><name><surname>Carroll</surname><given-names>MW</given-names></name></person-group><article-title>Development of a cost-effective ovine polyclonal antibodybased product, EBOTAb, to treat Ebola virus infection</article-title><source>J Infect Dis</source><year>2016</year><volume>213</volume><issue>7</issue><fpage>1124</fpage><lpage>1133</lpage><pub-id pub-id-type="doi">10.1093/infdis/jiv565</pub-id><pub-id pub-id-type="pmid">26715676</pub-id></element-citation></ref><ref id="CR52"><label>52.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Moore</surname><given-names>MJ</given-names></name><name><surname>Vasilieva</surname><given-names>N</given-names></name><name><surname>Sui</surname><given-names>J</given-names></name><name><surname>Wong</surname><given-names>SK</given-names></name><name><surname>Berne</surname><given-names>MA</given-names></name><name><surname>Somasundaran</surname><given-names>M</given-names></name><name><surname>Sullivan</surname><given-names>JL</given-names></name><name><surname>Luzuriaga</surname><given-names>K</given-names></name><name><surname>Greenough</surname><given-names>TC</given-names></name><name><surname>Choe</surname><given-names>H</given-names></name><name><surname>Farzan</surname><given-names>M</given-names></name></person-group><article-title>Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus</article-title><source>Nature</source><year>2003</year><volume>426</volume><issue>6965</issue><fpage>450</fpage><lpage>454</lpage><pub-id pub-id-type="doi">10.1038/nature02145</pub-id><pub-id pub-id-type="pmid">14647384</pub-id></element-citation></ref><ref id="CR53"><label>53.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Poutanen</surname><given-names>SM</given-names></name><name><surname>Low</surname><given-names>DE</given-names></name><name><surname>Henry</surname><given-names>B</given-names></name><name><surname>Finkelstein</surname><given-names>S</given-names></name><name><surname>Rose</surname><given-names>D</given-names></name><name><surname>Green</surname><given-names>K</given-names></name><name><surname>Tellier</surname><given-names>R</given-names></name><name><surname>Draker</surname><given-names>R</given-names></name><name><surname>Adachi</surname><given-names>D</given-names></name><name><surname>Ayers</surname><given-names>M</given-names></name><name><surname>Chan</surname><given-names>AK</given-names></name><name><surname>Skowronski</surname><given-names>DM</given-names></name><name><surname>Salit</surname><given-names>I</given-names></name><name><surname>Simor</surname><given-names>AE</given-names></name><name><surname>Slutsky</surname><given-names>AS</given-names></name><name><surname>Doyle</surname><given-names>PW</given-names></name><name><surname>Krajden</surname><given-names>M</given-names></name><name><surname>Petric</surname><given-names>M</given-names></name><name><surname>Brunham</surname><given-names>RC</given-names></name><name><surname>McGeer</surname><given-names>AJ</given-names></name><collab>National Microbiology Laboratory, Canada; Canadian Severe Acute Respiratory Syndrome Study Team</collab></person-group><article-title>Identification of severe acute respiratory syndrome in Canada</article-title><source>N Engl J Med</source><year>2003</year><volume>348</volume><issue>20</issue><fpage>1995</fpage><lpage>2005</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa030634</pub-id><pub-id pub-id-type="pmid">12671061</pub-id></element-citation></ref><ref id="CR54"><label>54.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qin</surname><given-names>E</given-names></name><name><surname>Zhu</surname><given-names>Q</given-names></name><name><surname>Yu</surname><given-names>M</given-names></name><name><surname>Fan</surname><given-names>B</given-names></name><name><surname>Chang</surname><given-names>G</given-names></name><name><surname>Si</surname><given-names>B</given-names></name><name><surname>Yang</surname><given-names>B</given-names></name><name><surname>Peng</surname><given-names>W</given-names></name><name><surname>Jiang</surname><given-names>T</given-names></name><name><surname>Liu</surname><given-names>B</given-names></name><name><surname>Deng</surname><given-names>Y</given-names></name><name><surname>Liu</surname><given-names>H</given-names></name><name><surname>Zhang</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>C</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Gan</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>X</given-names></name><name><surname>Lü</surname><given-names>F</given-names></name><name><surname>Tan</surname><given-names>G</given-names></name><name><surname>Cao</surname><given-names>W</given-names></name><name><surname>Yang</surname><given-names>R</given-names></name><name><surname>Wang</surname><given-names>J</given-names></name><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Xu</surname><given-names>Z L Y</given-names></name><name><surname>Wu</surname><given-names>Q</given-names></name><name><surname>Lin</surname><given-names>W</given-names></name><name><surname>Chen</surname><given-names>W</given-names></name><name><surname>Tang</surname><given-names>L</given-names></name><name><surname>Deng</surname><given-names>Y</given-names></name><name><surname>Han</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>C</given-names></name><name><surname>Lei</surname><given-names>M</given-names></name><name><surname>Li</surname><given-names>G</given-names></name><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Lü</surname><given-names>H</given-names></name><name><surname>Shi</surname><given-names>J</given-names></name><name><surname>Tong</surname><given-names>Z</given-names></name><name><surname>Zhang</surname><given-names>F</given-names></name><name><surname>Li</surname><given-names>S</given-names></name><name><surname>Liu</surname><given-names>B</given-names></name><name><surname>Liu</surname><given-names>S</given-names></name><name><surname>Dong</surname><given-names>W</given-names></name><name><surname>Wang</surname><given-names>J</given-names></name><name><surname>Wong</surname><given-names>GKS</given-names></name><name><surname>Yu</surname><given-names>J</given-names></name><name><surname>Yang</surname><given-names>H</given-names></name></person-group><article-title>A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01)</article-title><source>Chin Sci Bull</source><year>2003</year><volume>48</volume><issue>10</issue><fpage>941</fpage><lpage>948</lpage><pub-id pub-id-type="doi">10.1007/BF03184203</pub-id></element-citation></ref><ref id="CR55"><label>55.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gallagher</surname><given-names>TM</given-names></name><name><surname>Buchmeier</surname><given-names>MJ</given-names></name></person-group><article-title>Coronavirus spike proteins in viral entry and pathogenesis</article-title><source>Virology</source><year>2001</year><volume>279</volume><issue>2</issue><fpage>371</fpage><lpage>374</lpage><pub-id pub-id-type="doi">10.1006/viro.2000.0757</pub-id><pub-id pub-id-type="pmid">11162792</pub-id></element-citation></ref><ref id="CR56"><label>56.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moore</surname><given-names>KM</given-names></name><name><surname>Jackwood</surname><given-names>MW</given-names></name><name><surname>Hilt</surname><given-names>DA</given-names></name></person-group><article-title>Identification of amino acids involved in a serotype and neutralization specific epitope within the s1 subunit of avian infectious bronchitis virus</article-title><source>Arch Virol</source><year>1997</year><volume>142</volume><issue>11</issue><fpage>2249</fpage><lpage>2256</lpage><pub-id pub-id-type="doi">10.1007/s007050050239</pub-id><pub-id pub-id-type="pmid">9672590</pub-id></element-citation></ref><ref id="CR57"><label>57.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sui</surname><given-names>J</given-names></name><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Murakami</surname><given-names>A</given-names></name><name><surname>Tamin</surname><given-names>A</given-names></name><name><surname>Matthews</surname><given-names>LJ</given-names></name><name><surname>Wong</surname><given-names>SK</given-names></name><name><surname>Moore</surname><given-names>MJ</given-names></name><name><surname>Tallarico</surname><given-names>ASC</given-names></name><name><surname>Olurinde</surname><given-names>M</given-names></name><name><surname>Choe</surname><given-names>H</given-names></name><name><surname>Anderson</surname><given-names>LJ</given-names></name><name><surname>Bellini</surname><given-names>WJ</given-names></name><name><surname>Farzan</surname><given-names>M</given-names></name><name><surname>Marasco</surname><given-names>WA</given-names></name></person-group><article-title>Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association</article-title><source>Proc Natl Acad Sci USA</source><year>2004</year><volume>101</volume><issue>8</issue><fpage>2536</fpage><lpage>2541</lpage><pub-id pub-id-type="doi">10.1073/pnas.0307140101</pub-id><pub-id pub-id-type="pmid">14983044</pub-id></element-citation></ref><ref id="CR58"><label>58.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sui</surname><given-names>J</given-names></name><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Roberts</surname><given-names>A</given-names></name><name><surname>Matthews</surname><given-names>LJ</given-names></name><name><surname>Murakami</surname><given-names>A</given-names></name><name><surname>Vogel</surname><given-names>L</given-names></name><name><surname>Wong</surname><given-names>SK</given-names></name><name><surname>Subbarao</surname><given-names>K</given-names></name><name><surname>Farzan</surname><given-names>M</given-names></name><name><surname>Marasco</surname><given-names>WA</given-names></name></person-group><article-title>Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants</article-title><source>J Virol</source><year>2005</year><volume>79</volume><issue>10</issue><fpage>5900</fpage><lpage>5906</lpage><pub-id pub-id-type="doi">10.1128/JVI.79.10.5900-5906.2005</pub-id><pub-id pub-id-type="pmid">15857975</pub-id></element-citation></ref><ref id="CR59"><label>59.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>ZY</given-names></name><name><surname>Werner</surname><given-names>HC</given-names></name><name><surname>Kong</surname><given-names>WP</given-names></name><name><surname>Leung</surname><given-names>K</given-names></name><name><surname>Traggiai</surname><given-names>E</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name><name><surname>Nabel</surname><given-names>GJ</given-names></name></person-group><article-title>Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses</article-title><source>Proc Natl Acad Sci USA</source><year>2005</year><volume>102</volume><issue>3</issue><fpage>797</fpage><lpage>801</lpage><pub-id pub-id-type="doi">10.1073/pnas.0409065102</pub-id><pub-id pub-id-type="pmid">15642942</pub-id></element-citation></ref><ref id="CR60"><label>60.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhu</surname><given-names>Z</given-names></name><name><surname>Chakraborti</surname><given-names>S</given-names></name><name><surname>He</surname><given-names>Y</given-names></name><name><surname>Roberts</surname><given-names>A</given-names></name><name><surname>Sheahan</surname><given-names>T</given-names></name><name><surname>Xiao</surname><given-names>X</given-names></name><name><surname>Hensley</surname><given-names>LE</given-names></name><name><surname>Prabakaran</surname><given-names>P</given-names></name><name><surname>Rockx</surname><given-names>B</given-names></name><name><surname>Sidorov</surname><given-names>IA</given-names></name><name><surname>Corti</surname><given-names>D</given-names></name><name><surname>Vogel</surname><given-names>L</given-names></name><name><surname>Feng</surname><given-names>Y</given-names></name><name><surname>Kim</surname><given-names>JO</given-names></name><name><surname>Wang</surname><given-names>LF</given-names></name><name><surname>Baric</surname><given-names>R</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name><name><surname>Curtis</surname><given-names>KM</given-names></name><name><surname>Nabel</surname><given-names>GJ</given-names></name><name><surname>Subbarao</surname><given-names>K</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Dimitrov</surname><given-names>DS</given-names></name></person-group><article-title>Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies</article-title><source>Proc Natl Acad Sci USA</source><year>2007</year><volume>104</volume><issue>29</issue><fpage>12123</fpage><lpage>12128</lpage><pub-id pub-id-type="doi">10.1073/pnas.0701000104</pub-id><pub-id pub-id-type="pmid">17620608</pub-id></element-citation></ref><ref id="CR61"><label>61.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Boheemen</surname><given-names>S</given-names></name><name><surname>de Graaf</surname><given-names>M</given-names></name><name><surname>Lauber</surname><given-names>C</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>Raj</surname><given-names>VS</given-names></name><name><surname>Zaki</surname><given-names>AM</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Haagmans</surname><given-names>BL</given-names></name><name><surname>Gorbalenya</surname><given-names>AE</given-names></name><name><surname>Snijder</surname><given-names>EJ</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name></person-group><article-title>Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans</article-title><source>MBio</source><year>2012</year><volume>3</volume><issue>6</issue><fpage>e00473</fpage><lpage>e12</lpage><pub-id pub-id-type="pmid">23170002</pub-id></element-citation></ref><ref id="CR62"><label>62.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al-Tawfiq</surname><given-names>JA</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus: epidemiology and disease control measures</article-title><source>Infect Drug Resist</source><year>2014</year><volume>7</volume><fpage>281</fpage><lpage>287</lpage><pub-id pub-id-type="pmid">25395865</pub-id></element-citation></ref><ref id="CR63"><label>63.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Butler</surname><given-names>D</given-names></name></person-group><article-title>Receptor for new coronavirus found</article-title><source>Nature</source><year>2013</year><volume>495</volume><issue>7440</issue><fpage>149</fpage><lpage>150</lpage><pub-id pub-id-type="doi">10.1038/495149a</pub-id><pub-id pub-id-type="pmid">23486032</pub-id></element-citation></ref><ref id="CR64"><label>64.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peiris</surname><given-names>JS</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name></person-group><article-title>Severe acute respiratory syndrome</article-title><source>Nat Med</source><year>2004</year><volume>10</volume><issue>12</issue><fpage>S88</fpage><lpage>S97</lpage><pub-id pub-id-type="doi">10.1038/nm1143</pub-id><pub-id pub-id-type="pmid">15577937</pub-id></element-citation></ref><ref id="CR65"><label>65.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al-Tawfiq</surname><given-names>JA</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name></person-group><article-title>An update on Middle East respiratory syndrome: 2 years later</article-title><source>Expert Rev Respir Med</source><year>2015</year><volume>9</volume><issue>3</issue><fpage>327</fpage><lpage>335</lpage><pub-id pub-id-type="doi">10.1586/17476348.2015.1027689</pub-id><pub-id pub-id-type="pmid">25790840</pub-id></element-citation></ref><ref id="CR66"><label>66.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname><given-names>G</given-names></name><name><surname>Hu</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>Q</given-names></name><name><surname>Qi</surname><given-names>J</given-names></name><name><surname>Gao</surname><given-names>F</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Zhang</surname><given-names>Y</given-names></name><name><surname>Zhang</surname><given-names>W</given-names></name><name><surname>Yuan</surname><given-names>Y</given-names></name><name><surname>Bao</surname><given-names>J</given-names></name><name><surname>Zhang</surname><given-names>B</given-names></name><name><surname>Shi</surname><given-names>Y</given-names></name><name><surname>Yan</surname><given-names>J</given-names></name><name><surname>Gao</surname><given-names>GF</given-names></name></person-group><article-title>Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26</article-title><source>Nature</source><year>2013</year><volume>500</volume><issue>7461</issue><fpage>227</fpage><lpage>231</lpage><pub-id pub-id-type="doi">10.1038/nature12328</pub-id><pub-id pub-id-type="pmid">23831647</pub-id></element-citation></ref><ref id="CR67"><label>67.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gorrell</surname><given-names>MD</given-names></name><name><surname>Gysbers</surname><given-names>V</given-names></name><name><surname>McCaughan</surname><given-names>GW</given-names></name></person-group><article-title>CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes</article-title><source>Scand J Immunol</source><year>2001</year><volume>54</volume><issue>3</issue><fpage>249</fpage><lpage>264</lpage><pub-id pub-id-type="doi">10.1046/j.1365-3083.2001.00984.x</pub-id><pub-id pub-id-type="pmid">11555388</pub-id></element-citation></ref><ref id="CR68"><label>68.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>Y</given-names></name><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Liu</surname><given-names>C</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Ma</surname><given-names>C</given-names></name><name><surname>Tang</surname><given-names>J</given-names></name><name><surname>Baric</surname><given-names>RS</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Li</surname><given-names>F</given-names></name></person-group><article-title>Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus</article-title><source>Proc Natl Acad Sci USA</source><year>2014</year><volume>111</volume><issue>34</issue><fpage>12516</fpage><lpage>12521</lpage><pub-id pub-id-type="doi">10.1073/pnas.1405889111</pub-id><pub-id pub-id-type="pmid">25114257</pub-id></element-citation></ref><ref id="CR69"><label>69.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ying</surname><given-names>T</given-names></name><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Ju</surname><given-names>TW</given-names></name><name><surname>Prabakaran</surname><given-names>P</given-names></name><name><surname>Lau</surname><given-names>CC</given-names></name><name><surname>Lu</surname><given-names>L</given-names></name><name><surname>Liu</surname><given-names>Q</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Feng</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Zheng</surname><given-names>BJ</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Dimitrov</surname><given-names>DS</given-names></name></person-group><article-title>Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies</article-title><source>J Virol</source><year>2014</year><volume>88</volume><issue>14</issue><fpage>7796</fpage><lpage>7805</lpage><pub-id pub-id-type="doi">10.1128/JVI.00912-14</pub-id><pub-id pub-id-type="pmid">24789777</pub-id></element-citation></ref><ref id="CR70"><label>70.</label><element-citation publication-type="other"><source>Sci Transl Med</source><year>2014</year><volume>6</volume><issue>234</issue></element-citation></ref><ref id="CR71"><label>71.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tang</surname><given-names>XC</given-names></name><name><surname>Agnihothram</surname><given-names>SS</given-names></name><name><surname>Jiao</surname><given-names>Y</given-names></name><name><surname>Stanhope</surname><given-names>J</given-names></name><name><surname>Graham</surname><given-names>RL</given-names></name><name><surname>Peterson</surname><given-names>EC</given-names></name><name><surname>Avnir</surname><given-names>Y</given-names></name><name><surname>Tallarico</surname><given-names>AS</given-names></name><name><surname>Sheehan</surname><given-names>J</given-names></name><name><surname>Zhu</surname><given-names>Q</given-names></name><name><surname>Baric</surname><given-names>RS</given-names></name><name><surname>Marasco</surname><given-names>WA</given-names></name></person-group><article-title>Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution</article-title><source>Proc Natl Acad Sci USA</source><year>2014</year><volume>111</volume><issue>19</issue><fpage>E2018</fpage><lpage>E2026</lpage><pub-id pub-id-type="doi">10.1073/pnas.1402074111</pub-id><pub-id pub-id-type="pmid">24778221</pub-id></element-citation></ref><ref id="CR72"><label>72.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ying</surname><given-names>T</given-names></name><name><surname>Prabakaran</surname><given-names>P</given-names></name><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Shi</surname><given-names>W</given-names></name><name><surname>Feng</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Dimitrov</surname><given-names>DS</given-names></name><name><surname>Zhou</surname><given-names>T</given-names></name></person-group><article-title>Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody</article-title><source>Nat Commun</source><year>2015</year><volume>6</volume><fpage>8223</fpage><pub-id pub-id-type="doi">10.1038/ncomms9223</pub-id><pub-id pub-id-type="pmid">26370782</pub-id></element-citation></ref><ref id="CR73"><label>73.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Corti</surname><given-names>D</given-names></name><name><surname>Passini</surname><given-names>N</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name><name><surname>Zambon</surname><given-names>M</given-names></name></person-group><article-title>Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome</article-title><source>J Infect Public Health</source><year>2016</year><volume>9</volume><issue>3</issue><fpage>231</fpage><lpage>235</lpage><pub-id pub-id-type="doi">10.1016/j.jiph.2016.04.003</pub-id><pub-id pub-id-type="pmid">27102927</pub-id></element-citation></ref><ref id="CR74"><label>74.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pascal</surname><given-names>KE</given-names></name><name><surname>Coleman</surname><given-names>CM</given-names></name><name><surname>Mujica</surname><given-names>AO</given-names></name><name><surname>Kamat</surname><given-names>V</given-names></name><name><surname>Badithe</surname><given-names>A</given-names></name><name><surname>Fairhurst</surname><given-names>J</given-names></name><name><surname>Hunt</surname><given-names>C</given-names></name><name><surname>Strein</surname><given-names>J</given-names></name><name><surname>Berrebi</surname><given-names>A</given-names></name><name><surname>Sisk</surname><given-names>JM</given-names></name><name><surname>Matthews</surname><given-names>KL</given-names></name><name><surname>Babb</surname><given-names>R</given-names></name><name><surname>Chen</surname><given-names>G</given-names></name><name><surname>Lai</surname><given-names>KM</given-names></name><name><surname>Huang</surname><given-names>TT</given-names></name><name><surname>Olson</surname><given-names>W</given-names></name><name><surname>Yancopoulos</surname><given-names>GD</given-names></name><name><surname>Stahl</surname><given-names>N</given-names></name><name><surname>Frieman</surname><given-names>MB</given-names></name><name><surname>Kyratsous</surname><given-names>CA</given-names></name></person-group><article-title>Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection</article-title><source>Proc Natl Acad Sci USA</source><year>2015</year><volume>112</volume><issue>28</issue><fpage>8738</fpage><lpage>8743</lpage><pub-id pub-id-type="doi">10.1073/pnas.1510830112</pub-id><pub-id pub-id-type="pmid">26124093</pub-id></element-citation></ref><ref id="CR75"><label>75.</label><element-citation publication-type="other"><source>Sci Transl Med</source><year>2011</year><volume>3</volume><issue>105</issue></element-citation></ref><ref id="CR76"><label>76.</label><element-citation publication-type="other"><source>Sci Transl Med</source><year>2014</year><volume>6</volume><issue>242</issue></element-citation></ref><ref id="CR77"><label>77.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roopenian</surname><given-names>DC</given-names></name><name><surname>Akilesh</surname><given-names>S</given-names></name></person-group><article-title>FcRn: the neonatal Fc receptor comes of age</article-title><source>Nat Rev Immunol</source><year>2007</year><volume>7</volume><issue>9</issue><fpage>715</fpage><lpage>725</lpage><pub-id pub-id-type="doi">10.1038/nri2155</pub-id><pub-id pub-id-type="pmid">17703228</pub-id></element-citation></ref><ref id="CR78"><label>78.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Ying</surname><given-names>T</given-names></name></person-group><article-title>New directions for half-life extension of protein therapeutics: the rise of antibody Fc domains and fragments</article-title><source>Curr Pharm Biotechnol</source><year>2016</year><volume>17</volume><issue>15</issue><fpage>1348</fpage><lpage>1352</lpage><pub-id pub-id-type="doi">10.2174/1389201017666160823144032</pub-id><pub-id pub-id-type="pmid">27552847</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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