Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018
Identifieur interne : 000615 ( Pmc/Corpus ); précédent : 000614; suivant : 000616Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018
Auteurs : A. Tolah ; S. Al Masaudi ; S. El-Kafrawy ; A. Mirza ; S. Harakeh ; A. Hassan ; A. Alzahrani ; G. Alsaaidi ; A. Alagaili ; A. Hashem ; E. AzharSource :
- Journal of Infection and Public Health [ 1876-0341 ] ; 2020.
Url:
DOI: 10.1016/j.jiph.2020.01.178
PubMed: NONE
PubMed Central: 7129807
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018</title><author><name sortKey="Tolah, A" sort="Tolah, A" uniqKey="Tolah A" first="A." last="Tolah">A. Tolah</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0010">Department of Biological Science, Division of Microbiology, Faculty of science, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Masaudi, S Al" sort="Masaudi, S Al" uniqKey="Masaudi S" first="S. Al" last="Masaudi">S. Al Masaudi</name><affiliation><nlm:aff id="aff0010">Department of Biological Science, Division of Microbiology, Faculty of science, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="El Kafrawy, S" sort="El Kafrawy, S" uniqKey="El Kafrawy S" first="S." last="El-Kafrawy">S. El-Kafrawy</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Mirza, A" sort="Mirza, A" uniqKey="Mirza A" first="A." last="Mirza">A. Mirza</name><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Harakeh, S" sort="Harakeh, S" uniqKey="Harakeh S" first="S." last="Harakeh">S. Harakeh</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Hassan, A" sort="Hassan, A" uniqKey="Hassan A" first="A." last="Hassan">A. Hassan</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Alzahrani, A" sort="Alzahrani, A" uniqKey="Alzahrani A" first="A." last="Alzahrani">A. Alzahrani</name><affiliation><nlm:aff id="aff0020">Directorate of Agriculture, Ministry of Environment Water and Agriculture, Makkah Region, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Alsaaidi, G" sort="Alsaaidi, G" uniqKey="Alsaaidi G" first="G." last="Alsaaidi">G. Alsaaidi</name><affiliation><nlm:aff id="aff0020">Directorate of Agriculture, Ministry of Environment Water and Agriculture, Makkah Region, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Alagaili, A" sort="Alagaili, A" uniqKey="Alagaili A" first="A." last="Alagaili">A. Alagaili</name><affiliation><nlm:aff id="aff0025">KSU Mammals Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Hashem, A" sort="Hashem, A" uniqKey="Hashem A" first="A." last="Hashem">A. Hashem</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0030">Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0035">Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Azhar, E" sort="Azhar, E" uniqKey="Azhar E" first="E." last="Azhar">E. Azhar</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7129807</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129807</idno><idno type="RBID">PMC:7129807</idno><idno type="doi">10.1016/j.jiph.2020.01.178</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000615</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000615</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018</title><author><name sortKey="Tolah, A" sort="Tolah, A" uniqKey="Tolah A" first="A." last="Tolah">A. Tolah</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0010">Department of Biological Science, Division of Microbiology, Faculty of science, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Masaudi, S Al" sort="Masaudi, S Al" uniqKey="Masaudi S" first="S. Al" last="Masaudi">S. Al Masaudi</name><affiliation><nlm:aff id="aff0010">Department of Biological Science, Division of Microbiology, Faculty of science, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="El Kafrawy, S" sort="El Kafrawy, S" uniqKey="El Kafrawy S" first="S." last="El-Kafrawy">S. El-Kafrawy</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Mirza, A" sort="Mirza, A" uniqKey="Mirza A" first="A." last="Mirza">A. Mirza</name><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Harakeh, S" sort="Harakeh, S" uniqKey="Harakeh S" first="S." last="Harakeh">S. Harakeh</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Hassan, A" sort="Hassan, A" uniqKey="Hassan A" first="A." last="Hassan">A. Hassan</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Alzahrani, A" sort="Alzahrani, A" uniqKey="Alzahrani A" first="A." last="Alzahrani">A. Alzahrani</name><affiliation><nlm:aff id="aff0020">Directorate of Agriculture, Ministry of Environment Water and Agriculture, Makkah Region, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Alsaaidi, G" sort="Alsaaidi, G" uniqKey="Alsaaidi G" first="G." last="Alsaaidi">G. Alsaaidi</name><affiliation><nlm:aff id="aff0020">Directorate of Agriculture, Ministry of Environment Water and Agriculture, Makkah Region, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Alagaili, A" sort="Alagaili, A" uniqKey="Alagaili A" first="A." last="Alagaili">A. Alagaili</name><affiliation><nlm:aff id="aff0025">KSU Mammals Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Hashem, A" sort="Hashem, A" uniqKey="Hashem A" first="A." last="Hashem">A. Hashem</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0030">Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0035">Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Azhar, E" sort="Azhar, E" uniqKey="Azhar E" first="E." last="Azhar">E. Azhar</name><affiliation><nlm:aff id="aff0005">Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Infection and Public Health</title><idno type="ISSN">1876-0341</idno><idno type="eISSN">1876-035X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Public Health</journal-id><journal-id journal-id-type="iso-abbrev">J Infect Public Health</journal-id><journal-title-group><journal-title>Journal of Infection and Public Health</journal-title></journal-title-group><issn pub-type="ppub">1876-0341</issn><issn pub-type="epub">1876-035X</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7129807</article-id><article-id pub-id-type="publisher-id">S1876-0341(20)30179-9</article-id><article-id pub-id-type="doi">10.1016/j.jiph.2020.01.178</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Tolah</surname><given-names>A.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Masaudi</surname><given-names>S. AL</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>El-Kafrawy</surname><given-names>S.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0015" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Mirza</surname><given-names>A.</given-names></name><xref rid="aff0015" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Harakeh</surname><given-names>S.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0015" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Hassan</surname><given-names>A.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="aut0035"><name><surname>Alzahrani</surname><given-names>A.</given-names></name><xref rid="aff0020" ref-type="aff">4</xref></contrib><contrib contrib-type="author" id="aut0040"><name><surname>Alsaaidi</surname><given-names>G.</given-names></name><xref rid="aff0020" ref-type="aff">4</xref></contrib><contrib contrib-type="author" id="aut0045"><name><surname>Alagaili</surname><given-names>A.</given-names></name><xref rid="aff0025" ref-type="aff">5</xref></contrib><contrib contrib-type="author" id="aut0050"><name><surname>Hashem</surname><given-names>A.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0030" ref-type="aff">6</xref><xref rid="aff0035" ref-type="aff">7</xref></contrib><contrib contrib-type="author" id="aut0055"><name><surname>Azhar</surname><given-names>E.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0015" ref-type="aff">3</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</aff><aff id="aff0010"><label>2</label>Department of Biological Science, Division of Microbiology, Faculty of science, King Abdulaziz University, Jeddah, Saudi Arabia</aff><aff id="aff0015"><label>3</label>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia</aff><aff id="aff0020"><label>4</label>Directorate of Agriculture, Ministry of Environment Water and Agriculture, Makkah Region, Saudi Arabia</aff><aff id="aff0025"><label>5</label>KSU Mammals Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia</aff><aff id="aff0030"><label>6</label>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia</aff><aff id="aff0035"><label>7</label>Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</aff><pub-date pub-type="pmc-release"><day>5</day><month>2</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>5</day><month>2</month><year>2020</year></pub-date><volume>13</volume><issue>2</issue><fpage>371</fpage><lpage>371</lpage><permissions><copyright-statement>Copyright © 2020 Published by Elsevier Ltd.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005">The Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) is an endemic virus in Middle Eastern and African dromedaries. Annually, Saudi Arabia imports thousands of camels from the Horn of Africa, yet the epidemiology of the virus in these animals is largely unknown. Here, MERS-CoV prevalence was compared in imported African camels and their local counterparts.</p><p id="par0010">A total of 1399 paired sera and nasal swabs were collected between 2016 and 2018 from camels from Sudan (n = 829), Djibouti (n = 328) and Jeddah (n = 242). Imported animals were sampled on incoming ships at Jeddah Islamic seaport before unloading. Samples were screened for neutralizing antibodies (nAbs) and MERS-CoV viral RNA by RT-PCR.</p><p id="par0015">The overall seroprevalence was 92.7% and RNA detection rate was 17.2 %. Imported camels had higher seroprevalence compared to resident herds (93.8% vs 87.6%, <italic>p</italic> < 0.01) in contrast to RNA detection (13.3% vs 35.5%, <italic>p</italic> < 0.0001). Seroprevalence significantly increased with age (<italic>p</italic> < 0.0001) and viral RNA detection rate was ∼2-folds in camels < 2-year-old compared to older camels. RNA detection was higher in males verses females (24.3% vs 12.6%, <italic>p</italic> < 0.0001) but seroprevalence was similar. Concurrent positivity for viral RNA and nAbs was found in > 87 % of the RNA positive animals, increased with age and was sex-dependent. Importantly, reduced viral RNA load was positively correlated with nAb titers.</p><p id="par0020">Our data confirm MERS-CoV widespread in imported and domestic camels in Saudi Arabia and highlight the need for continuous active surveillance and better prevention measures. Further studies are also warranted to understand the correlates of protection in camels for proper vaccine development.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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