Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia
Identifieur interne : 000616 ( Pmc/Corpus ); précédent : 000615; suivant : 000617Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia
Auteurs : A. Degnah ; A. Hassan ; S. Al-Amri ; S. Hindawi ; E. Azhar ; A. HashemSource :
- Journal of Infection and Public Health [ 1876-0341 ] ; 2019.
Url:
DOI: 10.1016/j.jiph.2018.10.103
PubMed: NONE
PubMed Central: 7129841
Links to Exploration step
PMC:7129841Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia</title><author><name sortKey="Degnah, A" sort="Degnah, A" uniqKey="Degnah A" first="A." last="Degnah">A. Degnah</name><affiliation><nlm:aff id="aff0005">Faculty of Applied Medical Sciences, King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Hassan, A" sort="Hassan, A" uniqKey="Hassan A" first="A." last="Hassan">A. Hassan</name><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Al Amri, S" sort="Al Amri, S" uniqKey="Al Amri S" first="S." last="Al-Amri">S. Al-Amri</name><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Hindawi, S" sort="Hindawi, S" uniqKey="Hindawi S" first="S." last="Hindawi">S. Hindawi</name><affiliation><nlm:aff id="aff0015">Faculty of Medicine, King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Azhar, E" sort="Azhar, E" uniqKey="Azhar E" first="E." last="Azhar">E. Azhar</name><affiliation><nlm:aff id="aff0005">Faculty of Applied Medical Sciences, King Abdulaziz University</nlm:aff></affiliation><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Hashem, A" sort="Hashem, A" uniqKey="Hashem A" first="A." last="Hashem">A. Hashem</name><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Faculty of Medicine, King Abdulaziz University</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7129841</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129841</idno><idno type="RBID">PMC:7129841</idno><idno type="doi">10.1016/j.jiph.2018.10.103</idno><idno type="pmid">NONE</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000616</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000616</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia</title><author><name sortKey="Degnah, A" sort="Degnah, A" uniqKey="Degnah A" first="A." last="Degnah">A. Degnah</name><affiliation><nlm:aff id="aff0005">Faculty of Applied Medical Sciences, King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Hassan, A" sort="Hassan, A" uniqKey="Hassan A" first="A." last="Hassan">A. Hassan</name><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Al Amri, S" sort="Al Amri, S" uniqKey="Al Amri S" first="S." last="Al-Amri">S. Al-Amri</name><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Hindawi, S" sort="Hindawi, S" uniqKey="Hindawi S" first="S." last="Hindawi">S. Hindawi</name><affiliation><nlm:aff id="aff0015">Faculty of Medicine, King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Azhar, E" sort="Azhar, E" uniqKey="Azhar E" first="E." last="Azhar">E. Azhar</name><affiliation><nlm:aff id="aff0005">Faculty of Applied Medical Sciences, King Abdulaziz University</nlm:aff></affiliation><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation></author><author><name sortKey="Hashem, A" sort="Hashem, A" uniqKey="Hashem A" first="A." last="Hashem">A. Hashem</name><affiliation><nlm:aff id="aff0010">The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Faculty of Medicine, King Abdulaziz University</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Infection and Public Health</title><idno type="ISSN">1876-0341</idno><idno type="eISSN">1876-035X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Public Health</journal-id><journal-id journal-id-type="iso-abbrev">J Infect Public Health</journal-id><journal-title-group><journal-title>Journal of Infection and Public Health</journal-title></journal-title-group><issn pub-type="ppub">1876-0341</issn><issn pub-type="epub">1876-035X</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7129841</article-id><article-id pub-id-type="publisher-id">S1876-0341(18)30273-9</article-id><article-id pub-id-type="doi">10.1016/j.jiph.2018.10.103</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Degnah</surname><given-names>A.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Hassan</surname><given-names>A.</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Al-amri</surname><given-names>S.</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Hindawi</surname><given-names>S.</given-names></name><xref rid="aff0015" ref-type="aff">3</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Azhar</surname><given-names>E.</given-names></name><xref rid="aff0005" ref-type="aff">1</xref><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Hashem</surname><given-names>A.</given-names></name><xref rid="aff0010" ref-type="aff">2</xref><xref rid="aff0015" ref-type="aff">3</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Faculty of Applied Medical Sciences, King Abdulaziz University</aff><aff id="aff0010"><label>2</label>The Special Infectious Agents Unit (SIAU), King Fahd Medical Research Center (KFMRC), King Abdulaziz University</aff><aff id="aff0015"><label>3</label>Faculty of Medicine, King Abdulaziz University</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author.</corresp></author-notes><pub-date pub-type="pmc-release"><day>8</day><month>1</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2019-02-01"><season>January-February</season><year>2019</year></pub-date><pub-date pub-type="epub"><day>8</day><month>1</month><year>2019</year></pub-date><volume>12</volume><issue>1</issue><fpage>138</fpage><lpage>138</lpage><permissions><copyright-statement>Copyright © 2018 Published by Elsevier Ltd.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005"><bold>Background:</bold> The Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) is a novel zoonotic virus emerged in 2012 in the Middle East. Accumulating body of evidence suggests that dromedaries are the main known reservoir hosts. Nonetheless, both Human-to-human and camel-to-human transmissions have been reported. So far, only 2,090 confirmed cases have been reported in 27 countries with a high mortality rate of 30–40%. However, prevalence of MERS-CoV in the general population is still not clear and epidemiological studies are limited especially in Saudi Arabia which is the most affected country. Therefore, our main goal in this study was to determine the sero-prevalence of MERS-CoV among healthy people in the western region of Saudi Arabia.</p><p id="par0010"><bold>Methodology:</bold> A total of 7, 462 archived serum samples collected between 2011 and 2016 from healthy blood donors in the western region of Saudi Arabia were screened by ELISA tests for the presence of MERS-CoV antibodies. All ELISA positive samples were tested for presence of neutralizing antibodies using MERS-CoV neutralization assay.</p><p id="par0015"><bold>Results:</bold> The indirect ELISA results showed that the seroprevalence of MERS-CoV for the years 2011, 2012 and 2013 were 1.11% (1/90), 0.74% (10/1360) and 1.8% (18/999), respectively. Interestingly, testing samples from 2016 showed increased seroprevalence of 3.01% (151/5013).</p><p id="par0020">The cumulative overall seroprevalence of MERS-CoV for all years was 2.41% (180/7,462). Interestingly, none of the positive samples showed any evidence of neutralizing antibodies.</p><p id="par0025"><bold>Conclusion:</bold> Our data here showed that MERS-CoV or a closely related coronavirus might have been circulating before 2012 in Saudi Arabia. Data also suggest that there might be several cases that are undiagnosed or missed probably due to mild or asymptomatic infections which could resulted in the observed very low or undetectably neutralizing antibodies. Interestingly, we found that seroprevalence of MERS-CoV is increasing over the years underscoring the importance for continued active surveillance for MERS-CoV.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000616 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000616 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:7129841
|texte= Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:NONE" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |