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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mers Coronavirus Infection in Dromedary Camels</title><author><name sortKey="Van Den Brand, J M A" sort="Van Den Brand, J M A" uniqKey="Van Den Brand J" first="J. M. A." last="Van Den Brand">J. M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wohlsein, P" sort="Wohlsein, P" uniqKey="Wohlsein P" first="P." last="Wohlsein">P. Wohlsein</name><affiliation><nlm:aff id="aff2">Department of Pathology, University of Veterinary Medicine, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Stalin Raj, V" sort="Stalin Raj, V" uniqKey="Stalin Raj V" first="V." last="Stalin Raj">V. Stalin Raj</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smits, S L" sort="Smits, S L" uniqKey="Smits S" first="S. L." last="Smits">S. L. Smits</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schippers, D" sort="Schippers, D" uniqKey="Schippers D" first="D." last="Schippers">D. Schippers</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Segales, J" sort="Segales, J" uniqKey="Segales J" first="J." last="Segalés">J. Segalés</name><affiliation><nlm:aff id="aff3">Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Bensaid, A" sort="Bensaid, A" uniqKey="Bensaid A" first="A." last="Bensaid">A. Bensaid</name><affiliation><nlm:aff id="aff3">Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Solanes, D" sort="Solanes, D" uniqKey="Solanes D" first="D." last="Solanes">D. Solanes</name><affiliation><nlm:aff id="aff3">Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Volz, A" sort="Volz, A" uniqKey="Volz A" first="A." last="Volz">A. Volz</name><affiliation><nlm:aff id="aff4">Institute for Infectious Diseases and Zoönoses, LMU University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuiken, T" sort="Kuiken, T" uniqKey="Kuiken T" first="T." last="Kuiken">T. Kuiken</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Baumg Rtner, W" sort="Baumg Rtner, W" uniqKey="Baumg Rtner W" first="W." last="Baumg Rtner">W. Baumg Rtner</name><affiliation><nlm:aff id="aff2">Department of Pathology, University of Veterinary Medicine, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pathology, University of Veterinary Medicine, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, G" sort="Sutter, G" uniqKey="Sutter G" first="G." last="Sutter">G. Sutter</name><affiliation><nlm:aff id="aff4">Institute for Infectious Diseases and Zoönoses, LMU University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Haagmans, B L" sort="Haagmans, B L" uniqKey="Haagmans B" first="B. L." last="Haagmans">B. L. Haagmans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7130402</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130402</idno><idno type="RBID">PMC:7130402</idno><idno type="doi">10.1016/j.jcpa.2015.10.018</idno><idno type="pmid">NONE</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000603</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000603</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mers Coronavirus Infection in Dromedary Camels</title><author><name sortKey="Van Den Brand, J M A" sort="Van Den Brand, J M A" uniqKey="Van Den Brand J" first="J. M. A." last="Van Den Brand">J. M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wohlsein, P" sort="Wohlsein, P" uniqKey="Wohlsein P" first="P." last="Wohlsein">P. Wohlsein</name><affiliation><nlm:aff id="aff2">Department of Pathology, University of Veterinary Medicine, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Stalin Raj, V" sort="Stalin Raj, V" uniqKey="Stalin Raj V" first="V." last="Stalin Raj">V. Stalin Raj</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smits, S L" sort="Smits, S L" uniqKey="Smits S" first="S. L." last="Smits">S. L. Smits</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schippers, D" sort="Schippers, D" uniqKey="Schippers D" first="D." last="Schippers">D. Schippers</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Segales, J" sort="Segales, J" uniqKey="Segales J" first="J." last="Segalés">J. Segalés</name><affiliation><nlm:aff id="aff3">Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Bensaid, A" sort="Bensaid, A" uniqKey="Bensaid A" first="A." last="Bensaid">A. Bensaid</name><affiliation><nlm:aff id="aff3">Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Solanes, D" sort="Solanes, D" uniqKey="Solanes D" first="D." last="Solanes">D. Solanes</name><affiliation><nlm:aff id="aff3">Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Volz, A" sort="Volz, A" uniqKey="Volz A" first="A." last="Volz">A. Volz</name><affiliation><nlm:aff id="aff4">Institute for Infectious Diseases and Zoönoses, LMU University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Kuiken, T" sort="Kuiken, T" uniqKey="Kuiken T" first="T." last="Kuiken">T. Kuiken</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Baumg Rtner, W" sort="Baumg Rtner, W" uniqKey="Baumg Rtner W" first="W." last="Baumg Rtner">W. Baumg Rtner</name><affiliation><nlm:aff id="aff2">Department of Pathology, University of Veterinary Medicine, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pathology, University of Veterinary Medicine, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, G" sort="Sutter, G" uniqKey="Sutter G" first="G." last="Sutter">G. Sutter</name><affiliation><nlm:aff id="aff4">Institute for Infectious Diseases and Zoönoses, LMU University of Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Haagmans, B L" sort="Haagmans, B L" uniqKey="Haagmans B" first="B. L." last="Haagmans">B. L. Haagmans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Comparative Pathology</title><idno type="ISSN">0021-9975</idno><idno type="eISSN">1532-3129</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Comp Pathol</journal-id><journal-id journal-id-type="iso-abbrev">J. Comp. Pathol</journal-id><journal-title-group><journal-title>Journal of Comparative Pathology</journal-title></journal-title-group><issn pub-type="ppub">0021-9975</issn><issn pub-type="epub">1532-3129</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7130402</article-id><article-id pub-id-type="publisher-id">S0021-9975(15)00153-X</article-id><article-id pub-id-type="doi">10.1016/j.jcpa.2015.10.018</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Mers Coronavirus Infection in Dromedary Camels</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>van den Brand</surname><given-names>J.M.A.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Wohlsein</surname><given-names>P.</given-names></name><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Stalin Raj</surname><given-names>V.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Smits</surname><given-names>S.L.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Schippers</surname><given-names>D.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Segalés</surname><given-names>J.</given-names></name><xref rid="aff3" ref-type="aff">‡</xref></contrib><contrib contrib-type="author" id="au7"><name><surname>Bensaid</surname><given-names>A.</given-names></name><xref rid="aff3" ref-type="aff">‡</xref></contrib><contrib contrib-type="author" id="au8"><name><surname>Solanes</surname><given-names>D.</given-names></name><xref rid="aff3" ref-type="aff">‡</xref></contrib><contrib contrib-type="author" id="au9"><name><surname>Volz</surname><given-names>A.</given-names></name><xref rid="aff4" ref-type="aff">§</xref></contrib><contrib contrib-type="author" id="au10"><name><surname>Kuiken</surname><given-names>T.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au11"><name><surname>Baumgärtner</surname><given-names>W.</given-names></name><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au12"><name><surname>Osterhaus</surname><given-names>A.D.M.E.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au13"><name><surname>Sutter</surname><given-names>G.</given-names></name><xref rid="aff4" ref-type="aff">§</xref></contrib><contrib contrib-type="author" id="au14"><name><surname>Haagmans</surname><given-names>B.L.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib></contrib-group><aff id="aff1"><label>∗</label>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="aff2"><label>†</label>Department of Pathology, University of Veterinary Medicine, Hannover, Germany</aff><aff id="aff3"><label>‡</label>Centre de Recerca en Sanitat Animal (CReSA), Barcelona, Spain</aff><aff id="aff4"><label>§</label>Institute for Infectious Diseases and Zoönoses, LMU University of Munich, Munich, Germany</aff><pub-date pub-type="pmc-release"><day>5</day><month>2</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>5</day><month>2</month><year>2016</year></pub-date><volume>154</volume><issue>1</issue><fpage>64</fpage><lpage>64</lpage><permissions><copyright-statement>Copyright © 2015 Published by Elsevier Ltd.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="p0010"><bold>Introduction</bold>: Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus causing an ongoing outbreak in man, sometimes resulting in severe or even fatal pneumonia. Dromedary camels are suggested to be the reservoir host for MERS-CoV. Infected dromedaries shed the virus predominantly from the nose, but show no or only mild disease. To elucidate the pathogenesis of MERS-CoV infection, we inoculated dromedary camels with MERS-CoV.</p><p id="p0015"><bold>Materials and Methods</bold>: Four 6- to 8-month-old dromedaries, serologically negative for MERS-CoV, were inoculated intranasally with MERS-CoV. Collection of swabs and evaluation of clinical signs were performed daily. The dromedaries were killed 4 or 14 days (<italic>n</italic> = 2 per day) after inoculation. Necropsy examinations were performed and samples of respiratory and extra-respiratory tissues were taken for pathology, immunohistochemistry (IHC), in-situ hybridization (ISH) and virology.</p><p id="p0020"><bold>Results</bold>: The dromedaries demonstrated moderate rhinitis with nasal discharge, tracheitis and bronchitis associated with the presence of MERS-CoV by virus titration, intralesional virus antigen by IHC and viral RNA by ISH. High virus titres were excreted from the nose up to 6 days after inoculation. Virus antigen was present in a few cells of lymphoid organs such as pulmonary, tracheal and cervical lymph nodes and tonsils, but not in other respiratory or extra-respiratory tissues.</p><p id="p0025"><bold>Conclusions</bold>: Experimental MERS-CoV infection in dromedaries predominantly causes upper respiratory tract disease with no/mild clinical respiratory signs, which corresponds with the role of dromedaries as a reservoir for MERS-CoV. Studies on the vaccination of dromedaries against MERS-CoV are still ongoing.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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