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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mers coronavirus infection of rabbits</title><author><name sortKey="Van Den Brand, J M A" sort="Van Den Brand, J M A" uniqKey="Van Den Brand J" first="J. M. A." last="Van Den Brand">J. M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Haagmans, B L" sort="Haagmans, B L" uniqKey="Haagmans B" first="B. L." last="Haagmans">B. L. Haagmans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Provacia, L B" sort="Provacia, L B" uniqKey="Provacia L" first="L. B." last="Provacia">L. B. Provacia</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Raj, V S" sort="Raj, V S" uniqKey="Raj V" first="V. S." last="Raj">V. S. Raj</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Stittelaar, K J" sort="Stittelaar, K J" uniqKey="Stittelaar K" first="K. J." last="Stittelaar">K. J. Stittelaar</name><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Getu, S" sort="Getu, S" uniqKey="Getu S" first="S." last="Getu">S. Getu</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Waal, L" sort="De Waal, L" uniqKey="De Waal L" first="L." last="De Waal">L. De Waal</name><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bestebroer, T M" sort="Bestebroer, T M" uniqKey="Bestebroer T" first="T. M." last="Bestebroer">T. M. Bestebroer</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Amerongen, G" sort="Van Amerongen, G" uniqKey="Van Amerongen G" first="G." last="Van Amerongen">G. Van Amerongen</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verjans, G M G M" sort="Verjans, G M G M" uniqKey="Verjans G" first="G. M. G. M." last="Verjans">G. M. G. M. Verjans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fouchier, R A M" sort="Fouchier, R A M" uniqKey="Fouchier R" first="R. A. M." last="Fouchier">R. A. M. Fouchier</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smits, S L" sort="Smits, S L" uniqKey="Smits S" first="S. L." last="Smits">S. L. Smits</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuiken, T" sort="Kuiken, T" uniqKey="Kuiken T" first="T." last="Kuiken">T. Kuiken</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7130374</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130374</idno><idno type="RBID">PMC:7130374</idno><idno type="doi">10.1016/j.jcpa.2014.10.051</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000602</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000602</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mers coronavirus infection of rabbits</title><author><name sortKey="Van Den Brand, J M A" sort="Van Den Brand, J M A" uniqKey="Van Den Brand J" first="J. M. A." last="Van Den Brand">J. M. A. Van Den Brand</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Haagmans, B L" sort="Haagmans, B L" uniqKey="Haagmans B" first="B. L." last="Haagmans">B. L. Haagmans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Provacia, L B" sort="Provacia, L B" uniqKey="Provacia L" first="L. B." last="Provacia">L. B. Provacia</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Raj, V S" sort="Raj, V S" uniqKey="Raj V" first="V. S." last="Raj">V. S. Raj</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Stittelaar, K J" sort="Stittelaar, K J" uniqKey="Stittelaar K" first="K. J." last="Stittelaar">K. J. Stittelaar</name><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Getu, S" sort="Getu, S" uniqKey="Getu S" first="S." last="Getu">S. Getu</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Waal, L" sort="De Waal, L" uniqKey="De Waal L" first="L." last="De Waal">L. De Waal</name><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bestebroer, T M" sort="Bestebroer, T M" uniqKey="Bestebroer T" first="T. M." last="Bestebroer">T. M. Bestebroer</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Amerongen, G" sort="Van Amerongen, G" uniqKey="Van Amerongen G" first="G." last="Van Amerongen">G. Van Amerongen</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verjans, G M G M" sort="Verjans, G M G M" uniqKey="Verjans G" first="G. M. G. M." last="Verjans">G. M. G. M. Verjans</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fouchier, R A M" sort="Fouchier, R A M" uniqKey="Fouchier R" first="R. A. M." last="Fouchier">R. A. M. Fouchier</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Smits, S L" sort="Smits, S L" uniqKey="Smits S" first="S. L." last="Smits">S. L. Smits</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuiken, T" sort="Kuiken, T" uniqKey="Kuiken T" first="T." last="Kuiken">T. Kuiken</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name><affiliation><nlm:aff id="aff1">Department of Viroscience, Erasmus Medical Center, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Viroclinics Biosciences, Rotterdam, The Netherlands</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Comparative Pathology</title><idno type="ISSN">0021-9975</idno><idno type="eISSN">1532-3129</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Comp Pathol</journal-id><journal-id journal-id-type="iso-abbrev">J. Comp. Pathol</journal-id><journal-title-group><journal-title>Journal of Comparative Pathology</journal-title></journal-title-group><issn pub-type="ppub">0021-9975</issn><issn pub-type="epub">1532-3129</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7130374</article-id><article-id pub-id-type="publisher-id">S0021-9975(14)00195-9</article-id><article-id pub-id-type="doi">10.1016/j.jcpa.2014.10.051</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Mers coronavirus infection of rabbits</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>van den Brand</surname><given-names>J.M.A.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Haagmans</surname><given-names>B.L.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Provacia</surname><given-names>L.B.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Raj</surname><given-names>V.S.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Stittelaar</surname><given-names>K.J.</given-names></name><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Getu</surname><given-names>S.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au7"><name><surname>de Waal</surname><given-names>L.</given-names></name><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au8"><name><surname>Bestebroer</surname><given-names>T.M.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au9"><name><surname>van Amerongen</surname><given-names>G.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au10"><name><surname>Verjans</surname><given-names>G.M.G.M.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au11"><name><surname>Fouchier</surname><given-names>R.A.M.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au12"><name><surname>Smits</surname><given-names>S.L.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author" id="au13"><name><surname>Kuiken</surname><given-names>T.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref></contrib><contrib contrib-type="author" id="au14"><name><surname>Osterhaus</surname><given-names>A.D.M.E.</given-names></name><xref rid="aff1" ref-type="aff">∗</xref><xref rid="aff2" ref-type="aff">†</xref></contrib></contrib-group><aff id="aff1"><label>∗</label>Department of Viroscience, Erasmus Medical Center, The Netherlands</aff><aff id="aff2"><label>†</label>Viroclinics Biosciences, Rotterdam, The Netherlands</aff><pub-date pub-type="pmc-release"><day>28</day><month>1</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>1</month><year>2015</year></pub-date><volume>152</volume><issue>1</issue><fpage>53</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright © 2014 Published by Elsevier Ltd.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="p0010"><bold>Introduction</bold>: A new coronavirus (CoV), Middle East respiratory syndrome CoV (MERS-CoV), is causing an ongoing outbreak in people, sometimes resulting in severe or even fatal pneumonia. MERS-CoV uses dipeptidyl peptidase 4 (DPP4) as a functional receptor and is able to infect cells of a limited number of animal species including bats, camels, goats and non-human primates <italic>in vitro</italic>, but so far there is no good animal model for human disease. Because the virus binding region in rabbit DPP4 closely resembles that in human DPP4, we tested whether rabbits can be infected with MERS-CoV as an animal model for MERS-CoV infection in man.</p><p id="p0015"><bold>Materials and Methods</bold>: Sixteen rabbits, serologically negative for MERS-CoV, were inoculated with MERS-CoV or sham inoculum via nose and trachea and swabs were taken frequently. The rabbits were killed 3, 4 or 21 days (<italic>n</italic> = 4 per day) after inoculation and during necropsy examination samples were taken for pathology, immunohistochemistry, in-situ hybridization and virology.</p><p id="p0020"><bold>Results</bold>: The rabbits had no clinical signs and 3 or 4 days after inoculation. They had high viral loads as determined by PCR and scattered virus antigen expression in the lungs and nose, associated with mild alveolitis and moderate rhinitis.</p><p id="p0025"><bold>Conclusions</bold>: The results of this study demonstrate that rabbits can be infected with MERS-CoV with virus replication in the lungs and nose. Therefore, rabbits infected with MERS-CoV may be used as a model to study the pathogenesis of MERS, transmission of MERS-CoV and to test intervention strategies aimed at inhibition of MERS-CoV replication <italic>in vivo</italic>.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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