DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Identifieur interne : 000892 ( Pmc/Checkpoint ); précédent : 000891; suivant : 000893DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Auteurs : Leen J M. Seys [Belgique] ; W. Widagdo [Pays-Bas] ; Fien M. Verhamme [Belgique] ; Alex Kleinjan [Pays-Bas] ; Wim Janssens [Belgique] ; Guy F. Joos [Belgique] ; Ken R. Bracke [Belgique] ; Bart L. Haagmans [Pays-Bas] ; Guy G. Brusselle [Belgique]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2017.
Abstract
The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.
Url:
DOI: 10.1093/cid/cix741
PubMed: 29020176
PubMed Central: 7108100
Affiliations:
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This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Min, Ck" uniqKey="Min C">CK Min</name></author><author><name sortKey="Cheon, S" uniqKey="Cheon S">S Cheon</name></author><author><name sortKey="Ha, Ny" uniqKey="Ha N">NY Ha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name></author><author><name sortKey="Park, Jw" uniqKey="Park J">JW Park</name></author><author><name sortKey="Jung, Hd" uniqKey="Jung H">HD Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Gethamy, M" uniqKey="Al Gethamy M">M Al-Gethamy</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Hussain, R" uniqKey="Hussain R">R Hussain</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boonacker, E" uniqKey="Boonacker E">E Boonacker</name></author><author><name sortKey="Van Noorden, Cj" uniqKey="Van Noorden C">CJ Van Noorden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barreira Da Silva, R" uniqKey="Barreira Da Silva R">R Barreira da Silva</name></author><author><name sortKey="Laird, Me" uniqKey="Laird M">ME Laird</name></author><author><name sortKey="Yatim, N" uniqKey="Yatim N">N Yatim</name></author><author><name sortKey="Fiette, L" uniqKey="Fiette L">L Fiette</name></author><author><name sortKey="Ingersoll, Ma" uniqKey="Ingersoll M">MA Ingersoll</name></author><author><name sortKey="Albert, Ml" uniqKey="Albert M">ML Albert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortier, A" uniqKey="Mortier A">A Mortier</name></author><author><name sortKey="Gouwy, M" uniqKey="Gouwy M">M Gouwy</name></author><author><name sortKey="Van Damme, J" uniqKey="Van Damme J">J Van Damme</name></author><author><name sortKey="Proost, P" uniqKey="Proost P">P Proost</name></author><author><name sortKey="Struyf, S" uniqKey="Struyf S">S Struyf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanhoof, G" uniqKey="Vanhoof G">G Vanhoof</name></author><author><name sortKey="De Meester, I" uniqKey="De Meester I">I De Meester</name></author><author><name sortKey="Van Sande, M" uniqKey="Van Sande M">M van Sande</name></author><author><name sortKey="Scharpe, S" uniqKey="Scharpe S">S Scharpé</name></author><author><name sortKey="Yaron, A" uniqKey="Yaron A">A Yaron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Lambertz, Am" uniqKey="Lambertz A">AM Lambertz</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheuplein, Va" uniqKey="Scheuplein V">VA Scheuplein</name></author><author><name sortKey="Seifried, J" uniqKey="Seifried J">J Seifried</name></author><author><name sortKey="Malczyk, Ah" uniqKey="Malczyk A">AH Malczyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Widagdo, W" uniqKey="Widagdo W">W Widagdo</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Schipper, D" uniqKey="Schipper D">D Schipper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vliegen, G" uniqKey="Vliegen G">G Vliegen</name></author><author><name sortKey="Raju, Tk" uniqKey="Raju T">TK Raju</name></author><author><name sortKey="Adriaensen, D" uniqKey="Adriaensen D">D Adriaensen</name></author><author><name sortKey="Lambeir, Am" uniqKey="Lambeir A">AM Lambeir</name></author><author><name sortKey="De Meester, I" uniqKey="De Meester I">I De Meester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name></author><author><name sortKey="Watson, Jt" uniqKey="Watson J">JT Watson</name></author><author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A Almarashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vestbo, J" uniqKey="Vestbo J">J Vestbo</name></author><author><name sortKey="Hurd, Ss" uniqKey="Hurd S">SS Hurd</name></author><author><name sortKey="Agusti, Ag" uniqKey="Agusti A">AG Agustí</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brusselle, Gg" uniqKey="Brusselle G">GG Brusselle</name></author><author><name sortKey="Joos, Gf" uniqKey="Joos G">GF Joos</name></author><author><name sortKey="Bracke, Kr" uniqKey="Bracke K">KR Bracke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verhoeven, Gt" uniqKey="Verhoeven G">GT Verhoeven</name></author><author><name sortKey="Verbraak, Af" uniqKey="Verbraak A">AF Verbraak</name></author><author><name sortKey="Boere Van Der Straat, S" uniqKey="Boere Van Der Straat S">S Boere-van der Straat</name></author><author><name sortKey="Hoogsteden, Hc" uniqKey="Hoogsteden H">HC Hoogsteden</name></author><author><name sortKey="Bogaard, Jm" uniqKey="Bogaard J">JM Bogaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP Tashkin</name></author><author><name sortKey="Altose, Md" uniqKey="Altose M">MD Altose</name></author><author><name sortKey="Bleecker, Er" uniqKey="Bleecker E">ER Bleecker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braunstahl, Gj" uniqKey="Braunstahl G">GJ Braunstahl</name></author><author><name sortKey="Fokkens, Wj" uniqKey="Fokkens W">WJ Fokkens</name></author><author><name sortKey="Overbeek, Se" uniqKey="Overbeek S">SE Overbeek</name></author><author><name sortKey="Kleinjan, A" uniqKey="Kleinjan A">A KleinJan</name></author><author><name sortKey="Hoogsteden, Hc" uniqKey="Hoogsteden H">HC Hoogsteden</name></author><author><name sortKey="Prins, Jb" uniqKey="Prins J">JB Prins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demedts, Ik" uniqKey="Demedts I">IK Demedts</name></author><author><name sortKey="Brusselle, Gg" uniqKey="Brusselle G">GG Brusselle</name></author><author><name sortKey="Vermaelen, Ky" uniqKey="Vermaelen K">KY Vermaelen</name></author><author><name sortKey="Pauwels, Ra" uniqKey="Pauwels R">RA Pauwels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seys, Lj" uniqKey="Seys L">LJ Seys</name></author><author><name sortKey="Verhamme, Fm" uniqKey="Verhamme F">FM Verhamme</name></author><author><name sortKey="Schinwald, A" uniqKey="Schinwald A">A Schinwald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vandesompele, J" uniqKey="Vandesompele J">J Vandesompele</name></author><author><name sortKey="De Preter, K" uniqKey="De Preter K">K De Preter</name></author><author><name sortKey="Pattyn, F" uniqKey="Pattyn F">F Pattyn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author><author><name sortKey="Kanasaki, K" uniqKey="Kanasaki K">K Kanasaki</name></author><author><name sortKey="Koya, D" uniqKey="Koya D">D Koya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brightling, Ce" uniqKey="Brightling C">CE Brightling</name></author><author><name sortKey="Chanez, P" uniqKey="Chanez P">P Chanez</name></author><author><name sortKey="Leigh, R" uniqKey="Leigh R">R Leigh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verhamme, Fm" uniqKey="Verhamme F">FM Verhamme</name></author><author><name sortKey="Bracke, Kr" uniqKey="Bracke K">KR Bracke</name></author><author><name sortKey="Joos, Gf" uniqKey="Joos G">GF Joos</name></author><author><name sortKey="Brusselle, Gg" uniqKey="Brusselle G">GG Brusselle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, V" uniqKey="Kim V">V Kim</name></author><author><name sortKey="Rogers, Tj" uniqKey="Rogers T">TJ Rogers</name></author><author><name sortKey="Criner, Gj" uniqKey="Criner G">GJ Criner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, J" uniqKey="Zhong J">J Zhong</name></author><author><name sortKey="Rao, X" uniqKey="Rao X">X Rao</name></author><author><name sortKey="Rajagopalan, S" uniqKey="Rajagopalan S">S Rajagopalan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacheco, R" uniqKey="Pacheco R">R Pacheco</name></author><author><name sortKey="Martinez Navio, Jm" uniqKey="Martinez Navio J">JM Martinez-Navio</name></author><author><name sortKey="Lejeune, M" uniqKey="Lejeune M">M Lejeune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bracke, Kr" uniqKey="Bracke K">KR Bracke</name></author><author><name sortKey="Demedts, Ik" uniqKey="Demedts I">IK Demedts</name></author><author><name sortKey="Joos, Gf" uniqKey="Joos G">GF Joos</name></author><author><name sortKey="Brusselle, Gg" uniqKey="Brusselle G">GG Brusselle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Somborac Ba Ura, A" uniqKey="Somborac Ba Ura A">A Somborac-Bačura</name></author><author><name sortKey="Buljevi, S" uniqKey="Buljevi S">S Buljević</name></author><author><name sortKey="Rumora, L" uniqKey="Rumora L">L Rumora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Xy" uniqKey="Chang X">XY Chang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Jia, Xq" uniqKey="Jia X">XQ Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decramer, M" uniqKey="Decramer M">M Decramer</name></author><author><name sortKey="Janssens, W" uniqKey="Janssens W">W Janssens</name></author><author><name sortKey="Miravitlles, M" uniqKey="Miravitlles M">M Miravitlles</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29020176</article-id><article-id pub-id-type="pmc">7108100</article-id><article-id pub-id-type="doi">10.1093/cid/cix741</article-id><article-id pub-id-type="publisher-id">cix741</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject></subj-group></article-categories><title-group><article-title>DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Seys</surname><given-names>Leen J M</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Widagdo</surname><given-names>W</given-names></name><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Verhamme</surname><given-names>Fien M</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Kleinjan</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="AF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Janssens</surname><given-names>Wim</given-names></name><xref ref-type="aff" rid="AF0005">5</xref></contrib><contrib contrib-type="author"><name><surname>Joos</surname><given-names>Guy F</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Bracke</surname><given-names>Ken R</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Haagmans</surname><given-names>Bart L</given-names></name><xref ref-type="aff" rid="AF0003">3</xref><xref ref-type="author-notes" rid="fn-0001"></xref></contrib><contrib contrib-type="author"><name><surname>Brusselle</surname><given-names>Guy G</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="author-notes" rid="fn-0001"></xref><xref ref-type="corresp" rid="c1"></xref><pmc-comment>Guy.Brusselle@UGent.be </pmc-comment>
</contrib></contrib-group><aff id="AF0001"><label>1</label>Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium</aff><aff id="AF0002"><label>2</label>Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium</aff><aff id="AF0003"><label>3</label>Departments of Viroscience, Rotterdam, The Netherlands</aff><aff id="AF0004"><label>4</label>Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="AF0005"><label>5</label>University Hospital Leuven, Respiratory Division and Rehabilitation, Leuven, Belgium</aff><author-notes><fn id="fn-0001"><p>B. L. H. and G. G. B. contributed equally to this manuscript.</p></fn><corresp id="c1">Correspondence: Prof. Dr. G. G. Brusselle, Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium (<email>Guy.Brusselle@UGent.be</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>1</month><year>2018</year></pub-date><pub-date pub-type="epub" iso-8601-date="2017-08-17"><day>17</day><month>8</month><year>2017</year></pub-date><volume>66</volume><issue>1</issue><fpage>45</fpage><lpage>53</lpage><history><date date-type="received"><day>03</day><month>5</month><year>2017</year></date><date date-type="accepted"><day>12</day><month>8</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</copyright-statement><copyright-year>2017</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="cix741.pdf"></self-uri><abstract abstract-type="teaser"><p>The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.</p></abstract><abstract><title>Abstract</title><sec id="s1"><title>Background</title><p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes pneumonia with a relatively high case fatality rate in humans. Smokers and chronic obstructive pulmonary disease (COPD) patients have been reported to be more susceptible to MERS-CoV infection. Here, we determined the expression of MERS-CoV receptor, dipeptidyl peptidase IV (DPP4), in lung tissues of smokers without airflow limitation and COPD patients in comparison to nonsmoking individuals (never-smokers).</p></sec><sec id="s2"><title>Methods</title><p>DPP4 expression was measured in lung tissue of lung resection specimens of never-smokers, smokers without airflow limitation, COPD GOLD stage II patients and in lung explants of end-stage COPD patients. Both control subjects and COPD patients were well phenotyped and age-matched. The mRNA expression was determined using qRT-PCR and protein expression was quantified using immunohistochemistry.</p></sec><sec id="s3"><title>Results</title><p>In smokers and subjects with COPD, both DPP4 mRNA and protein expression were significantly higher compared to never-smokers. Additionally, we found that both DPP4 mRNA and protein expression were inversely correlated with lung function and diffusing capacity parameters.</p></sec><sec id="s4"><title>Conclusions</title><p>We provide evidence that DPP4 is upregulated in the lungs of smokers and COPD patients, which could partially explain why these individuals are more susceptible to MERS-CoV infection. These data also highlight a possible role of DPP4 in COPD pathogenesis.</p></sec></abstract><kwd-group><kwd>Middle East respiratory syndrome coronavirus (MERS-CoV)</kwd><kwd>dipeptidyl peptidase 4 (DPP4)</kwd><kwd>smoking</kwd><kwd>chronic obstructive pulmonary disease (COPD)</kwd></kwd-group><counts><page-count count="9"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Belgique</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><country name="Belgique"><noRegion><name sortKey="Seys, Leen J M" sort="Seys, Leen J M" uniqKey="Seys L" first="Leen J M" last="Seys">Leen J M. Seys</name></noRegion><name sortKey="Bracke, Ken R" sort="Bracke, Ken R" uniqKey="Bracke K" first="Ken R" last="Bracke">Ken R. Bracke</name><name sortKey="Brusselle, Guy G" sort="Brusselle, Guy G" uniqKey="Brusselle G" first="Guy G" last="Brusselle">Guy G. Brusselle</name><name sortKey="Janssens, Wim" sort="Janssens, Wim" uniqKey="Janssens W" first="Wim" last="Janssens">Wim Janssens</name><name sortKey="Joos, Guy F" sort="Joos, Guy F" uniqKey="Joos G" first="Guy F" last="Joos">Guy F. Joos</name><name sortKey="Seys, Leen J M" sort="Seys, Leen J M" uniqKey="Seys L" first="Leen J M" last="Seys">Leen J M. Seys</name><name sortKey="Verhamme, Fien M" sort="Verhamme, Fien M" uniqKey="Verhamme F" first="Fien M" last="Verhamme">Fien M. Verhamme</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W" last="Widagdo">W. Widagdo</name></region><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. 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