DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Identifieur interne : 000B80 ( Pmc/Curation ); précédent : 000B79; suivant : 000B81DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Auteurs : Leen J M. Seys [Belgique] ; W. Widagdo [Pays-Bas] ; Fien M. Verhamme [Belgique] ; Alex Kleinjan [Pays-Bas] ; Wim Janssens [Belgique] ; Guy F. Joos [Belgique] ; Ken R. Bracke [Belgique] ; Bart L. Haagmans [Pays-Bas] ; Guy G. Brusselle [Belgique]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2017.
Abstract
The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.
Url:
DOI: 10.1093/cid/cix741
PubMed: 29020176
PubMed Central: 7108100
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<front><div type="abstract" xml:lang="en"><p>The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">cid</journal-id>
<journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">1058-4838</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
<publisher-loc>US</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29020176</article-id>
<article-id pub-id-type="pmc">7108100</article-id>
<article-id pub-id-type="doi">10.1093/cid/cix741</article-id>
<article-id pub-id-type="publisher-id">cix741</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject>
</subj-group>
</article-categories>
<title-group><article-title>DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Seys</surname>
<given-names>Leen J M</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Widagdo</surname>
<given-names>W</given-names>
</name>
<xref ref-type="aff" rid="AF0003">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Verhamme</surname>
<given-names>Fien M</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kleinjan</surname>
<given-names>Alex</given-names>
</name>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Janssens</surname>
<given-names>Wim</given-names>
</name>
<xref ref-type="aff" rid="AF0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Joos</surname>
<given-names>Guy F</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bracke</surname>
<given-names>Ken R</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haagmans</surname>
<given-names>Bart L</given-names>
</name>
<xref ref-type="aff" rid="AF0003">3</xref>
<xref ref-type="author-notes" rid="fn-0001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brusselle</surname>
<given-names>Guy G</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="author-notes" rid="fn-0001"></xref>
<xref ref-type="corresp" rid="c1"></xref>
<pmc-comment>Guy.Brusselle@UGent.be </pmc-comment>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium</aff>
<aff id="AF0002"><label>2</label>
Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium</aff>
<aff id="AF0003"><label>3</label>
Departments of Viroscience, Rotterdam, The Netherlands</aff>
<aff id="AF0004"><label>4</label>
Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands</aff>
<aff id="AF0005"><label>5</label>
University Hospital Leuven, Respiratory Division and Rehabilitation, Leuven, Belgium</aff>
<author-notes><fn id="fn-0001"><p>B. L. H. and G. G. B. contributed equally to this manuscript.</p>
</fn>
<corresp id="c1">Correspondence: Prof. Dr. G. G. Brusselle, Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium (<email>Guy.Brusselle@UGent.be</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>1</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2017-08-17"><day>17</day>
<month>8</month>
<year>2017</year>
</pub-date>
<volume>66</volume>
<issue>1</issue>
<fpage>45</fpage>
<lpage>53</lpage>
<history><date date-type="received"><day>03</day>
<month>5</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>12</day>
<month>8</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</copyright-statement>
<copyright-year>2017</copyright-year>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p>
</license>
</permissions>
<self-uri xlink:href="cix741.pdf"></self-uri>
<abstract abstract-type="teaser"><p>The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.</p>
</abstract>
<abstract><title>Abstract</title>
<sec id="s1"><title>Background</title>
<p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes pneumonia with a relatively high case fatality rate in humans. Smokers and chronic obstructive pulmonary disease (COPD) patients have been reported to be more susceptible to MERS-CoV infection. Here, we determined the expression of MERS-CoV receptor, dipeptidyl peptidase IV (DPP4), in lung tissues of smokers without airflow limitation and COPD patients in comparison to nonsmoking individuals (never-smokers).</p>
</sec>
<sec id="s2"><title>Methods</title>
<p>DPP4 expression was measured in lung tissue of lung resection specimens of never-smokers, smokers without airflow limitation, COPD GOLD stage II patients and in lung explants of end-stage COPD patients. Both control subjects and COPD patients were well phenotyped and age-matched. The mRNA expression was determined using qRT-PCR and protein expression was quantified using immunohistochemistry.</p>
</sec>
<sec id="s3"><title>Results</title>
<p>In smokers and subjects with COPD, both DPP4 mRNA and protein expression were significantly higher compared to never-smokers. Additionally, we found that both DPP4 mRNA and protein expression were inversely correlated with lung function and diffusing capacity parameters.</p>
</sec>
<sec id="s4"><title>Conclusions</title>
<p>We provide evidence that DPP4 is upregulated in the lungs of smokers and COPD patients, which could partially explain why these individuals are more susceptible to MERS-CoV infection. These data also highlight a possible role of DPP4 in COPD pathogenesis.</p>
</sec>
</abstract>
<kwd-group><kwd>Middle East respiratory syndrome coronavirus (MERS-CoV)</kwd>
<kwd>dipeptidyl peptidase 4 (DPP4)</kwd>
<kwd>smoking</kwd>
<kwd>chronic obstructive pulmonary disease (COPD)</kwd>
</kwd-group>
<counts><page-count count="9"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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