Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
Identifieur interne : 000742 ( Pmc/Checkpoint ); précédent : 000741; suivant : 000743Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
Auteurs : Jennifer L. Mckimm-BreschkinSource :
- Antiviral Research [ 0166-3542 ] ; 2017.
Abstract
The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.
Url:
DOI: 10.1016/j.antiviral.2017.11.013
PubMed: 29162476
PubMed Central: 7133686
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.</p>
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</TEI>
<pmc article-type="other"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antiviral Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Antiviral Res</journal-id>
<journal-title-group><journal-title>Antiviral Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0166-3542</issn>
<issn pub-type="epub">1872-9096</issn>
<publisher><publisher-name>Elsevier B.V.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29162476</article-id>
<article-id pub-id-type="pmc">7133686</article-id>
<article-id pub-id-type="publisher-id">S0166-3542(17)30739-8</article-id>
<article-id pub-id-type="doi">10.1016/j.antiviral.2017.11.013</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au1"><name><surname>McKimm-Breschkin</surname>
<given-names>Jennifer L.</given-names>
</name>
<email>jmbvirology@gmail.com</email>
<xref rid="cor1" ref-type="corresp">∗</xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Australia</aff>
<contrib-group><contrib contrib-type="author" id="au2"><name><surname>Jiang</surname>
<given-names>Shibo</given-names>
</name>
</contrib>
</contrib-group>
<aff id="aff2">College of Basic Medical Sciences, Fudan University, Shanghai, China</aff>
<aff id="aff7">Lindsley F. Kimball Research Institute, New York Blood Center, NY, USA</aff>
<contrib-group><contrib contrib-type="author" id="au3"><name><surname>Hui</surname>
<given-names>David S.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="aff3">Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region</aff>
<contrib-group><contrib contrib-type="author" id="au4"><name><surname>Beigel</surname>
<given-names>John H.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="aff4">Leidos Biomedical Research, Inc., Support to National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA</aff>
<contrib-group><contrib contrib-type="author" id="au5"><name><surname>Govorkova</surname>
<given-names>Elena A.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="aff5">Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, USA</aff>
<contrib-group><contrib contrib-type="author" id="au6"><name><surname>Lee</surname>
<given-names>Nelson</given-names>
</name>
</contrib>
</contrib-group>
<aff id="aff6">Faculty of Medicine and Dentistry, University of Alberta, Canada</aff>
<author-notes><corresp id="cor1"><label>∗</label>
Corresponding author. Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, 792 Elizabeth Street, Melbourne, 3000, Australia. <email>jmbvirology@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>21</day>
<month>11</month>
<year>2017</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>11</month>
<year>2017</year>
</pub-date>
<volume>149</volume>
<fpage>118</fpage>
<lpage>142</lpage>
<history><date date-type="received"><day>9</day>
<month>11</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>14</day>
<month>11</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© 2017 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>Elsevier B.V.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0010"><p>The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV). Updates were presented on several therapeutics currently in clinical trials, including influenza polymerase inhibitors pimodivir/JNJ6362387, S033188, favipiravir, monoclonal antibodies MHAA45449A and VIS410, and host directed strategies for influenza including nitazoxanide, and polymerase ALS-008112 and fusion inhibitors AK0529, GS-5806 for RSV. Updates were also given on the use of the currently licensed neuraminidase inhibitors. Given the location in China, there were also presentations on the use of Traditional Chinese Medicines. Following on from the previous conference, there were ongoing discussions on appropriate endpoints for severe influenza in clinical trials from regulators and clinicians, an issue which remains unresolved. The aim of this conference summary is to provide information for not only conference participants, but a detailed referenced review of the current status of clinical trials, and pre-clinical development of therapeutics and vaccines for influenza and other respiratory diseases for a broader audience.</p>
</abstract>
<abstract abstract-type="author-highlights" id="abs0015"><title>Highlights</title>
<p><list list-type="simple" id="ulist0010"><list-item id="u0010"><label>•</label>
<p id="p0010">Details of presentations given at the recent isirv-AVG conference held in Shanghai, June 2017 are summarized.</p>
</list-item>
<list-item id="u0015"><label>•</label>
<p id="p0015">Topics covered clinical features, management, immune responses and virology of respiratory infections.</p>
</list-item>
<list-item id="u0020"><label>•</label>
<p id="p0020">Viruses discussed included influenza, RSV, SARS, MERS-CoV, EV-D68, adenovirus Type 80 and metapneumovirus.</p>
</list-item>
<list-item id="u0025"><label>•</label>
<p id="p0025">Influenza vaccines, polymerase inhibitors, monoclonal antibodies and cell targeted therapies were discussed.</p>
</list-item>
<list-item id="u0030"><label>•</label>
<p id="p0030">RSV vaccines, polymerase and fusion inhibitors were discussed.</p>
</list-item>
</list>
</p>
</abstract>
<kwd-group id="kwrds0010"><title>Keywords</title>
<kwd>Influenza</kwd>
<kwd>RSV</kwd>
<kwd>Antivirals</kwd>
<kwd>Vaccines</kwd>
<kwd>Isirv-AVG</kwd>
</kwd-group>
<kwd-group id="kwrds0015"><title>Abbreviations</title>
<kwd>ARDS, Acute respiratory distress syndrome</kwd>
<kwd>AUC, Area under the curve</kwd>
<kwd>CAP, Community acquired pneumonia</kwd>
<kwd>HA, hemagglutinin</kwd>
<kwd>HPAI, Highly pathogenic avian influenza</kwd>
<kwd>LPM, Live poultry markets</kwd>
<kwd>MERS-CoV, Middle East respiratory syndrome corona virus</kwd>
<kwd>MN, microneutralization</kwd>
<kwd>NA, neuraminidase</kwd>
<kwd>NAI, neuraminidase inhibitor</kwd>
<kwd>PCT, Placebo controlled trial</kwd>
<kwd>PRNT, plaque reduction neutralization titer</kwd>
<kwd>RDB, randomized double blind</kwd>
<kwd>S/ARI, Severe/Acute respiratory infection</kwd>
<kwd>SARS-CoV, Severe acute respiratory syndrome corona virus</kwd>
<kwd>TCID<sub>50</sub>
, 50% tissue culture infectivity dose</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Mckimm Breschkin, Jennifer L" sort="Mckimm Breschkin, Jennifer L" uniqKey="Mckimm Breschkin J" first="Jennifer L." last="Mckimm-Breschkin">Jennifer L. Mckimm-Breschkin</name>
</noCountry>
</tree>
</affiliations>
</record>
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