Intensive care admission for Coronavirus OC43 respiratory tract infections
Identifieur interne : 000555 ( Pmc/Checkpoint ); précédent : 000554; suivant : 000556Intensive care admission for Coronavirus OC43 respiratory tract infections
Auteurs : D. Vandroux [France] ; N. Allou [France] ; J. Jabot [France] ; G. Li Pat Yuen [Réunion] ; E. Brottet [Réunion] ; B. Roquebert [France, Réunion] ; O. Martinet [France]Source :
- Medecine et Maladies Infectieuses [ 0399-077X ] ; 2018.
Abstract
To analyze acute manifestations of
Retrospective and monocentric study performed during a
Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from
As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.
Url:
DOI: 10.1016/j.medmal.2018.01.001
PubMed: 29402475
PubMed Central: 7126704
Affiliations:
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PMC:7126704Le document en format XML
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OC43 respiratory tract infections</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intensive care admission for <italic>Coronavirus</italic>
OC43 respiratory tract infections</title>
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<author><name sortKey="Brottet, E" sort="Brottet, E" uniqKey="Brottet E" first="E." last="Brottet">E. Brottet</name>
<affiliation wicri:level="1"><nlm:aff id="aff0020">Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</nlm:aff>
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<author><name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name>
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<country xml:lang="fr">France</country>
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<placeName><region type="region" nuts="2">La Réunion</region>
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<author><name sortKey="Martinet, O" sort="Martinet, O" uniqKey="Martinet O" first="O." last="Martinet">O. Martinet</name>
<affiliation wicri:level="3"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea>
<placeName><region type="region" nuts="2">La Réunion</region>
<settlement type="city">Saint-Denis-de-La-Réunion</settlement>
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<series><title level="j">Medecine et Maladies Infectieuses</title>
<idno type="ISSN">0399-077X</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><italic>Coronavirus</italic>
OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.</p>
</sec>
<sec><title>Objectives</title>
<p>To analyze acute manifestations of <italic>Coronavirus</italic>
OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).</p>
</sec>
<sec><title>Patients and methods</title>
<p>Retrospective and monocentric study performed during a <italic>Coronavirus</italic>
OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.</p>
</sec>
<sec><title>Results</title>
<p>Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from <italic>Haemophilus influenzae</italic>
co-infection.</p>
</sec>
<sec><title>Conclusion</title>
<p>As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Mal Infect</journal-id>
<journal-id journal-id-type="iso-abbrev">Med Mal Infect</journal-id>
<journal-title-group><journal-title>Medecine et Maladies Infectieuses</journal-title>
</journal-title-group>
<issn pub-type="ppub">0399-077X</issn>
<issn pub-type="epub">1769-6690</issn>
<publisher><publisher-name>Elsevier Masson SAS.</publisher-name>
</publisher>
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<article-meta><article-id pub-id-type="pmid">29402475</article-id>
<article-id pub-id-type="pmc">7126704</article-id>
<article-id pub-id-type="publisher-id">S0399-077X(17)30047-1</article-id>
<article-id pub-id-type="doi">10.1016/j.medmal.2018.01.001</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Intensive care admission for <italic>Coronavirus</italic>
OC43 respiratory tract infections</article-title>
<trans-title-group xml:lang="fr"><trans-title>Admissions en réanimation pour infection respiratoire à <italic>Coronavirus</italic>
OC43</trans-title>
</trans-title-group>
</title-group>
<contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Vandroux</surname>
<given-names>D.</given-names>
</name>
<email>vandroux.david@gmail.com</email>
<xref rid="aff0005" ref-type="aff">a</xref>
<xref rid="aff0010" ref-type="aff">b</xref>
<xref rid="cor0005" ref-type="corresp">⁎</xref>
</contrib>
<contrib contrib-type="author" id="aut0010"><name><surname>Allou</surname>
<given-names>N.</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="aut0015"><name><surname>Jabot</surname>
<given-names>J.</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="aut0020"><name><surname>Li Pat Yuen</surname>
<given-names>G.</given-names>
</name>
<xref rid="aff0015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="aut0025"><name><surname>Brottet</surname>
<given-names>E.</given-names>
</name>
<xref rid="aff0020" ref-type="aff">d</xref>
</contrib>
<contrib contrib-type="author" id="aut0030"><name><surname>Roquebert</surname>
<given-names>B.</given-names>
</name>
<xref rid="aff0010" ref-type="aff">b</xref>
<xref rid="aff0015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="aut0035"><name><surname>Martinet</surname>
<given-names>O.</given-names>
</name>
<xref rid="aff0005" ref-type="aff">a</xref>
</contrib>
</contrib-group>
<aff id="aff0005"><label>a</label>
Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</aff>
<aff id="aff0010"><label>b</label>
CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</aff>
<aff id="aff0015"><label>c</label>
Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</aff>
<aff id="aff0020"><label>d</label>
Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</aff>
<author-notes><corresp id="cor0005"><label>⁎</label>
Corresponding author. Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France. <email>vandroux.david@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>7</day>
<month>3</month>
<year>2018</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub"><day>7</day>
<month>3</month>
<year>2018</year>
</pub-date>
<volume>48</volume>
<issue>2</issue>
<fpage>141</fpage>
<lpage>144</lpage>
<history><date date-type="received"><day>3</day>
<month>2</month>
<year>2017</year>
</date>
<date date-type="rev-recd"><day>24</day>
<month>5</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>3</day>
<month>1</month>
<year>2018</year>
</date>
</history>
<permissions><copyright-statement>© 2018 Elsevier Masson SAS. All rights reserved.</copyright-statement>
<copyright-year>2018</copyright-year>
<copyright-holder>Elsevier Masson SAS</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs0010"><sec><title>Background</title>
<p><italic>Coronavirus</italic>
OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.</p>
</sec>
<sec><title>Objectives</title>
<p>To analyze acute manifestations of <italic>Coronavirus</italic>
OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).</p>
</sec>
<sec><title>Patients and methods</title>
<p>Retrospective and monocentric study performed during a <italic>Coronavirus</italic>
OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.</p>
</sec>
<sec><title>Results</title>
<p>Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from <italic>Haemophilus influenzae</italic>
co-infection.</p>
</sec>
<sec><title>Conclusion</title>
<p>As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.</p>
</sec>
</abstract>
<trans-abstract xml:lang="fr"><title>Résumé</title>
<sec><title>Introduction</title>
<p>L’infection à <italic>Coronavirus</italic>
OC43 peut induire des pneumopathies sévères chez les patients présentant des comorbidités lors d’épisodes hivernaux en climat tempéré.</p>
</sec>
<sec><title>Patients et méthodes</title>
<p>Analyse rétrospective, monocentrique des cas d’infections à <italic>Coronavirus</italic>
OC43 admis en réanimation. L’utilisation d’une PCR multiplex pour les infections respiratoires a permis de détecter une épidémie de bronchopneumopathies à <italic>Coronavirus</italic>
OC43 durant l’hiver austral 2016 à La Réunion: sept admissions en réanimation.</p>
</sec>
<sec><title>Résultats</title>
<p>Des patients, âgés de 71 [67 ; 76] ans en moyenne, présentaient un indice de gravité simplifié II de 42 [28 ; 53] et une ventilation mécanique était requise pour 43 %. Les comorbidités comprenaient diabète (87 %), insuffisance respiratoire chronique (57 %) et insuffisance rénale chronique (29 %). Un décès est survenu au cours d’une co-infection à <italic>Haemophilus influenzae.</italic>
</p>
</sec>
<sec><title>Conclusion</title>
<p>Comme pour le MERS <italic>Coronavirus</italic>
, les comorbidités impactent l’évolution clinique d’une infection et conduisent à des admissions en réanimation.</p>
</sec>
</trans-abstract>
<kwd-group id="kwd0005"><title>Keywords</title>
<kwd><italic>Coronavirus</italic>
OC43</kwd>
<kwd>multiplex PCR</kwd>
</kwd-group>
<kwd-group xml:lang="fr" id="kwd0010"><title>Mots clés</title>
<kwd><italic>Coronavirus</italic>
OC43</kwd>
<kwd>PCR multiplex</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>Réunion</li>
</country>
<region><li>La Réunion</li>
</region>
<settlement><li>Saint-Denis-de-La-Réunion</li>
<li>Saint-Pierre (Réunion)</li>
</settlement>
</list>
<tree><country name="France"><region name="La Réunion"><name sortKey="Vandroux, D" sort="Vandroux, D" uniqKey="Vandroux D" first="D." last="Vandroux">D. Vandroux</name>
</region>
<name sortKey="Allou, N" sort="Allou, N" uniqKey="Allou N" first="N." last="Allou">N. Allou</name>
<name sortKey="Jabot, J" sort="Jabot, J" uniqKey="Jabot J" first="J." last="Jabot">J. Jabot</name>
<name sortKey="Martinet, O" sort="Martinet, O" uniqKey="Martinet O" first="O." last="Martinet">O. Martinet</name>
<name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name>
<name sortKey="Vandroux, D" sort="Vandroux, D" uniqKey="Vandroux D" first="D." last="Vandroux">D. Vandroux</name>
</country>
<country name="Réunion"><noRegion><name sortKey="Li Pat Yuen, G" sort="Li Pat Yuen, G" uniqKey="Li Pat Yuen G" first="G." last="Li Pat Yuen">G. Li Pat Yuen</name>
</noRegion>
<name sortKey="Brottet, E" sort="Brottet, E" uniqKey="Brottet E" first="E." last="Brottet">E. Brottet</name>
<name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name>
</country>
</tree>
</affiliations>
</record>
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