Intensive care admission for Coronavirus OC43 respiratory tract infections
Identifieur interne : 000727 ( Pmc/Corpus ); précédent : 000726; suivant : 000728Intensive care admission for Coronavirus OC43 respiratory tract infections
Auteurs : D. Vandroux ; N. Allou ; J. Jabot ; G. Li Pat Yuen ; E. Brottet ; B. Roquebert ; O. MartinetSource :
- Medecine et Maladies Infectieuses [ 0399-077X ] ; 2018.
Abstract
To analyze acute manifestations of
Retrospective and monocentric study performed during a
Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from
As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.
Url:
DOI: 10.1016/j.medmal.2018.01.001
PubMed: 29402475
PubMed Central: 7126704
Links to Exploration step
PMC:7126704Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intensive care admission for <italic>Coronavirus</italic> OC43 respiratory tract infections</title><author><name sortKey="Vandroux, D" sort="Vandroux, D" uniqKey="Vandroux D" first="D." last="Vandroux">D. Vandroux</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff></affiliation></author><author><name sortKey="Allou, N" sort="Allou, N" uniqKey="Allou N" first="N." last="Allou">N. Allou</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation></author><author><name sortKey="Jabot, J" sort="Jabot, J" uniqKey="Jabot J" first="J." last="Jabot">J. Jabot</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation></author><author><name sortKey="Li Pat Yuen, G" sort="Li Pat Yuen, G" uniqKey="Li Pat Yuen G" first="G." last="Li Pat Yuen">G. Li Pat Yuen</name><affiliation><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff></affiliation></author><author><name sortKey="Brottet, E" sort="Brottet, E" uniqKey="Brottet E" first="E." last="Brottet">E. Brottet</name><affiliation><nlm:aff id="aff0020">Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</nlm:aff></affiliation></author><author><name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name><affiliation><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff></affiliation></author><author><name sortKey="Martinet, O" sort="Martinet, O" uniqKey="Martinet O" first="O." last="Martinet">O. Martinet</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29402475</idno><idno type="pmc">7126704</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126704</idno><idno type="RBID">PMC:7126704</idno><idno type="doi">10.1016/j.medmal.2018.01.001</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000727</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intensive care admission for <italic>Coronavirus</italic> OC43 respiratory tract infections</title><author><name sortKey="Vandroux, D" sort="Vandroux, D" uniqKey="Vandroux D" first="D." last="Vandroux">D. Vandroux</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff></affiliation></author><author><name sortKey="Allou, N" sort="Allou, N" uniqKey="Allou N" first="N." last="Allou">N. Allou</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation></author><author><name sortKey="Jabot, J" sort="Jabot, J" uniqKey="Jabot J" first="J." last="Jabot">J. Jabot</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation></author><author><name sortKey="Li Pat Yuen, G" sort="Li Pat Yuen, G" uniqKey="Li Pat Yuen G" first="G." last="Li Pat Yuen">G. Li Pat Yuen</name><affiliation><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff></affiliation></author><author><name sortKey="Brottet, E" sort="Brottet, E" uniqKey="Brottet E" first="E." last="Brottet">E. Brottet</name><affiliation><nlm:aff id="aff0020">Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</nlm:aff></affiliation></author><author><name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name><affiliation><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff></affiliation></author><author><name sortKey="Martinet, O" sort="Martinet, O" uniqKey="Martinet O" first="O." last="Martinet">O. Martinet</name><affiliation><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff></affiliation></author></analytic><series><title level="j">Medecine et Maladies Infectieuses</title><idno type="ISSN">0399-077X</idno><idno type="eISSN">1769-6690</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p><italic>Coronavirus</italic> OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.</p></sec><sec><title>Objectives</title><p>To analyze acute manifestations of <italic>Coronavirus</italic> OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).</p></sec><sec><title>Patients and methods</title><p>Retrospective and monocentric study performed during a <italic>Coronavirus</italic> OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.</p></sec><sec><title>Results</title><p>Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from <italic>Haemophilus influenzae</italic> co-infection.</p></sec><sec><title>Conclusion</title><p>As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morfopoulou, S" uniqKey="Morfopoulou S">S. Morfopoulou</name></author><author><name sortKey="Brown, J R" uniqKey="Brown J">J.R. Brown</name></author><author><name sortKey="Davies, E G" uniqKey="Davies E">E.G. Davies</name></author><author><name sortKey="Anderson, G" uniqKey="Anderson G">G. Anderson</name></author><author><name sortKey="Virasami, A" uniqKey="Virasami A">A. Virasami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vabret, A" uniqKey="Vabret A">A. Vabret</name></author><author><name sortKey="Mourez, T" uniqKey="Mourez T">T. Mourez</name></author><author><name sortKey="Gouarin, S" uniqKey="Gouarin S">S. Gouarin</name></author><author><name sortKey="Petitjean, J" uniqKey="Petitjean J">J. Petitjean</name></author><author><name sortKey="Freymuth, F" uniqKey="Freymuth F">F. Freymuth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filleul, L" uniqKey="Filleul L">L. Filleul</name></author><author><name sortKey="Brottet, E" uniqKey="Brottet E">E. Brottet</name></author><author><name sortKey="Gauzere, B A" uniqKey="Gauzere B">B.A. Gauzere</name></author><author><name sortKey="Winer, A" uniqKey="Winer A">A. Winer</name></author><author><name sortKey="Vandroux, D" uniqKey="Vandroux D">D. Vandroux</name></author><author><name sortKey="Michault, A" uniqKey="Michault A">A. Michault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fine, M J" uniqKey="Fine M">M.J. Fine</name></author><author><name sortKey="Auble, T E" uniqKey="Auble T">T.E. Auble</name></author><author><name sortKey="Yealy, D M" uniqKey="Yealy D">D.M. Yealy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patrick Dm1" uniqKey="Patrick Dm1">Patrick DM1</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M. Petric</name></author><author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M. Skowronski</name></author><author><name sortKey="Guasparini, R" uniqKey="Guasparini R">R. Guasparini</name></author><author><name sortKey="Booth, T F" uniqKey="Booth T">T.F. Booth</name></author><author><name sortKey="Krajden, M" uniqKey="Krajden M">M. Krajden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Templeton, K E" uniqKey="Templeton K">K.E. Templeton</name></author><author><name sortKey="Scheltinga, S A" uniqKey="Scheltinga S">S.A. Scheltinga</name></author><author><name sortKey="Van Den Eeden, W C" uniqKey="Van Den Eeden W">W.C. van den Eeden</name></author><author><name sortKey="Graffelman, A W" uniqKey="Graffelman A">A.W. Graffelman</name></author><author><name sortKey="Van Den Broek, P J" uniqKey="Van Den Broek P">P.J. van den Broek</name></author><author><name sortKey="Claas, E C J" uniqKey="Claas E">E.C.J. Claas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Khannaq, M N" uniqKey="Al Khannaq M">M.N. Al-Khannaq</name></author><author><name sortKey="Tien Ng, K" uniqKey="Tien Ng K">K. Tien Ng</name></author><author><name sortKey="Oong, X Y" uniqKey="Oong X">X.Y. Oong</name></author><author><name sortKey="Pang, Y K" uniqKey="Pang Y">Y.K. Pang</name></author><author><name sortKey="Takebe, Y" uniqKey="Takebe Y">Y. Takebe</name></author><author><name sortKey="Chook, J B" uniqKey="Chook J">J.B. Chook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trombetta, H" uniqKey="Trombetta H">H. Trombetta</name></author><author><name sortKey="Faggion, H Z" uniqKey="Faggion H">H.Z. Faggion</name></author><author><name sortKey="Leotte, J" uniqKey="Leotte J">J. Leotte</name></author><author><name sortKey="Nogueira, M B" uniqKey="Nogueira M">M.B. Nogueira</name></author><author><name sortKey="Vidal, L R" uniqKey="Vidal L">L.R. Vidal</name></author><author><name sortKey="Raboni, S M" uniqKey="Raboni S">S.M. Raboni</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Mal Infect</journal-id><journal-id journal-id-type="iso-abbrev">Med Mal Infect</journal-id><journal-title-group><journal-title>Medecine et Maladies Infectieuses</journal-title></journal-title-group><issn pub-type="ppub">0399-077X</issn><issn pub-type="epub">1769-6690</issn><publisher><publisher-name>Elsevier Masson SAS.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29402475</article-id><article-id pub-id-type="pmc">7126704</article-id><article-id pub-id-type="publisher-id">S0399-077X(17)30047-1</article-id><article-id pub-id-type="doi">10.1016/j.medmal.2018.01.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Intensive care admission for <italic>Coronavirus</italic> OC43 respiratory tract infections</article-title><trans-title-group xml:lang="fr"><trans-title>Admissions en réanimation pour infection respiratoire à <italic>Coronavirus</italic> OC43</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Vandroux</surname><given-names>D.</given-names></name><email>vandroux.david@gmail.com</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Allou</surname><given-names>N.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Jabot</surname><given-names>J.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Li Pat Yuen</surname><given-names>G.</given-names></name><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Brottet</surname><given-names>E.</given-names></name><xref rid="aff0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Roquebert</surname><given-names>B.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="aut0035"><name><surname>Martinet</surname><given-names>O.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</aff><aff id="aff0010"><label>b</label>CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</aff><aff id="aff0015"><label>c</label>Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</aff><aff id="aff0020"><label>d</label>Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author. Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France. <email>vandroux.david@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>7</day><month>3</month><year>2018</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>7</day><month>3</month><year>2018</year></pub-date><volume>48</volume><issue>2</issue><fpage>141</fpage><lpage>144</lpage><history><date date-type="received"><day>3</day><month>2</month><year>2017</year></date><date date-type="rev-recd"><day>24</day><month>5</month><year>2017</year></date><date date-type="accepted"><day>3</day><month>1</month><year>2018</year></date></history><permissions><copyright-statement>© 2018 Elsevier Masson SAS. All rights reserved.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder>Elsevier Masson SAS</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><sec><title>Background</title><p><italic>Coronavirus</italic> OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.</p></sec><sec><title>Objectives</title><p>To analyze acute manifestations of <italic>Coronavirus</italic> OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).</p></sec><sec><title>Patients and methods</title><p>Retrospective and monocentric study performed during a <italic>Coronavirus</italic> OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.</p></sec><sec><title>Results</title><p>Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from <italic>Haemophilus influenzae</italic> co-infection.</p></sec><sec><title>Conclusion</title><p>As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.</p></sec></abstract><trans-abstract xml:lang="fr"><title>Résumé</title><sec><title>Introduction</title><p>L’infection à <italic>Coronavirus</italic> OC43 peut induire des pneumopathies sévères chez les patients présentant des comorbidités lors d’épisodes hivernaux en climat tempéré.</p></sec><sec><title>Patients et méthodes</title><p>Analyse rétrospective, monocentrique des cas d’infections à <italic>Coronavirus</italic> OC43 admis en réanimation. L’utilisation d’une PCR multiplex pour les infections respiratoires a permis de détecter une épidémie de bronchopneumopathies à <italic>Coronavirus</italic> OC43 durant l’hiver austral 2016 à La Réunion: sept admissions en réanimation.</p></sec><sec><title>Résultats</title><p>Des patients, âgés de 71 [67 ; 76] ans en moyenne, présentaient un indice de gravité simplifié II de 42 [28 ; 53] et une ventilation mécanique était requise pour 43 %. Les comorbidités comprenaient diabète (87 %), insuffisance respiratoire chronique (57 %) et insuffisance rénale chronique (29 %). Un décès est survenu au cours d’une co-infection à <italic>Haemophilus influenzae.</italic></p></sec><sec><title>Conclusion</title><p>Comme pour le MERS <italic>Coronavirus</italic>, les comorbidités impactent l’évolution clinique d’une infection et conduisent à des admissions en réanimation.</p></sec></trans-abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd><italic>Coronavirus</italic> OC43</kwd><kwd>multiplex PCR</kwd></kwd-group><kwd-group xml:lang="fr" id="kwd0010"><title>Mots clés</title><kwd><italic>Coronavirus</italic> OC43</kwd><kwd>PCR multiplex</kwd></kwd-group></article-meta></front><body><sec id="sec0005"><label>1</label><title>Background</title><p id="par0005">Human <italic>Coronavirus</italic> infections, including <italic>Coronavirus</italic> OC43, usually result in upper respiratory tract infections such as common cold. However, these viruses are responsible for severe lower respiratory tract illness in patients presenting with comorbidities, and may be associated with the development of neurological diseases such as encephalitis <xref rid="bib0050" ref-type="bibr">[1]</xref>. Coronaviruses are enveloped viruses with a large positive-sense, single-stranded RNA genome and a helical nucleocapsid. The epidemiological surveillance of <italic>Coronavirus</italic> infections is facilitated by real-time polymerase chain reaction (RT-PCR) techniques used for routine diagnosis. In the Northern Hemisphere, <italic>Coronavirus</italic> infections have a seasonal distribution and seem to be uncommon outside the cold season running from December to May <xref rid="bib0055" ref-type="bibr">[2]</xref>.</p><p id="par0010">Reunion Island is a Southern Hemisphere French overseas territory with 843,529 inhabitants located in the Indian Ocean between Madagascar and Mauritius islands. The climate is tropical with moderate temperatures and the cold and dry season runs from May to November concomitantly with the influenza season <xref rid="bib0060" ref-type="bibr">[3]</xref>. In 2016, no <italic>Coronavirus</italic> OC43 strain was detected before June in the hospital. As of July, a <italic>Coronavirus</italic> OC43 strain was detected in 26 samples by Fast-Track Diagnostics<sup>®</sup> respiratory pathogens assay: seven from the sentinel practitioner network and 19 from hospital settings. Seven of these hospital strains were detected in patients admitted to the intensive care unit (ICU). A flowchart describing admissions to the ICU during this period is presented in <xref rid="fig0005" ref-type="fig">Fig. 1</xref>.<fig id="fig0005"><label>Fig. 1</label><caption><p>Flow chart describing ICU admissions in Saint-Denis, Reunion Island, with the proportion of respiratory samples for PCR multiplex and the proportion of mechanical ventilation during the influenza season (June 15, 2016–September 30, 2016).</p></caption><caption><p>Flux des patients admis en réanimation polyvalente à Saint-Denis-de-La-Réunion avec la proportion de tests PCR multiplex et de ventilation mécanique pendant la saison grippale d’hiver austral (15 juin 2016–30 septembre 2016).</p></caption><graphic xlink:href="gr1_lrg"></graphic></fig></p></sec><sec id="sec0010"><label>2</label><title>Patients and methods</title><p id="par0015">We carried out a retrospective review of the medical records to describe the clinical features of seven patients presenting with <italic>Coronavirus</italic> infection and the impact on the ICU. We collected demographic data, reason for admission, concomitant medical conditions, history of illness, clinical characteristics, results of laboratory investigations, disease assessment score including Simplified Acute Physiology Score II (SAPS II) and pneumonia severity index (PSI) of FINE <xref rid="bib0065" ref-type="bibr">[4]</xref>, management, and outcome. SAPS II score is used to assess disease severity and is calculated using the worst 12 physiological indicators during the first 24 hours in the ICU. Continuous variables are presented as median and interquartile range, and categorical variables are reported as number or frequency. As per French law (L.1121-1 paragraph 1 and R1121-2 Public Health Code), neither informed consent nor approval from an ethics committee were necessary for anonymous data extraction from an analysis of patients’ medical charts.</p></sec><sec id="sec0015"><label>3</label><title>Results</title><p id="par0020">The study population characteristics are provided in <xref rid="tbl0005" ref-type="table">Table 1</xref>. A comparison between our cohort of patients and patients hospitalized in the medical ward is shown in <xref rid="tbl0010" ref-type="table">Table 2</xref>. All patients were residents of Reunion Island and none had traveled recently. All patients were admitted for respiratory failure caused by viral pneumonia, but three patients also presented with pulmonary edema and one with septic shock. The median age of patients was 71 [67;76] years. Infections occurred in elderly patients presenting with several comorbidities who were admitted for serious conditions as evidenced by a high SAPS II and PSI scores. Time between onset of clinical signs and ICU admission was short for two patients presenting with chronic disease failure. The other patients presented with influenza-like illness several days before hospitalization. Chest radiographic findings were abnormal for all patients. Biological results revealed that all patients had leukocytosis with lymphopenia. Three patients required mechanical ventilation for 4, 6, and 7 days. No patient needed a respiratory assistance with extracorporeal membrane oxygenation. All patients but one were treated with empirical antibacterial drugs: spiramycin and cefotaxime or piperacillin/tazobactam. One (14%) patient died: a 79-year-old woman presenting with type 2 diabetes, severe chronic obstructive pulmonary disease, and prior exposure to traditional firewood for cooking. She was admitted for acute exacerbation and septic shock. The laboratory detected <italic>Coronavirus</italic> OC43 and <italic>Haemophilus influenzae</italic> in the respiratory specimen. She died despite six days of mechanical ventilation.<table-wrap position="float" id="tbl0005"><label>Table 1</label><caption><p>Characteristics of seven patients admitted to the ICU for <italic>Coronavirus</italic> OC43 community-acquired pneumonia<italic>.</italic></p><p>Caractéristiques de sept patients admis en réanimation pour pneumopathie à <italic>Coronavirus</italic> OC43.</p></caption><alt-text id="at1">Table 1</alt-text><table frame="hsides" rules="groups"><thead><tr><th align="left">Characteristics</th><th align="left">Data (<italic>n</italic> = 7)</th></tr></thead><tbody><tr><td align="left"><italic>Body mass index</italic></td><td align="left">29 [26;30]</td></tr><tr><td align="left"><italic>Medical history</italic></td><td></td></tr><tr><td align="left"> Diabetes</td><td align="left">6 (87)</td></tr><tr><td align="left"> Chronic respiratory failure</td><td align="left">4 (57)</td></tr><tr><td align="left"> Chronic renal failure</td><td align="left">2 (29)</td></tr><tr><td align="left"> Heart failure</td><td align="left">2 (29)</td></tr><tr><td align="left"> Cirrhosis</td><td align="left">1 (14)</td></tr><tr><td align="left"><italic>Severity assessment scores at admission</italic></td><td></td></tr><tr><td align="left"> Simplified Acute Physiology Score II</td><td align="left">42 [28;53]</td></tr><tr><td align="left"> Pneumonia Severity Index</td><td align="left">159 (139;182)</td></tr><tr><td align="left"> Leukocytes</td><td align="left">12,960 [11,440;13,830]</td></tr><tr><td align="left"> Lymphocytes</td><td align="left">1,320 [940;1,485]</td></tr><tr><td align="left"> Pro b-type natriuretic peptide</td><td align="left">587 [224;700]</td></tr><tr><td align="left"> Procalcitonin</td><td align="left">0.22 [1.16;0.25]</td></tr><tr><td align="left"> Lactic acid</td><td align="left">1.7 [1.3;2.0]</td></tr><tr><td align="left"><italic>Duration of ICU stay</italic></td><td align="left">6 [3.5;7.5]</td></tr><tr><td align="left"><italic>ICU management</italic></td><td></td></tr><tr><td align="left"> Mechanical ventilation</td><td align="left">3 (43)</td></tr><tr><td align="left"> Non-invasive ventilation</td><td align="left">5 (71)</td></tr><tr><td align="left"> High-flow nasal cannula oxygen therapy</td><td align="left">1 (14)</td></tr><tr><td align="left"> Renal replacement therapy</td><td align="left">2 (29)</td></tr><tr><td align="left"><italic>Death</italic></td><td align="left">1 (14)</td></tr></tbody></table><table-wrap-foot><fn><p>ICU: intensive care unit. Data is presented as number (%) or median [interquartile range].</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="tbl0010"><label>Table 2</label><caption><p>Comparison of patients hospitalized in the intensive care unit and in the medical ward during an OC43 <italic>Coronavirus</italic> outbreak.</p><p>Comparaison de patients hospitalisés en réanimation et en soins courants durant la période d’infection à <italic>Coronavirus</italic> OC43.</p></caption><alt-text id="at2">Table 2</alt-text><table frame="hsides" rules="groups"><thead><tr><th align="left">Characteristics</th><th align="left">ICU patients<break></break><italic>n</italic> = 7</th><th align="left">Medical ward patients<break></break><italic>n</italic> = 12</th></tr></thead><tbody><tr><td align="left">Age</td><td align="left">71 [67;76]</td><td align="left">34 [9;62]</td></tr><tr><td align="left">Aged < 12 years (<italic>n</italic>)</td><td align="left">0</td><td align="left">4</td></tr><tr><td align="left">Female sex</td><td align="left">3 (43)</td><td align="left">7 (58)</td></tr><tr><td align="left">Diabetes</td><td align="left">6(87)</td><td align="left">2 (17)</td></tr><tr><td align="left">Chronic renal failure</td><td align="left">2 (29)</td><td align="left">3 (25)</td></tr><tr><td align="left">Duration of hospital stay (days)</td><td align="left">14 [9.5;26]</td><td align="left">4.5 [3.25;5.75]</td></tr><tr><td align="left">Pneumonia severity index<xref rid="tblfn0005" ref-type="table-fn">a</xref></td><td align="left">159 [139;182]</td><td align="left">73 [40.5;107]</td></tr></tbody></table><table-wrap-foot><fn><p>Data is presented as number (%) or median [interquartile range]. ICU: Intensive Care Unit</p></fn></table-wrap-foot><table-wrap-foot><fn id="tblfn0005"><label>a</label><p id="npar0005">The Pneumonia Severity Index is only calculated for patients over 18 years of age.</p></fn></table-wrap-foot></table-wrap></p></sec><sec id="sec0020"><label>4</label><title>Discussion</title><p id="par0025">The small number of patients, not necessarily requiring mechanical ventilation, and the duration of stay seem to indicate a low epidemic impact. However, <italic>Coronavirus</italic> epidemics may be contemporaneous with an influenza outbreak.</p><p id="par0030">Clinical aspects of <italic>Coronavirus</italic> infection cannot be recognized in the absence of laboratory investigations as coronaviruses are usually responsible for illness that cannot be distinguished from that caused by many other viruses. A cross reactivity between <italic>Coronavirus</italic> (in particular SARS-CoV and OC43) must be considered when interpreting serological tests for <italic>Coronavirus</italic><xref rid="bib0070" ref-type="bibr">[5]</xref>. Since the emergence in the 1990s of nucleic acid amplification-based techniques, especially PCR, the diagnosis of several viral agents causing pulmonary infections has greatly improved. The use of a multiplex PCR test for respiratory tract infection allows for a high rate of detection of etiological agents, and enables the detection of <italic>Coronavirus</italic> outbreaks <xref rid="bib0075" ref-type="bibr">[6]</xref>. Antiviral drugs are yet to be developed in the treatment of <italic>Coronavirus</italic> infections, but characterization of such severe infections in patients presenting with comorbidities or in immunocompromised patients could enhance the medical research. These outbreaks mainly occur when the temperature is low. However, <italic>Coronavirus</italic> OC43 outbreaks have been reported in tropical climates: Malaysia <xref rid="bib0080" ref-type="bibr">[7]</xref> and Brazil <xref rid="bib0085" ref-type="bibr">[8]</xref> in 2012-2013. The 2016 Southern Hemisphere's winter in Reunion Island was among the coldest of the last decade <xref rid="bib0090" ref-type="bibr">[9]</xref>. This could have induced a small increase in ICU admissions of elderly and frail patients.</p></sec><sec id="sec0025"><label>5</label><title>Conclusion</title><p id="par0035">OC43 infection cannot be detected on the sole basis of clinical signs. The presence of underlying comorbidities impacted the clinical outcomes of OC43 infections, similar to what is observed in the ongoing MERS-CoV infection in the Middle East.</p></sec><sec id="sec0030"><title>Contribution of authors</title><p id="par0040">All authors contributed to the interpretation of results, the article revision, and approved the final version of the article.</p><p id="par0045">DV wrote the article. DV and EB conducted the data analysis. JJ, NA, and OM contributed to collecting the data in the intensive care unit. BR and GLPY performed the characterization of viruses.</p></sec><sec id="sec0035"><title>Disclosure of interest</title><p id="par0050">The authors declare that they have no competing interest.</p></sec></body><back><ref-list id="bibl0005"><title>References</title><ref id="bib0050"><label>1</label><element-citation publication-type="journal" id="sbref0050"><person-group person-group-type="author"><name><surname>Morfopoulou</surname><given-names>S.</given-names></name><name><surname>Brown</surname><given-names>J.R.</given-names></name><name><surname>Davies</surname><given-names>E.G.</given-names></name><name><surname>Anderson</surname><given-names>G.</given-names></name><name><surname>Virasami</surname><given-names>A.</given-names></name></person-group><article-title>Human <italic>Coronavirus</italic> OC43 associated with fatal encephalitis</article-title><source>N Engl J Med</source><volume>375</volume><year>2016</year><fpage>5</fpage></element-citation></ref><ref id="bib0055"><label>2</label><element-citation publication-type="journal" id="sbref0055"><person-group person-group-type="author"><name><surname>Vabret</surname><given-names>A.</given-names></name><name><surname>Mourez</surname><given-names>T.</given-names></name><name><surname>Gouarin</surname><given-names>S.</given-names></name><name><surname>Petitjean</surname><given-names>J.</given-names></name><name><surname>Freymuth</surname><given-names>F.</given-names></name></person-group><article-title>An outbreak of <italic>Coronavirus</italic> OC43 respiratory infection in Normandy, France</article-title><source>Clin Infect Dis</source><volume>36</volume><year>2003</year><fpage>985</fpage><lpage>989</lpage><pub-id pub-id-type="pmid">12684910</pub-id></element-citation></ref><ref id="bib0060"><label>3</label><element-citation publication-type="journal" id="sbref0060"><person-group person-group-type="author"><name><surname>Filleul</surname><given-names>L.</given-names></name><name><surname>Brottet</surname><given-names>E.</given-names></name><name><surname>Gauzere</surname><given-names>B.A.</given-names></name><name><surname>Winer</surname><given-names>A.</given-names></name><name><surname>Vandroux</surname><given-names>D.</given-names></name><name><surname>Michault</surname><given-names>A.</given-names></name></person-group><article-title>Reunion, a sentinel territory for influenza surveillance in Europe</article-title><source>Euro Surveill</source><volume>17</volume><issue>27</issue><year>2012</year><comment>[pii=20212]</comment></element-citation></ref><ref id="bib0065"><label>4</label><element-citation publication-type="journal" id="sbref0065"><person-group person-group-type="author"><name><surname>Fine</surname><given-names>M.J.</given-names></name><name><surname>Auble</surname><given-names>T.E.</given-names></name><name><surname>Yealy</surname><given-names>D.M.</given-names></name></person-group><article-title>A prediction rule to identify low-risk patients with community-acquired pneumonia</article-title><source>N Engl J Med</source><volume>336</volume><year>1997</year><fpage>243</fpage><lpage>250</lpage><pub-id pub-id-type="pmid">8995086</pub-id></element-citation></ref><ref id="bib0070"><label>5</label><element-citation publication-type="journal" id="sbref0070"><person-group person-group-type="author"><name><surname>Patrick DM1</surname></name><name><surname>Petric</surname><given-names>M.</given-names></name><name><surname>Skowronski</surname><given-names>D.M.</given-names></name><name><surname>Guasparini</surname><given-names>R.</given-names></name><name><surname>Booth</surname><given-names>T.F.</given-names></name><name><surname>Krajden</surname><given-names>M.</given-names></name></person-group><article-title>An outbreak of human <italic>Coronavirus</italic> OC43 infection and serological cross-reactivity with SARS <italic>Coronavirus</italic></article-title><source>Can J Infect Dis Med Microbiol</source><volume>17</volume><issue>6</issue><year>2006</year><fpage>330</fpage><lpage>336</lpage><pub-id pub-id-type="pmid">18382647</pub-id></element-citation></ref><ref id="bib0075"><label>6</label><element-citation publication-type="journal" id="sbref0075"><person-group person-group-type="author"><name><surname>Templeton</surname><given-names>K.E.</given-names></name><name><surname>Scheltinga</surname><given-names>S.A.</given-names></name><name><surname>van den Eeden</surname><given-names>W.C.</given-names></name><name><surname>Graffelman</surname><given-names>A.W.</given-names></name><name><surname>van den Broek</surname><given-names>P.J.</given-names></name><name><surname>Claas</surname><given-names>E.C.J.</given-names></name></person-group><article-title>Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction</article-title><source>Clin Infect Dis</source><volume>41</volume><year>2005</year><fpage>345</fpage><lpage>351</lpage><pub-id pub-id-type="pmid">16007532</pub-id></element-citation></ref><ref id="bib0080"><label>7</label><element-citation publication-type="journal" id="sbref0080"><person-group person-group-type="author"><name><surname>Al-Khannaq</surname><given-names>M.N.</given-names></name><name><surname>Tien Ng</surname><given-names>K.</given-names></name><name><surname>Oong</surname><given-names>X.Y.</given-names></name><name><surname>Pang</surname><given-names>Y.K.</given-names></name><name><surname>Takebe</surname><given-names>Y.</given-names></name><name><surname>Chook</surname><given-names>J.B.</given-names></name></person-group><article-title>Molecular epidemiology and evolionary histories of human <italic>Coronavirus</italic> OC43 and HKU1 among patients with upper respiratory tract infections in Kuala Lumpur, Malaysia</article-title><source>Virol J</source><volume>13</volume><year>2016</year><fpage>33</fpage><pub-id pub-id-type="pmid">26916286</pub-id></element-citation></ref><ref id="bib0085"><label>8</label><element-citation publication-type="journal" id="sbref0085"><person-group person-group-type="author"><name><surname>Trombetta</surname><given-names>H.</given-names></name><name><surname>Faggion</surname><given-names>H.Z.</given-names></name><name><surname>Leotte</surname><given-names>J.</given-names></name><name><surname>Nogueira</surname><given-names>M.B.</given-names></name><name><surname>Vidal</surname><given-names>L.R.</given-names></name><name><surname>Raboni</surname><given-names>S.M.</given-names></name></person-group><article-title>Human coronavirus and severe acute respiratory infection in Southern Brazil</article-title><source>Pathog Glob Health</source><volume>110</volume><issue>3</issue><year>2016</year><fpage>113</fpage><lpage>118</lpage><pub-id pub-id-type="pmid">27195607</pub-id></element-citation></ref><ref id="bib0090"><label>9</label><element-citation publication-type="other" id="sbref0090"><ext-link ext-link-type="uri" xlink:href="http://www.meteofrance.re/climat/previsions-saisonnieres" id="intr0005">http://www.meteofrance.re/climat/previsions-saisonnieres</ext-link></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000727 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000727 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:7126704
|texte= Intensive care admission for Coronavirus OC43 respiratory tract infections
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:29402475" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |