Intensive care admission for Coronavirus OC43 respiratory tract infections
Identifieur interne : 000727 ( Pmc/Curation ); précédent : 000726; suivant : 000728Intensive care admission for Coronavirus OC43 respiratory tract infections
Auteurs : D. Vandroux [France] ; N. Allou [France] ; J. Jabot [France] ; G. Li Pat Yuen [Réunion] ; E. Brottet [Réunion] ; B. Roquebert [France, Réunion] ; O. Martinet [France]Source :
- Medecine et Maladies Infectieuses [ 0399-077X ] ; 2018.
Abstract
To analyze acute manifestations of
Retrospective and monocentric study performed during a
Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from
As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.
Url:
DOI: 10.1016/j.medmal.2018.01.001
PubMed: 29402475
PubMed Central: 7126704
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Vandroux</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre</wicri:regionArea></affiliation></author><author><name sortKey="Allou, N" sort="Allou, N" uniqKey="Allou N" first="N." last="Allou">N. Allou</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation></author><author><name sortKey="Jabot, J" sort="Jabot, J" uniqKey="Jabot J" first="J." last="Jabot">J. Jabot</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation></author><author><name sortKey="Li Pat Yuen, G" sort="Li Pat Yuen, G" uniqKey="Li Pat Yuen G" first="G." last="Li Pat Yuen">G. 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Brottet</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</nlm:aff><country xml:lang="fr" wicri:curation="lc">Réunion</country><wicri:regionArea>Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9</wicri:regionArea></affiliation></author><author><name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name><affiliation wicri:level="1"><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff><country xml:lang="fr" wicri:curation="lc">Réunion</country><wicri:regionArea>Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis</wicri:regionArea></affiliation></author><author><name sortKey="Martinet, O" sort="Martinet, O" uniqKey="Martinet O" first="O." last="Martinet">O. Martinet</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29402475</idno><idno type="pmc">7126704</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126704</idno><idno type="RBID">PMC:7126704</idno><idno type="doi">10.1016/j.medmal.2018.01.001</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000727</idno><idno type="wicri:Area/Pmc/Curation">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000727</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intensive care admission for <italic>Coronavirus</italic> OC43 respiratory tract infections</title><author><name sortKey="Vandroux, D" sort="Vandroux, D" uniqKey="Vandroux D" first="D." last="Vandroux">D. Vandroux</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre</wicri:regionArea></affiliation></author><author><name sortKey="Allou, N" sort="Allou, N" uniqKey="Allou N" first="N." last="Allou">N. Allou</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation></author><author><name sortKey="Jabot, J" sort="Jabot, J" uniqKey="Jabot J" first="J." last="Jabot">J. Jabot</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation></author><author><name sortKey="Li Pat Yuen, G" sort="Li Pat Yuen, G" uniqKey="Li Pat Yuen G" first="G." last="Li Pat Yuen">G. Li Pat Yuen</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff><country xml:lang="fr" wicri:curation="lc">Réunion</country><wicri:regionArea>Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis</wicri:regionArea></affiliation></author><author><name sortKey="Brottet, E" sort="Brottet, E" uniqKey="Brottet E" first="E." last="Brottet">E. Brottet</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</nlm:aff><country xml:lang="fr" wicri:curation="lc">Réunion</country><wicri:regionArea>Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9</wicri:regionArea></affiliation></author><author><name sortKey="Roquebert, B" sort="Roquebert, B" uniqKey="Roquebert B" first="B." last="Roquebert">B. Roquebert</name><affiliation wicri:level="1"><nlm:aff id="aff0010">CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</nlm:aff><country xml:lang="fr" wicri:curation="lc">Réunion</country><wicri:regionArea>Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis</wicri:regionArea></affiliation></author><author><name sortKey="Martinet, O" sort="Martinet, O" uniqKey="Martinet O" first="O." last="Martinet">O. Martinet</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion</wicri:regionArea></affiliation></author></analytic><series><title level="j">Medecine et Maladies Infectieuses</title><idno type="ISSN">0399-077X</idno><idno type="eISSN">1769-6690</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p><italic>Coronavirus</italic> OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.</p></sec><sec><title>Objectives</title><p>To analyze acute manifestations of <italic>Coronavirus</italic> OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).</p></sec><sec><title>Patients and methods</title><p>Retrospective and monocentric study performed during a <italic>Coronavirus</italic> OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.</p></sec><sec><title>Results</title><p>Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from <italic>Haemophilus influenzae</italic> co-infection.</p></sec><sec><title>Conclusion</title><p>As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morfopoulou, S" uniqKey="Morfopoulou S">S. Morfopoulou</name></author><author><name sortKey="Brown, J R" uniqKey="Brown J">J.R. 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Raboni</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Mal Infect</journal-id><journal-id journal-id-type="iso-abbrev">Med Mal Infect</journal-id><journal-title-group><journal-title>Medecine et Maladies Infectieuses</journal-title></journal-title-group><issn pub-type="ppub">0399-077X</issn><issn pub-type="epub">1769-6690</issn><publisher><publisher-name>Elsevier Masson SAS.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29402475</article-id><article-id pub-id-type="pmc">7126704</article-id><article-id pub-id-type="publisher-id">S0399-077X(17)30047-1</article-id><article-id pub-id-type="doi">10.1016/j.medmal.2018.01.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Intensive care admission for <italic>Coronavirus</italic> OC43 respiratory tract infections</article-title><trans-title-group xml:lang="fr"><trans-title>Admissions en réanimation pour infection respiratoire à <italic>Coronavirus</italic> OC43</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Vandroux</surname><given-names>D.</given-names></name><email>vandroux.david@gmail.com</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Allou</surname><given-names>N.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Jabot</surname><given-names>J.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Li Pat Yuen</surname><given-names>G.</given-names></name><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Brottet</surname><given-names>E.</given-names></name><xref rid="aff0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Roquebert</surname><given-names>B.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="aut0035"><name><surname>Martinet</surname><given-names>O.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France</aff><aff id="aff0010"><label>b</label>CHU La-Réunion, Inserm, CIC 1410, 97410 Saint-Pierre, France</aff><aff id="aff0015"><label>c</label>Laboratoire de biologie moléculaire, service de microbiologie, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis, Reunion</aff><aff id="aff0020"><label>d</label>Santé publique France, CIRE océan indien, 2, bis avenue Georges-Brassens, CS 61002, 97443 Saint-Denis cedex 9, Reunion</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author. Service de réanimation polyvalente, hôpital Félix-Guyon, CHU La-Réunion, allée des topazes, CS11021, 97400 Saint-Denis-de-La-Réunion, France. <email>vandroux.david@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>7</day><month>3</month><year>2018</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>7</day><month>3</month><year>2018</year></pub-date><volume>48</volume><issue>2</issue><fpage>141</fpage><lpage>144</lpage><history><date date-type="received"><day>3</day><month>2</month><year>2017</year></date><date date-type="rev-recd"><day>24</day><month>5</month><year>2017</year></date><date date-type="accepted"><day>3</day><month>1</month><year>2018</year></date></history><permissions><copyright-statement>© 2018 Elsevier Masson SAS. All rights reserved.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder>Elsevier Masson SAS</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><sec><title>Background</title><p><italic>Coronavirus</italic> OC43 infection causes severe pneumonia in patients presenting with comorbidities, but clinical signs alone do not allow for viral identification.</p></sec><sec><title>Objectives</title><p>To analyze acute manifestations of <italic>Coronavirus</italic> OC43 infections and outcomes of patients admitted to an intensive care unit (ICU).</p></sec><sec><title>Patients and methods</title><p>Retrospective and monocentric study performed during a <italic>Coronavirus</italic> OC43 outbreak. We used multiplex PCR to detect an OC43 outbreak in Reunion Island during the 2016 Southern Hemisphere's winter: seven admissions to the ICU.</p></sec><sec><title>Results</title><p>Mean age of patients was 71 [67;76] years, SAPS II was 42 [28;53], pneumonia severity index 159 [139;182] vs 73 [40.5;107] for patients in medical wards, and 43% required mechanical ventilation. Comorbidities were diabetes mellitus (87%), chronic respiratory failure (57%), and chronic renal failure (29%). One patient died from <italic>Haemophilus influenzae</italic> co-infection.</p></sec><sec><title>Conclusion</title><p>As for MERS Co-V infections, underlying comorbidities impacted the clinical outcomes of OC43 infections.</p></sec></abstract><trans-abstract xml:lang="fr"><title>Résumé</title><sec><title>Introduction</title><p>L’infection à <italic>Coronavirus</italic> OC43 peut induire des pneumopathies sévères chez les patients présentant des comorbidités lors d’épisodes hivernaux en climat tempéré.</p></sec><sec><title>Patients et méthodes</title><p>Analyse rétrospective, monocentrique des cas d’infections à <italic>Coronavirus</italic> OC43 admis en réanimation. L’utilisation d’une PCR multiplex pour les infections respiratoires a permis de détecter une épidémie de bronchopneumopathies à <italic>Coronavirus</italic> OC43 durant l’hiver austral 2016 à La Réunion: sept admissions en réanimation.</p></sec><sec><title>Résultats</title><p>Des patients, âgés de 71 [67 ; 76] ans en moyenne, présentaient un indice de gravité simplifié II de 42 [28 ; 53] et une ventilation mécanique était requise pour 43 %. Les comorbidités comprenaient diabète (87 %), insuffisance respiratoire chronique (57 %) et insuffisance rénale chronique (29 %). Un décès est survenu au cours d’une co-infection à <italic>Haemophilus influenzae.</italic></p></sec><sec><title>Conclusion</title><p>Comme pour le MERS <italic>Coronavirus</italic>, les comorbidités impactent l’évolution clinique d’une infection et conduisent à des admissions en réanimation.</p></sec></trans-abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd><italic>Coronavirus</italic> OC43</kwd><kwd>multiplex PCR</kwd></kwd-group><kwd-group xml:lang="fr" id="kwd0010"><title>Mots clés</title><kwd><italic>Coronavirus</italic> OC43</kwd><kwd>PCR multiplex</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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