Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?
Identifieur interne : 002670 ( Ncbi/Merge ); précédent : 002669; suivant : 002671Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?
Auteurs : Ali S. Omrani ; Ziad A. MemishSource :
- Current Treatment Options in Infectious Diseases [ 1523-3820 ] ; 2015.
Abstract
Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.
Url:
DOI: 10.1007/s40506-015-0048-2
PubMed: 32226324
PubMed Central: 7100761
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<front><div type="abstract" xml:lang="en"><p id="Par1">Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.</p>
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<double pmid="32226324"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?</title>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id>
<institution-id institution-id-type="ISNI">0000000121914301</institution-id>
<institution>Department of Medicine, Section of Infectious Diseases,</institution>
<institution>King Faisal Specialist Hospital and Research Centre,</institution>
</institution-wrap>
Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id>
<institution>College of Medicine,</institution>
<institution>Alfaisal University & Ministry of Health,</institution>
</institution-wrap>
P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">11514 Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">32226324</idno>
<idno type="pmc">7100761</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100761</idno>
<idno type="RBID">PMC:7100761</idno>
<idno type="doi">10.1007/s40506-015-0048-2</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000507</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000507</idno>
<idno type="wicri:Area/Pmc/Curation">000507</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000507</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D02</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D02</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?</title>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id>
<institution-id institution-id-type="ISNI">0000000121914301</institution-id>
<institution>Department of Medicine, Section of Infectious Diseases,</institution>
<institution>King Faisal Specialist Hospital and Research Centre,</institution>
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Riyadh, Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry>
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<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
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P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff>
<wicri:noCountry code="subfield">11514 Kingdom of Saudi Arabia</wicri:noCountry>
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</analytic>
<series><title level="j">Current Treatment Options in Infectious Diseases</title>
<idno type="ISSN">1523-3820</idno>
<idno type="eISSN">1534-6250</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.</p>
</div>
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<affiliation><nlm:affiliation>1Department of Medicine, Section of Infectious Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
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<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name>
<affiliation><nlm:affiliation>2College of Medicine, Alfaisal University & Ministry of Health, P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia.</nlm:affiliation>
<wicri:noCountry code="subField">11514 Kingdom of Saudi Arabia</wicri:noCountry>
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<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name>
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<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
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<wicri:noCountry code="subField">11514 Kingdom of Saudi Arabia</wicri:noCountry>
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<series><title level="j">Current treatment options in infectious diseases</title>
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<front><div type="abstract" xml:lang="en">Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.</div>
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