Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?
Identifieur interne : 000507 ( Pmc/Curation ); précédent : 000506; suivant : 000508Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?
Auteurs : Ali S. Omrani ; Ziad A. MemishSource :
- Current Treatment Options in Infectious Diseases [ 1523-3820 ] ; 2015.
Abstract
Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.
Url:
DOI: 10.1007/s40506-015-0048-2
PubMed: 32226324
PubMed Central: 7100761
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Ali S. Omrani<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University & Ministry of Health,</institution></institution-wrap>P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11514 Kingdom of Saudi Arabia</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?</title><author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University & Ministry of Health,</institution></institution-wrap>P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11514 Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32226324</idno><idno type="pmc">7100761</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100761</idno><idno type="RBID">PMC:7100761</idno><idno type="doi">10.1007/s40506-015-0048-2</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000507</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000507</idno><idno type="wicri:Area/Pmc/Curation">000507</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000507</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?</title><author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University & Ministry of Health,</institution></institution-wrap>P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11514 Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Current Treatment Options in Infectious Diseases</title><idno type="ISSN">1523-3820</idno><idno type="eISSN">1534-6250</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Curr Treat Options Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Curr Treat Options Infect Dis</journal-id><journal-title-group><journal-title>Current Treatment Options in Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1523-3820</issn><issn pub-type="epub">1534-6250</issn><publisher><publisher-name>Springer US</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32226324</article-id><article-id pub-id-type="pmc">7100761</article-id><article-id pub-id-type="publisher-id">48</article-id><article-id pub-id-type="doi">10.1007/s40506-015-0048-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Viral Infections (J Tang, Section Editor)</subject></subj-group></article-categories><title-group><article-title>Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: How Close Are We?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Omrani</surname><given-names>Ali S.</given-names></name><degrees>MBBCh, MSc, FRCP, FRCPath</degrees><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Memish</surname><given-names>Ziad A.</given-names></name><degrees>MD, FRCPC, FRCPL, FRCPE, FACP</degrees><address><phone>+966505483515</phone><email>zmemish@yahoo.com</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, Kingdom of Saudi Arabia</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University & Ministry of Health,</institution></institution-wrap>P.O. Box 54146, Riyadh, 11514 Kingdom of Saudi Arabia</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><year>2015</year></pub-date><volume>7</volume><issue>3</issue><fpage>202</fpage><lpage>216</lpage><permissions><copyright-statement>© Springer Science+Business Media New York 2015</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Over 1100 cases of MERS-CoV have been reported since it was first identified in June 2012. Clinical presentation ranges from asymptomatic or mild illness to rapidly progressive disease with multi-organ failure and high mortality. Treatment has been largely supportive. A large number of compounds have been shown to have significant in vitro inhibitory activity against MERS-CoV. Until recently, macaques were the only suitable animal models for animal studies, hindering further clinical development of MERS-CoV therapy. However, the recent successful development of MERS-CoV infection model in transduced mice offers opportunities to accelerate clinical development of therapeutic agents for MERS-CoV infection. Currently available evidence supports further clinical investigation of interferon-based treatment regimens for patients with MERS-CoV. Combining interferon with mycophenolate and/or high-dose ribavirin appears especially promising. Monoclonal antibodies against various targets within MERS-CoV Spike protein have yielded encouraging in-vitro results. However, their safety and efficacy require confirmation in animal models and exploratory clinical trials.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>MERS-CoV</kwd><kwd>Coronavirus</kwd><kwd>Middle East</kwd><kwd>Therapy</kwd><kwd>Interferon</kwd><kwd>Ribavirin</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media New York 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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