Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome
Identifieur interne : 002151 ( Ncbi/Merge ); précédent : 002150; suivant : 002152Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome
Auteurs : Basem M. Alraddadi ; Ismael Qushmaq ; Fahad M. Al-Hameed ; Yasser Mandourah ; Ghaleb A. Almekhlafi ; Jesna Jose ; Awad Al-Omari ; Ayman Kharaba ; Abdullah Almotairi ; Kasim Al Khatib ; Sarah Shalhoub ; Ahmed Abdulmomen ; Ahmed Mady ; Othman Solaiman ; Abdulsalam M. Al-Aithan ; Rajaa Al-Raddadi ; Ahmed Ragab ; Hanan H. Balkhy ; Abdulrahman Al Harthy ; Musharaf Sadat ; Haytham Tlayjeh ; Laura Merson ; Frederick G. Hayden ; Robert A. Fowler ; Yaseen M. ArabiSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- MESH :
- geographic : Saudi Arabia.
- complications : Coronavirus Infections.
- statistics & numerical data : Noninvasive Ventilation.
- Aged, Critical Illness, Female, Humans, Intensive Care Units, Male, Middle Aged, Respiratory Distress Syndrome, Adult, Retrospective Studies, Treatment Failure, Treatment Outcome.
Abstract
Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.
Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).
Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60]
In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.
Url:
DOI: 10.1111/irv.12635
PubMed: 30884185
PubMed Central: 6586182
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Alraddadi</name><affiliation><nlm:aff id="irv12635-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="irv12635-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Ameed, Fahad M" sort="Al Ameed, Fahad M" uniqKey="Al Ameed F" first="Fahad M." last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation><nlm:aff id="irv12635-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation><nlm:aff id="irv12635-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation><nlm:aff id="irv12635-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation><nlm:aff id="irv12635-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Al Mari, Awad" sort="Al Mari, Awad" uniqKey="Al Mari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation><nlm:aff id="irv12635-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation><nlm:aff id="irv12635-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation><nlm:aff id="irv12635-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation><nlm:aff id="irv12635-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation><nlm:aff id="irv12635-aff-0010"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation><nlm:aff id="irv12635-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation><nlm:aff id="irv12635-aff-0013"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation><nlm:aff id="irv12635-aff-0015"></nlm:aff></affiliation></author><author><name sortKey="Al Ithan, Abdulsalam M" sort="Al Ithan, Abdulsalam M" uniqKey="Al Ithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation><nlm:aff id="irv12635-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Al Addadi, Rajaa" sort="Al Addadi, Rajaa" uniqKey="Al Addadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation><nlm:aff id="irv12635-aff-0017"></nlm:aff></affiliation></author><author><name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name><affiliation><nlm:aff id="irv12635-aff-0018"></nlm:aff></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation><nlm:aff id="irv12635-aff-0019"></nlm:aff></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation><nlm:aff id="irv12635-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author><author><name sortKey="Tlayjeh, Haytham" sort="Tlayjeh, Haytham" uniqKey="Tlayjeh H" first="Haytham" last="Tlayjeh">Haytham Tlayjeh</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation><nlm:aff id="irv12635-aff-0021"></nlm:aff></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation><nlm:aff id="irv12635-aff-0022"></nlm:aff></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation><nlm:aff id="irv12635-aff-0023"></nlm:aff></affiliation></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Coronavirus Infections (complications)</term><term>Critical Illness</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Noninvasive Ventilation (statistics & numerical data)</term><term>Respiratory Distress Syndrome, Adult</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Maladie grave</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Syndrome de détresse respiratoire de l'adulte</term><term>Unités de soins intensifs</term><term>Ventilation non effractive ()</term><term>Échec thérapeutique</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Noninvasive Ventilation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Critical Illness</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Respiratory Distress Syndrome, Adult</term><term>Retrospective Studies</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Maladie grave</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Syndrome de détresse respiratoire de l'adulte</term><term>Unités de soins intensifs</term><term>Ventilation non effractive</term><term>Échec thérapeutique</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="irv12635-sec-0001"><title>Background</title><p>Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.</p></sec><sec id="irv12635-sec-0002"><title>Methods</title><p>Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).</p></sec><sec id="irv12635-sec-0003"><title>Results</title><p>Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60] <italic>P</italic> = 0.27).</p></sec><sec id="irv12635-sec-0004"><title>Conclusions</title><p>In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="30884185"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome</title><author><name sortKey="Alraddadi, Basem M" sort="Alraddadi, Basem M" uniqKey="Alraddadi B" first="Basem M." last="Alraddadi">Basem M. Alraddadi</name><affiliation><nlm:aff id="irv12635-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="irv12635-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Ameed, Fahad M" sort="Al Ameed, Fahad M" uniqKey="Al Ameed F" first="Fahad M." last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation><nlm:aff id="irv12635-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation><nlm:aff id="irv12635-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation><nlm:aff id="irv12635-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation><nlm:aff id="irv12635-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Al Mari, Awad" sort="Al Mari, Awad" uniqKey="Al Mari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation><nlm:aff id="irv12635-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation><nlm:aff id="irv12635-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation><nlm:aff id="irv12635-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation><nlm:aff id="irv12635-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation><nlm:aff id="irv12635-aff-0010"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation><nlm:aff id="irv12635-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation><nlm:aff id="irv12635-aff-0013"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation><nlm:aff id="irv12635-aff-0015"></nlm:aff></affiliation></author><author><name sortKey="Al Ithan, Abdulsalam M" sort="Al Ithan, Abdulsalam M" uniqKey="Al Ithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation><nlm:aff id="irv12635-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Al Addadi, Rajaa" sort="Al Addadi, Rajaa" uniqKey="Al Addadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation><nlm:aff id="irv12635-aff-0017"></nlm:aff></affiliation></author><author><name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name><affiliation><nlm:aff id="irv12635-aff-0018"></nlm:aff></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation><nlm:aff id="irv12635-aff-0019"></nlm:aff></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation><nlm:aff id="irv12635-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author><author><name sortKey="Tlayjeh, Haytham" sort="Tlayjeh, Haytham" uniqKey="Tlayjeh H" first="Haytham" last="Tlayjeh">Haytham Tlayjeh</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation><nlm:aff id="irv12635-aff-0021"></nlm:aff></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation><nlm:aff id="irv12635-aff-0022"></nlm:aff></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation><nlm:aff id="irv12635-aff-0023"></nlm:aff></affiliation></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30884185</idno><idno type="pmc">6586182</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586182</idno><idno type="RBID">PMC:6586182</idno><idno type="doi">10.1111/irv.12635</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000D29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D29</idno><idno type="wicri:Area/Pmc/Curation">000D29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D29</idno><idno type="wicri:Area/Pmc/Checkpoint">000222</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000222</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome</title><author><name sortKey="Alraddadi, Basem M" sort="Alraddadi, Basem M" uniqKey="Alraddadi B" first="Basem M." last="Alraddadi">Basem M. Alraddadi</name><affiliation><nlm:aff id="irv12635-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation><nlm:aff id="irv12635-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Ameed, Fahad M" sort="Al Ameed, Fahad M" uniqKey="Al Ameed F" first="Fahad M." last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation><nlm:aff id="irv12635-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation><nlm:aff id="irv12635-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation><nlm:aff id="irv12635-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation><nlm:aff id="irv12635-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Al Mari, Awad" sort="Al Mari, Awad" uniqKey="Al Mari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation><nlm:aff id="irv12635-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation><nlm:aff id="irv12635-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation><nlm:aff id="irv12635-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation><nlm:aff id="irv12635-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation><nlm:aff id="irv12635-aff-0010"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation><nlm:aff id="irv12635-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation><nlm:aff id="irv12635-aff-0013"></nlm:aff></affiliation><affiliation><nlm:aff id="irv12635-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation><nlm:aff id="irv12635-aff-0015"></nlm:aff></affiliation></author><author><name sortKey="Al Ithan, Abdulsalam M" sort="Al Ithan, Abdulsalam M" uniqKey="Al Ithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation><nlm:aff id="irv12635-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Al Addadi, Rajaa" sort="Al Addadi, Rajaa" uniqKey="Al Addadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation><nlm:aff id="irv12635-aff-0017"></nlm:aff></affiliation></author><author><name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name><affiliation><nlm:aff id="irv12635-aff-0018"></nlm:aff></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation><nlm:aff id="irv12635-aff-0019"></nlm:aff></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation><nlm:aff id="irv12635-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author><author><name sortKey="Tlayjeh, Haytham" sort="Tlayjeh, Haytham" uniqKey="Tlayjeh H" first="Haytham" last="Tlayjeh">Haytham Tlayjeh</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation><nlm:aff id="irv12635-aff-0021"></nlm:aff></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation><nlm:aff id="irv12635-aff-0022"></nlm:aff></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation><nlm:aff id="irv12635-aff-0023"></nlm:aff></affiliation></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation><nlm:aff id="irv12635-aff-0020"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="irv12635-sec-0001"><title>Background</title><p>Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.</p></sec><sec id="irv12635-sec-0002"><title>Methods</title><p>Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).</p></sec><sec id="irv12635-sec-0003"><title>Results</title><p>Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60] <italic>P</italic> = 0.27).</p></sec><sec id="irv12635-sec-0004"><title>Conclusions</title><p>In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome.</title><author><name sortKey="Alraddadi, Basem M" sort="Alraddadi, Basem M" uniqKey="Alraddadi B" first="Basem M" last="Alraddadi">Basem M. Alraddadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad M" sort="Al Hameed, Fahad M" uniqKey="Al Hameed F" first="Fahad M" last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:affiliation>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A" last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:affiliation>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, Dr. Sulaiman Al-Habib Group Hospitals, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Dr. Sulaiman Al-Habib Group Hospitals, College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care, Ohoud Hospitals, King Fahad Hospital, Al-Madinah Al-Monawarah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, Ohoud Hospitals, King Fahad Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Intensive Care, Tanta University Hospitals, Tanta, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesiology, Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M" last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdulaziz Hospital, Al Ahsa, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdulaziz Hospital, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Family and Community Medicine, King Abdulaziz University Hospital, Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Family and Community Medicine, King Abdulaziz University Hospital, Ministry of Health, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:affiliation>Infection Prevention and Control Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infection Prevention and Control Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Tlayjeh, Haytham" sort="Tlayjeh, Haytham" uniqKey="Tlayjeh H" first="Haytham" last="Tlayjeh">Haytham Tlayjeh</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Data Observatory, Churchill Hospital, Oxford University, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Headington, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Infectious Diseases Data Observatory, Churchill Hospital, Oxford University, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Headington</wicri:regionArea><wicri:noRegion>Headington</wicri:noRegion></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30884185</idno><idno type="pmid">30884185</idno><idno type="doi">10.1111/irv.12635</idno><idno type="wicri:Area/PubMed/Corpus">000605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000605</idno><idno type="wicri:Area/PubMed/Curation">000605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000605</idno><idno type="wicri:Area/PubMed/Checkpoint">000445</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000445</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome.</title><author><name sortKey="Alraddadi, Basem M" sort="Alraddadi, Basem M" uniqKey="Alraddadi B" first="Basem M" last="Alraddadi">Basem M. Alraddadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad M" sort="Al Hameed, Fahad M" uniqKey="Al Hameed F" first="Fahad M" last="Al-Hameed">Fahad M. Al-Hameed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:affiliation>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A" last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:affiliation>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Prince Sultan Military Medical City, Military Medical Services, Ministry of Defense, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, Dr. Sulaiman Al-Habib Group Hospitals, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Dr. Sulaiman Al-Habib Group Hospitals, College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care, Ohoud Hospitals, King Fahad Hospital, Al-Madinah Al-Monawarah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, Ohoud Hospitals, King Fahad Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Intensive Care, Tanta University Hospitals, Tanta, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesiology, Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M" last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdulaziz Hospital, Al Ahsa, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdulaziz Hospital, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Family and Community Medicine, King Abdulaziz University Hospital, Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Family and Community Medicine, King Abdulaziz University Hospital, Ministry of Health, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmed" sort="Ragab, Ahmed" uniqKey="Ragab A" first="Ahmed" last="Ragab">Ahmed Ragab</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:affiliation>Infection Prevention and Control Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infection Prevention and Control Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Tlayjeh, Haytham" sort="Tlayjeh, Haytham" uniqKey="Tlayjeh H" first="Haytham" last="Tlayjeh">Haytham Tlayjeh</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Data Observatory, Churchill Hospital, Oxford University, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Headington, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Infectious Diseases Data Observatory, Churchill Hospital, Oxford University, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Headington</wicri:regionArea><wicri:noRegion>Headington</wicri:noRegion></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Coronavirus Infections (complications)</term><term>Critical Illness</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Noninvasive Ventilation (statistics & numerical data)</term><term>Respiratory Distress Syndrome, Adult</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Maladie grave</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Syndrome de détresse respiratoire de l'adulte</term><term>Unités de soins intensifs</term><term>Ventilation non effractive ()</term><term>Échec thérapeutique</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Noninvasive Ventilation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Critical Illness</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Respiratory Distress Syndrome, Adult</term><term>Retrospective Studies</term><term>Treatment Failure</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Maladie grave</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Syndrome de détresse respiratoire de l'adulte</term><term>Unités de soins intensifs</term><term>Ventilation non effractive</term><term>Échec thérapeutique</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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