Macrolides in critically ill patients with Middle East Respiratory Syndrome
Identifieur interne : 002094 ( Ncbi/Merge ); précédent : 002093; suivant : 002095Macrolides in critically ill patients with Middle East Respiratory Syndrome
Auteurs : Yaseen M. Arabi [Arabie saoudite] ; Ahmad M. Deeb [Arabie saoudite] ; Fahad Al-Hameed [Arabie saoudite] ; Yasser Mandourah [Arabie saoudite] ; Ghaleb A. Almekhlafi [Arabie saoudite] ; Anees A. Sindi [Arabie saoudite] ; Awad Al-Omari [Arabie saoudite] ; Sarah Shalhoub [Arabie saoudite, Canada] ; Ahmed Mady [Arabie saoudite, Égypte] ; Basem Alraddadi [Arabie saoudite] ; Abdullah Almotairi [Arabie saoudite] ; Kasim Al Khatib [Arabie saoudite] ; Ahmed Abdulmomen [Arabie saoudite] ; Ismael Qushmaq [Arabie saoudite] ; Othman Solaiman [Arabie saoudite] ; Abdulsalam M. Al-Aithan [Arabie saoudite] ; Rajaa Al-Raddadi [Arabie saoudite] ; Ahmad Ragab [Arabie saoudite] ; Abdulrahman Al Harthy [Arabie saoudite] ; Ayman Kharaba [Arabie saoudite] ; Jesna Jose [Arabie saoudite] ; Tarek Dabbagh [Arabie saoudite] ; Robert A. Fowler [Canada] ; Hanan H. Balkhy [Arabie saoudite] ; Laura Merson [Royaume-Uni] ; Frederick G. Hayden [États-Unis]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antibactériens (administration et posologie), Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Humains, Infections à coronavirus (mortalité), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Macrolides (administration et posologie), Maladie grave (), Mâle, Sujet âgé, Unités de soins intensifs (), Études rétrospectives.
- MESH :
- administration et posologie : Antibactériens, Macrolides.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- mortalité : Infections à coronavirus.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Maladie grave, Mâle, Sujet âgé, Unités de soins intensifs, Études rétrospectives.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Adult, Aged, Anti-Bacterial Agents (administration & dosage), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Critical Illness (therapy), Female, Humans, Intensive Care Units (statistics & numerical data), Macrolides (administration & dosage), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Retrospective Studies, Saudi Arabia.
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Macrolides.
- geographic : Saudi Arabia.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- mortality : Coronavirus Infections.
- statistics & numerical data : Intensive Care Units.
- therapy : Critical Illness.
- virology : Coronavirus Infections.
- Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
More than one-third of critically ill patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) received empiric therapy with macrolides. Macrolide therapy is not significantly associated with a reduction in 90-day mortality of critically ill patients with MERS-CoV. Macrolide therapy is not significantly associated with improvement in MERS-CoV RNA clearance of critically ill patients with MERS-CoV.
Url:
DOI: 10.1016/j.ijid.2019.01.041
PubMed: 30690213
PubMed Central: 7110878
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000D55
- to stream Pmc, to step Curation: 000D55
- to stream Pmc, to step Checkpoint: 000252
- to stream PubMed, to step Corpus: 000657
- to stream PubMed, to step Curation: 000657
- to stream PubMed, to step Checkpoint: 000487
Links to Exploration step
PMC:7110878Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Macrolides in critically ill patients with Middle East Respiratory Syndrome</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M." last="Deeb">Ahmad M. Deeb</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name><affiliation wicri:level="1"><nlm:aff id="aff0020">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A." last="Sindi">Anees A. Sindi</name><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0045">Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="1"><nlm:aff id="aff0050">Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0145">Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0060">Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:aff id="aff0070">Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:aff id="aff0075">Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:aff id="aff0080">Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:aff id="aff0085">King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:aff id="aff0090">Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0150">King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0095">King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name><affiliation wicri:level="1"><nlm:aff id="aff0100">Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:aff id="aff0105">Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:aff id="aff0110">Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0115">King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:aff id="aff0120">Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0125">Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0130">Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="3"><nlm:aff id="aff0135">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:aff id="aff0140">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30690213</idno><idno type="pmc">7110878</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110878</idno><idno type="RBID">PMC:7110878</idno><idno type="doi">10.1016/j.ijid.2019.01.041</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000D55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D55</idno><idno type="wicri:Area/Pmc/Curation">000D55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D55</idno><idno type="wicri:Area/Pmc/Checkpoint">000252</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000252</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:30690213</idno><idno type="wicri:Area/PubMed/Corpus">000657</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000657</idno><idno type="wicri:Area/PubMed/Curation">000657</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000657</idno><idno type="wicri:Area/PubMed/Checkpoint">000487</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000487</idno><idno type="wicri:Area/Ncbi/Merge">002094</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Macrolides in critically ill patients with Middle East Respiratory Syndrome</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M." last="Deeb">Ahmad M. Deeb</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name><affiliation wicri:level="1"><nlm:aff id="aff0020">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A." last="Sindi">Anees A. Sindi</name><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0045">Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="1"><nlm:aff id="aff0050">Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0145">Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0060">Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:aff id="aff0070">Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:aff id="aff0075">Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:aff id="aff0080">Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:aff id="aff0085">King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:aff id="aff0090">Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0150">King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0095">King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name><affiliation wicri:level="1"><nlm:aff id="aff0100">Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:aff id="aff0105">Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:aff id="aff0110">Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0115">King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:aff id="aff0120">Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0125">Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0130">Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="3"><nlm:aff id="aff0135">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:aff id="aff0140">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Critical Illness (therapy)</term><term>Female</term><term>Humans</term><term>Intensive Care Units (statistics & numerical data)</term><term>Macrolides (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Retrospective Studies</term><term>Saudi Arabia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antibactériens (administration et posologie)</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Macrolides (administration et posologie)</term><term>Maladie grave ()</term><term>Mâle</term><term>Sujet âgé</term><term>Unités de soins intensifs ()</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Macrolides</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Macrolides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Critical Illness</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Maladie grave</term><term>Mâle</term><term>Sujet âgé</term><term>Unités de soins intensifs</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">More than one-third of critically ill patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) received empiric therapy with macrolides.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Macrolide therapy is not significantly associated with a reduction in 90-day mortality of critically ill patients with MERS-CoV.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Macrolide therapy is not significantly associated with improvement in MERS-CoV RNA clearance of critically ill patients with MERS-CoV.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amsden, G W" uniqKey="Amsden G">G.W. Amsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y M" uniqKey="Arabi Y">Y.M. Arabi</name></author><author><name sortKey="Al Omari, A" uniqKey="Al Omari A">A. Al-Omari</name></author><author><name sortKey="Mandourah, Y" uniqKey="Mandourah Y">Y. Mandourah</name></author><author><name sortKey="Al Hameed, F" uniqKey="Al Hameed F">F. Al-Hameed</name></author><author><name sortKey="Sindi, A A" uniqKey="Sindi A">A.A. Sindi</name></author><author><name sortKey="Alraddadi, B" uniqKey="Alraddadi B">B. Alraddadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigelman, A" uniqKey="Beigelman A">A. Beigelman</name></author><author><name sortKey="Bacharier, L B" uniqKey="Bacharier L">L.B. Bacharier</name></author><author><name sortKey="Baty, J" uniqKey="Baty J">J. Baty</name></author><author><name sortKey="Buller, R" uniqKey="Buller R">R. Buller</name></author><author><name sortKey="Mason, S" uniqKey="Mason S">S. Mason</name></author><author><name sortKey="Schechtman, K B" uniqKey="Schechtman K">K.B. Schechtman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigelman, A" uniqKey="Beigelman A">A. Beigelman</name></author><author><name sortKey="Mikols, C L" uniqKey="Mikols C">C.L. Mikols</name></author><author><name sortKey="Gunsten, S P" uniqKey="Gunsten S">S.P. Gunsten</name></author><author><name sortKey="Cannon, C L" uniqKey="Cannon C">C.L. Cannon</name></author><author><name sortKey="Brody, S L" uniqKey="Brody S">S.L. Brody</name></author><author><name sortKey="Walter, M J" uniqKey="Walter M">M.J. Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermejo Martin, J F" uniqKey="Bermejo Martin J">J.F. Bermejo-Martin</name></author><author><name sortKey="Kelvin, D J" uniqKey="Kelvin D">D.J. Kelvin</name></author><author><name sortKey="Eiros, J M" uniqKey="Eiros J">J.M. Eiros</name></author><author><name sortKey="Castrodeza, J" uniqKey="Castrodeza J">J. Castrodeza</name></author><author><name sortKey="Ortiz De Lejarazu, R" uniqKey="Ortiz De Lejarazu R">R. Ortiz de Lejarazu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gielen, V" uniqKey="Gielen V">V. Gielen</name></author><author><name sortKey="Johnston, S L" uniqKey="Johnston S">S.L. Johnston</name></author><author><name sortKey="Edwards, M R" uniqKey="Edwards M">M.R. Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higashi, F" uniqKey="Higashi F">F. Higashi</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H. Kubo</name></author><author><name sortKey="Yasuda, H" uniqKey="Yasuda H">H. Yasuda</name></author><author><name sortKey="Nukiwa, T" uniqKey="Nukiwa T">T. Nukiwa</name></author><author><name sortKey="Yamaya, M" uniqKey="Yamaya M">M. Yamaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, I F N" uniqKey="Hung I">I.F.N. Hung</name></author><author><name sortKey="To, K K W" uniqKey="To K">K.K.W. To</name></author><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name></author><author><name sortKey="Cheng, V C C" uniqKey="Cheng V">V.C.C. Cheng</name></author><author><name sortKey="Liu, K S H" uniqKey="Liu K">K.S.H. Liu</name></author><author><name sortKey="Tam, A" uniqKey="Tam A">A. Tam</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kakeya, H" uniqKey="Kakeya H">H. Kakeya</name></author><author><name sortKey="Seki, M" uniqKey="Seki M">M. Seki</name></author><author><name sortKey="Izumikawa, K" uniqKey="Izumikawa K">K. Izumikawa</name></author><author><name sortKey="Kosai, K" uniqKey="Kosai K">K. Kosai</name></author><author><name sortKey="Morinaga, Y" uniqKey="Morinaga Y">Y. Morinaga</name></author><author><name sortKey="Kurihara, S" uniqKey="Kurihara S">S. Kurihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanoh, S" uniqKey="Kanoh S">S. Kanoh</name></author><author><name sortKey="Rubin, B K" uniqKey="Rubin B">B.K. Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kneyber, M C" uniqKey="Kneyber M">M.C. Kneyber</name></author><author><name sortKey="Van Woensel, J B" uniqKey="Van Woensel J">J.B. van Woensel</name></author><author><name sortKey="Uijtendaal, E" uniqKey="Uijtendaal E">E. Uijtendaal</name></author><author><name sortKey="Uiterwaal, C S" uniqKey="Uiterwaal C">C.S. Uiterwaal</name></author><author><name sortKey="Kimpen, J L" uniqKey="Kimpen J">J.L. Kimpen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name></author><author><name sortKey="Chan, M C W" uniqKey="Chan M">M.C.W. Chan</name></author><author><name sortKey="Yeung, E S L" uniqKey="Yeung E">E.S.L. Yeung</name></author><author><name sortKey="Tam, W W S" uniqKey="Tam W">W.W.S. Tam</name></author><author><name sortKey="Tsang, O T Y" uniqKey="Tsang O">O.T.Y. Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lendermon, E A" uniqKey="Lendermon E">E.A. Lendermon</name></author><author><name sortKey="Coon, T A" uniqKey="Coon T">T.A. Coon</name></author><author><name sortKey="Bednash, J S" uniqKey="Bednash J">J.S. Bednash</name></author><author><name sortKey="Weathington, N M" uniqKey="Weathington N">N.M. Weathington</name></author><author><name sortKey="Mcdyer, J F" uniqKey="Mcdyer J">J.F. McDyer</name></author><author><name sortKey="Mallampalli, R K" uniqKey="Mallampalli R">R.K. Mallampalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Loeches, I" uniqKey="Martin Loeches I">I. Martin-Loeches</name></author><author><name sortKey="Bermejo Martin, J F" uniqKey="Bermejo Martin J">J.F. Bermejo-Martin</name></author><author><name sortKey="Valles, J" uniqKey="Valles J">J. Valles</name></author><author><name sortKey="Granada, R" uniqKey="Granada R">R. Granada</name></author><author><name sortKey="Vidaur, L" uniqKey="Vidaur L">L. Vidaur</name></author><author><name sortKey="Vergara Serrano, J C" uniqKey="Vergara Serrano J">J.C. Vergara-Serrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccallum, G B" uniqKey="Mccallum G">G.B. McCallum</name></author><author><name sortKey="Morris, P S" uniqKey="Morris P">P.S. Morris</name></author><author><name sortKey="Chatfield, M D" uniqKey="Chatfield M">M.D. Chatfield</name></author><author><name sortKey="Maclennan, C" uniqKey="Maclennan C">C. Maclennan</name></author><author><name sortKey="White, A V" uniqKey="White A">A.V. White</name></author><author><name sortKey="Sloots, T P" uniqKey="Sloots T">T.P. Sloots</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Min, J Y" uniqKey="Min J">J.Y. Min</name></author><author><name sortKey="Jang, Y J" uniqKey="Jang Y">Y.J. Jang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mosquera, R A" uniqKey="Mosquera R">R.A. Mosquera</name></author><author><name sortKey="Stark, J M" uniqKey="Stark J">J.M. Stark</name></author><author><name sortKey="Atkins, C L" uniqKey="Atkins C">C.L. Atkins</name></author><author><name sortKey="Colasurdo, G N" uniqKey="Colasurdo G">G.N. Colasurdo</name></author><author><name sortKey="Chevalier, J" uniqKey="Chevalier J">J. Chevalier</name></author><author><name sortKey="Samuels, C L" uniqKey="Samuels C">C.L. Samuels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H. Nakamura</name></author><author><name sortKey="Fujishima, S" uniqKey="Fujishima S">S. Fujishima</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T. Inoue</name></author><author><name sortKey="Ohkubo, Y" uniqKey="Ohkubo Y">Y. Ohkubo</name></author><author><name sortKey="Soejima, K" uniqKey="Soejima K">K. Soejima</name></author><author><name sortKey="Waki, Y" uniqKey="Waki Y">Y. Waki</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ninomiya, K" uniqKey="Ninomiya K">K. Ninomiya</name></author><author><name sortKey="Fukui, T" uniqKey="Fukui T">T. Fukui</name></author><author><name sortKey="Imai, T" uniqKey="Imai T">T. Imai</name></author><author><name sortKey="Matsui, M" uniqKey="Matsui M">M. Matsui</name></author><author><name sortKey="Matsuoka, K" uniqKey="Matsuoka K">K. Matsuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, L A" uniqKey="Pinto L">L.A. Pinto</name></author><author><name sortKey="Pitrez, P M" uniqKey="Pitrez P">P.M. Pitrez</name></author><author><name sortKey="Luisi, F" uniqKey="Luisi F">F. Luisi</name></author><author><name sortKey="De Mello, P P" uniqKey="De Mello P">P.P. de Mello</name></author><author><name sortKey="Gerhardt, M" uniqKey="Gerhardt M">M. Gerhardt</name></author><author><name sortKey="Ferlini, R" uniqKey="Ferlini R">R. Ferlini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schogler, A" uniqKey="Schogler A">A. Schogler</name></author><author><name sortKey="Kopf, B S" uniqKey="Kopf B">B.S. Kopf</name></author><author><name sortKey="Edwards, M R" uniqKey="Edwards M">M.R. Edwards</name></author><author><name sortKey="Johnston, S L" uniqKey="Johnston S">S.L. Johnston</name></author><author><name sortKey="Casaulta, C" uniqKey="Casaulta C">C. Casaulta</name></author><author><name sortKey="Kieninger, E" uniqKey="Kieninger E">E. Kieninger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinahara, W" uniqKey="Shinahara W">W. Shinahara</name></author><author><name sortKey="Takahashi, E" uniqKey="Takahashi E">E. Takahashi</name></author><author><name sortKey="Sawabuchi, T" uniqKey="Sawabuchi T">T. Sawabuchi</name></author><author><name sortKey="Arai, M" uniqKey="Arai M">M. Arai</name></author><author><name sortKey="Hirotsu, N" uniqKey="Hirotsu N">N. Hirotsu</name></author><author><name sortKey="Takasaki, Y" uniqKey="Takasaki Y">Y. Takasaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T. Suzuki</name></author><author><name sortKey="Yamaya, M" uniqKey="Yamaya M">M. Yamaya</name></author><author><name sortKey="Sekizawa, K" uniqKey="Sekizawa K">K. Sekizawa</name></author><author><name sortKey="Hosoda, M" uniqKey="Hosoda M">M. Hosoda</name></author><author><name sortKey="Yamada, N" uniqKey="Yamada N">N. Yamada</name></author><author><name sortKey="Ishizuka, S" uniqKey="Ishizuka S">S. Ishizuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tahan, F" uniqKey="Tahan F">F. Tahan</name></author><author><name sortKey="Ozcan, A" uniqKey="Ozcan A">A. Ozcan</name></author><author><name sortKey="Koc, N" uniqKey="Koc N">N. Koc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Us, D" uniqKey="Us D">D. Us</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, J L" uniqKey="Vincent J">J.L. Vincent</name></author><author><name sortKey="De Mendonca, A" uniqKey="De Mendonca A">A. de Mendonca</name></author><author><name sortKey="Cantraine, F" uniqKey="Cantraine F">F. Cantraine</name></author><author><name sortKey="Moreno, R" uniqKey="Moreno R">R. Moreno</name></author><author><name sortKey="Takala, J" uniqKey="Takala J">J. Takala</name></author><author><name sortKey="Suter, P M" uniqKey="Suter P">P.M. Suter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wales, D" uniqKey="Wales D">D. Wales</name></author><author><name sortKey="Woodhead, M" uniqKey="Woodhead M">M. Woodhead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walkey, A J" uniqKey="Walkey A">A.J. Walkey</name></author><author><name sortKey="Wiener, R S" uniqKey="Wiener R">R.S. Wiener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Nikrad, M P" uniqKey="Nikrad M">M.P. Nikrad</name></author><author><name sortKey="Travanty, E A" uniqKey="Travanty E">E.A. Travanty</name></author><author><name sortKey="Zhou, B" uniqKey="Zhou B">B. Zhou</name></author><author><name sortKey="Phang, T" uniqKey="Phang T">T. Phang</name></author><author><name sortKey="Gao, B" uniqKey="Gao B">B. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarogoulidis, P" uniqKey="Zarogoulidis P">P. Zarogoulidis</name></author><author><name sortKey="Papanas, N" uniqKey="Papanas N">N. Papanas</name></author><author><name sortKey="Kioumis, I" uniqKey="Kioumis I">I. Kioumis</name></author><author><name sortKey="Chatzaki, E" uniqKey="Chatzaki E">E. Chatzaki</name></author><author><name sortKey="Maltezos, E" uniqKey="Maltezos E">E. Maltezos</name></author><author><name sortKey="Zarogoulidis, K" uniqKey="Zarogoulidis K">K. Zarogoulidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author><author><name sortKey="Jia, L" uniqKey="Jia L">L. Jia</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="30690213"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Macrolides in critically ill patients with Middle East Respiratory Syndrome</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M." last="Deeb">Ahmad M. Deeb</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name><affiliation wicri:level="1"><nlm:aff id="aff0020">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A." last="Sindi">Anees A. Sindi</name><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0045">Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="1"><nlm:aff id="aff0050">Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0145">Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0060">Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:aff id="aff0070">Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:aff id="aff0075">Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:aff id="aff0080">Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:aff id="aff0085">King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:aff id="aff0090">Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0150">King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0095">King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name><affiliation wicri:level="1"><nlm:aff id="aff0100">Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:aff id="aff0105">Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:aff id="aff0110">Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0115">King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:aff id="aff0120">Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0125">Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0130">Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="3"><nlm:aff id="aff0135">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:aff id="aff0140">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30690213</idno><idno type="pmc">7110878</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110878</idno><idno type="RBID">PMC:7110878</idno><idno type="doi">10.1016/j.ijid.2019.01.041</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000D55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D55</idno><idno type="wicri:Area/Pmc/Curation">000D55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D55</idno><idno type="wicri:Area/Pmc/Checkpoint">000252</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000252</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Macrolides in critically ill patients with Middle East Respiratory Syndrome</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M." last="Deeb">Ahmad M. Deeb</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard − Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name><affiliation wicri:level="1"><nlm:aff id="aff0020">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Ministry of the National Guard − Health Affairs, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A." last="Sindi">Anees A. Sindi</name><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0045">Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="1"><nlm:aff id="aff0050">Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0145">Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0060">Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0040">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:aff id="aff0070">Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:aff id="aff0075">Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:aff id="aff0080">Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:aff id="aff0065">Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:aff id="aff0085">King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M." last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:aff id="aff0090">Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0150">King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:aff id="aff0095">King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name><affiliation wicri:level="1"><nlm:aff id="aff0100">Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:aff id="aff0055">Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:aff id="aff0105">Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:aff id="aff0110">Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0115">King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:aff id="aff0120">Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0125">Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:aff id="aff0005">College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0130">Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infection Prevention and Control, Ministry of the National Guard – Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="3"><nlm:aff id="aff0135">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:aff id="aff0140">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">More than one-third of critically ill patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) received empiric therapy with macrolides.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Macrolide therapy is not significantly associated with a reduction in 90-day mortality of critically ill patients with MERS-CoV.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Macrolide therapy is not significantly associated with improvement in MERS-CoV RNA clearance of critically ill patients with MERS-CoV.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amsden, G W" uniqKey="Amsden G">G.W. Amsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Y M" uniqKey="Arabi Y">Y.M. Arabi</name></author><author><name sortKey="Al Omari, A" uniqKey="Al Omari A">A. Al-Omari</name></author><author><name sortKey="Mandourah, Y" uniqKey="Mandourah Y">Y. Mandourah</name></author><author><name sortKey="Al Hameed, F" uniqKey="Al Hameed F">F. Al-Hameed</name></author><author><name sortKey="Sindi, A A" uniqKey="Sindi A">A.A. Sindi</name></author><author><name sortKey="Alraddadi, B" uniqKey="Alraddadi B">B. Alraddadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigelman, A" uniqKey="Beigelman A">A. Beigelman</name></author><author><name sortKey="Bacharier, L B" uniqKey="Bacharier L">L.B. Bacharier</name></author><author><name sortKey="Baty, J" uniqKey="Baty J">J. Baty</name></author><author><name sortKey="Buller, R" uniqKey="Buller R">R. Buller</name></author><author><name sortKey="Mason, S" uniqKey="Mason S">S. Mason</name></author><author><name sortKey="Schechtman, K B" uniqKey="Schechtman K">K.B. Schechtman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigelman, A" uniqKey="Beigelman A">A. Beigelman</name></author><author><name sortKey="Mikols, C L" uniqKey="Mikols C">C.L. Mikols</name></author><author><name sortKey="Gunsten, S P" uniqKey="Gunsten S">S.P. Gunsten</name></author><author><name sortKey="Cannon, C L" uniqKey="Cannon C">C.L. Cannon</name></author><author><name sortKey="Brody, S L" uniqKey="Brody S">S.L. Brody</name></author><author><name sortKey="Walter, M J" uniqKey="Walter M">M.J. Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermejo Martin, J F" uniqKey="Bermejo Martin J">J.F. Bermejo-Martin</name></author><author><name sortKey="Kelvin, D J" uniqKey="Kelvin D">D.J. Kelvin</name></author><author><name sortKey="Eiros, J M" uniqKey="Eiros J">J.M. Eiros</name></author><author><name sortKey="Castrodeza, J" uniqKey="Castrodeza J">J. Castrodeza</name></author><author><name sortKey="Ortiz De Lejarazu, R" uniqKey="Ortiz De Lejarazu R">R. Ortiz de Lejarazu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gielen, V" uniqKey="Gielen V">V. Gielen</name></author><author><name sortKey="Johnston, S L" uniqKey="Johnston S">S.L. Johnston</name></author><author><name sortKey="Edwards, M R" uniqKey="Edwards M">M.R. Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higashi, F" uniqKey="Higashi F">F. Higashi</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H. Kubo</name></author><author><name sortKey="Yasuda, H" uniqKey="Yasuda H">H. Yasuda</name></author><author><name sortKey="Nukiwa, T" uniqKey="Nukiwa T">T. Nukiwa</name></author><author><name sortKey="Yamaya, M" uniqKey="Yamaya M">M. Yamaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, I F N" uniqKey="Hung I">I.F.N. Hung</name></author><author><name sortKey="To, K K W" uniqKey="To K">K.K.W. To</name></author><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name></author><author><name sortKey="Cheng, V C C" uniqKey="Cheng V">V.C.C. Cheng</name></author><author><name sortKey="Liu, K S H" uniqKey="Liu K">K.S.H. Liu</name></author><author><name sortKey="Tam, A" uniqKey="Tam A">A. Tam</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kakeya, H" uniqKey="Kakeya H">H. Kakeya</name></author><author><name sortKey="Seki, M" uniqKey="Seki M">M. Seki</name></author><author><name sortKey="Izumikawa, K" uniqKey="Izumikawa K">K. Izumikawa</name></author><author><name sortKey="Kosai, K" uniqKey="Kosai K">K. Kosai</name></author><author><name sortKey="Morinaga, Y" uniqKey="Morinaga Y">Y. Morinaga</name></author><author><name sortKey="Kurihara, S" uniqKey="Kurihara S">S. Kurihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanoh, S" uniqKey="Kanoh S">S. Kanoh</name></author><author><name sortKey="Rubin, B K" uniqKey="Rubin B">B.K. Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kneyber, M C" uniqKey="Kneyber M">M.C. Kneyber</name></author><author><name sortKey="Van Woensel, J B" uniqKey="Van Woensel J">J.B. van Woensel</name></author><author><name sortKey="Uijtendaal, E" uniqKey="Uijtendaal E">E. Uijtendaal</name></author><author><name sortKey="Uiterwaal, C S" uniqKey="Uiterwaal C">C.S. Uiterwaal</name></author><author><name sortKey="Kimpen, J L" uniqKey="Kimpen J">J.L. Kimpen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name></author><author><name sortKey="Chan, M C W" uniqKey="Chan M">M.C.W. Chan</name></author><author><name sortKey="Yeung, E S L" uniqKey="Yeung E">E.S.L. Yeung</name></author><author><name sortKey="Tam, W W S" uniqKey="Tam W">W.W.S. Tam</name></author><author><name sortKey="Tsang, O T Y" uniqKey="Tsang O">O.T.Y. Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lendermon, E A" uniqKey="Lendermon E">E.A. Lendermon</name></author><author><name sortKey="Coon, T A" uniqKey="Coon T">T.A. Coon</name></author><author><name sortKey="Bednash, J S" uniqKey="Bednash J">J.S. Bednash</name></author><author><name sortKey="Weathington, N M" uniqKey="Weathington N">N.M. Weathington</name></author><author><name sortKey="Mcdyer, J F" uniqKey="Mcdyer J">J.F. McDyer</name></author><author><name sortKey="Mallampalli, R K" uniqKey="Mallampalli R">R.K. Mallampalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Loeches, I" uniqKey="Martin Loeches I">I. Martin-Loeches</name></author><author><name sortKey="Bermejo Martin, J F" uniqKey="Bermejo Martin J">J.F. Bermejo-Martin</name></author><author><name sortKey="Valles, J" uniqKey="Valles J">J. Valles</name></author><author><name sortKey="Granada, R" uniqKey="Granada R">R. Granada</name></author><author><name sortKey="Vidaur, L" uniqKey="Vidaur L">L. Vidaur</name></author><author><name sortKey="Vergara Serrano, J C" uniqKey="Vergara Serrano J">J.C. Vergara-Serrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccallum, G B" uniqKey="Mccallum G">G.B. McCallum</name></author><author><name sortKey="Morris, P S" uniqKey="Morris P">P.S. Morris</name></author><author><name sortKey="Chatfield, M D" uniqKey="Chatfield M">M.D. Chatfield</name></author><author><name sortKey="Maclennan, C" uniqKey="Maclennan C">C. Maclennan</name></author><author><name sortKey="White, A V" uniqKey="White A">A.V. White</name></author><author><name sortKey="Sloots, T P" uniqKey="Sloots T">T.P. Sloots</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Min, J Y" uniqKey="Min J">J.Y. Min</name></author><author><name sortKey="Jang, Y J" uniqKey="Jang Y">Y.J. Jang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mosquera, R A" uniqKey="Mosquera R">R.A. Mosquera</name></author><author><name sortKey="Stark, J M" uniqKey="Stark J">J.M. Stark</name></author><author><name sortKey="Atkins, C L" uniqKey="Atkins C">C.L. Atkins</name></author><author><name sortKey="Colasurdo, G N" uniqKey="Colasurdo G">G.N. Colasurdo</name></author><author><name sortKey="Chevalier, J" uniqKey="Chevalier J">J. Chevalier</name></author><author><name sortKey="Samuels, C L" uniqKey="Samuels C">C.L. Samuels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H. Nakamura</name></author><author><name sortKey="Fujishima, S" uniqKey="Fujishima S">S. Fujishima</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T. Inoue</name></author><author><name sortKey="Ohkubo, Y" uniqKey="Ohkubo Y">Y. Ohkubo</name></author><author><name sortKey="Soejima, K" uniqKey="Soejima K">K. Soejima</name></author><author><name sortKey="Waki, Y" uniqKey="Waki Y">Y. Waki</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ninomiya, K" uniqKey="Ninomiya K">K. Ninomiya</name></author><author><name sortKey="Fukui, T" uniqKey="Fukui T">T. Fukui</name></author><author><name sortKey="Imai, T" uniqKey="Imai T">T. Imai</name></author><author><name sortKey="Matsui, M" uniqKey="Matsui M">M. Matsui</name></author><author><name sortKey="Matsuoka, K" uniqKey="Matsuoka K">K. Matsuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, L A" uniqKey="Pinto L">L.A. Pinto</name></author><author><name sortKey="Pitrez, P M" uniqKey="Pitrez P">P.M. Pitrez</name></author><author><name sortKey="Luisi, F" uniqKey="Luisi F">F. Luisi</name></author><author><name sortKey="De Mello, P P" uniqKey="De Mello P">P.P. de Mello</name></author><author><name sortKey="Gerhardt, M" uniqKey="Gerhardt M">M. Gerhardt</name></author><author><name sortKey="Ferlini, R" uniqKey="Ferlini R">R. Ferlini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schogler, A" uniqKey="Schogler A">A. Schogler</name></author><author><name sortKey="Kopf, B S" uniqKey="Kopf B">B.S. Kopf</name></author><author><name sortKey="Edwards, M R" uniqKey="Edwards M">M.R. Edwards</name></author><author><name sortKey="Johnston, S L" uniqKey="Johnston S">S.L. Johnston</name></author><author><name sortKey="Casaulta, C" uniqKey="Casaulta C">C. Casaulta</name></author><author><name sortKey="Kieninger, E" uniqKey="Kieninger E">E. Kieninger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinahara, W" uniqKey="Shinahara W">W. Shinahara</name></author><author><name sortKey="Takahashi, E" uniqKey="Takahashi E">E. Takahashi</name></author><author><name sortKey="Sawabuchi, T" uniqKey="Sawabuchi T">T. Sawabuchi</name></author><author><name sortKey="Arai, M" uniqKey="Arai M">M. Arai</name></author><author><name sortKey="Hirotsu, N" uniqKey="Hirotsu N">N. Hirotsu</name></author><author><name sortKey="Takasaki, Y" uniqKey="Takasaki Y">Y. Takasaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T. Suzuki</name></author><author><name sortKey="Yamaya, M" uniqKey="Yamaya M">M. Yamaya</name></author><author><name sortKey="Sekizawa, K" uniqKey="Sekizawa K">K. Sekizawa</name></author><author><name sortKey="Hosoda, M" uniqKey="Hosoda M">M. Hosoda</name></author><author><name sortKey="Yamada, N" uniqKey="Yamada N">N. Yamada</name></author><author><name sortKey="Ishizuka, S" uniqKey="Ishizuka S">S. Ishizuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tahan, F" uniqKey="Tahan F">F. Tahan</name></author><author><name sortKey="Ozcan, A" uniqKey="Ozcan A">A. Ozcan</name></author><author><name sortKey="Koc, N" uniqKey="Koc N">N. Koc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Us, D" uniqKey="Us D">D. Us</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, J L" uniqKey="Vincent J">J.L. Vincent</name></author><author><name sortKey="De Mendonca, A" uniqKey="De Mendonca A">A. de Mendonca</name></author><author><name sortKey="Cantraine, F" uniqKey="Cantraine F">F. Cantraine</name></author><author><name sortKey="Moreno, R" uniqKey="Moreno R">R. Moreno</name></author><author><name sortKey="Takala, J" uniqKey="Takala J">J. Takala</name></author><author><name sortKey="Suter, P M" uniqKey="Suter P">P.M. Suter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wales, D" uniqKey="Wales D">D. Wales</name></author><author><name sortKey="Woodhead, M" uniqKey="Woodhead M">M. Woodhead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walkey, A J" uniqKey="Walkey A">A.J. Walkey</name></author><author><name sortKey="Wiener, R S" uniqKey="Wiener R">R.S. Wiener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Nikrad, M P" uniqKey="Nikrad M">M.P. Nikrad</name></author><author><name sortKey="Travanty, E A" uniqKey="Travanty E">E.A. Travanty</name></author><author><name sortKey="Zhou, B" uniqKey="Zhou B">B. Zhou</name></author><author><name sortKey="Phang, T" uniqKey="Phang T">T. Phang</name></author><author><name sortKey="Gao, B" uniqKey="Gao B">B. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarogoulidis, P" uniqKey="Zarogoulidis P">P. Zarogoulidis</name></author><author><name sortKey="Papanas, N" uniqKey="Papanas N">N. Papanas</name></author><author><name sortKey="Kioumis, I" uniqKey="Kioumis I">I. Kioumis</name></author><author><name sortKey="Chatzaki, E" uniqKey="Chatzaki E">E. Chatzaki</name></author><author><name sortKey="Maltezos, E" uniqKey="Maltezos E">E. Maltezos</name></author><author><name sortKey="Zarogoulidis, K" uniqKey="Zarogoulidis K">K. Zarogoulidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author><author><name sortKey="Jia, L" uniqKey="Jia L">L. Jia</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Macrolides in critically ill patients with Middle East Respiratory Syndrome.</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: arabi@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M" last="Deeb">Ahmad M. Deeb</name><affiliation wicri:level="1"><nlm:affiliation>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: rn_a_deeb@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Intensive Care, Ministry of the National Guard - Health Affairs, Jeddah, Saudi Arabia. Electronic address: Hameedf@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Intensive Care, Ministry of the National Guard - Health Affairs, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: Yasser.mandourah@me.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A" last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: gmekhlafi@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A" last="Sindi">Anees A. Sindi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: ansindi@gmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia. Electronic address: dr_awad_ksa@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada. Electronic address: sarah.shalhoub@googlemail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia; Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt. Electronic address: afmady@hotmail.com.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia; Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: basemalraddadi@gmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address: aalmotairi@kfmc.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia. Electronic address: kasimalkhatib@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: aturk@ksu.edu.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: iqushmaq@kfshrc.edu.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: omsmd@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M" last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia; King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia. Electronic address: AithanA@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia; King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:affiliation>King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia. Electronic address: saudiresearcher@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia. Electronic address: ahmadragab63@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia. Electronic address: a_almshal@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia. Electronic address: a7yman@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: joseje@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address: DabbaghT@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada. Electronic address: rob.fowler@sunnybrook.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Infection Prevention and Control, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: BalkhyH@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Infection Prevention and Control, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="3"><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom. Electronic address: laura.merson@ndm.ox.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States. Electronic address: fgh@virginia.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30690213</idno><idno type="pmid">30690213</idno><idno type="doi">10.1016/j.ijid.2019.01.041</idno><idno type="wicri:Area/PubMed/Corpus">000657</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000657</idno><idno type="wicri:Area/PubMed/Curation">000657</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000657</idno><idno type="wicri:Area/PubMed/Checkpoint">000487</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000487</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Macrolides in critically ill patients with Middle East Respiratory Syndrome.</title><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: arabi@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M" last="Deeb">Ahmad M. Deeb</name><affiliation wicri:level="1"><nlm:affiliation>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: rn_a_deeb@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Intensive Care, Ministry of the National Guard - Health Affairs, Jeddah, Saudi Arabia. Electronic address: Hameedf@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Intensive Care, Ministry of the National Guard - Health Affairs, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: Yasser.mandourah@me.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A" last="Almekhlafi">Ghaleb A. Almekhlafi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: gmekhlafi@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A" last="Sindi">Anees A. Sindi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: ansindi@gmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia. Electronic address: dr_awad_ksa@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada. Electronic address: sarah.shalhoub@googlemail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia; Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt. Electronic address: afmady@hotmail.com.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia; Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: basemalraddadi@gmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address: aalmotairi@kfmc.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia. Electronic address: kasimalkhatib@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea><wicri:noRegion>Makkah</wicri:noRegion></affiliation></author><author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: aturk@ksu.edu.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: iqushmaq@kfshrc.edu.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name><affiliation wicri:level="1"><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: omsmd@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M" last="Al-Aithan">Abdulsalam M. Al-Aithan</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia; King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia. Electronic address: AithanA@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia; King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea><wicri:noRegion>Al Ahsa</wicri:noRegion></affiliation></author><author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name><affiliation wicri:level="1"><nlm:affiliation>King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia. Electronic address: saudiresearcher@yahoo.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia. Electronic address: ahmadragab63@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia. Electronic address: a_almshal@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia. Electronic address: a7yman@hotmail.com.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion></affiliation></author><author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: joseje@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address: DabbaghT@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada. Electronic address: rob.fowler@sunnybrook.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Infection Prevention and Control, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: BalkhyH@ngha.med.sa.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Infection Prevention and Control, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="3"><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom. Electronic address: laura.merson@ndm.ox.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name><affiliation wicri:level="2"><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States. Electronic address: fgh@virginia.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="eISSN">1878-3511</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Critical Illness (therapy)</term><term>Female</term><term>Humans</term><term>Intensive Care Units (statistics & numerical data)</term><term>Macrolides (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Retrospective Studies</term><term>Saudi Arabia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antibactériens (administration et posologie)</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Macrolides (administration et posologie)</term><term>Maladie grave ()</term><term>Mâle</term><term>Sujet âgé</term><term>Unités de soins intensifs ()</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Macrolides</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Macrolides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Critical Illness</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Maladie grave</term><term>Mâle</term><term>Sujet âgé</term><term>Unités de soins intensifs</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002094 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002094 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:7110878
|texte= Macrolides in critically ill patients with Middle East Respiratory Syndrome
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:30690213" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |