MersV1, PubMed, Checkpoint, bibRecord, 000487

Macrolides in critically ill patients with Middle East Respiratory Syndrome.

Identifieur interne : 000487 ( PubMed/Checkpoint ); précédent : 000486; suivant : 000488

Macrolides in critically ill patients with Middle East Respiratory Syndrome.

Source :

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2019.

RBID : pubmed:30690213

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Antibactériens (administration et posologie), Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Humains, Infections à coronavirus (mortalité), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Macrolides (administration et posologie), Maladie grave (), Mâle, Sujet âgé, Unités de soins intensifs (), Études rétrospectives.
MESH :
- administration et posologie : Antibactériens, Macrolides.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- mortalité : Infections à coronavirus.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Maladie grave, Mâle, Sujet âgé, Unités de soins intensifs, Études rétrospectives.
Wicri :
- geographic : Arabie saoudite.

English descriptors

KwdEn :
- Adult, Aged, Anti-Bacterial Agents (administration & dosage), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Critical Illness (therapy), Female, Humans, Intensive Care Units (statistics & numerical data), Macrolides (administration & dosage), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Retrospective Studies, Saudi Arabia.
MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Macrolides.
- geographic : Saudi Arabia.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- mortality : Coronavirus Infections.
- statistics & numerical data : Intensive Care Units.
- therapy : Critical Illness.
- virology : Coronavirus Infections.
- Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies.

Abstract

Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS.

DOI: 10.1016/j.ijid.2019.01.041
PubMed: 30690213

Affiliations:

Arabie saoudite, Canada, Royaume-Uni, Égypte, États-Unis
Angleterre, Grand Londres, Ontario, Oxfordshire, Virginie
Londres, Oxford, Toronto
Université de Toronto

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Le document en format XML

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<author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name>
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</affiliation>
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<author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name>
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<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
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<author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name>
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<author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name>
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<wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea>
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<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name>
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</placeName>
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<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Macrolides in critically ill patients with Middle East Respiratory Syndrome.</title>
<author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: arabi@ngha.med.sa.</nlm:affiliation>
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<author><name sortKey="Deeb, Ahmad M" sort="Deeb, Ahmad M" uniqKey="Deeb A" first="Ahmad M" last="Deeb">Ahmad M. Deeb</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: rn_a_deeb@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
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</affiliation>
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<author><name sortKey="Al Hameed, Fahad" sort="Al Hameed, Fahad" uniqKey="Al Hameed F" first="Fahad" last="Al-Hameed">Fahad Al-Hameed</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Intensive Care, Ministry of the National Guard - Health Affairs, Jeddah, Saudi Arabia. Electronic address: Hameedf@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
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<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
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<author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: Yasser.mandourah@me.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A" last="Almekhlafi">Ghaleb A. Almekhlafi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: gmekhlafi@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sindi, Anees A" sort="Sindi, Anees A" uniqKey="Sindi A" first="Anees A" last="Sindi">Anees A. Sindi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: ansindi@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Anesthesia and Critical Care, Faculty of Medicine, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh, Saudi Arabia. Electronic address: dr_awad_ksa@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Intensive Care, Dr Sulaiman Al-Habib Group Hospitals, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London, Canada. Electronic address: sarah.shalhoub@googlemail.com.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, University of Western Ontario, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mady, Ahmed" sort="Mady, Ahmed" uniqKey="Mady A" first="Ahmed" last="Mady">Ahmed Mady</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia; Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta, Egypt. Electronic address: afmady@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia; Department of Anesthesiology and Intensive Care, Tanta University Hospitals, Tanta</wicri:regionArea>
<wicri:noRegion>Tanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: basemalraddadi@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Almotairi, Abdullah" sort="Almotairi, Abdullah" uniqKey="Almotairi A" first="Abdullah" last="Almotairi">Abdullah Almotairi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address: aalmotairi@kfmc.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Critical Care Medicine, King Fahad Medical City, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Khatib, Kasim" sort="Al Khatib, Kasim" uniqKey="Al Khatib K" first="Kasim" last="Al Khatib">Kasim Al Khatib</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia. Electronic address: kasimalkhatib@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Intensive Care Department, Al-Noor Specialist Hospital, Makkah</wicri:regionArea>
<wicri:noRegion>Makkah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abdulmomen, Ahmed" sort="Abdulmomen, Ahmed" uniqKey="Abdulmomen A" first="Ahmed" last="Abdulmomen">Ahmed Abdulmomen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: aturk@ksu.edu.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Critical Care Medicine, King Saud University, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qushmaq, Ismael" sort="Qushmaq, Ismael" uniqKey="Qushmaq I" first="Ismael" last="Qushmaq">Ismael Qushmaq</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia. Electronic address: iqushmaq@kfshrc.edu.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solaiman, Othman" sort="Solaiman, Othman" uniqKey="Solaiman O" first="Othman" last="Solaiman">Othman Solaiman</name>
<affiliation wicri:level="1"><nlm:affiliation>King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: omsmd@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Aithan, Abdulsalam M" sort="Al Aithan, Abdulsalam M" uniqKey="Al Aithan A" first="Abdulsalam M" last="Al-Aithan">Abdulsalam M. Al-Aithan</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia; King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia. Electronic address: AithanA@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Al Ahsa, Saudi Arabia; King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Al Ahsa</wicri:regionArea>
<wicri:noRegion>Al Ahsa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Raddadi, Rajaa" sort="Al Raddadi, Rajaa" uniqKey="Al Raddadi R" first="Rajaa" last="Al-Raddadi">Rajaa Al-Raddadi</name>
<affiliation wicri:level="1"><nlm:affiliation>King Abdulaziz University, Department of Family and Community Medicine, Jeddah, Saudi Arabia. Electronic address: saudiresearcher@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Abdulaziz University, Department of Family and Community Medicine, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ragab, Ahmad" sort="Ragab, Ahmad" uniqKey="Ragab A" first="Ahmad" last="Ragab">Ahmad Ragab</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Fahd Hospital, Jeddah, Saudi Arabia. Electronic address: ahmadragab63@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Intensive Care Department, King Fahd Hospital, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Harthy, Abdulrahman" sort="Al Harthy, Abdulrahman" uniqKey="Al Harthy A" first="Abdulrahman" last="Al Harthy">Abdulrahman Al Harthy</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, King Saud Medical City, Riyadh, Saudi Arabia. Electronic address: a_almshal@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Intensive Care Department, King Saud Medical City, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kharaba, Ayman" sort="Kharaba, Ayman" uniqKey="Kharaba A" first="Ayman" last="Kharaba">Ayman Kharaba</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah, Saudi Arabia. Electronic address: a7yman@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Critical Care, King Fahad Hospital, Ohoud Hospital, Al-Madinah Al-Monawarah</wicri:regionArea>
<wicri:noRegion>Al-Madinah Al-Monawarah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jose, Jesna" sort="Jose, Jesna" uniqKey="Jose J" first="Jesna" last="Jose">Jesna Jose</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: joseje@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dabbagh, Tarek" sort="Dabbagh, Tarek" uniqKey="Dabbagh T" first="Tarek" last="Dabbagh">Tarek Dabbagh</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address: DabbaghT@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario, Canada. Electronic address: rob.fowler@sunnybrook.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H" last="Balkhy">Hanan H. Balkhy</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Infection Prevention and Control, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: BalkhyH@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Infection Prevention and Control, Ministry of the National Guard - Health Affairs, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name>
<affiliation wicri:level="3"><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford, United Kingdom. Electronic address: laura.merson@ndm.ox.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Infectious Diseases Data Observatory, Oxford University, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G" last="Hayden">Frederick G. Hayden</name>
<affiliation wicri:level="2"><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States. Electronic address: fgh@virginia.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
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<series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title>
<idno type="eISSN">1878-3511</idno>
<imprint><date when="2019" type="published">2019</date>
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<term>Aged</term>
<term>Anti-Bacterial Agents (administration & dosage)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (virology)</term>
<term>Critical Illness (therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units (statistics & numerical data)</term>
<term>Macrolides (administration & dosage)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
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<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en">Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30690213</PMID>
<DateCompleted><Year>2019</Year>
<Month>08</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3511</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>81</Volume>
<PubDate><Year>2019</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</Title>
<ISOAbbreviation>Int. J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Macrolides in critically ill patients with Middle East Respiratory Syndrome.</ArticleTitle>
<Pagination><MedlinePgn>184-190</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1201-9712(19)30052-9</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijid.2019.01.041</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This retrospective analysis of a multicenter cohort database included 14 tertiary-care hospitals in five cities in Saudi Arabia. Multivariate logistic-regression analysis was used to determine the association of macrolide therapy with 90-day mortality, and the Cox-proportional hazard model to determine the association of macrolide therapy with MERS-CoV RNA clearance.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 349 critically ill MERS patients, 136 (39%) received macrolide therapy. Azithromycin was most commonly used (97/136; 71.3%). Macrolide therapy was commonly started before the patient arrived in the intensive care unit (ICU) (51/136; 37.5%), or on day1 in ICU (53/136; 39%). On admission to ICU, the baseline characteristics of patients who received and did not receive macrolides were similar, including demographic data and sequential organ failure assessment score. However, patients who received macrolides were more likely to be admitted with community-acquired MERS (P=0.02). Macrolide therapy was not independently associated with a significant difference in 90-day mortality (adjusted odds ratio [OR]: 0.84; 95% confidence interval [CI] :0.47-1.51; P=0.56) or MERS-CoV RNA clearance (adjusted HR: 0.88; 95% CI:0.47-1.64; P=0.68).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings indicate that macrolide therapy is not associated with a reduction in 90-day mortality or improvement in MERS-CoV RNA clearance.</AbstractText>
<CopyrightInformation>Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arabi</LastName>
<ForeName>Yaseen M</ForeName>
<Initials>YM</Initials>
<AffiliationInfo><Affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: arabi@ngha.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deeb</LastName>
<ForeName>Ahmad M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Research Office, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. Electronic address: rn_a_deeb@hotmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Hameed</LastName>
<ForeName>Fahad</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Intensive Care, Ministry of the National Guard - Health Affairs, Jeddah, Saudi Arabia. Electronic address: Hameedf@ngha.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mandourah</LastName>
<ForeName>Yasser</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. Electronic address: Yasser.mandourah@me.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Almekhlafi</LastName>
<ForeName>Ghaleb A</ForeName>
<Initials>GA</Initials>
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<Initials>A</Initials>
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<Initials>J</Initials>
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EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000487 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000487 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:30690213
   |texte=   Macrolides in critically ill patients with Middle East Respiratory Syndrome.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:30690213" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Macrolides in critically ill patients with Middle East Respiratory Syndrome.

Macrolides in critically ill patients with Middle East Respiratory Syndrome.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki