Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents
Identifieur interne : 001A12 ( Ncbi/Merge ); précédent : 001A11; suivant : 001A13Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents
Auteurs : Ryan Ritterson ; Rocco CasagrandeSource :
- mSphere [ 2379-5042 ] ; 2017.
Abstract
Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services,
Url:
DOI: 10.1128/mSphere.00010-17
PubMed: 28405626
PubMed Central: 5371692
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sortKey="Ritterson, Ryan" sort="Ritterson, Ryan" uniqKey="Ritterson R" first="Ryan" last="Ritterson">Ryan Ritterson</name></author><author><name sortKey="Casagrande, Rocco" sort="Casagrande, Rocco" uniqKey="Casagrande R" first="Rocco" last="Casagrande">Rocco Casagrande</name></author></analytic><series><title level="j">mSphere</title><idno type="eISSN">2379-5042</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, <italic>U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza</italic>, <italic>MERS</italic>, <italic>and SARS Viruses</italic>, 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uniqKey="Chu J">J Chu</name></author><author><name sortKey="Fields, D" uniqKey="Fields D">D Fields</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Kazmierczak, M" uniqKey="Kazmierczak M">M Kazmierczak</name></author><author><name sortKey="Isbell, M" uniqKey="Isbell M">M Isbell</name></author><author><name sortKey="Hulme Lowe, C" uniqKey="Hulme Lowe C">C Hulme-Lowe</name></author><author><name sortKey="Lauer, E" uniqKey="Lauer E">E Lauer</name></author><author><name sortKey="Finnegan, M" uniqKey="Finnegan M">M Finnegan</name></author><author><name sortKey="Krem, H" uniqKey="Krem H">H Krem</name></author><author><name sortKey="Cerles, A" uniqKey="Cerles A">A Cerles</name></author><author><name sortKey="Venugopalan, G" uniqKey="Venugopalan G">G 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Hardy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Barach, P" uniqKey="Barach P">P Barach</name></author><author><name sortKey="Small, Sd" uniqKey="Small S">SD Small</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phimister, Jr" uniqKey="Phimister J">JR Phimister</name></author><author><name sortKey="Oktem, U" uniqKey="Oktem U">U Oktem</name></author><author><name sortKey="Kleindorfer, Pr" uniqKey="Kleindorfer P">PR Kleindorfer</name></author><author><name sortKey="Kunreuther, H" uniqKey="Kunreuther H">H Kunreuther</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Young, A" uniqKey="Young A">A Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, A" uniqKey="Young A">A Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, P" uniqKey="Berg P">P Berg</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author><author><name sortKey="Brenner, S" uniqKey="Brenner S">S Brenner</name></author><author><name sortKey="Roblin, Ro" uniqKey="Roblin R">RO Roblin</name></author><author><name sortKey="Singer, Mf" uniqKey="Singer M">MF Singer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mccarthy, M" uniqKey="Mccarthy M">M McCarthy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="28405626"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents</title><author><name sortKey="Ritterson, Ryan" sort="Ritterson, Ryan" uniqKey="Ritterson R" first="Ryan" last="Ritterson">Ryan Ritterson</name></author><author><name sortKey="Casagrande, Rocco" sort="Casagrande, Rocco" uniqKey="Casagrande R" first="Rocco" last="Casagrande">Rocco Casagrande</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28405626</idno><idno type="pmc">5371692</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371692</idno><idno type="RBID">PMC:5371692</idno><idno type="doi">10.1128/mSphere.00010-17</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000817</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000817</idno><idno type="wicri:Area/Pmc/Curation">000817</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000817</idno><idno type="wicri:Area/Pmc/Checkpoint">000922</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000922</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents</title><author><name sortKey="Ritterson, Ryan" sort="Ritterson, Ryan" uniqKey="Ritterson R" first="Ryan" last="Ritterson">Ryan Ritterson</name></author><author><name sortKey="Casagrande, Rocco" sort="Casagrande, Rocco" uniqKey="Casagrande R" first="Rocco" last="Casagrande">Rocco Casagrande</name></author></analytic><series><title level="j">mSphere</title><idno type="eISSN">2379-5042</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, <italic>U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza</italic>, <italic>MERS</italic>, <italic>and SARS Viruses</italic>, 2014).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Kazmierczak, M" uniqKey="Kazmierczak M">M Kazmierczak</name></author><author><name sortKey="Isbell, M" uniqKey="Isbell M">M Isbell</name></author><author><name sortKey="Hulme Lowe, C" uniqKey="Hulme Lowe C">C Hulme-Lowe</name></author><author><name sortKey="Lauer, E" uniqKey="Lauer E">E Lauer</name></author><author><name sortKey="Finnegan, M" uniqKey="Finnegan M">M Finnegan</name></author><author><name sortKey="Krem, H" uniqKey="Krem H">H Krem</name></author><author><name sortKey="Cerles, A" uniqKey="Cerles A">A Cerles</name></author><author><name sortKey="Venugopalan, G" uniqKey="Venugopalan G">G Venugopalan</name></author><author><name sortKey="Handoko, R" uniqKey="Handoko R">R Handoko</name></author><author><name sortKey="Chu, J" uniqKey="Chu J">J Chu</name></author><author><name sortKey="Fields, D" uniqKey="Fields D">D Fields</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Kazmierczak, M" uniqKey="Kazmierczak M">M Kazmierczak</name></author><author><name sortKey="Isbell, M" uniqKey="Isbell M">M Isbell</name></author><author><name sortKey="Hulme Lowe, C" uniqKey="Hulme Lowe C">C Hulme-Lowe</name></author><author><name sortKey="Lauer, E" uniqKey="Lauer E">E Lauer</name></author><author><name sortKey="Finnegan, M" uniqKey="Finnegan M">M Finnegan</name></author><author><name sortKey="Krem, H" uniqKey="Krem H">H Krem</name></author><author><name sortKey="Cerles, A" uniqKey="Cerles A">A Cerles</name></author><author><name sortKey="Venugopalan, G" uniqKey="Venugopalan G">G Venugopalan</name></author><author><name sortKey="Handoko, R" uniqKey="Handoko R">R Handoko</name></author><author><name sortKey="Chu, J" uniqKey="Chu J">J Chu</name></author><author><name sortKey="Fields, D" uniqKey="Fields D">D Fields</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nordgren, Ld" uniqKey="Nordgren L">LD Nordgren</name></author><author><name sortKey="Gerberich, Sg" uniqKey="Gerberich S">SG Gerberich</name></author><author><name sortKey="Alexander, Bh" uniqKey="Alexander B">BH Alexander</name></author><author><name sortKey="Church, Tr" uniqKey="Church T">TR Church</name></author><author><name sortKey="Bender, Jb" uniqKey="Bender J">JB Bender</name></author><author><name sortKey="Ryan, Ad" uniqKey="Ryan A">AD Ryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mauger, P" uniqKey="Mauger P">P Mauger</name></author><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirwan, B" uniqKey="Kirwan B">B Kirwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spurgin, A" uniqKey="Spurgin A">A Spurgin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reynard, Wd" uniqKey="Reynard W">WD Reynard</name></author><author><name sortKey="Billings, Ce" uniqKey="Billings C">CE Billings</name></author><author><name sortKey="Cheaney, Es" uniqKey="Cheaney E">ES Cheaney</name></author><author><name sortKey="Hardy, R" uniqKey="Hardy R">R Hardy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Barach, P" uniqKey="Barach P">P Barach</name></author><author><name sortKey="Small, Sd" uniqKey="Small S">SD Small</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phimister, Jr" uniqKey="Phimister J">JR Phimister</name></author><author><name sortKey="Oktem, U" uniqKey="Oktem U">U Oktem</name></author><author><name sortKey="Kleindorfer, Pr" uniqKey="Kleindorfer P">PR Kleindorfer</name></author><author><name sortKey="Kunreuther, H" uniqKey="Kunreuther H">H Kunreuther</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Young, A" uniqKey="Young A">A Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, A" uniqKey="Young A">A Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, P" uniqKey="Berg P">P Berg</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author><author><name sortKey="Brenner, S" uniqKey="Brenner S">S Brenner</name></author><author><name sortKey="Roblin, Ro" uniqKey="Roblin R">RO Roblin</name></author><author><name sortKey="Singer, Mf" uniqKey="Singer M">MF Singer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mccarthy, M" uniqKey="Mccarthy M">M McCarthy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents.</title><author><name sortKey="Ritterson, Ryan" sort="Ritterson, Ryan" uniqKey="Ritterson R" first="Ryan" last="Ritterson">Ryan Ritterson</name><affiliation wicri:level="2"><nlm:affiliation>Gryphon Scientific, LLC, Takoma Park, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gryphon Scientific, LLC, Takoma Park, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Casagrande, Rocco" sort="Casagrande, Rocco" uniqKey="Casagrande R" first="Rocco" last="Casagrande">Rocco Casagrande</name><affiliation wicri:level="2"><nlm:affiliation>Gryphon Scientific, LLC, Takoma Park, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gryphon Scientific, LLC, Takoma Park, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2017 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:28405626</idno><idno type="pmid">28405626</idno><idno type="doi">10.1128/mSphere.00010-17</idno><idno type="wicri:Area/PubMed/Corpus">000D20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D20</idno><idno type="wicri:Area/PubMed/Curation">000D20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D20</idno><idno type="wicri:Area/PubMed/Checkpoint">002A19</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents.</title><author><name sortKey="Ritterson, Ryan" sort="Ritterson, Ryan" uniqKey="Ritterson R" first="Ryan" last="Ritterson">Ryan Ritterson</name><affiliation wicri:level="2"><nlm:affiliation>Gryphon Scientific, LLC, Takoma Park, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gryphon Scientific, LLC, Takoma Park, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Casagrande, Rocco" sort="Casagrande, Rocco" uniqKey="Casagrande R" first="Rocco" last="Casagrande">Rocco Casagrande</name><affiliation wicri:level="2"><nlm:affiliation>Gryphon Scientific, LLC, Takoma Park, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gryphon Scientific, LLC, Takoma Park, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">mSphere</title><idno type="ISSN">2379-5042</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our firm conducted a risk/benefit assessment of "gain-of-function" research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, <i>U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza</i>, <i>MERS</i>, <i>and SARS Viruses</i>, 2014). Due to significant missing but theoretically acquirable data, our biosafety assessment faced limitations, and we were forced to provide a relative, instead of absolute, measure of risk (Gryphon Scientific, LLC, <i>Risk and Benefit Analysis of Gain of Function Research</i>, 2016). Here, we argue that many of these types of missing data represent large and stunning gaps in our knowledge of biosafety and argue that these missing data, once acquired via primary research efforts, would improve biosafety risk assessments and could be incorporated into biosafety practices to reduce risk of accidents. Governments invest billions in biological research; at least a small fraction of this support is warranted to prevent biological accidents.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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