Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents
Identifieur interne : 000817 ( Pmc/Curation ); précédent : 000816; suivant : 000818Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents
Auteurs : Ryan Ritterson ; Rocco CasagrandeSource :
- mSphere [ 2379-5042 ] ; 2017.
Abstract
Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services,
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DOI: 10.1128/mSphere.00010-17
PubMed: 28405626
PubMed Central: 5371692
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type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000817</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents</title><author><name sortKey="Ritterson, Ryan" sort="Ritterson, Ryan" uniqKey="Ritterson R" first="Ryan" last="Ritterson">Ryan Ritterson</name></author><author><name sortKey="Casagrande, Rocco" sort="Casagrande, Rocco" uniqKey="Casagrande R" first="Rocco" last="Casagrande">Rocco Casagrande</name></author></analytic><series><title level="j">mSphere</title><idno type="eISSN">2379-5042</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, <italic>U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza</italic>, <italic>MERS</italic>, <italic>and SARS Viruses</italic>, 2014).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Kazmierczak, M" uniqKey="Kazmierczak M">M Kazmierczak</name></author><author><name sortKey="Isbell, M" uniqKey="Isbell M">M Isbell</name></author><author><name sortKey="Hulme Lowe, C" uniqKey="Hulme Lowe C">C Hulme-Lowe</name></author><author><name sortKey="Lauer, E" uniqKey="Lauer E">E Lauer</name></author><author><name sortKey="Finnegan, M" uniqKey="Finnegan M">M Finnegan</name></author><author><name sortKey="Krem, H" uniqKey="Krem H">H Krem</name></author><author><name sortKey="Cerles, A" uniqKey="Cerles A">A Cerles</name></author><author><name sortKey="Venugopalan, G" uniqKey="Venugopalan G">G Venugopalan</name></author><author><name sortKey="Handoko, R" uniqKey="Handoko R">R Handoko</name></author><author><name sortKey="Chu, J" uniqKey="Chu J">J Chu</name></author><author><name sortKey="Fields, D" uniqKey="Fields D">D Fields</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Kazmierczak, M" uniqKey="Kazmierczak M">M Kazmierczak</name></author><author><name sortKey="Isbell, M" uniqKey="Isbell M">M Isbell</name></author><author><name sortKey="Hulme Lowe, C" uniqKey="Hulme Lowe C">C Hulme-Lowe</name></author><author><name sortKey="Lauer, E" uniqKey="Lauer E">E Lauer</name></author><author><name sortKey="Finnegan, M" uniqKey="Finnegan M">M Finnegan</name></author><author><name sortKey="Krem, H" uniqKey="Krem H">H Krem</name></author><author><name sortKey="Cerles, A" uniqKey="Cerles A">A Cerles</name></author><author><name sortKey="Venugopalan, G" uniqKey="Venugopalan G">G Venugopalan</name></author><author><name sortKey="Handoko, R" uniqKey="Handoko R">R Handoko</name></author><author><name sortKey="Chu, J" uniqKey="Chu J">J Chu</name></author><author><name sortKey="Fields, D" uniqKey="Fields D">D Fields</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nordgren, Ld" uniqKey="Nordgren L">LD Nordgren</name></author><author><name sortKey="Gerberich, Sg" uniqKey="Gerberich S">SG Gerberich</name></author><author><name sortKey="Alexander, Bh" uniqKey="Alexander B">BH Alexander</name></author><author><name sortKey="Church, Tr" uniqKey="Church T">TR Church</name></author><author><name sortKey="Bender, Jb" uniqKey="Bender J">JB Bender</name></author><author><name sortKey="Ryan, Ad" uniqKey="Ryan A">AD Ryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mauger, P" uniqKey="Mauger P">P Mauger</name></author><author><name sortKey="Ritterson, R" uniqKey="Ritterson R">R Ritterson</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R Casagrande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirwan, B" uniqKey="Kirwan B">B Kirwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spurgin, A" uniqKey="Spurgin A">A Spurgin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reynard, Wd" uniqKey="Reynard W">WD Reynard</name></author><author><name sortKey="Billings, Ce" uniqKey="Billings C">CE Billings</name></author><author><name sortKey="Cheaney, Es" uniqKey="Cheaney E">ES Cheaney</name></author><author><name sortKey="Hardy, R" uniqKey="Hardy R">R Hardy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Barach, P" uniqKey="Barach P">P Barach</name></author><author><name sortKey="Small, Sd" uniqKey="Small S">SD Small</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phimister, Jr" uniqKey="Phimister J">JR Phimister</name></author><author><name sortKey="Oktem, U" uniqKey="Oktem U">U Oktem</name></author><author><name sortKey="Kleindorfer, Pr" uniqKey="Kleindorfer P">PR Kleindorfer</name></author><author><name sortKey="Kunreuther, H" uniqKey="Kunreuther H">H Kunreuther</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Young, A" uniqKey="Young A">A Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, A" uniqKey="Young A">A Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, P" uniqKey="Berg P">P Berg</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author><author><name sortKey="Brenner, S" uniqKey="Brenner S">S Brenner</name></author><author><name sortKey="Roblin, Ro" uniqKey="Roblin R">RO Roblin</name></author><author><name sortKey="Singer, Mf" uniqKey="Singer M">MF Singer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mccarthy, M" uniqKey="Mccarthy M">M McCarthy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="discussion"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">mSphere</journal-id><journal-id journal-id-type="iso-abbrev">mSphere</journal-id><journal-id journal-id-type="hwp">msph</journal-id><journal-id journal-id-type="pmc">msph</journal-id><journal-id journal-id-type="publisher-id">mSphere</journal-id><journal-title-group><journal-title>mSphere</journal-title></journal-title-group><issn pub-type="epub">2379-5042</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28405626</article-id><article-id pub-id-type="pmc">5371692</article-id><article-id pub-id-type="publisher-id">mSphere00010-17</article-id><article-id pub-id-type="doi">10.1128/mSphere.00010-17</article-id><article-categories><subj-group subj-group-type="heading"><subject>Perspective</subject><subj-group><subject>Applied and Environmental Science</subject></subj-group></subj-group></article-categories><title-group><article-title>Basic Scholarship in Biosafety Is Critically Needed To Reduce Risk of Laboratory Accidents</article-title><alt-title alt-title-type="running-head">Perspective</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ritterson</surname><given-names>Ryan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Casagrande</surname><given-names>Rocco</given-names></name></contrib><aff id="aff1">Gryphon Scientific, LLC, Takoma Park, Maryland, USA</aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Imperiale</surname><given-names>Michael J.</given-names></name><role>Editor</role><aff>University of Michigan</aff></contrib></contrib-group><author-notes><corresp id="cor1">Address correspondence to Ryan Ritterson, <email>rritterson@gryphonscientific.com</email>.</corresp><fn fn-type="other"><p><bold>Citation</bold> Ritterson R, Casagrande R. 2017. Basic scholarship in biosafety is critically needed to reduce risk of laboratory accidents. mSphere 2:e00010-17. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/mSphere.00010-17">https://doi.org/10.1128/mSphere.00010-17</ext-link>.</p></fn></author-notes><pub-date pub-type="epub"><day>29</day><month>3</month><year>2017</year></pub-date><pub-date pub-type="collection"><season>Mar-Apr</season><year>2017</year></pub-date><volume>2</volume><issue>2</issue><elocation-id>e00010-17</elocation-id><permissions><copyright-statement>Copyright © 2017 Ritterson and Casagrande.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Ritterson and Casagrande</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="sph002172261001.pdf"></self-uri><abstract abstract-type="precis"><p>Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, <italic>U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza</italic>, <italic>MERS</italic>, <italic>and SARS Viruses</italic>, 2014).</p></abstract><abstract><title>ABSTRACT</title><p>Our firm conducted a risk/benefit assessment of “gain-of-function” research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, <italic>U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza</italic>, <italic>MERS</italic>, <italic>and SARS Viruses</italic>, 2014). Due to significant missing but theoretically acquirable data, our biosafety assessment faced limitations, and we were forced to provide a relative, instead of absolute, measure of risk (Gryphon Scientific, LLC, <italic>Risk and Benefit Analysis of Gain of Function Research</italic>, 2016). Here, we argue that many of these types of missing data represent large and stunning gaps in our knowledge of biosafety and argue that these missing data, once acquired via primary research efforts, would improve biosafety risk assessments and could be incorporated into biosafety practices to reduce risk of accidents. Governments invest billions in biological research; at least a small fraction of this support is warranted to prevent biological accidents.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>biosafety</kwd><kwd>conduct of research</kwd><kwd>gain of function</kwd><kwd>science policy</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="27"></ref-count><page-count count="5"></page-count><word-count count="3544"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>March/April 2017</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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