Current advancements and potential strategies in the development of MERS-CoV vaccines
Identifieur interne : 000D43 ( Ncbi/Merge ); précédent : 000D42; suivant : 000D44Current advancements and potential strategies in the development of MERS-CoV vaccines
Auteurs : Naru Zhang [États-Unis] ; Shibo Jiang [États-Unis, République populaire de Chine] ; Lanying Du [États-Unis]Source :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Adjuvants immunologiques (isolement et purification), Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Découverte de médicament (tendances), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Infections à coronavirus (), Modèles animaux de maladie humaine, Moyen Orient (épidémiologie), Vaccination (), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins antiviraux (isolement et purification), Vaccins sous-unitaires (génétique), Vaccins sous-unitaires (immunologie), Vaccins sous-unitaires (isolement et purification).
- MESH :
- administration et posologie : Adjuvants immunologiques.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux, Vaccins sous-unitaires.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux, Vaccins sous-unitaires.
- isolement et purification : Adjuvants immunologiques, Vaccins antiviraux, Vaccins sous-unitaires.
- tendances : Découverte de médicament.
- épidémiologie : Moyen Orient.
- Animaux, Humains, Infections à coronavirus, Modèles animaux de maladie humaine, Vaccination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adjuvants, Immunologic (isolation & purification), Animals, Coronavirus Infections (prevention & control), Disease Models, Animal, Drug Discovery (trends), Humans, Middle East (epidemiology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Vaccination (methods), Vaccines, Subunit (genetics), Vaccines, Subunit (immunology), Vaccines, Subunit (isolation & purification), Viral Vaccines (genetics), Viral Vaccines (immunology), Viral Vaccines (isolation & purification).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic.
- chemical , genetics : Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines.
- chemical , immunology : Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines.
- chemical , isolation & purification : Adjuvants, Immunologic, Vaccines, Subunit, Viral Vaccines.
- geographic , epidemiology : Middle East.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- methods : Vaccination.
- prevention & control : Coronavirus Infections.
- trends : Drug Discovery.
- Animals, Disease Models, Animal, Humans.
Abstract
Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the
Url:
DOI: 10.1586/14760584.2014.912134
PubMed: 24766432
PubMed Central: 4241375
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PMC:4241375Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the <italic>in vivo</italic>
efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future.</p>
</div>
</front>
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<double pmid="24766432"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current advancements and potential strategies in the development of MERS-CoV vaccines</title>
<author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution>
<addr-line>New York, NY,</addr-line>
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution>
<addr-line>New York, NY,</addr-line>
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University,</institution>
<addr-line>Shanghai,</addr-line>
<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution>
<addr-line>New York, NY,</addr-line>
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24766432</idno>
<idno type="pmc">4241375</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241375</idno>
<idno type="RBID">PMC:4241375</idno>
<idno type="doi">10.1586/14760584.2014.912134</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001325</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001325</idno>
<idno type="wicri:Area/Pmc/Curation">001325</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001325</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001107</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001107</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current advancements and potential strategies in the development of MERS-CoV vaccines</title>
<author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution>
<addr-line>New York, NY,</addr-line>
<country>USA</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution>
<addr-line>New York, NY,</addr-line>
<country>USA</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University,</institution>
<addr-line>Shanghai,</addr-line>
<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution>
<addr-line>New York, NY,</addr-line>
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Expert Review of Vaccines</title>
<idno type="ISSN">1476-0584</idno>
<idno type="eISSN">1744-8395</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the <italic>in vivo</italic>
efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future.</p>
</div>
</front>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current advancements and potential strategies in the development of MERS-CoV vaccines.</title>
<author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
</author>
<author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24766432</idno>
<idno type="pmid">24766432</idno>
<idno type="doi">10.1586/14760584.2014.912134</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Current advancements and potential strategies in the development of MERS-CoV vaccines.</title>
<author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
</author>
<author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
</author>
</analytic>
<series><title level="j">Expert review of vaccines</title>
<idno type="eISSN">1744-8395</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (administration & dosage)</term>
<term>Adjuvants, Immunologic (isolation & purification)</term>
<term>Animals</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Disease Models, Animal</term>
<term>Drug Discovery (trends)</term>
<term>Humans</term>
<term>Middle East (epidemiology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Vaccination (methods)</term>
<term>Vaccines, Subunit (genetics)</term>
<term>Vaccines, Subunit (immunology)</term>
<term>Vaccines, Subunit (isolation & purification)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (immunology)</term>
<term>Viral Vaccines (isolation & purification)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term>
<term>Adjuvants immunologiques (isolement et purification)</term>
<term>Animaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Découverte de médicament (tendances)</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Modèles animaux de maladie humaine</term>
<term>Moyen Orient (épidémiologie)</term>
<term>Vaccination ()</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins antiviraux (isolement et purification)</term>
<term>Vaccins sous-unitaires (génétique)</term>
<term>Vaccins sous-unitaires (immunologie)</term>
<term>Vaccins sous-unitaires (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccines, Subunit</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccines, Subunit</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Adjuvants, Immunologic</term>
<term>Vaccines, Subunit</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Middle East</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Vaccins antiviraux</term>
<term>Vaccins sous-unitaires</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Vaccins antiviraux</term>
<term>Vaccins sous-unitaires</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Adjuvants immunologiques</term>
<term>Vaccins antiviraux</term>
<term>Vaccins sous-unitaires</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Découverte de médicament</term>
</keywords>
<keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Discovery</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Moyen Orient</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Modèles animaux de maladie humaine</term>
<term>Vaccination</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the in vivo efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future. </div>
</front>
</TEI>
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