Current advancements and potential strategies in the development of MERS-CoV vaccines
Identifieur interne : 001107 ( Pmc/Checkpoint ); précédent : 001106; suivant : 001108Current advancements and potential strategies in the development of MERS-CoV vaccines
Auteurs : Naru Zhang [États-Unis] ; Shibo Jiang [États-Unis, République populaire de Chine] ; Lanying Du [États-Unis]Source :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Abstract
Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the
Url:
DOI: 10.1586/14760584.2014.912134
PubMed: 24766432
PubMed Central: 4241375
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current advancements and potential strategies in the development of MERS-CoV vaccines</title><author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University,</institution><addr-line>Shanghai,</addr-line><country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24766432</idno><idno type="pmc">4241375</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241375</idno><idno type="RBID">PMC:4241375</idno><idno type="doi">10.1586/14760584.2014.912134</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001325</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001325</idno><idno type="wicri:Area/Pmc/Curation">001325</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001325</idno><idno type="wicri:Area/Pmc/Checkpoint">001107</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001107</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current advancements and potential strategies in the development of MERS-CoV vaccines</title><author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University,</institution><addr-line>Shanghai,</addr-line><country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Expert Review of Vaccines</title><idno type="ISSN">1476-0584</idno><idno type="eISSN">1744-8395</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the <italic>in vivo</italic> efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author><author><name sortKey="Olival, K" uniqKey="Olival K">K Olival</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Al Dhahiry, Sh" uniqKey="Al Dhahiry S">SH Al 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Expert Rev Vaccines</journal-id><journal-id journal-id-type="iso-abbrev">Expert Rev Vaccines</journal-id><journal-id journal-id-type="publisher-id">IERV</journal-id><journal-id journal-id-type="publisher-id">ierv20</journal-id><journal-title-group><journal-title>Expert Review of Vaccines</journal-title></journal-title-group><issn pub-type="ppub">1476-0584</issn><issn pub-type="epub">1744-8395</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24766432</article-id><article-id pub-id-type="pmc">4241375</article-id><article-id pub-id-type="publisher-id">912134</article-id><article-id pub-id-type="doi">10.1586/14760584.2014.912134</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Current advancements and potential strategies in the development of MERS-CoV vaccines</article-title><alt-title alt-title-type="running-title">Vaccine for MERS</alt-title><alt-title alt-title-type="running-authors">Zhang, Jiang & Du</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Naru</given-names></name><xref ref-type="aff" rid="AFF0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Shibo</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0001"><sup>a</sup></xref><xref ref-type="aff" rid="AFF0002"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Du</surname><given-names>Lanying</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0001"><sup>a</sup></xref></contrib><aff id="AFF0001"><label>a</label><institution>Lindsley F. Kimball Research Institute, New York Blood Center,</institution><addr-line>New York, NY,</addr-line><country>USA</country></aff><aff id="AFF0002"><label>b</label><institution>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University,</institution><addr-line>Shanghai,</addr-line><country>China</country></aff></contrib-group><author-notes><corresp id="AN0001">*Authors for Correspondence: <phone>+1 212 570 3058; +1 212 570 3459</phone><email xlink:href="sjiang@nybloodcenter.org">sjiang@nybloodcenter.org</email>; <email xlink:href="ldu@nybloodcenter.org">ldu@nybloodcenter.org</email></corresp></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>26</day><month>4</month><year>2014</year></pub-date><volume>13</volume><issue>6</issue><fpage seq="7">761</fpage><lpage>774</lpage><permissions><copyright-statement>© Informa UK, Ltd.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Informa UK, Ltd.</copyright-holder><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="IERV_13_912134.pdf"></self-uri><abstract><p>Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the <italic>in vivo</italic> efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords:</title><kwd>adjuvants</kwd><kwd>administration routes</kwd><kwd>coronavirus</kwd><kwd>MERS-CoV</kwd><kwd>Middle East respiratory syndrome</kwd><kwd>receptor-binding domain</kwd><kwd>spike protein</kwd><kwd>subunit vaccines</kwd><kwd>vaccines</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="2"></table-count><ref-count count="128"></ref-count><page-count count="14"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name></noRegion><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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