Monoclonal antibodies to an HIV-1 group O envelope recombinant.
Identifieur interne : 000051 ( Ncbi/Merge ); précédent : 000050; suivant : 000052Monoclonal antibodies to an HIV-1 group O envelope recombinant.
Auteurs : J W Scheffel [États-Unis] ; R. Ziemann ; D. Hawksworth ; J. Tyner ; R K Hickman ; J. HackettSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 1999.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (), Anticorps monoclonaux (immunologie), Données de séquences moléculaires, Femelle, Protéine d'enveloppe gp120 du VIH (), Protéine d'enveloppe gp120 du VIH (immunologie), Protéine d'enveloppe gp41 du VIH (), Protéine d'enveloppe gp41 du VIH (immunologie), Protéines recombinantes (), Protéines recombinantes (immunologie), Souris, Séquence d'acides aminés, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
- MESH :
- immunologie : Anticorps monoclonaux, Protéine d'enveloppe gp120 du VIH, Protéine d'enveloppe gp41 du VIH, Protéines recombinantes, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- Animaux, Anticorps monoclonaux, Données de séquences moléculaires, Femelle, Protéine d'enveloppe gp120 du VIH, Protéine d'enveloppe gp41 du VIH, Protéines recombinantes, Souris, Séquence d'acides aminés, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Monoclonal (chemistry), Antibodies, Monoclonal (immunology), Female, HIV Envelope Protein gp120 (chemistry), HIV Envelope Protein gp120 (immunology), HIV Envelope Protein gp41 (chemistry), HIV Envelope Protein gp41 (immunology), HIV-1 (classification), HIV-1 (immunology), Immunoenzyme Techniques, Mice, Molecular Sequence Data, Recombinant Proteins (chemistry), Recombinant Proteins (immunology).
- MESH :
- chemical , chemistry : Antibodies, Monoclonal, HIV Envelope Protein gp120, HIV Envelope Protein gp41, Recombinant Proteins.
- chemical , immunology : Antibodies, Monoclonal, HIV Envelope Protein gp120, HIV Envelope Protein gp41, Recombinant Proteins.
- classification : HIV-1.
- immunology : HIV-1.
- Amino Acid Sequence, Animals, Female, Immunoenzyme Techniques, Mice, Molecular Sequence Data.
Abstract
Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.
DOI: 10.1097/00126334-199911010-00002
PubMed: 10770341
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pubmed:10770341Le document en format XML
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Ziemann</name></author><author><name sortKey="Hawksworth, D" sort="Hawksworth, D" uniqKey="Hawksworth D" first="D" last="Hawksworth">D. Hawksworth</name></author><author><name sortKey="Tyner, J" sort="Tyner, J" uniqKey="Tyner J" first="J" last="Tyner">J. Tyner</name></author><author><name sortKey="Hickman, R K" sort="Hickman, R K" uniqKey="Hickman R" first="R K" last="Hickman">R K Hickman</name></author><author><name sortKey="Hackett, J" sort="Hackett, J" uniqKey="Hackett J" first="J" last="Hackett">J. 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These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10770341</PMID><DateCompleted><Year>2000</Year><Month>05</Month><Day>02</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1525-4135</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>3</Issue><PubDate><Year>1999</Year><Month>Nov</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of acquired immune deficiency syndromes (1999)</Title><ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation></Journal><ArticleTitle>Monoclonal antibodies to an HIV-1 group O envelope recombinant.</ArticleTitle><Pagination><MedlinePgn>221-7</MedlinePgn></Pagination><Abstract><AbstractText>Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Scheffel</LastName><ForeName>J W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Hybridoma Development and Sourcing, Abbott Laboratories, Abbott Park, Illinois 60064, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziemann</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Hawksworth</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Tyner</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hickman</LastName><ForeName>R K</ForeName><Initials>RK</Initials></Author><Author ValidYN="Y"><LastName>Hackett</LastName><ForeName>J</ForeName><Initials>J</Initials><Suffix>Jr</Suffix></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Acquir Immune Defic Syndr</MedlineTA><NlmUniqueID>100892005</NlmUniqueID><ISSNLinking>1525-4135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015699">HIV Envelope Protein gp120</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015700">HIV Envelope Protein gp41</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015699" MajorTopicYN="N">HIV Envelope Protein gp120</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015700" MajorTopicYN="N">HIV Envelope Protein gp41</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007124" MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>4</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>4</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10770341</ArticleId><ArticleId IdType="doi">10.1097/00126334-199911010-00002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Hackett, J" sort="Hackett, J" uniqKey="Hackett J" first="J" last="Hackett">J. Hackett</name><name sortKey="Hawksworth, D" sort="Hawksworth, D" uniqKey="Hawksworth D" first="D" last="Hawksworth">D. Hawksworth</name><name sortKey="Hickman, R K" sort="Hickman, R K" uniqKey="Hickman R" first="R K" last="Hickman">R K Hickman</name><name sortKey="Tyner, J" sort="Tyner, J" uniqKey="Tyner J" first="J" last="Tyner">J. Tyner</name><name sortKey="Ziemann, R" sort="Ziemann, R" uniqKey="Ziemann R" first="R" last="Ziemann">R. Ziemann</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Scheffel, J W" sort="Scheffel, J W" uniqKey="Scheffel J" first="J W" last="Scheffel">J W Scheffel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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