Monoclonal antibodies to an HIV-1 group O envelope recombinant.
Identifieur interne : 002594 ( PubMed/Curation ); précédent : 002593; suivant : 002595Monoclonal antibodies to an HIV-1 group O envelope recombinant.
Auteurs : J W Scheffel [États-Unis] ; R. Ziemann ; D. Hawksworth ; J. Tyner ; R K Hickman ; J. HackettSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 1999.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (), Anticorps monoclonaux (immunologie), Données de séquences moléculaires, Femelle, Protéine d'enveloppe gp120 du VIH (), Protéine d'enveloppe gp120 du VIH (immunologie), Protéine d'enveloppe gp41 du VIH (), Protéine d'enveloppe gp41 du VIH (immunologie), Protéines recombinantes (), Protéines recombinantes (immunologie), Souris, Séquence d'acides aminés, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
- MESH :
- immunologie : Anticorps monoclonaux, Protéine d'enveloppe gp120 du VIH, Protéine d'enveloppe gp41 du VIH, Protéines recombinantes, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- Animaux, Anticorps monoclonaux, Données de séquences moléculaires, Femelle, Protéine d'enveloppe gp120 du VIH, Protéine d'enveloppe gp41 du VIH, Protéines recombinantes, Souris, Séquence d'acides aminés, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Monoclonal (chemistry), Antibodies, Monoclonal (immunology), Female, HIV Envelope Protein gp120 (chemistry), HIV Envelope Protein gp120 (immunology), HIV Envelope Protein gp41 (chemistry), HIV Envelope Protein gp41 (immunology), HIV-1 (classification), HIV-1 (immunology), Immunoenzyme Techniques, Mice, Molecular Sequence Data, Recombinant Proteins (chemistry), Recombinant Proteins (immunology).
- MESH :
- chemical , chemistry : Antibodies, Monoclonal, HIV Envelope Protein gp120, HIV Envelope Protein gp41, Recombinant Proteins.
- chemical , immunology : Antibodies, Monoclonal, HIV Envelope Protein gp120, HIV Envelope Protein gp41, Recombinant Proteins.
- classification : HIV-1.
- immunology : HIV-1.
- Amino Acid Sequence, Animals, Female, Immunoenzyme Techniques, Mice, Molecular Sequence Data.
Abstract
Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.
DOI: 10.1097/00126334-199911010-00002
PubMed: 10770341
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pubmed:10770341Le document en format XML
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<term>Antibodies, Monoclonal (chemistry)</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Female</term>
<term>HIV Envelope Protein gp120 (chemistry)</term>
<term>HIV Envelope Protein gp120 (immunology)</term>
<term>HIV Envelope Protein gp41 (chemistry)</term>
<term>HIV Envelope Protein gp41 (immunology)</term>
<term>HIV-1 (classification)</term>
<term>HIV-1 (immunology)</term>
<term>Immunoenzyme Techniques</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Recombinant Proteins (chemistry)</term>
<term>Recombinant Proteins (immunology)</term>
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<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Protéine d'enveloppe gp120 du VIH ()</term>
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<term>Protéine d'enveloppe gp41 du VIH (immunologie)</term>
<term>Protéines recombinantes ()</term>
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<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Techniques immunoenzymatiques</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
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<term>HIV Envelope Protein gp120</term>
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<term>Protéine d'enveloppe gp120 du VIH</term>
<term>Protéine d'enveloppe gp41 du VIH</term>
<term>Protéines recombinantes</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
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<term>Female</term>
<term>Immunoenzyme Techniques</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
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<term>Anticorps monoclonaux</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Protéine d'enveloppe gp120 du VIH</term>
<term>Protéine d'enveloppe gp41 du VIH</term>
<term>Protéines recombinantes</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.</div>
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