Synthesis of oligonucleotides containing the oxidatively modified kappaB site: unique binding affinity to the NFkappaB p50 homodimer.
Identifieur interne : 000052 ( Ncbi/Merge ); précédent : 000051; suivant : 000053Synthesis of oligonucleotides containing the oxidatively modified kappaB site: unique binding affinity to the NFkappaB p50 homodimer.
Auteurs : A. Kittaka [Japon] ; H. Takayama ; C. Horii ; T. Kuze ; H. Tanaka ; K T Nakamura ; T. Miyasaka ; J. InoueSource :
- Nucleic acids symposium series [ 0261-3166 ] ; 1999.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Facteur de transcription NF-kappa B.
- synthèse chimique : Oligodésoxyribonucléotides.
- ADN, Dimérisation, Facteur de transcription NF-kappa B, Oligodésoxyribonucléotides, Oxydoréduction, Sites de fixation, Séquence nucléotidique.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Oligodeoxyribonucleotides.
- chemical , chemistry : DNA, NF-kappa B, Oligodeoxyribonucleotides.
- chemical , metabolism : NF-kappa B.
- Base Sequence, Binding Sites, Dimerization, Oxidation-Reduction.
Abstract
Synthesis of oligonucleotide 26-mers including single 5-formyl-2'-deoxyuridine (1) or 5-formyl-2'-O-methyluridine (2) in place of thymidine at the kappaB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFkappaB p50 homodimer in binding.
DOI: 10.1093/nass/42.1.33
PubMed: 10780365
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pubmed:10780365Le document en format XML
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Horii</name></author><author><name sortKey="Kuze, T" sort="Kuze, T" uniqKey="Kuze T" first="T" last="Kuze">T. Kuze</name></author><author><name sortKey="Tanaka, H" sort="Tanaka, H" uniqKey="Tanaka H" first="H" last="Tanaka">H. Tanaka</name></author><author><name sortKey="Nakamura, K T" sort="Nakamura, K T" uniqKey="Nakamura K" first="K T" last="Nakamura">K T Nakamura</name></author><author><name sortKey="Miyasaka, T" sort="Miyasaka, T" uniqKey="Miyasaka T" first="T" last="Miyasaka">T. Miyasaka</name></author><author><name sortKey="Inoue, J" sort="Inoue, J" uniqKey="Inoue J" first="J" last="Inoue">J. 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Kittaka</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Takayama, H" sort="Takayama, H" uniqKey="Takayama H" first="H" last="Takayama">H. Takayama</name></author><author><name sortKey="Horii, C" sort="Horii, C" uniqKey="Horii C" first="C" last="Horii">C. Horii</name></author><author><name sortKey="Kuze, T" sort="Kuze, T" uniqKey="Kuze T" first="T" last="Kuze">T. Kuze</name></author><author><name sortKey="Tanaka, H" sort="Tanaka, H" uniqKey="Tanaka H" first="H" last="Tanaka">H. Tanaka</name></author><author><name sortKey="Nakamura, K T" sort="Nakamura, K T" uniqKey="Nakamura K" first="K T" last="Nakamura">K T Nakamura</name></author><author><name sortKey="Miyasaka, T" sort="Miyasaka, T" uniqKey="Miyasaka T" first="T" last="Miyasaka">T. Miyasaka</name></author><author><name sortKey="Inoue, J" sort="Inoue, J" uniqKey="Inoue J" first="J" last="Inoue">J. Inoue</name></author></analytic><series><title level="j">Nucleic acids symposium series</title><idno type="ISSN">0261-3166</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>Binding Sites</term><term>DNA (chemistry)</term><term>Dimerization</term><term>NF-kappa B (chemistry)</term><term>NF-kappa B (metabolism)</term><term>Oligodeoxyribonucleotides (chemical synthesis)</term><term>Oligodeoxyribonucleotides (chemistry)</term><term>Oxidation-Reduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ()</term><term>Dimérisation</term><term>Facteur de transcription NF-kappa B ()</term><term>Facteur de transcription NF-kappa B (métabolisme)</term><term>Oligodésoxyribonucléotides ()</term><term>Oligodésoxyribonucléotides (synthèse chimique)</term><term>Oxydoréduction</term><term>Sites de fixation</term><term>Séquence nucléotidique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Oligodeoxyribonucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term><term>NF-kappa B</term><term>Oligodeoxyribonucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>NF-kappa B</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Oligodésoxyribonucléotides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>Binding Sites</term><term>Dimerization</term><term>Oxidation-Reduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>Dimérisation</term><term>Facteur de transcription NF-kappa B</term><term>Oligodésoxyribonucléotides</term><term>Oxydoréduction</term><term>Sites de fixation</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Synthesis of oligonucleotide 26-mers including single 5-formyl-2'-deoxyuridine (1) or 5-formyl-2'-O-methyluridine (2) in place of thymidine at the kappaB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFkappaB p50 homodimer in binding.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10780365</PMID><DateCompleted><Year>2000</Year><Month>06</Month><Day>29</Day></DateCompleted><DateRevised><Year>2019</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0261-3166</ISSN><JournalIssue CitedMedium="Print"><Issue>42</Issue><PubDate><Year>1999</Year></PubDate></JournalIssue><Title>Nucleic acids symposium series</Title><ISOAbbreviation>Nucleic Acids Symp. Ser.</ISOAbbreviation></Journal><ArticleTitle>Synthesis of oligonucleotides containing the oxidatively modified kappaB site: unique binding affinity to the NFkappaB p50 homodimer.</ArticleTitle><Pagination><MedlinePgn>33-4</MedlinePgn></Pagination><Abstract><AbstractText>Synthesis of oligonucleotide 26-mers including single 5-formyl-2'-deoxyuridine (1) or 5-formyl-2'-O-methyluridine (2) in place of thymidine at the kappaB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFkappaB p50 homodimer in binding.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kittaka</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takayama</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Horii</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Kuze</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>K T</ForeName><Initials>KT</Initials></Author><Author ValidYN="Y"><LastName>Miyasaka</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Inoue</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucleic Acids Symp Ser</MedlineTA><NlmUniqueID>8007206</NlmUniqueID><ISSNLinking>0261-3166</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009838">Oligodeoxyribonucleotides</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019281" MajorTopicYN="N">Dimerization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009838" MajorTopicYN="N">Oligodeoxyribonucleotides</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>4</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>7</Month><Day>6</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>4</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10780365</ArticleId><ArticleId IdType="doi">10.1093/nass/42.1.33</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Horii, C" sort="Horii, C" uniqKey="Horii C" first="C" last="Horii">C. Horii</name><name sortKey="Inoue, J" sort="Inoue, J" uniqKey="Inoue J" first="J" last="Inoue">J. Inoue</name><name sortKey="Kuze, T" sort="Kuze, T" uniqKey="Kuze T" first="T" last="Kuze">T. Kuze</name><name sortKey="Miyasaka, T" sort="Miyasaka, T" uniqKey="Miyasaka T" first="T" last="Miyasaka">T. Miyasaka</name><name sortKey="Nakamura, K T" sort="Nakamura, K T" uniqKey="Nakamura K" first="K T" last="Nakamura">K T Nakamura</name><name sortKey="Takayama, H" sort="Takayama, H" uniqKey="Takayama H" first="H" last="Takayama">H. Takayama</name><name sortKey="Tanaka, H" sort="Tanaka, H" uniqKey="Tanaka H" first="H" last="Tanaka">H. Tanaka</name></noCountry><country name="Japon"><noRegion><name sortKey="Kittaka, A" sort="Kittaka, A" uniqKey="Kittaka A" first="A" last="Kittaka">A. Kittaka</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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