Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen
Identifieur interne : 000F25 ( Ncbi/Curation ); précédent : 000F24; suivant : 000F26Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen
Auteurs : Nikolaos Spanakis [Grèce] ; Sotirios Tsiodras [Grèce] ; Bart L. Haagmans [Pays-Bas] ; V. Stalin Raj [Pays-Bas] ; Kostantinos Pontikis [Grèce] ; Antonia Koutsoukou [Grèce] ; Nikolaos G. Koulouris [Grèce] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Marion P. G. Koopmans [Pays-Bas] ; Athanassios Tsakris [Grèce]Source :
- International Journal of Antimicrobial Agents [ 0924-8579 ] ; 2014.
Descripteurs français
- KwdFr :
- Antiviraux (usage thérapeutique), Association de médicaments, Association médicamenteuse, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Excrétion virale, Grèce, Humains, Infections de l'appareil respiratoire (traitement médicamenteux), Infections de l'appareil respiratoire (virologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lopinavir, Mâle, Phylogénie, Ribavirine (usage thérapeutique), Ritonavir, Virémie.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections de l'appareil respiratoire, Infections à coronavirus.
- usage thérapeutique : Antiviraux, Ribavirine.
- virologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- Association de médicaments, Association médicamenteuse, Coronavirus du syndrome respiratoire du Moyen-Orient, Excrétion virale, Grèce, Humains, Lopinavir, Mâle, Phylogénie, Ritonavir, Virémie.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Combinations, Drug Therapy, Combination, Greece, Humans, Lopinavir, Male, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Phylogeny, Respiratory Tract Infections (drug therapy), Respiratory Tract Infections (virology), Ribavirin (therapeutic use), Ritonavir, Viremia, Virus Shedding.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Ribavirin.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Coronavirus Infections, Respiratory Tract Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Respiratory Tract Infections.
- chemical : Drug Combinations, Drug Therapy, Combination, Greece, Humans, Lopinavir, Male, Phylogeny, Ritonavir, Viremia, Virus Shedding.
Abstract
Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece. MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy. The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.
Url:
DOI: 10.1016/j.ijantimicag.2014.07.026
PubMed: 25288266
PubMed Central: 7127532
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.</p>
</list-item>
</list>
</p>
</div>
</front>
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