MersV1, Ncbi, Merge, bibRecord, 000F25

Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

Identifieur interne : 000F25 ( Ncbi/Merge ); précédent : 000F24; suivant : 000F26

Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

Auteurs : Nikolaos Spanakis [Grèce] ; Sotirios Tsiodras [Grèce] ; Bart L. Haagmans [Pays-Bas] ; V. Stalin Raj [Pays-Bas] ; Kostantinos Pontikis [Grèce] ; Antonia Koutsoukou [Grèce] ; Nikolaos G. Koulouris [Grèce] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Marion P. G. Koopmans [Pays-Bas] ; Athanassios Tsakris [Grèce]

Source :

International Journal of Antimicrobial Agents [ 0924-8579 ] ; 2014.

RBID : PMC:7127532

Descripteurs français

KwdFr :
- Antiviraux (usage thérapeutique), Association de médicaments, Association médicamenteuse, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Excrétion virale, Grèce, Humains, Infections de l'appareil respiratoire (traitement médicamenteux), Infections de l'appareil respiratoire (virologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lopinavir, Mâle, Phylogénie, Ribavirine (usage thérapeutique), Ritonavir, Virémie.
MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections de l'appareil respiratoire, Infections à coronavirus.
- usage thérapeutique : Antiviraux, Ribavirine.
- virologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- Association de médicaments, Association médicamenteuse, Coronavirus du syndrome respiratoire du Moyen-Orient, Excrétion virale, Grèce, Humains, Lopinavir, Mâle, Phylogénie, Ritonavir, Virémie.

English descriptors

KwdEn :
- Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Combinations, Drug Therapy, Combination, Greece, Humans, Lopinavir, Male, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Phylogeny, Respiratory Tract Infections (drug therapy), Respiratory Tract Infections (virology), Ribavirin (therapeutic use), Ritonavir, Viremia, Virus Shedding.
MESH :
- chemical , therapeutic use : Antiviral Agents, Ribavirin.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Coronavirus Infections, Respiratory Tract Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Respiratory Tract Infections.
- chemical : Drug Combinations, Drug Therapy, Combination, Greece, Humans, Lopinavir, Male, Phylogeny, Ritonavir, Viremia, Virus Shedding.

Abstract

Highlights

•

Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece.

•

MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy.

•

The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127532

DOI: 10.1016/j.ijantimicag.2014.07.026
PubMed: 25288266
PubMed Central: 7127532

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PMC:7127532

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.</p>
</list-item>
</list>
</p>
</div>
</front>
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</TEI>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
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<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Pontikis, Kostantinos" sort="Pontikis, Kostantinos" uniqKey="Pontikis K" first="Kostantinos" last="Pontikis">Kostantinos Pontikis</name>
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<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea>
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<author><name sortKey="Koutsoukou, Antonia" sort="Koutsoukou, Antonia" uniqKey="Koutsoukou A" first="Antonia" last="Koutsoukou">Antonia Koutsoukou</name>
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<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea>
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<author><name sortKey="Koulouris, Nikolaos G" sort="Koulouris, Nikolaos G" uniqKey="Koulouris N" first="Nikolaos G." last="Koulouris">Nikolaos G. Koulouris</name>
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<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea>
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<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name>
<affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Tsakris, Athanassios" sort="Tsakris, Athanassios" uniqKey="Tsakris A" first="Athanassios" last="Tsakris">Athanassios Tsakris</name>
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<wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea>
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<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127532</idno>
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<idno type="doi">10.1016/j.ijantimicag.2014.07.026</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen</title>
<author><name sortKey="Spanakis, Nikolaos" sort="Spanakis, Nikolaos" uniqKey="Spanakis N" first="Nikolaos" last="Spanakis">Nikolaos Spanakis</name>
<affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea>
<wicri:noRegion>115 27 Athens</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name>
<affiliation wicri:level="3"><nlm:aff id="aff0010">Hellenic Centre for Disease Control and Prevention, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Centre for Disease Control and Prevention, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Internal Medicine, University of Athens Medical School, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Internal Medicine, University of Athens Medical School, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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</affiliation>
</author>
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<affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
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<affiliation wicri:level="3"><nlm:aff id="aff0025">First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
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<affiliation wicri:level="3"><nlm:aff id="aff0025">First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
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<affiliation wicri:level="3"><nlm:aff id="aff0025">First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
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<affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<author><name sortKey="Tsakris, Athanassios" sort="Tsakris, Athanassios" uniqKey="Tsakris A" first="Athanassios" last="Tsakris">Athanassios Tsakris</name>
<affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea>
<wicri:noRegion>115 27 Athens</wicri:noRegion>
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</analytic>
<series><title level="j">International Journal of Antimicrobial Agents</title>
<idno type="ISSN">0924-8579</idno>
<idno type="eISSN">1872-7913</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.</p>
</list-item>
</list>
</p>
</div>
</front>
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<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
<author><name sortKey="Alhammadi, M A" uniqKey="Alhammadi M">M.A. Alhammadi</name>
</author>
<author><name sortKey="Siu, L Y" uniqKey="Siu L">L.Y. Siu</name>
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<author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
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<author><name sortKey="Ababneh, M" uniqKey="Ababneh M">M. Ababneh</name>
</author>
<author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
<author><name sortKey="Eljarah, A" uniqKey="Eljarah A">A. Eljarah</name>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen.</title>
<author><name sortKey="Spanakis, Nikolaos" sort="Spanakis, Nikolaos" uniqKey="Spanakis N" first="Nikolaos" last="Spanakis">Nikolaos Spanakis</name>
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<wicri:noRegion>115 27 Athens</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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</affiliation>
</author>
<author><name sortKey="Pontikis, Kostantinos" sort="Pontikis, Kostantinos" uniqKey="Pontikis K" first="Kostantinos" last="Pontikis">Kostantinos Pontikis</name>
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<country xml:lang="fr">Grèce</country>
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</affiliation>
</author>
<author><name sortKey="Koutsoukou, Antonia" sort="Koutsoukou, Antonia" uniqKey="Koutsoukou A" first="Antonia" last="Koutsoukou">Antonia Koutsoukou</name>
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<country xml:lang="fr">Grèce</country>
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<author><name sortKey="Koulouris, Nikolaos G" sort="Koulouris, Nikolaos G" uniqKey="Koulouris N" first="Nikolaos G" last="Koulouris">Nikolaos G. Koulouris</name>
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<country xml:lang="fr">Grèce</country>
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<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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</author>
<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsakris, Athanassios" sort="Tsakris, Athanassios" uniqKey="Tsakris A" first="Athanassios" last="Tsakris">Athanassios Tsakris</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece. Electronic address: atsakris@med.uoa.gr.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea>
<wicri:noRegion>115 27 Athens</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen.</title>
<author><name sortKey="Spanakis, Nikolaos" sort="Spanakis, Nikolaos" uniqKey="Spanakis N" first="Nikolaos" last="Spanakis">Nikolaos Spanakis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea>
<wicri:noRegion>115 27 Athens</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name>
<affiliation wicri:level="3"><nlm:affiliation>Hellenic Centre for Disease Control and Prevention, Athens, Greece; Department of Internal Medicine, University of Athens Medical School, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Centre for Disease Control and Prevention, Athens, Greece; Department of Internal Medicine, University of Athens Medical School, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
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</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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<author><name sortKey="Pontikis, Kostantinos" sort="Pontikis, Kostantinos" uniqKey="Pontikis K" first="Kostantinos" last="Pontikis">Kostantinos Pontikis</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Respiratory Medicine, University of Athens Medical School and 'Sotiria' Chest Diseases Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and 'Sotiria' Chest Diseases Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
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</author>
<author><name sortKey="Koutsoukou, Antonia" sort="Koutsoukou, Antonia" uniqKey="Koutsoukou A" first="Antonia" last="Koutsoukou">Antonia Koutsoukou</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Respiratory Medicine, University of Athens Medical School and 'Sotiria' Chest Diseases Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and 'Sotiria' Chest Diseases Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koulouris, Nikolaos G" sort="Koulouris, Nikolaos G" uniqKey="Koulouris N" first="Nikolaos G" last="Koulouris">Nikolaos G. Koulouris</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Respiratory Medicine, University of Athens Medical School and 'Sotiria' Chest Diseases Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and 'Sotiria' Chest Diseases Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P G" last="Koopmans">Marion P G. Koopmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsakris, Athanassios" sort="Tsakris, Athanassios" uniqKey="Tsakris A" first="Athanassios" last="Tsakris">Athanassios Tsakris</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece. Electronic address: atsakris@med.uoa.gr.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea>
<wicri:noRegion>115 27 Athens</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of antimicrobial agents</title>
<idno type="eISSN">1872-7913</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Drug Combinations</term>
<term>Drug Therapy, Combination</term>
<term>Greece</term>
<term>Humans</term>
<term>Lopinavir</term>
<term>Male</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Phylogeny</term>
<term>Respiratory Tract Infections (drug therapy)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>Ribavirin (therapeutic use)</term>
<term>Ritonavir</term>
<term>Viremia</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Association médicamenteuse</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Excrétion virale</term>
<term>Grèce</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire (traitement médicamenteux)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Lopinavir</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Ribavirine (usage thérapeutique)</term>
<term>Ritonavir</term>
<term>Virémie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Ribavirin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Ribavirine</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term>
<term>Drug Therapy, Combination</term>
<term>Greece</term>
<term>Humans</term>
<term>Lopinavir</term>
<term>Male</term>
<term>Phylogeny</term>
<term>Ritonavir</term>
<term>Viremia</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Association de médicaments</term>
<term>Association médicamenteuse</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Excrétion virale</term>
<term>Grèce</term>
<term>Humains</term>
<term>Lopinavir</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Ritonavir</term>
<term>Virémie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Serological, molecular and phylogenetic analyses of a recently imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) in Greece are reported. Although MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, viraemia was last detected 2 days after initiation of triple combination therapy with pegylated interferon, ribavirin and lopinavir/ritonavir, administered from Day 13 of illness. Phylogenetic analysis of the virus showed close similarity with other human MERS-CoVs from the recent Jeddah outbreak in Saudi Arabia. Immunoglobulin G (IgG) titres peaked 3 weeks after the onset of illness, whilst IgM levels remained constantly elevated during the follow-up period (second to fifth week of illness). Serological testing confirmed by virus neutralisation assay detected an additional case that was a close contact of the patient. </div>
</front>
</TEI>
</pubmed>
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Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

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