New autoantibodies in early rheumatoid arthritis
Identifieur interne : 000A93 ( Ncbi/Checkpoint ); précédent : 000A92; suivant : 000A94New autoantibodies in early rheumatoid arthritis
Auteurs : Caroline Charpin [France] ; Fanny Arnoux [France] ; Marielle Martin [France] ; Eric Toussirot [France] ; Nathalie Lambert [France] ; Nathalie Balandraud [France] ; Daniel Wendling [France] ; Elisabeth Diot [France] ; Jean Roudier [France] ; Isabelle Auger [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse par réseau de protéines, Autoanticorps (immunologie), Autoanticorps (sang), Autoantigènes (immunologie), Cartographie épitopique, Femelle, Humains, Marqueurs biologiques (sang), Mâle, Polyarthrite rhumatoïde (diagnostic), Polyarthrite rhumatoïde (immunologie), Polyarthrite rhumatoïde (sang), Test ELISA.
- MESH :
- diagnostic : Polyarthrite rhumatoïde.
- immunologie : Autoanticorps, Autoantigènes, Polyarthrite rhumatoïde.
- sang : Autoanticorps, Marqueurs biologiques, Polyarthrite rhumatoïde.
- Adulte, Adulte d'âge moyen, Analyse par réseau de protéines, Cartographie épitopique, Femelle, Humains, Mâle, Test ELISA.
English descriptors
- KwdEn :
- Adult, Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (diagnosis), Arthritis, Rheumatoid (immunology), Autoantibodies (blood), Autoantibodies (immunology), Autoantigens (immunology), Biomarkers (blood), Enzyme-Linked Immunosorbent Assay, Epitope Mapping, Female, Humans, Male, Middle Aged, Protein Array Analysis.
- MESH :
- chemical , blood : Autoantibodies, Biomarkers.
- blood : Arthritis, Rheumatoid.
- diagnosis : Arthritis, Rheumatoid.
- immunology : Arthritis, Rheumatoid, Autoantibodies, Autoantigens.
- Adult, Enzyme-Linked Immunosorbent Assay, Epitope Mapping, Female, Humans, Male, Middle Aged, Protein Array Analysis.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.
We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.
WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.
We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.
Url:
DOI: 10.1186/ar4255
PubMed: 23886014
PubMed Central: 3978570
Affiliations:
- France
- Bourgogne-Franche-Comté, Centre-Val de Loire, Franche-Comté, Provence-Alpes-Côte d'Azur, Région Centre
- Besançon, Marseille, Tours
- Université d'Aix-Marseille
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PMC:3978570Le document en format XML
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<author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name>
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<series><title level="j">Arthritis Research & Therapy</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Arthritis, Rheumatoid (blood)</term>
<term>Arthritis, Rheumatoid (diagnosis)</term>
<term>Arthritis, Rheumatoid (immunology)</term>
<term>Autoantibodies (blood)</term>
<term>Autoantibodies (immunology)</term>
<term>Autoantigens (immunology)</term>
<term>Biomarkers (blood)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Epitope Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Protein Array Analysis</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse par réseau de protéines</term>
<term>Autoanticorps (immunologie)</term>
<term>Autoanticorps (sang)</term>
<term>Autoantigènes (immunologie)</term>
<term>Cartographie épitopique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Marqueurs biologiques (sang)</term>
<term>Mâle</term>
<term>Polyarthrite rhumatoïde (diagnostic)</term>
<term>Polyarthrite rhumatoïde (immunologie)</term>
<term>Polyarthrite rhumatoïde (sang)</term>
<term>Test ELISA</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term>
<term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Autoanticorps</term>
<term>Autoantigènes</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Autoantibodies</term>
<term>Autoantigens</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Autoanticorps</term>
<term>Marqueurs biologiques</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Epitope Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Protein Array Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse par réseau de protéines</term>
<term>Cartographie épitopique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Test ELISA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.</p>
</sec>
<sec><title>Methods</title>
<p>We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.</p>
</sec>
<sec><title>Results</title>
<p>WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.</p>
</sec>
<sec><title>Conclusions</title>
<p>We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.</p>
</sec>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>Centre-Val de Loire</li>
<li>Franche-Comté</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région Centre</li>
</region>
<settlement><li>Besançon</li>
<li>Marseille</li>
<li>Tours</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name>
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<name sortKey="Arnoux, Fanny" sort="Arnoux, Fanny" uniqKey="Arnoux F" first="Fanny" last="Arnoux">Fanny Arnoux</name>
<name sortKey="Auger, Isabelle" sort="Auger, Isabelle" uniqKey="Auger I" first="Isabelle" last="Auger">Isabelle Auger</name>
<name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name>
<name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name>
<name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name>
<name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name>
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<name sortKey="Martin, Marielle" sort="Martin, Marielle" uniqKey="Martin M" first="Marielle" last="Martin">Marielle Martin</name>
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<name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name>
<name sortKey="Toussirot, Eric" sort="Toussirot, Eric" uniqKey="Toussirot E" first="Eric" last="Toussirot">Eric Toussirot</name>
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</country>
</tree>
</affiliations>
</record>
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