New autoantibodies in early rheumatoid arthritis
Identifieur interne : 000941 ( Pmc/Curation ); précédent : 000940; suivant : 000942New autoantibodies in early rheumatoid arthritis
Auteurs : Caroline Charpin [France] ; Fanny Arnoux [France] ; Marielle Martin [France] ; Eric Toussirot [France] ; Nathalie Lambert [France] ; Nathalie Balandraud [France] ; Daniel Wendling [France] ; Elisabeth Diot [France] ; Jean Roudier [France] ; Isabelle Auger [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2013.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.
We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.
WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.
We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.
Url:
DOI: 10.1186/ar4255
PubMed: 23886014
PubMed Central: 3978570
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Besançon</wicri:regionArea></affiliation></author><author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name><affiliation wicri:level="1"><nlm:aff id="I4">Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours</wicri:regionArea></affiliation></author><author><name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Auger, Isabelle" sort="Auger, Isabelle" uniqKey="Auger I" first="Isabelle" last="Auger">Isabelle Auger</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23886014</idno><idno type="pmc">3978570</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978570</idno><idno type="RBID">PMC:3978570</idno><idno type="doi">10.1186/ar4255</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000941</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000941</idno><idno type="wicri:Area/Pmc/Curation">000941</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000941</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New autoantibodies in early rheumatoid arthritis</title><author><name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Arnoux, Fanny" sort="Arnoux, Fanny" uniqKey="Arnoux F" first="Fanny" last="Arnoux">Fanny Arnoux</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Marielle" sort="Martin, Marielle" uniqKey="Martin M" first="Marielle" last="Martin">Marielle Martin</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Toussirot, Eric" sort="Toussirot, Eric" uniqKey="Toussirot E" first="Eric" last="Toussirot">Eric Toussirot</name><affiliation wicri:level="1"><nlm:aff id="I3">Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Nathalie" sort="Lambert, Nathalie" uniqKey="Lambert N" first="Nathalie" last="Lambert">Nathalie Lambert</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation wicri:level="1"><nlm:aff id="I3">Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon</wicri:regionArea></affiliation></author><author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name><affiliation wicri:level="1"><nlm:aff id="I4">Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours</wicri:regionArea></affiliation></author><author><name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Auger, Isabelle" sort="Auger, Isabelle" uniqKey="Auger I" first="Isabelle" last="Auger">Isabelle Auger</name><affiliation wicri:level="1"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.</p></sec><sec><title>Methods</title><p>We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.</p></sec><sec><title>Results</title><p>WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.</p></sec><sec><title>Conclusions</title><p>We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schellekens, Ga" uniqKey="Schellekens G">GA Schellekens</name></author><author><name sortKey="Visser, H" uniqKey="Visser H">H Visser</name></author><author><name sortKey="De Jong, Ba" uniqKey="De Jong B">BA de Jong</name></author><author><name sortKey="Van Den Hoogen, Fh" uniqKey="Van Den Hoogen F">FH van den Hoogen</name></author><author><name sortKey="Hazes, Jm" uniqKey="Hazes J">JM Hazes</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author><author><name sortKey="Van Venrooij, Wj" uniqKey="Van Venrooij W">WJ van Venrooij</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Neogi, T" uniqKey="Neogi T">T Neogi</name></author><author><name sortKey="Silman, Aj" uniqKey="Silman A">AJ Silman</name></author><author><name sortKey="Funovits, J" uniqKey="Funovits J">J Funovits</name></author><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Bingham, Co" uniqKey="Bingham C">CO Bingham</name></author><author><name sortKey="Birnbaum, Ns" uniqKey="Birnbaum N">NS Birnbaum</name></author><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Bykerk, Vp" uniqKey="Bykerk V">VP Bykerk</name></author><author><name sortKey="Cohen, Md" uniqKey="Cohen M">MD Cohen</name></author><author><name sortKey="Combe, B" uniqKey="Combe B">B Combe</name></author><author><name sortKey="Costenbader, Kh" uniqKey="Costenbader K">KH Costenbader</name></author><author><name sortKey="Dougados, M" uniqKey="Dougados M">M Dougados</name></author><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author><author><name sortKey="Ferraccioli, G" uniqKey="Ferraccioli G">G Ferraccioli</name></author><author><name sortKey="Hazes, Jm" uniqKey="Hazes J">JM Hazes</name></author><author><name sortKey="Hobbs, K" uniqKey="Hobbs K">K Hobbs</name></author><author><name sortKey="Huizinga, Tw" uniqKey="Huizinga T">TW Huizinga</name></author><author><name sortKey="Kavanaugh, A" uniqKey="Kavanaugh A">A Kavanaugh</name></author><author><name sortKey="Kay, J" uniqKey="Kay J">J Kay</name></author><author><name sortKey="Kvien, Tk" uniqKey="Kvien T">TK Kvien</name></author><author><name sortKey="Laing, T" uniqKey="Laing T">T Laing</name></author><author><name sortKey="Mease, P" uniqKey="Mease P">P Mease</name></author><author><name sortKey="Menard, Ha" uniqKey="Menard H">HA Ménard</name></author><author><name sortKey="Moreland, Lw" uniqKey="Moreland L">LW Moreland</name></author><author><name sortKey="Naden, Rl" uniqKey="Naden R">RL Naden</name></author><author><name sortKey="Pincus, T" uniqKey="Pincus T">T Pincus</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Stanislawska Biernat, E" uniqKey="Stanislawska Biernat E">E Stanislawska-Biernat</name></author><author><name sortKey="Symmons, D" uniqKey="Symmons D">D Symmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Auger, I" uniqKey="Auger I">I Auger</name></author><author><name sortKey="Balandraud, N" uniqKey="Balandraud N">N Balandraud</name></author><author><name sortKey="Rak, Jm" uniqKey="Rak J">JM Rak</name></author><author><name sortKey="Lambert, Nc" uniqKey="Lambert N">NC Lambert</name></author><author><name sortKey="Martin, M" uniqKey="Martin M">M Martin</name></author><author><name sortKey="Roudier, J" uniqKey="Roudier J">J Roudier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takizawa, Y" uniqKey="Takizawa Y">Y Takizawa</name></author><author><name sortKey="Sawada, T" uniqKey="Sawada T">T Sawada</name></author><author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A Suzuki</name></author><author><name sortKey="Yamada, R" uniqKey="Yamada R">R Yamada</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name></author><author><name sortKey="Yamamoto, K" uniqKey="Yamamoto K">K Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roth, Eb" uniqKey="Roth E">EB Roth</name></author><author><name sortKey="Stenberg, P" uniqKey="Stenberg P">P Stenberg</name></author><author><name sortKey="Book, C" uniqKey="Book C">C Book</name></author><author><name sortKey="Sjoberg, K" uniqKey="Sjoberg K">K Sjöberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halvorsen, Eh" uniqKey="Halvorsen E">EH Halvorsen</name></author><author><name sortKey="Pollmann, S" uniqKey="Pollmann S">S Pollmann</name></author><author><name sortKey="Gilboe, Im" uniqKey="Gilboe I">IM Gilboe</name></author><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Landewe, R" uniqKey="Landewe R">R Landewé</name></author><author><name sortKey=" Deg Rd, S" uniqKey=" Deg Rd S">S Ødegård</name></author><author><name sortKey="Kvien, Tk" uniqKey="Kvien T">TK Kvien</name></author><author><name sortKey="Molberg, " uniqKey="Molberg ">Ø Molberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author><author><name sortKey="Jia, R" uniqKey="Jia R">R Jia</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Auger, I" uniqKey="Auger I">I Auger</name></author><author><name sortKey="Martin, M" uniqKey="Martin M">M Martin</name></author><author><name sortKey="Balandraud, N" uniqKey="Balandraud N">N Balandraud</name></author><author><name sortKey="Roudier, J" uniqKey="Roudier J">J Roudier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luchi, S" uniqKey="Luchi S">S Luchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behrends, C" uniqKey="Behrends C">C Behrends</name></author><author><name sortKey="Sowa, Me" uniqKey="Sowa M">ME Sowa</name></author><author><name sortKey="Gygi, Sp" uniqKey="Gygi S">SP Gygi</name></author><author><name sortKey="Harper, Jw" uniqKey="Harper J">JW Harper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gehring, Nh" uniqKey="Gehring N">NH Gehring</name></author><author><name sortKey="Lamprinaki, S" uniqKey="Lamprinaki S">S Lamprinaki</name></author><author><name sortKey="Kulozik, Ae" uniqKey="Kulozik A">AE Kulozik</name></author><author><name sortKey="Hentze, Mw" uniqKey="Hentze M">MW Hentze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldbach Mansky, R" uniqKey="Goldbach Mansky R">R Goldbach-Mansky</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Mccoy, A" uniqKey="Mccoy A">A McCoy</name></author><author><name sortKey="Hoxworth, J" uniqKey="Hoxworth J">J Hoxworth</name></author><author><name sortKey="Yarboro, C" uniqKey="Yarboro C">C Yarboro</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Steiner, G" uniqKey="Steiner G">G Steiner</name></author><author><name sortKey="Rosen, A" uniqKey="Rosen A">A Rosen</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Menard, Ha" uniqKey="Menard H">HA Ménard</name></author><author><name sortKey="Zhou, Zj" uniqKey="Zhou Z">ZJ Zhou</name></author><author><name sortKey="Palosuo, T" uniqKey="Palosuo T">T Palosuo</name></author><author><name sortKey="Van Venrooij, Wj" uniqKey="Van Venrooij W">WJ Van Venrooij</name></author><author><name sortKey="Wilder, Rl" uniqKey="Wilder R">RL Wilder</name></author><author><name sortKey="Klippel, Jh" uniqKey="Klippel J">JH Klippel</name></author><author><name sortKey="Schumacher, Hr" uniqKey="Schumacher H">HR Schumacher</name></author><author><name sortKey="El Gabalawy, Hs" uniqKey="El Gabalawy H">HS El-Gabalawy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guzian, Mc" uniqKey="Guzian M">MC Guzian</name></author><author><name sortKey="Carrier, N" uniqKey="Carrier N">N Carrier</name></author><author><name sortKey="Cossette, P" uniqKey="Cossette P">P Cossette</name></author><author><name sortKey="De Brum Fernandes, Aj" uniqKey="De Brum Fernandes A">AJ de Brum-Fernandes</name></author><author><name sortKey="Liang, P" uniqKey="Liang P">P Liang</name></author><author><name sortKey="Menard, Ha" uniqKey="Menard H">HA Ménard</name></author><author><name sortKey="Boire, G" uniqKey="Boire G">G Boire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gendi, N" uniqKey="Gendi N">N Gendi</name></author><author><name sortKey="Welsh, K" uniqKey="Welsh K">K Welsh</name></author><author><name sortKey="Van Venrooij, W" uniqKey="Van Venrooij W">W Van Venrooij</name></author><author><name sortKey="Vancheeswaran, R" uniqKey="Vancheeswaran R">R Vancheeswaran</name></author><author><name sortKey="Gilroy, J" uniqKey="Gilroy J">J Gilroy</name></author><author><name sortKey="Black, C" uniqKey="Black C">C Black</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Arthritis Res Ther</journal-id><journal-id journal-id-type="iso-abbrev">Arthritis Res. Ther</journal-id><journal-title-group><journal-title>Arthritis Research & Therapy</journal-title></journal-title-group><issn pub-type="ppub">1478-6354</issn><issn pub-type="epub">1478-6362</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23886014</article-id><article-id pub-id-type="pmc">3978570</article-id><article-id pub-id-type="publisher-id">ar4255</article-id><article-id pub-id-type="doi">10.1186/ar4255</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>New autoantibodies in early rheumatoid arthritis</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Charpin</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>caroline.charpin@gmail.com</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Arnoux</surname><given-names>Fanny</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>fannyarnoux@hotmail.fr</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Martin</surname><given-names>Marielle</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>marielle.martin@inserm.fr</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Toussirot</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>etoussirot@chu-besancon.fr</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Lambert</surname><given-names>Nathalie</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>nathalie.lambert@inserm.fr</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Balandraud</surname><given-names>Nathalie</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>natbalandraud@gmail.com</email></contrib><contrib contrib-type="author" id="A7"><name><surname>Wendling</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>dwendling@chu-besancon.fr</email></contrib><contrib contrib-type="author" id="A8"><name><surname>Diot</surname><given-names>Elisabeth</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>ediot@med.univ-tours.fr</email></contrib><contrib contrib-type="author" id="A9"><name><surname>Roudier</surname><given-names>Jean</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>jean.roudier@inserm.fr</email></contrib><contrib contrib-type="author" corresp="yes" id="A10"><name><surname>Auger</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>isabelle.auger@inserm.fr</email></contrib></contrib-group><aff id="I1"><label>1</label>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</aff><aff id="I2"><label>2</label>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</aff><aff id="I3"><label>3</label>Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon, France</aff><aff id="I4"><label>4</label>Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours, France</aff><pub-date pub-type="ppub"><year>2013</year></pub-date><pub-date pub-type="epub"><day>25</day><month>7</month><year>2013</year></pub-date><volume>15</volume><issue>4</issue><fpage>R78</fpage><lpage>R78</lpage><history><date date-type="received"><day>18</day><month>12</month><year>2012</year></date><date date-type="rev-recd"><day>19</day><month>3</month><year>2013</year></date><date date-type="accepted"><day>25</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Charpin et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Charpin et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://arthritis-research.com/content/15/4/R78"></self-uri><abstract><sec><title>Introduction</title><p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.</p></sec><sec><title>Methods</title><p>We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.</p></sec><sec><title>Results</title><p>WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.</p></sec><sec><title>Conclusions</title><p>We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.</p></sec></abstract><kwd-group><kwd>rheumatoid arthritis</kwd><kwd>autoantibodies</kwd><kwd>early biomarkers</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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