New autoantibodies in early rheumatoid arthritis
Identifieur interne : 001193 ( Pmc/Checkpoint ); précédent : 001192; suivant : 001194New autoantibodies in early rheumatoid arthritis
Auteurs : Caroline Charpin [France] ; Fanny Arnoux [France] ; Marielle Martin [France] ; Eric Toussirot [France] ; Nathalie Lambert [France] ; Nathalie Balandraud [France] ; Daniel Wendling [France] ; Elisabeth Diot [France] ; Jean Roudier [France] ; Isabelle Auger [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2013.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.
We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.
WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.
We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.
Url:
DOI: 10.1186/ar4255
PubMed: 23886014
PubMed Central: 3978570
Affiliations:
- France
- Bourgogne-Franche-Comté, Centre-Val de Loire, Franche-Comté, Provence-Alpes-Côte d'Azur, Région Centre
- Besançon, Marseille, Tours
- Université d'Aix-Marseille
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<author><name sortKey="Lambert, Nathalie" sort="Lambert, Nathalie" uniqKey="Lambert N" first="Nathalie" last="Lambert">Nathalie Lambert</name>
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<author><name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name>
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<author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name>
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<region type="old region" nuts="2">Région Centre</region>
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<author><name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name>
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<author><name sortKey="Auger, Isabelle" sort="Auger, Isabelle" uniqKey="Auger I" first="Isabelle" last="Auger">Isabelle Auger</name>
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<series><title level="j">Arthritis Research & Therapy</title>
<idno type="ISSN">1478-6354</idno>
<idno type="eISSN">1478-6362</idno>
<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.</p>
</sec>
<sec><title>Methods</title>
<p>We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.</p>
</sec>
<sec><title>Results</title>
<p>WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.</p>
</sec>
<sec><title>Conclusions</title>
<p>We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schellekens, Ga" uniqKey="Schellekens G">GA Schellekens</name>
</author>
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</author>
<author><name sortKey="De Jong, Ba" uniqKey="De Jong B">BA de Jong</name>
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<author><name sortKey="Van Venrooij, Wj" uniqKey="Van Venrooij W">WJ van Venrooij</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name>
</author>
<author><name sortKey="Neogi, T" uniqKey="Neogi T">T Neogi</name>
</author>
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</author>
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<pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Arthritis Res Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">Arthritis Res. Ther</journal-id>
<journal-title-group><journal-title>Arthritis Research & Therapy</journal-title>
</journal-title-group>
<issn pub-type="ppub">1478-6354</issn>
<issn pub-type="epub">1478-6362</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23886014</article-id>
<article-id pub-id-type="pmc">3978570</article-id>
<article-id pub-id-type="publisher-id">ar4255</article-id>
<article-id pub-id-type="doi">10.1186/ar4255</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>New autoantibodies in early rheumatoid arthritis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="A1"><name><surname>Charpin</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>caroline.charpin@gmail.com</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Arnoux</surname>
<given-names>Fanny</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>fannyarnoux@hotmail.fr</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Martin</surname>
<given-names>Marielle</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>marielle.martin@inserm.fr</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Toussirot</surname>
<given-names>Eric</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>etoussirot@chu-besancon.fr</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Lambert</surname>
<given-names>Nathalie</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>nathalie.lambert@inserm.fr</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Balandraud</surname>
<given-names>Nathalie</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>natbalandraud@gmail.com</email>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Wendling</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>dwendling@chu-besancon.fr</email>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Diot</surname>
<given-names>Elisabeth</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>ediot@med.univ-tours.fr</email>
</contrib>
<contrib contrib-type="author" id="A9"><name><surname>Roudier</surname>
<given-names>Jean</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>jean.roudier@inserm.fr</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A10"><name><surname>Auger</surname>
<given-names>Isabelle</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>isabelle.auger@inserm.fr</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</aff>
<aff id="I2"><label>2</label>
Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</aff>
<aff id="I3"><label>3</label>
Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon, France</aff>
<aff id="I4"><label>4</label>
Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours, France</aff>
<pub-date pub-type="ppub"><year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>7</month>
<year>2013</year>
</pub-date>
<volume>15</volume>
<issue>4</issue>
<fpage>R78</fpage>
<lpage>R78</lpage>
<history><date date-type="received"><day>18</day>
<month>12</month>
<year>2012</year>
</date>
<date date-type="rev-recd"><day>19</day>
<month>3</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>25</day>
<month>7</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 Charpin et al.; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>Charpin et al.; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://arthritis-research.com/content/15/4/R78"></self-uri>
<abstract><sec><title>Introduction</title>
<p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.</p>
</sec>
<sec><title>Methods</title>
<p>We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.</p>
</sec>
<sec><title>Results</title>
<p>WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.</p>
</sec>
<sec><title>Conclusions</title>
<p>We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.</p>
</sec>
</abstract>
<kwd-group><kwd>rheumatoid arthritis</kwd>
<kwd>autoantibodies</kwd>
<kwd>early biomarkers</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>Centre-Val de Loire</li>
<li>Franche-Comté</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région Centre</li>
</region>
<settlement><li>Besançon</li>
<li>Marseille</li>
<li>Tours</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name>
</region>
<name sortKey="Arnoux, Fanny" sort="Arnoux, Fanny" uniqKey="Arnoux F" first="Fanny" last="Arnoux">Fanny Arnoux</name>
<name sortKey="Auger, Isabelle" sort="Auger, Isabelle" uniqKey="Auger I" first="Isabelle" last="Auger">Isabelle Auger</name>
<name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name>
<name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name>
<name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name>
<name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name>
<name sortKey="Lambert, Nathalie" sort="Lambert, Nathalie" uniqKey="Lambert N" first="Nathalie" last="Lambert">Nathalie Lambert</name>
<name sortKey="Martin, Marielle" sort="Martin, Marielle" uniqKey="Martin M" first="Marielle" last="Martin">Marielle Martin</name>
<name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name>
<name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name>
<name sortKey="Toussirot, Eric" sort="Toussirot, Eric" uniqKey="Toussirot E" first="Eric" last="Toussirot">Eric Toussirot</name>
<name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name>
</country>
</tree>
</affiliations>
</record>
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