MersV1, Ncbi, Checkpoint, bibRecord, 000051

Monoclonal antibodies to an HIV-1 group O envelope recombinant.

Identifieur interne : 000051 ( Ncbi/Checkpoint ); précédent : 000050; suivant : 000052

Monoclonal antibodies to an HIV-1 group O envelope recombinant.

Auteurs : J W Scheffel [États-Unis] ; R. Ziemann ; D. Hawksworth ; J. Tyner ; R K Hickman ; J. Hackett

Source :

Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 1999.

RBID : pubmed:10770341

Descripteurs français

KwdFr :
- Animaux, Anticorps monoclonaux (), Anticorps monoclonaux (immunologie), Données de séquences moléculaires, Femelle, Protéine d'enveloppe gp120 du VIH (), Protéine d'enveloppe gp120 du VIH (immunologie), Protéine d'enveloppe gp41 du VIH (), Protéine d'enveloppe gp41 du VIH (immunologie), Protéines recombinantes (), Protéines recombinantes (immunologie), Souris, Séquence d'acides aminés, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
MESH :
- immunologie : Anticorps monoclonaux, Protéine d'enveloppe gp120 du VIH, Protéine d'enveloppe gp41 du VIH, Protéines recombinantes, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- Animaux, Anticorps monoclonaux, Données de séquences moléculaires, Femelle, Protéine d'enveloppe gp120 du VIH, Protéine d'enveloppe gp41 du VIH, Protéines recombinantes, Souris, Séquence d'acides aminés, Techniques immunoenzymatiques, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Monoclonal (chemistry), Antibodies, Monoclonal (immunology), Female, HIV Envelope Protein gp120 (chemistry), HIV Envelope Protein gp120 (immunology), HIV Envelope Protein gp41 (chemistry), HIV Envelope Protein gp41 (immunology), HIV-1 (classification), HIV-1 (immunology), Immunoenzyme Techniques, Mice, Molecular Sequence Data, Recombinant Proteins (chemistry), Recombinant Proteins (immunology).
MESH :
- chemical , chemistry : Antibodies, Monoclonal, HIV Envelope Protein gp120, HIV Envelope Protein gp41, Recombinant Proteins.
- chemical , immunology : Antibodies, Monoclonal, HIV Envelope Protein gp120, HIV Envelope Protein gp41, Recombinant Proteins.
- classification : HIV-1.
- immunology : HIV-1.
- Amino Acid Sequence, Animals, Female, Immunoenzyme Techniques, Mice, Molecular Sequence Data.

Abstract

Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.

DOI: 10.1097/00126334-199911010-00002
PubMed: 10770341

Affiliations:

États-Unis

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to stream PubMed, to step Curation: 002594
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to stream Ncbi, to step Curation: 000051

Links to Exploration step

pubmed:10770341

Le document en format XML

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<author><name sortKey="Ziemann, R" sort="Ziemann, R" uniqKey="Ziemann R" first="R" last="Ziemann">R. Ziemann</name>
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<author><name sortKey="Hawksworth, D" sort="Hawksworth, D" uniqKey="Hawksworth D" first="D" last="Hawksworth">D. Hawksworth</name>
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<author><name sortKey="Hickman, R K" sort="Hickman, R K" uniqKey="Hickman R" first="R K" last="Hickman">R K Hickman</name>
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<term>Animals</term>
<term>Antibodies, Monoclonal (chemistry)</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Female</term>
<term>HIV Envelope Protein gp120 (chemistry)</term>
<term>HIV Envelope Protein gp120 (immunology)</term>
<term>HIV Envelope Protein gp41 (chemistry)</term>
<term>HIV Envelope Protein gp41 (immunology)</term>
<term>HIV-1 (classification)</term>
<term>HIV-1 (immunology)</term>
<term>Immunoenzyme Techniques</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Recombinant Proteins (chemistry)</term>
<term>Recombinant Proteins (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux ()</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Protéine d'enveloppe gp120 du VIH ()</term>
<term>Protéine d'enveloppe gp120 du VIH (immunologie)</term>
<term>Protéine d'enveloppe gp41 du VIH ()</term>
<term>Protéine d'enveloppe gp41 du VIH (immunologie)</term>
<term>Protéines recombinantes ()</term>
<term>Protéines recombinantes (immunologie)</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Techniques immunoenzymatiques</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>HIV Envelope Protein gp120</term>
<term>HIV Envelope Protein gp41</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>HIV Envelope Protein gp120</term>
<term>HIV Envelope Protein gp41</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps monoclonaux</term>
<term>Protéine d'enveloppe gp120 du VIH</term>
<term>Protéine d'enveloppe gp41 du VIH</term>
<term>Protéines recombinantes</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
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<term>Animals</term>
<term>Female</term>
<term>Immunoenzyme Techniques</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
</keywords>
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<term>Anticorps monoclonaux</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Protéine d'enveloppe gp120 du VIH</term>
<term>Protéine d'enveloppe gp41 du VIH</term>
<term>Protéines recombinantes</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Techniques immunoenzymatiques</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
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<front><div type="abstract" xml:lang="en">Monoclonal antibodies were developed to a recombinant HIV-I group O envelope protein derived from the isolate HAM112. These monoclonal antibodies were characterized for reactivity to a series of overlapping synthetic peptides (29-30 mers) covering gp120 C-terminal and gp41 ectodomain regions of the HIV-1 group O envelope protein. Most of these monoclonal antibodies reacted with peptides spanning sequences analogous to HIV-1 group M epitopes identified from studies in mice and humans. However, several of the antibodies that were nonreactive to individual peptides did react to a mixture of longer peptides from the N-terminal and C-terminal helical regions of the gp41 ectodomain. The monoclonal antibodies described in this study are valuable tools for characterization of antigenic differences between HIV-1 group O and group M viruses.</div>
</front>
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</country>
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<name sortKey="Hickman, R K" sort="Hickman, R K" uniqKey="Hickman R" first="R K" last="Hickman">R K Hickman</name>
<name sortKey="Tyner, J" sort="Tyner, J" uniqKey="Tyner J" first="J" last="Tyner">J. Tyner</name>
<name sortKey="Ziemann, R" sort="Ziemann, R" uniqKey="Ziemann R" first="R" last="Ziemann">R. Ziemann</name>
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<country name="États-Unis"><noRegion><name sortKey="Scheffel, J W" sort="Scheffel, J W" uniqKey="Scheffel J" first="J W" last="Scheffel">J W Scheffel</name>
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Monoclonal antibodies to an HIV-1 group O envelope recombinant.

Monoclonal antibodies to an HIV-1 group O envelope recombinant.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki