Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
Identifieur interne : 003138 ( Main/Merge ); précédent : 003137; suivant : 003139Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
Auteurs : Aftab A. Ansari [États-Unis] ; Ann E. Mayne [États-Unis] ; Nattawat Onlamoon [Thaïlande] ; Kovit Pattanapanyasat [Thaïlande] ; Kazuyasu Mori [Japon] ; Francois Villinger [États-Unis]Source :
- Immunologic Research [ 0257-277X ] ; 2004-06-01.
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- topic : Sida.
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Abstract
Abstract: Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses, and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.
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DOI: 10.1385/IR:29:1-3:001
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Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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