Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
Identifieur interne : 000196 ( Istex/Corpus ); précédent : 000195; suivant : 000197Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
Auteurs : Aftab A. Ansari ; Ann E. Mayne ; Nattawat Onlamoon ; Kovit Pattanapanyasat ; Kazuyasu Mori ; Francois VillingerSource :
- Immunologic Research [ 0257-277X ] ; 2004-06-01.
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Abstract
Abstract: Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses, and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.
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DOI: 10.1385/IR:29:1-3:001
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ISTEX:9494FC40E50F816748754F41523A209A126BC971Le document en format XML
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DisplayOrder="Western"><GivenName>Nattawat</GivenName><FamilyName>Onlamoon</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Kovit</GivenName><FamilyName>Pattanapanyasat</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Kazuyasu</GivenName><FamilyName>Mori</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Francois</GivenName><FamilyName>Villinger</FamilyName></AuthorName></Author><Affiliation ID="Aff2"><OrgDivision>Division of Instrumentation</OrgDivision><OrgName>Mahidol University School of Medicine, Sriraj Hospital</OrgName><OrgAddress><City>Bangkok</City><Country>Thailand</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Tsukuba Primate Research Center</OrgDivision><OrgName>National Center for AIDS Research</OrgName><OrgAddress><City>Tsukuba</City><Country>Japan</Country></OrgAddress></Affiliation><Affiliation ID="Aff1"><OrgDivision>Department of Pathology and Laboratory Medicine</OrgDivision><OrgName>Emory University School of Medicine</OrgName><OrgAddress><Street>Room 2309 WMB, 1639 Pierce Drive</Street><Postcode>30322</Postcode><City>Atlanta</City><State>GA</State></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses, and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.</Para></Abstract><KeywordGroup Language="En"><Heading>Key Words</Heading><Keyword>Nonhuman primate</Keyword><Keyword>cytokines</Keyword><Keyword>antiviral immunity</Keyword><Keyword>SIV</Keyword><Keyword>AIDS</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS</title></titleInfo><name type="personal"><namePart type="given">Aftab</namePart><namePart type="given">A.</namePart><namePart type="family">Ansari</namePart><affiliation>Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room 2309 WMB, 1639 Pierce Drive, 30322, Atlanta, GA</affiliation><affiliation>E-mail: pathaaa@emory.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ann</namePart><namePart type="given">E.</namePart><namePart type="family">Mayne</namePart><affiliation>Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room 2309 WMB, 1639 Pierce Drive, 30322, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nattawat</namePart><namePart type="family">Onlamoon</namePart><affiliation>Division of Instrumentation, Mahidol University School of Medicine, Sriraj Hospital, Bangkok, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kovit</namePart><namePart type="family">Pattanapanyasat</namePart><affiliation>Division of Instrumentation, Mahidol University School of Medicine, Sriraj Hospital, Bangkok, Thailand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kazuyasu</namePart><namePart type="family">Mori</namePart><affiliation>Tsukuba Primate Research Center, National Center for AIDS Research, Tsukuba, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francois</namePart><namePart type="family">Villinger</namePart><affiliation>Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room 2309 WMB, 1639 Pierce Drive, 30322, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Humana Press</publisher><place><placeTerm type="text">Totowa</placeTerm></place><dateIssued encoding="w3cdtf">2004-06-01</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses, and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.</abstract><note>Immunology at Emory University</note><subject lang="en"><genre>Key Words</genre><topic>Nonhuman primate</topic><topic>cytokines</topic><topic>antiviral immunity</topic><topic>SIV</topic><topic>AIDS</topic></subject><relatedItem type="host"><titleInfo><title>Immunologic Research</title></titleInfo><titleInfo type="abbreviated"><title>Immunol Res</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2004-06-01</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Allergology</topic><topic>Immunology</topic><topic>Medicine/Public Health, general</topic><topic>Internal Medicine</topic></subject><identifier type="ISSN">0257-277X</identifier><identifier type="eISSN">1559-0755</identifier><identifier type="JournalID">12026</identifier><identifier type="IssueArticleCount">26</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>2004</date><detail type="volume"><number>29</number><caption>vol.</caption></detail><detail type="issue"><number>1-3</number><caption>no.</caption></detail><extent unit="pages"><start>1</start><end>17</end></extent></part><recordInfo><recordOrigin>Humana Press Inc., 2004</recordOrigin></recordInfo></relatedItem><identifier type="istex">9494FC40E50F816748754F41523A209A126BC971</identifier><identifier type="ark">ark:/67375/VQC-F4TDG4HS-F</identifier><identifier type="DOI">10.1385/IR:29:1-3:001</identifier><identifier type="ArticleID">291103001</identifier><identifier type="ArticleID">Art291103001</identifier><accessCondition type="use and reproduction" contentType="copyright">Humana Press Inc, 2004</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Humana Press Inc, 2004</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-F4TDG4HS-F/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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