Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.
Identifieur interne : 001B89 ( Main/Merge ); précédent : 001B88; suivant : 001B90Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.
Auteurs : Hiroshi Kometani [Japon] ; Masao Kawatani [Japon] ; Genrei Ohta [Japon] ; Shintaro Okazaki [Japon] ; Kazumasa Ogura [Japon] ; Motoko Yasutomi [Japon] ; Akihiko Tanizawa [Japon] ; Yusei Ohshima [Japon]Source :
- Brain & development [ 1872-7131 ] ; 2014.
Descripteurs français
- KwdFr :
- Ampicilline (usage thérapeutique), Antibactériens (usage thérapeutique), Corps calleux (), Corps calleux (anatomopathologie), Diagnostic différentiel, Encéphalite (anatomopathologie), Encéphalite (métabolisme), Encéphalite (traitement médicamenteux), Enfant, Enterococcus faecalis, Humains, Imagerie par résonance magnétique, Infections bactériennes à Gram positif (métabolisme), Interleukine-6 (métabolisme), Mâle, Néphrite (anatomopathologie), Néphrite (métabolisme), Néphrite (traitement médicamenteux), Résultat thérapeutique, Tomodensitométrie.
- MESH :
- anatomopathologie : Corps calleux, Encéphalite, Néphrite.
- métabolisme : Encéphalite, Infections bactériennes à Gram positif, Interleukine-6, Néphrite.
- traitement médicamenteux : Encéphalite, Néphrite.
- usage thérapeutique : Ampicilline, Antibactériens.
- Corps calleux, Diagnostic différentiel, Enfant, Enterococcus faecalis, Humains, Imagerie par résonance magnétique, Mâle, Résultat thérapeutique, Tomodensitométrie.
English descriptors
- KwdEn :
- Ampicillin (therapeutic use), Anti-Bacterial Agents (therapeutic use), Child, Corpus Callosum (drug effects), Corpus Callosum (pathology), Diagnosis, Differential, Encephalitis (drug therapy), Encephalitis (metabolism), Encephalitis (pathology), Enterococcus faecalis, Gram-Positive Bacterial Infections (metabolism), Humans, Interleukin-6 (metabolism), Magnetic Resonance Imaging, Male, Nephritis (drug therapy), Nephritis (metabolism), Nephritis (pathology), Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- chemical , metabolism : Interleukin-6.
- chemical , therapeutic use : Ampicillin, Anti-Bacterial Agents.
- drug effects : Corpus Callosum.
- drug therapy : Encephalitis, Nephritis.
- metabolism : Encephalitis, Gram-Positive Bacterial Infections, Nephritis.
- pathology : Corpus Callosum, Encephalitis, Nephritis.
- Child, Diagnosis, Differential, Enterococcus faecalis, Humans, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS.
DOI: 10.1016/j.braindev.2013.07.012
PubMed: 23978488
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sortKey="Kometani, Hiroshi" sort="Kometani, Hiroshi" uniqKey="Kometani H" first="Hiroshi" last="Kometani">Hiroshi Kometani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. 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qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term><term>Encéphalite</term><term>Néphrite</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Callosum</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Encephalitis</term><term>Nephritis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Encephalitis</term><term>Gram-Positive Bacterial Infections</term><term>Nephritis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphalite</term><term>Infections bactériennes à Gram positif</term><term>Interleukine-6</term><term>Néphrite</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term><term>Encephalitis</term><term>Nephritis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Encéphalite</term><term>Néphrite</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Ampicilline</term><term>Antibactériens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Diagnosis, Differential</term><term>Enterococcus faecalis</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Corps calleux</term><term>Diagnostic différentiel</term><term>Enfant</term><term>Enterococcus faecalis</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Tomodensitométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS. </div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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