Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.
Identifieur interne : 001C06 ( PubMed/Corpus ); précédent : 001C05; suivant : 001C07Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.
Auteurs : Hiroshi Kometani ; Masao Kawatani ; Genrei Ohta ; Shintaro Okazaki ; Kazumasa Ogura ; Motoko Yasutomi ; Akihiko Tanizawa ; Yusei OhshimaSource :
- Brain & development [ 1872-7131 ] ; 2014.
English descriptors
- KwdEn :
- Ampicillin (therapeutic use), Anti-Bacterial Agents (therapeutic use), Child, Corpus Callosum (drug effects), Corpus Callosum (pathology), Diagnosis, Differential, Encephalitis (drug therapy), Encephalitis (metabolism), Encephalitis (pathology), Enterococcus faecalis, Gram-Positive Bacterial Infections (metabolism), Humans, Interleukin-6 (metabolism), Magnetic Resonance Imaging, Male, Nephritis (drug therapy), Nephritis (metabolism), Nephritis (pathology), Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- chemical , metabolism : Interleukin-6.
- chemical , therapeutic use : Ampicillin, Anti-Bacterial Agents.
- drug effects : Corpus Callosum.
- drug therapy : Encephalitis, Nephritis.
- metabolism : Encephalitis, Gram-Positive Bacterial Infections, Nephritis.
- pathology : Corpus Callosum, Encephalitis, Nephritis.
- Child, Diagnosis, Differential, Enterococcus faecalis, Humans, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS.
DOI: 10.1016/j.braindev.2013.07.012
PubMed: 23978488
Links to Exploration step
pubmed:23978488Le document en format XML
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Electronic address: hkometa@hotmail.co.jp.</nlm:affiliation></affiliation></author><author><name sortKey="Kawatani, Masao" sort="Kawatani, Masao" uniqKey="Kawatani M" first="Masao" last="Kawatani">Masao Kawatani</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ohta, Genrei" sort="Ohta, Genrei" uniqKey="Ohta G" first="Genrei" last="Ohta">Genrei Ohta</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Okazaki, Shintaro" sort="Okazaki, Shintaro" uniqKey="Okazaki S" first="Shintaro" last="Okazaki">Shintaro Okazaki</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ogura, Kazumasa" sort="Ogura, Kazumasa" uniqKey="Ogura K" first="Kazumasa" last="Ogura">Kazumasa Ogura</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yasutomi, Motoko" sort="Yasutomi, Motoko" uniqKey="Yasutomi M" first="Motoko" last="Yasutomi">Motoko Yasutomi</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tanizawa, Akihiko" sort="Tanizawa, Akihiko" uniqKey="Tanizawa A" first="Akihiko" last="Tanizawa">Akihiko Tanizawa</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ohshima, Yusei" sort="Ohshima, Yusei" uniqKey="Ohshima Y" first="Yusei" last="Ohshima">Yusei Ohshima</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23978488</idno><idno type="pmid">23978488</idno><idno type="doi">10.1016/j.braindev.2013.07.012</idno><idno type="wicri:Area/PubMed/Corpus">001C06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.</title><author><name sortKey="Kometani, Hiroshi" sort="Kometani, Hiroshi" uniqKey="Kometani H" first="Hiroshi" last="Kometani">Hiroshi Kometani</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address: hkometa@hotmail.co.jp.</nlm:affiliation></affiliation></author><author><name sortKey="Kawatani, Masao" sort="Kawatani, Masao" uniqKey="Kawatani M" first="Masao" last="Kawatani">Masao Kawatani</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ohta, Genrei" sort="Ohta, Genrei" uniqKey="Ohta G" first="Genrei" last="Ohta">Genrei Ohta</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Okazaki, Shintaro" sort="Okazaki, Shintaro" uniqKey="Okazaki S" first="Shintaro" last="Okazaki">Shintaro Okazaki</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ogura, Kazumasa" sort="Ogura, Kazumasa" uniqKey="Ogura K" first="Kazumasa" last="Ogura">Kazumasa Ogura</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yasutomi, Motoko" sort="Yasutomi, Motoko" uniqKey="Yasutomi M" first="Motoko" last="Yasutomi">Motoko Yasutomi</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tanizawa, Akihiko" sort="Tanizawa, Akihiko" uniqKey="Tanizawa A" first="Akihiko" last="Tanizawa">Akihiko Tanizawa</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ohshima, Yusei" sort="Ohshima, Yusei" uniqKey="Ohshima Y" first="Yusei" last="Ohshima">Yusei Ohshima</name><affiliation><nlm:affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Brain & development</title><idno type="eISSN">1872-7131</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ampicillin (therapeutic use)</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Child</term><term>Corpus Callosum (drug effects)</term><term>Corpus Callosum (pathology)</term><term>Diagnosis, Differential</term><term>Encephalitis (drug therapy)</term><term>Encephalitis (metabolism)</term><term>Encephalitis (pathology)</term><term>Enterococcus faecalis</term><term>Gram-Positive Bacterial Infections (metabolism)</term><term>Humans</term><term>Interleukin-6 (metabolism)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Nephritis (drug therapy)</term><term>Nephritis (metabolism)</term><term>Nephritis (pathology)</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ampicillin</term><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Callosum</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Encephalitis</term><term>Nephritis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Encephalitis</term><term>Gram-Positive Bacterial Infections</term><term>Nephritis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term><term>Encephalitis</term><term>Nephritis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Diagnosis, Differential</term><term>Enterococcus faecalis</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23978488</PMID><DateCompleted><Year>2015</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2014</Year><Month>06</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7131</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Brain & development</Title><ISOAbbreviation>Brain Dev.</ISOAbbreviation></Journal><ArticleTitle>Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.</ArticleTitle><Pagination><MedlinePgn>551-3</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.braindev.2013.07.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0387-7604(13)00233-7</ELocationID><Abstract><AbstractText>This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS. </AbstractText><CopyrightInformation>Copyright © 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kometani</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address: hkometa@hotmail.co.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kawatani</LastName><ForeName>Masao</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohta</LastName><ForeName>Genrei</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okazaki</LastName><ForeName>Shintaro</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogura</LastName><ForeName>Kazumasa</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yasutomi</LastName><ForeName>Motoko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanizawa</LastName><ForeName>Akihiko</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohshima</LastName><ForeName>Yusei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Dev</MedlineTA><NlmUniqueID>7909235</NlmUniqueID><ISSNLinking>0387-7604</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>7C782967RD</RegistryNumber><NameOfSubstance UI="D000667">Ampicillin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000667" MajorTopicYN="N">Ampicillin</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003337" MajorTopicYN="N">Corpus Callosum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004660" MajorTopicYN="N">Encephalitis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013293" MajorTopicYN="Y">Enterococcus faecalis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016908" MajorTopicYN="N">Gram-Positive Bacterial Infections</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009393" MajorTopicYN="N">Nephritis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute focal bacterial nephritis</Keyword><Keyword MajorTopicYN="N">Corpus callosum</Keyword><Keyword MajorTopicYN="N">Cytokine</Keyword><Keyword MajorTopicYN="N">Encephalitis</Keyword><Keyword MajorTopicYN="N">Encephalopathy</Keyword><Keyword MajorTopicYN="N">Splenium</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>11</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>07</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23978488</ArticleId><ArticleId IdType="pii">S0387-7604(13)00233-7</ArticleId><ArticleId IdType="doi">10.1016/j.braindev.2013.07.012</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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