Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.
Identifieur interne : 001833 ( PubMed/Checkpoint ); précédent : 001832; suivant : 001834Marked elevation of interleukin-6 in mild encephalopathy with a reversible splenial lesion (MERS) associated with acute focal bacterial nephritis caused by Enterococcus faecalis.
Auteurs : Hiroshi Kometani [Japon] ; Masao Kawatani [Japon] ; Genrei Ohta [Japon] ; Shintaro Okazaki [Japon] ; Kazumasa Ogura [Japon] ; Motoko Yasutomi [Japon] ; Akihiko Tanizawa [Japon] ; Yusei Ohshima [Japon]Source :
- Brain & development [ 1872-7131 ] ; 2014.
Descripteurs français
- KwdFr :
- Ampicilline (usage thérapeutique), Antibactériens (usage thérapeutique), Corps calleux (), Corps calleux (anatomopathologie), Diagnostic différentiel, Encéphalite (anatomopathologie), Encéphalite (métabolisme), Encéphalite (traitement médicamenteux), Enfant, Enterococcus faecalis, Humains, Imagerie par résonance magnétique, Infections bactériennes à Gram positif (métabolisme), Interleukine-6 (métabolisme), Mâle, Néphrite (anatomopathologie), Néphrite (métabolisme), Néphrite (traitement médicamenteux), Résultat thérapeutique, Tomodensitométrie.
- MESH :
- anatomopathologie : Corps calleux, Encéphalite, Néphrite.
- métabolisme : Encéphalite, Infections bactériennes à Gram positif, Interleukine-6, Néphrite.
- traitement médicamenteux : Encéphalite, Néphrite.
- usage thérapeutique : Ampicilline, Antibactériens.
- Corps calleux, Diagnostic différentiel, Enfant, Enterococcus faecalis, Humains, Imagerie par résonance magnétique, Mâle, Résultat thérapeutique, Tomodensitométrie.
English descriptors
- KwdEn :
- Ampicillin (therapeutic use), Anti-Bacterial Agents (therapeutic use), Child, Corpus Callosum (drug effects), Corpus Callosum (pathology), Diagnosis, Differential, Encephalitis (drug therapy), Encephalitis (metabolism), Encephalitis (pathology), Enterococcus faecalis, Gram-Positive Bacterial Infections (metabolism), Humans, Interleukin-6 (metabolism), Magnetic Resonance Imaging, Male, Nephritis (drug therapy), Nephritis (metabolism), Nephritis (pathology), Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- chemical , metabolism : Interleukin-6.
- chemical , therapeutic use : Ampicillin, Anti-Bacterial Agents.
- drug effects : Corpus Callosum.
- drug therapy : Encephalitis, Nephritis.
- metabolism : Encephalitis, Gram-Positive Bacterial Infections, Nephritis.
- pathology : Corpus Callosum, Encephalitis, Nephritis.
- Child, Diagnosis, Differential, Enterococcus faecalis, Humans, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS.
DOI: 10.1016/j.braindev.2013.07.012
PubMed: 23978488
Affiliations:
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pubmed:23978488Le document en format XML
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<front><div type="abstract" xml:lang="en">This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS. </div>
</front>
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<Abstract><AbstractText>This report describes two cases of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with acute focal bacterial nephritis (AFBN). The patients, who presented with fever and delirious behavior, exhibited hyponatremia and markedly elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) and serum. Enterococcus faecalis was detected in the urine culture. After ampicillin treatment, their consciousness improved without neurological sequelae. Moreover, a diffusion-weighted MRI abnormality, i.e., intensified signals in splenium of the corpus callosum, disappeared. MERS is a possible complication of AFBN. Elevated CSF IL-6 levels suggest that remote activation of intracerebral immune response through the immune-neuroendocrine pathway might play an important role in the pathophysiology of MERS. </AbstractText>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D013293" MajorTopicYN="Y">Enterococcus faecalis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016908" MajorTopicYN="N">Gram-Positive Bacterial Infections</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009393" MajorTopicYN="N">Nephritis</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute focal bacterial nephritis</Keyword>
<Keyword MajorTopicYN="N">Corpus callosum</Keyword>
<Keyword MajorTopicYN="N">Cytokine</Keyword>
<Keyword MajorTopicYN="N">Encephalitis</Keyword>
<Keyword MajorTopicYN="N">Encephalopathy</Keyword>
<Keyword MajorTopicYN="N">Splenium</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>11</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2013</Year>
<Month>07</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2013</Year>
<Month>07</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>8</Month>
<Day>28</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
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<PubMedPubDate PubStatus="medline"><Year>2015</Year>
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<ArticleIdList><ArticleId IdType="pubmed">23978488</ArticleId>
<ArticleId IdType="pii">S0387-7604(13)00233-7</ArticleId>
<ArticleId IdType="doi">10.1016/j.braindev.2013.07.012</ArticleId>
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<affiliations><list><country><li>Japon</li>
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</list>
<tree><country name="Japon"><noRegion><name sortKey="Kometani, Hiroshi" sort="Kometani, Hiroshi" uniqKey="Kometani H" first="Hiroshi" last="Kometani">Hiroshi Kometani</name>
</noRegion>
<name sortKey="Kawatani, Masao" sort="Kawatani, Masao" uniqKey="Kawatani M" first="Masao" last="Kawatani">Masao Kawatani</name>
<name sortKey="Ogura, Kazumasa" sort="Ogura, Kazumasa" uniqKey="Ogura K" first="Kazumasa" last="Ogura">Kazumasa Ogura</name>
<name sortKey="Ohshima, Yusei" sort="Ohshima, Yusei" uniqKey="Ohshima Y" first="Yusei" last="Ohshima">Yusei Ohshima</name>
<name sortKey="Ohta, Genrei" sort="Ohta, Genrei" uniqKey="Ohta G" first="Genrei" last="Ohta">Genrei Ohta</name>
<name sortKey="Okazaki, Shintaro" sort="Okazaki, Shintaro" uniqKey="Okazaki S" first="Shintaro" last="Okazaki">Shintaro Okazaki</name>
<name sortKey="Tanizawa, Akihiko" sort="Tanizawa, Akihiko" uniqKey="Tanizawa A" first="Akihiko" last="Tanizawa">Akihiko Tanizawa</name>
<name sortKey="Yasutomi, Motoko" sort="Yasutomi, Motoko" uniqKey="Yasutomi M" first="Motoko" last="Yasutomi">Motoko Yasutomi</name>
</country>
</tree>
</affiliations>
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