The SARS-CoV Fusion Peptide Forms an Extended Bipartite Fusion Platform that Perturbs Membrane Order in a Calcium-Dependent Manner
Identifieur interne : 000B62 ( Main/Merge ); précédent : 000B61; suivant : 000B63The SARS-CoV Fusion Peptide Forms an Extended Bipartite Fusion Platform that Perturbs Membrane Order in a Calcium-Dependent Manner
Auteurs : Alex L. Lai [États-Unis] ; Jean K. Millet [États-Unis] ; Susan Daniel [États-Unis] ; Jack H. Freed [États-Unis] ; Gary R. Whittaker [États-Unis]Source :
- Journal of Molecular Biology [ 0022-2836 ] ; 2017.
Descripteurs français
- KwdFr :
- Calcium (métabolisme), Cellules HEK293, Conformation des protéines, Fragments peptidiques (), Fragments peptidiques (métabolisme), Fusion membranaire (physiologie), Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Pénétration virale, Similitude de séquences, Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (métabolisme).
- MESH :
- métabolisme : Calcium, Fragments peptidiques, Glycoprotéine de spicule des coronavirus, Virus du SRAS.
- physiologie : Fusion membranaire.
- Cellules HEK293, Conformation des protéines, Fragments peptidiques, Glycoprotéine de spicule des coronavirus, Humains, Pénétration virale, Similitude de séquences, Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Base Sequence, Calcium (metabolism), HEK293 Cells, Humans, Membrane Fusion (physiology), Peptide Fragments (chemistry), Peptide Fragments (metabolism), Protein Conformation, SARS Virus (chemistry), SARS Virus (metabolism), Sequence Homology, Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (metabolism), Virus Internalization.
- MESH :
- chemical , chemistry : Peptide Fragments, Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Calcium, Peptide Fragments, Spike Glycoprotein, Coronavirus.
- chemistry : SARS Virus.
- metabolism : SARS Virus.
- physiology : Membrane Fusion.
- Amino Acid Sequence, Base Sequence, HEK293 Cells, Humans, Protein Conformation, Sequence Homology, Virus Internalization.
Abstract
Coronaviruses (CoVs) are a major infectious disease threat and include the pathogenic human pathogens of zoonotic origin: severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV). Entry of CoVs into host cells is mediated by the viral spike (S) protein, which is structurally categorized as a class I viral fusion protein, within the same group as influenza virus and HIV. However, S proteins have two distinct cleavage sites that can be activated by a much wider range of proteases. The exact location of the CoV fusion peptide (FP) has been disputed. However, most evidence suggests that the domain immediately downstream of the S2′ cleavage site is the FP (amino acids 798–818 SFIEDLLFNKVTLADAGFMKQY for SARS-CoV, FP1). In our previous electron spin resonance spectroscopic studies, the membrane-ordering effect of influenza virus, HIV, and Dengue virus FPs has been consistently observed. In this study, we used this effect as a criterion to identify and characterize the
Url:
DOI: 10.1016/j.jmb.2017.10.017
PubMed: 29056462
PubMed Central: 5705393
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PMC:5705393Le document en format XML
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<term>HEK293 Cells</term>
<term>Humans</term>
<term>Membrane Fusion (physiology)</term>
<term>Peptide Fragments (chemistry)</term>
<term>Peptide Fragments (metabolism)</term>
<term>Protein Conformation</term>
<term>SARS Virus (chemistry)</term>
<term>SARS Virus (metabolism)</term>
<term>Sequence Homology</term>
<term>Spike Glycoprotein, Coronavirus (chemistry)</term>
<term>Spike Glycoprotein, Coronavirus (metabolism)</term>
<term>Virus Internalization</term>
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<term>Fragments peptidiques (métabolisme)</term>
<term>Fusion membranaire (physiologie)</term>
<term>Glycoprotéine de spicule des coronavirus ()</term>
<term>Glycoprotéine de spicule des coronavirus (métabolisme)</term>
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<term>Pénétration virale</term>
<term>Similitude de séquences</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (métabolisme)</term>
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<term>Glycoprotéine de spicule des coronavirus</term>
<term>Virus du SRAS</term>
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<term>Sequence Homology</term>
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<front><div type="abstract" xml:lang="en"><p>Coronaviruses (CoVs) are a major infectious disease threat and include the pathogenic human pathogens of zoonotic origin: severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV). Entry of CoVs into host cells is mediated by the viral spike (S) protein, which is structurally categorized as a class I viral fusion protein, within the same group as influenza virus and HIV. However, S proteins have two distinct cleavage sites that can be activated by a much wider range of proteases. The exact location of the CoV fusion peptide (FP) has been disputed. However, most evidence suggests that the domain immediately downstream of the S2′ cleavage site is the FP (amino acids 798–818 SFIEDLLFNKVTLADAGFMKQY for SARS-CoV, FP1). In our previous electron spin resonance spectroscopic studies, the membrane-ordering effect of influenza virus, HIV, and Dengue virus FPs has been consistently observed. In this study, we used this effect as a criterion to identify and characterize the <italic>bona fide</italic>
SARS-CoV FP. Our results indicate that both FP1 and the region immediately downstream (amino acids 816–835 KQYGECLGDINARDLICAQKF, FP2) induce significant membrane ordering. Furthermore, their effects are calcium dependent, which is consistent with <italic>in vivo</italic>
data showing that calcium is required for SARS-CoV S-mediated fusion. Isothermal titration calorimetry showed a direct interaction between calcium cations and both FPs. This Ca<sup>2 +</sup>
-dependency membrane ordering was not observed with influenza FP, indicating that the CoV FP exhibits a mechanistically different behavior. Membrane-ordering effects are greater and penetrate deeper into membranes when FP1 and FP2 act in a concerted manner, suggesting that they form an extended fusion “platform.”</p>
</div>
</front>
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</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
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{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:5705393 |texte= The SARS-CoV Fusion Peptide Forms an Extended Bipartite Fusion Platform that Perturbs Membrane Order in a Calcium-Dependent Manner }}
Pour générer des pages wiki
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