Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
Identifieur interne : 000B39 ( Main/Merge ); précédent : 000B38; suivant : 000B40Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
Auteurs : Qian Xie [République populaire de Chine] ; Yujuan Cao [République populaire de Chine] ; Juan Su [République populaire de Chine] ; Jie Wu [République populaire de Chine] ; Xianbo Wu [République populaire de Chine] ; Chengsong Wan [République populaire de Chine] ; Mingliang He [République populaire de Chine] ; Changwen Ke [République populaire de Chine] ; Bao Zhang [République populaire de Chine] ; Wei Zhao [République populaire de Chine]Source :
- Archives of Virology [ 0304-8608 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Analyse de séquence d'ADN, Biologie informatique, Cadres ouverts de lecture, Chine, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Délétion de gène, Fièvre (virologie), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Partie nasale du pharynx (virologie), Protéines de l'enveloppe virale (génétique), Toux (virologie), Variation génétique, Voyage.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Protéines de l'enveloppe virale.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Fièvre, Infections à coronavirus, Partie nasale du pharynx, Toux.
- Adulte, Analyse de séquence d'ADN, Biologie informatique, Cadres ouverts de lecture, Chine, Délétion de gène, Humains, Variation génétique, Voyage.
English descriptors
- KwdEn :
- Adult, China, Computational Biology, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Cough (virology), Fever (virology), Gene Deletion, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasopharynx (virology), Open Reading Frames, Sequence Analysis, DNA, Travel, Viral Envelope Proteins (genetics).
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Cough, Fever, Nasopharynx.
- Adult, China, Computational Biology, Gene Deletion, Genetic Variation, Humans, Open Reading Frames, Sequence Analysis, DNA, Travel.
Abstract
Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.
The online version of this article (doi:10.1007/s00705-017-3361-x) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00705-017-3361-x
PubMed: 28421366
PubMed Central: 5506503
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PMC:5506503Le document en format XML
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<author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
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<series><title level="j">Archives of Virology</title>
<idno type="ISSN">0304-8608</idno>
<idno type="eISSN">1432-8798</idno>
<imprint><date when="2017">2017</date>
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<term>China</term>
<term>Computational Biology</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Cough (virology)</term>
<term>Fever (virology)</term>
<term>Gene Deletion</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Nasopharynx (virology)</term>
<term>Open Reading Frames</term>
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<term>Viral Envelope Proteins (genetics)</term>
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<term>Analyse de séquence d'ADN</term>
<term>Biologie informatique</term>
<term>Cadres ouverts de lecture</term>
<term>Chine</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Délétion de gène</term>
<term>Fièvre (virologie)</term>
<term>Humains</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Protéines de l'enveloppe virale</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fièvre</term>
<term>Infections à coronavirus</term>
<term>Partie nasale du pharynx</term>
<term>Toux</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Cough</term>
<term>Fever</term>
<term>Nasopharynx</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>China</term>
<term>Computational Biology</term>
<term>Gene Deletion</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Open Reading Frames</term>
<term>Sequence Analysis, DNA</term>
<term>Travel</term>
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<term>Analyse de séquence d'ADN</term>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1007/s00705-017-3361-x) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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