Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.
Identifieur interne : 000A76 ( PubMed/Checkpoint ); précédent : 000A75; suivant : 000A77Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.
Auteurs : Qian Xie [République populaire de Chine] ; Yujuan Cao [République populaire de Chine] ; Juan Su [République populaire de Chine] ; Jie Wu [République populaire de Chine] ; Xianbo Wu [République populaire de Chine] ; Chengsong Wan [République populaire de Chine] ; Mingliang He [République populaire de Chine] ; Changwen Ke [République populaire de Chine] ; Bao Zhang [République populaire de Chine] ; Wei Zhao [République populaire de Chine]Source :
- Archives of virology [ 1432-8798 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Analyse de séquence d'ADN, Biologie informatique, Cadres ouverts de lecture, Chine, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Délétion de gène, Fièvre (virologie), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Partie nasale du pharynx (virologie), Protéines de l'enveloppe virale (génétique), Toux (virologie), Variation génétique, Voyage.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Protéines de l'enveloppe virale.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Fièvre, Infections à coronavirus, Partie nasale du pharynx, Toux.
- Adulte, Analyse de séquence d'ADN, Biologie informatique, Cadres ouverts de lecture, Chine, Délétion de gène, Humains, Variation génétique, Voyage.
English descriptors
- KwdEn :
- Adult, China, Computational Biology, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Cough (virology), Fever (virology), Gene Deletion, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasopharynx (virology), Open Reading Frames, Sequence Analysis, DNA, Travel, Viral Envelope Proteins (genetics).
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Cough, Fever, Nasopharynx.
- Adult, China, Computational Biology, Gene Deletion, Genetic Variation, Humans, Open Reading Frames, Sequence Analysis, DNA, Travel.
Abstract
Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.
DOI: 10.1007/s00705-017-3361-x
PubMed: 28421366
Affiliations:
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uniqKey="Su J" first="Juan" last="Su">Juan Su</name><affiliation wicri:level="3"><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><affiliation wicri:level="3"><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="He, Mingliang" sort="He, Mingliang" uniqKey="He M" first="Mingliang" last="He">Mingliang He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><affiliation wicri:level="3"><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. kecw1965@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao 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Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhaowei@smu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28421366</idno><idno type="pmid">28421366</idno><idno type="doi">10.1007/s00705-017-3361-x</idno><idno type="wicri:Area/PubMed/Corpus">000D12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" 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populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Yujuan" sort="Cao, Yujuan" uniqKey="Cao Y" first="Yujuan" last="Cao">Yujuan Cao</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="Su, Juan" sort="Su, Juan" uniqKey="Su J" first="Juan" last="Su">Juan Su</name><affiliation wicri:level="3"><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><affiliation wicri:level="3"><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="He, Mingliang" sort="He, Mingliang" uniqKey="He M" first="Mingliang" last="He">Mingliang He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><affiliation wicri:level="3"><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. kecw1965@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhang20051005@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhaowei@smu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515</wicri:regionArea><wicri:noRegion>510515</wicri:noRegion></affiliation></author></analytic><series><title level="j">Archives of virology</title><idno type="eISSN">1432-8798</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>China</term><term>Computational Biology</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Cough (virology)</term><term>Fever (virology)</term><term>Gene Deletion</term><term>Genetic Variation</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Nasopharynx (virology)</term><term>Open Reading Frames</term><term>Sequence Analysis, DNA</term><term>Travel</term><term>Viral Envelope Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Analyse de séquence d'ADN</term><term>Biologie informatique</term><term>Cadres ouverts de lecture</term><term>Chine</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Délétion de gène</term><term>Fièvre (virologie)</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Partie nasale du pharynx (virologie)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Toux (virologie)</term><term>Variation génétique</term><term>Voyage</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fièvre</term><term>Infections à coronavirus</term><term>Partie nasale du pharynx</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Cough</term><term>Fever</term><term>Nasopharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>China</term><term>Computational Biology</term><term>Gene Deletion</term><term>Genetic Variation</term><term>Humans</term><term>Open Reading Frames</term><term>Sequence Analysis, DNA</term><term>Travel</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Analyse de séquence d'ADN</term><term>Biologie informatique</term><term>Cadres ouverts de lecture</term><term>Chine</term><term>Délétion de gène</term><term>Humains</term><term>Variation génétique</term><term>Voyage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28421366</PMID><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-8798</ISSN><JournalIssue CitedMedium="Internet"><Volume>162</Volume><Issue>8</Issue><PubDate><Year>2017</Year><Month>08</Month></PubDate></JournalIssue><Title>Archives of virology</Title><ISOAbbreviation>Arch. Virol.</ISOAbbreviation></Journal><ArticleTitle>Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.</ArticleTitle><Pagination><MedlinePgn>2445-2449</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00705-017-3361-x</ELocationID><Abstract><AbstractText>Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Xie</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Cao</LastName><ForeName>Yujuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xianbo</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Chengsong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Mingliang</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ke</LastName><ForeName>Changwen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. kecw1965@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhang</LastName><ForeName>Bao</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhang20051005@126.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China. zhang20051005@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhao</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhaowei@smu.edu.cn.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China. zhaowei@smu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>Arch Virol</MedlineTA><NlmUniqueID>7506870</NlmUniqueID><ISSNLinking>0304-8608</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus 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last="Su">Juan Su</name><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao Zhang</name><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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