Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.
Identifieur interne : 000D12 ( PubMed/Corpus ); précédent : 000D11; suivant : 000D13Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.
Auteurs : Qian Xie ; Yujuan Cao ; Juan Su ; Jie Wu ; Xianbo Wu ; Chengsong Wan ; Mingliang He ; Changwen Ke ; Bao Zhang ; Wei ZhaoSource :
- Archives of virology [ 1432-8798 ] ; 2017.
English descriptors
- KwdEn :
- Adult, China, Computational Biology, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Cough (virology), Fever (virology), Gene Deletion, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasopharynx (virology), Open Reading Frames, Sequence Analysis, DNA, Travel, Viral Envelope Proteins (genetics).
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Cough, Fever, Nasopharynx.
- Adult, China, Computational Biology, Gene Deletion, Genetic Variation, Humans, Open Reading Frames, Sequence Analysis, DNA, Travel.
Abstract
Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.
DOI: 10.1007/s00705-017-3361-x
PubMed: 28421366
Links to Exploration step
pubmed:28421366Le document en format XML
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<front><div type="abstract" xml:lang="en">Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</div>
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<Abstract><AbstractText>Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</AbstractText>
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