Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.
Identifieur interne : 000D12 ( PubMed/Corpus ); précédent : 000D11; suivant : 000D13Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.
Auteurs : Qian Xie ; Yujuan Cao ; Juan Su ; Jie Wu ; Xianbo Wu ; Chengsong Wan ; Mingliang He ; Changwen Ke ; Bao Zhang ; Wei ZhaoSource :
- Archives of virology [ 1432-8798 ] ; 2017.
English descriptors
- KwdEn :
- Adult, China, Computational Biology, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Cough (virology), Fever (virology), Gene Deletion, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasopharynx (virology), Open Reading Frames, Sequence Analysis, DNA, Travel, Viral Envelope Proteins (genetics).
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Cough, Fever, Nasopharynx.
- Adult, China, Computational Biology, Gene Deletion, Genetic Variation, Humans, Open Reading Frames, Sequence Analysis, DNA, Travel.
Abstract
Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.
DOI: 10.1007/s00705-017-3361-x
PubMed: 28421366
Links to Exploration step
pubmed:28421366Le document en format XML
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1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Juan" sort="Su, Juan" uniqKey="Su J" first="Juan" last="Su">Juan Su</name><affiliation><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><affiliation><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Mingliang" sort="He, Mingliang" uniqKey="He M" first="Mingliang" last="He">Mingliang 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510515, People's Republic of China. zhang20051005@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhaowei@smu.edu.cn.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28421366</idno><idno type="pmid">28421366</idno><idno type="doi">10.1007/s00705-017-3361-x</idno><idno type="wicri:Area/PubMed/Corpus">000D12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.</title><author><name sortKey="Xie, Qian" sort="Xie, Qian" uniqKey="Xie Q" first="Qian" last="Xie">Qian Xie</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Yujuan" sort="Cao, Yujuan" uniqKey="Cao Y" first="Yujuan" last="Cao">Yujuan Cao</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Juan" sort="Su, Juan" uniqKey="Su J" first="Juan" last="Su">Juan Su</name><affiliation><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><affiliation><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Mingliang" sort="He, Mingliang" uniqKey="He M" first="Mingliang" last="He">Mingliang He</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><affiliation><nlm:affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. kecw1965@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao Zhang</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhang20051005@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><affiliation><nlm:affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhaowei@smu.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Archives of virology</title><idno type="eISSN">1432-8798</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>China</term><term>Computational Biology</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Cough (virology)</term><term>Fever (virology)</term><term>Gene Deletion</term><term>Genetic Variation</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Nasopharynx (virology)</term><term>Open Reading Frames</term><term>Sequence Analysis, DNA</term><term>Travel</term><term>Viral Envelope Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Cough</term><term>Fever</term><term>Nasopharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>China</term><term>Computational Biology</term><term>Gene Deletion</term><term>Genetic Variation</term><term>Humans</term><term>Open Reading Frames</term><term>Sequence Analysis, DNA</term><term>Travel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28421366</PMID><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-8798</ISSN><JournalIssue CitedMedium="Internet"><Volume>162</Volume><Issue>8</Issue><PubDate><Year>2017</Year><Month>08</Month></PubDate></JournalIssue><Title>Archives of virology</Title><ISOAbbreviation>Arch. Virol.</ISOAbbreviation></Journal><ArticleTitle>Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms.</ArticleTitle><Pagination><MedlinePgn>2445-2449</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00705-017-3361-x</ELocationID><Abstract><AbstractText>Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Xie</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Cao</LastName><ForeName>Yujuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xianbo</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Chengsong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Mingliang</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ke</LastName><ForeName>Changwen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. kecw1965@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhang</LastName><ForeName>Bao</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhang20051005@126.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China. zhang20051005@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhao</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023 Shatai Road, Guangzhou, 510515, People's Republic of China. zhaowei@smu.edu.cn.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health, Southern Medical University, Guangzhou, 510515, China. zhaowei@smu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>Arch Virol</MedlineTA><NlmUniqueID>7506870</NlmUniqueID><ISSNLinking>0304-8608</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus 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