Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Identifieur interne : 001C62 ( Main/Exploration ); précédent : 001C61; suivant : 001C63Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Auteurs : Adeyemi O. Adedeji [États-Unis] ; Kamalendra Singh [États-Unis] ; Ademola Kassim [États-Unis] ; Christopher M. Coleman [États-Unis] ; Ruth Elliott [États-Unis] ; Susan R. Weiss [États-Unis] ; Matthew B. Frieman [États-Unis] ; Stefan G. Sarafianos [États-Unis]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Antiviraux (), Antiviraux (pharmacologie), Cellules Vero, Concentration inhibitrice 50, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Données de séquences moléculaires, Fibroblastes (), Fibroblastes (anatomopathologie), Fibroblastes (virologie), Helicase (), Helicase (antagonistes et inhibiteurs), Humains, Liaison aux protéines, Lignée cellulaire, Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Relation dose-effet des médicaments, Réplication virale (), Similitude de séquences d'acides aminés, Simulation de docking moléculaire, Sites de fixation, Souris, Séquence d'acides aminés, Triazoles (), Triazoles (pharmacologie), Virus de l'hépatite murine (), Virus de l'hépatite murine (physiologie), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Fibroblastes.
- antagonistes et inhibiteurs : Helicase, Protéines virales.
- pharmacologie : Antiviraux, Triazoles.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus de l'hépatite murine, Virus du SRAS.
- virologie : Fibroblastes.
- Alignement de séquences, Animaux, Antiviraux, Cellules Vero, Concentration inhibitrice 50, Coronavirus du syndrome respiratoire du Moyen-Orient, Données de séquences moléculaires, Fibroblastes, Helicase, Humains, Liaison aux protéines, Lignée cellulaire, Protéines virales, Relation dose-effet des médicaments, Réplication virale, Similitude de séquences d'acides aminés, Simulation de docking moléculaire, Sites de fixation, Souris, Séquence d'acides aminés, Triazoles, Virus de l'hépatite murine, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Binding Sites, Cell Line, Chlorocebus aethiops, DNA Helicases (antagonists & inhibitors), DNA Helicases (chemistry), Dose-Response Relationship, Drug, Fibroblasts (drug effects), Fibroblasts (pathology), Fibroblasts (virology), Humans, Inhibitory Concentration 50, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Molecular Docking Simulation, Molecular Sequence Data, Murine hepatitis virus (drug effects), Murine hepatitis virus (physiology), Protein Binding, SARS Virus (drug effects), SARS Virus (physiology), Sequence Alignment, Sequence Homology, Amino Acid, Triazoles (chemistry), Triazoles (pharmacology), Vero Cells, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Virus Replication (drug effects).
- MESH :
- chemical , antagonists & inhibitors : DNA Helicases, Viral Proteins.
- chemical , chemistry : Antiviral Agents, DNA Helicases, Triazoles, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Triazoles.
- drug effects : Fibroblasts, Middle East Respiratory Syndrome Coronavirus, Murine hepatitis virus, SARS Virus, Virus Replication.
- pathology : Fibroblasts.
- physiology : Middle East Respiratory Syndrome Coronavirus, Murine hepatitis virus, SARS Virus.
- virology : Fibroblasts.
- Amino Acid Sequence, Animals, Binding Sites, Cell Line, Chlorocebus aethiops, Dose-Response Relationship, Drug, Humans, Inhibitory Concentration 50, Mice, Molecular Docking Simulation, Molecular Sequence Data, Protein Binding, Sequence Alignment, Sequence Homology, Amino Acid, Vero Cells.
Abstract
We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.
DOI: 10.1128/AAC.02994-14
PubMed: 24841268
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001978
- to stream PubMed, to step Curation: 001978
- to stream PubMed, to step Checkpoint: 001916
- to stream Ncbi, to step Merge: 000D68
- to stream Ncbi, to step Curation: 000D68
- to stream Ncbi, to step Checkpoint: 000D68
- to stream Main, to step Merge: 001C75
- to stream Main, to step Curation: 001C62
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.</title>
<author><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singh, Kamalendra" sort="Singh, Kamalendra" uniqKey="Singh K" first="Kamalendra" last="Singh">Kamalendra Singh</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kassim, Ademola" sort="Kassim, Ademola" uniqKey="Kassim A" first="Ademola" last="Kassim">Ademola Kassim</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M" last="Coleman">Christopher M. Coleman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elliott, Ruth" sort="Elliott, Ruth" uniqKey="Elliott R" first="Ruth" last="Elliott">Ruth Elliott</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R" last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B" last="Frieman">Matthew B. Frieman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA Department of Biochemistry, University of Missouri, Columbia, Missouri, USA sarafianoss@missouri.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA Department of Biochemistry, University of Missouri, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24841268</idno>
<idno type="pmid">24841268</idno>
<idno type="doi">10.1128/AAC.02994-14</idno>
<idno type="wicri:Area/PubMed/Corpus">001978</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001978</idno>
<idno type="wicri:Area/PubMed/Curation">001978</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001978</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001916</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001916</idno>
<idno type="wicri:Area/Ncbi/Merge">000D68</idno>
<idno type="wicri:Area/Ncbi/Curation">000D68</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D68</idno>
<idno type="wicri:Area/Main/Merge">001C75</idno>
<idno type="wicri:Area/Main/Curation">001C62</idno>
<idno type="wicri:Area/Main/Exploration">001C62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.</title>
<author><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singh, Kamalendra" sort="Singh, Kamalendra" uniqKey="Singh K" first="Kamalendra" last="Singh">Kamalendra Singh</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kassim, Ademola" sort="Kassim, Ademola" uniqKey="Kassim A" first="Ademola" last="Kassim">Ademola Kassim</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M" last="Coleman">Christopher M. Coleman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elliott, Ruth" sort="Elliott, Ruth" uniqKey="Elliott R" first="Ruth" last="Elliott">Ruth Elliott</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R" last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B" last="Frieman">Matthew B. Frieman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name>
<affiliation wicri:level="2"><nlm:affiliation>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA Department of Biochemistry, University of Missouri, Columbia, Missouri, USA sarafianoss@missouri.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA Department of Biochemistry, University of Missouri, Columbia, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Antimicrobial agents and chemotherapy</title>
<idno type="eISSN">1098-6596</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Binding Sites</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>DNA Helicases (chemistry)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Fibroblasts (drug effects)</term>
<term>Fibroblasts (pathology)</term>
<term>Fibroblasts (virology)</term>
<term>Humans</term>
<term>Inhibitory Concentration 50</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Molecular Docking Simulation</term>
<term>Molecular Sequence Data</term>
<term>Murine hepatitis virus (drug effects)</term>
<term>Murine hepatitis virus (physiology)</term>
<term>Protein Binding</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Triazoles (chemistry)</term>
<term>Triazoles (pharmacology)</term>
<term>Vero Cells</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (chemistry)</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Cellules Vero</term>
<term>Concentration inhibitrice 50</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Données de séquences moléculaires</term>
<term>Fibroblastes ()</term>
<term>Fibroblastes (anatomopathologie)</term>
<term>Fibroblastes (virologie)</term>
<term>Helicase ()</term>
<term>Helicase (antagonistes et inhibiteurs)</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Protéines virales ()</term>
<term>Protéines virales (antagonistes et inhibiteurs)</term>
<term>Relation dose-effet des médicaments</term>
<term>Réplication virale ()</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Simulation de docking moléculaire</term>
<term>Sites de fixation</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Triazoles ()</term>
<term>Triazoles (pharmacologie)</term>
<term>Virus de l'hépatite murine ()</term>
<term>Virus de l'hépatite murine (physiologie)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>DNA Helicases</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>DNA Helicases</term>
<term>Triazoles</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Triazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fibroblastes</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Helicase</term>
<term>Protéines virales</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fibroblasts</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Murine hepatitis virus</term>
<term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibroblasts</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Triazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Virus de l'hépatite murine</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Murine hepatitis virus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fibroblastes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Fibroblasts</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Binding Sites</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>Dose-Response Relationship, Drug</term>
<term>Humans</term>
<term>Inhibitory Concentration 50</term>
<term>Mice</term>
<term>Molecular Docking Simulation</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Antiviraux</term>
<term>Cellules Vero</term>
<term>Concentration inhibitrice 50</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Données de séquences moléculaires</term>
<term>Fibroblastes</term>
<term>Helicase</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Protéines virales</term>
<term>Relation dose-effet des médicaments</term>
<term>Réplication virale</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Simulation de docking moléculaire</term>
<term>Sites de fixation</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Triazoles</term>
<term>Virus de l'hépatite murine</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors. </div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Missouri (État)</li>
<li>Pennsylvanie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Adedeji, Adeyemi O" sort="Adedeji, Adeyemi O" uniqKey="Adedeji A" first="Adeyemi O" last="Adedeji">Adeyemi O. Adedeji</name>
</region>
<name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M" last="Coleman">Christopher M. Coleman</name>
<name sortKey="Elliott, Ruth" sort="Elliott, Ruth" uniqKey="Elliott R" first="Ruth" last="Elliott">Ruth Elliott</name>
<name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B" last="Frieman">Matthew B. Frieman</name>
<name sortKey="Kassim, Ademola" sort="Kassim, Ademola" uniqKey="Kassim A" first="Ademola" last="Kassim">Ademola Kassim</name>
<name sortKey="Sarafianos, Stefan G" sort="Sarafianos, Stefan G" uniqKey="Sarafianos S" first="Stefan G" last="Sarafianos">Stefan G. Sarafianos</name>
<name sortKey="Singh, Kamalendra" sort="Singh, Kamalendra" uniqKey="Singh K" first="Kamalendra" last="Singh">Kamalendra Singh</name>
<name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R" last="Weiss">Susan R. Weiss</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:24841268 |texte= Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24841268" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |