Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Identifieur interne : 000D68 ( Ncbi/Curation ); précédent : 000D67; suivant : 000D69Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Auteurs : Adeyemi O. Adedeji [États-Unis] ; Kamalendra Singh [États-Unis] ; Ademola Kassim [États-Unis] ; Christopher M. Coleman [États-Unis] ; Ruth Elliott [États-Unis] ; Susan R. Weiss [États-Unis] ; Matthew B. Frieman [États-Unis] ; Stefan G. Sarafianos [États-Unis]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Antiviraux (), Antiviraux (pharmacologie), Cellules Vero, Concentration inhibitrice 50, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Données de séquences moléculaires, Fibroblastes (), Fibroblastes (anatomopathologie), Fibroblastes (virologie), Helicase (), Helicase (antagonistes et inhibiteurs), Humains, Liaison aux protéines, Lignée cellulaire, Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Relation dose-effet des médicaments, Réplication virale (), Similitude de séquences d'acides aminés, Simulation de docking moléculaire, Sites de fixation, Souris, Séquence d'acides aminés, Triazoles (), Triazoles (pharmacologie), Virus de l'hépatite murine (), Virus de l'hépatite murine (physiologie), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Fibroblastes.
- antagonistes et inhibiteurs : Helicase, Protéines virales.
- pharmacologie : Antiviraux, Triazoles.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus de l'hépatite murine, Virus du SRAS.
- virologie : Fibroblastes.
- Alignement de séquences, Animaux, Antiviraux, Cellules Vero, Concentration inhibitrice 50, Coronavirus du syndrome respiratoire du Moyen-Orient, Données de séquences moléculaires, Fibroblastes, Helicase, Humains, Liaison aux protéines, Lignée cellulaire, Protéines virales, Relation dose-effet des médicaments, Réplication virale, Similitude de séquences d'acides aminés, Simulation de docking moléculaire, Sites de fixation, Souris, Séquence d'acides aminés, Triazoles, Virus de l'hépatite murine, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Binding Sites, Cell Line, Chlorocebus aethiops, DNA Helicases (antagonists & inhibitors), DNA Helicases (chemistry), Dose-Response Relationship, Drug, Fibroblasts (drug effects), Fibroblasts (pathology), Fibroblasts (virology), Humans, Inhibitory Concentration 50, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Molecular Docking Simulation, Molecular Sequence Data, Murine hepatitis virus (drug effects), Murine hepatitis virus (physiology), Protein Binding, SARS Virus (drug effects), SARS Virus (physiology), Sequence Alignment, Sequence Homology, Amino Acid, Triazoles (chemistry), Triazoles (pharmacology), Vero Cells, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Virus Replication (drug effects).
- MESH :
- chemical , antagonists & inhibitors : DNA Helicases, Viral Proteins.
- chemical , chemistry : Antiviral Agents, DNA Helicases, Triazoles, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Triazoles.
- drug effects : Fibroblasts, Middle East Respiratory Syndrome Coronavirus, Murine hepatitis virus, SARS Virus, Virus Replication.
- pathology : Fibroblasts.
- physiology : Middle East Respiratory Syndrome Coronavirus, Murine hepatitis virus, SARS Virus.
- virology : Fibroblasts.
- Amino Acid Sequence, Animals, Binding Sites, Cell Line, Chlorocebus aethiops, Dose-Response Relationship, Drug, Humans, Inhibitory Concentration 50, Mice, Molecular Docking Simulation, Molecular Sequence Data, Protein Binding, Sequence Alignment, Sequence Homology, Amino Acid, Vero Cells.
Abstract
We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.
DOI: 10.1128/AAC.02994-14
PubMed: 24841268
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<term>Animals</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Binding Sites</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
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<term>Fibroblasts (virology)</term>
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<term>Inhibitory Concentration 50</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Molecular Docking Simulation</term>
<term>Molecular Sequence Data</term>
<term>Murine hepatitis virus (drug effects)</term>
<term>Murine hepatitis virus (physiology)</term>
<term>Protein Binding</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Triazoles (chemistry)</term>
<term>Triazoles (pharmacology)</term>
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<term>Virus Replication</term>
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<term>Animals</term>
<term>Binding Sites</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>Dose-Response Relationship, Drug</term>
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<term>Inhibitory Concentration 50</term>
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<term>Animaux</term>
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<term>Concentration inhibitrice 50</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Données de séquences moléculaires</term>
<term>Fibroblastes</term>
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<term>Humains</term>
<term>Liaison aux protéines</term>
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<front><div type="abstract" xml:lang="en">We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors. </div>
</front>
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