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Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

Identifieur interne : 001978 ( PubMed/Curation ); précédent : 001977; suivant : 001979

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

Auteurs : Adeyemi O. Adedeji [États-Unis] ; Kamalendra Singh [États-Unis] ; Ademola Kassim [États-Unis] ; Christopher M. Coleman [États-Unis] ; Ruth Elliott [États-Unis] ; Susan R. Weiss [États-Unis] ; Matthew B. Frieman [États-Unis] ; Stefan G. Sarafianos [États-Unis]

Source :

Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2014.

RBID : pubmed:24841268

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Binding Sites, Cell Line, Chlorocebus aethiops, DNA Helicases (antagonists & inhibitors), DNA Helicases (chemistry), Dose-Response Relationship, Drug, Fibroblasts (drug effects), Fibroblasts (pathology), Fibroblasts (virology), Humans, Inhibitory Concentration 50, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Molecular Docking Simulation, Molecular Sequence Data, Murine hepatitis virus (drug effects), Murine hepatitis virus (physiology), Protein Binding, SARS Virus (drug effects), SARS Virus (physiology), Sequence Alignment, Sequence Homology, Amino Acid, Triazoles (chemistry), Triazoles (pharmacology), Vero Cells, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Virus Replication (drug effects).
MESH :
- chemical , antagonists & inhibitors : DNA Helicases, Viral Proteins.
- chemical , chemistry : Antiviral Agents, DNA Helicases, Triazoles, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Triazoles.
- drug effects : Fibroblasts, Middle East Respiratory Syndrome Coronavirus, Murine hepatitis virus, SARS Virus, Virus Replication.
- pathology : Fibroblasts.
- physiology : Middle East Respiratory Syndrome Coronavirus, Murine hepatitis virus, SARS Virus.
- virology : Fibroblasts.
- Amino Acid Sequence, Animals, Binding Sites, Cell Line, Chlorocebus aethiops, Dose-Response Relationship, Drug, Humans, Inhibitory Concentration 50, Mice, Molecular Docking Simulation, Molecular Sequence Data, Protein Binding, Sequence Alignment, Sequence Homology, Amino Acid, Vero Cells.

Abstract

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.

DOI: 10.1128/AAC.02994-14
PubMed: 24841268

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<front><div type="abstract" xml:lang="en">We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors. </div>
</front>
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<Title>Antimicrobial agents and chemotherapy</Title>
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<ArticleTitle>Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.</ArticleTitle>
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<Abstract><AbstractText>We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors. </AbstractText>
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   |texte=   Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
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Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

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