Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides : an in vitro model for treatment
Identifieur interne : 004847 ( Main/Exploration ); précédent : 004846; suivant : 004848Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides : an in vitro model for treatment
Auteurs : J. Lisziewicz [États-Unis] ; D. Sun [États-Unis] ; M. Klotman [États-Unis] ; S. Agrawal ; P. Zamecnik ; R. Gallo [États-Unis]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1992.
Descripteurs français
- KwdFr :
- Cellules cultivées, Données de séquences moléculaires, Facteurs temps, Humains, Mutation, Oligonucléotides antisens (), Oligonucléotides antisens (pharmacologie), Réplication virale (), Survie cellulaire (), Séquence nucléotidique, Techniques in vitro, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (croissance et développement), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique).
- MESH :
- croissance et développement : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- génétique : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- pharmacologie : Oligonucléotides antisens.
- Pascal (Inist)
- Cellules cultivées, Données de séquences moléculaires, Facteurs temps, Humains, Mutation, Oligonucléotides antisens, Réplication virale, Survie cellulaire, Séquence nucléotidique, Techniques in vitro, Virus HIV1, Antiviral, Inhibition, Infection, Modèle, Replication in vitro, Immunodéficit acquis syndrome, Spécificité, Séquence nucléotide, Chimiothérapie, Traitement, In vitro, Synthèse chimique, Mécanisme action, Lignée MOLT3, DNA antisens.
English descriptors
- KwdEn :
- AIDS, Antisense DNA, Antiviral, Base Sequence, Cell Survival (drug effects), Cells, Cultured, Chemical synthesis, Chemotherapy, HIV-1 (genetics), HIV-1 (growth & development), HIV-1 virus, Humans, In Vitro Techniques, In vitro, In vitro replication, Infection, Inhibition, Mechanism of action, Models, Molecular Sequence Data, Mutation, Nucleotide sequence, Oligonucleotides, Antisense (chemistry), Oligonucleotides, Antisense (pharmacology), Specificity, Time Factors, Treatment, Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Oligonucleotides, Antisense.
- drug effects : Cell Survival, Virus Replication.
- genetics : HIV-1.
- growth & development : HIV-1.
- chemical , pharmacology : Oligonucleotides, Antisense.
- Base Sequence, Cells, Cultured, Humans, In Vitro Techniques, Molecular Sequence Data, Mutation, Time Factors.
Abstract
We have developed a culture system, simulating in vivo conditions of human immunodeficiency virus type 1 (HIV-1) injection, to evaluate the long-term efficacy of antisense oligonucleotide treatment. Five oligonucleotide phosphorothioates (28-mers), complementary to different regions of HIV-1 RNA, blocked replication of the virus in a sequence-specific manner at 1 μM concentration. Variations in antiviral activity were seen among the different oligonucleotides, invealing an effect of target selection
Affiliations:
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Le document en format XML
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<term>Antisense DNA</term>
<term>Antiviral</term>
<term>Base Sequence</term>
<term>Cell Survival (drug effects)</term>
<term>Cells, Cultured</term>
<term>Chemical synthesis</term>
<term>Chemotherapy</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (growth & development)</term>
<term>HIV-1 virus</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>In vitro</term>
<term>In vitro replication</term>
<term>Infection</term>
<term>Inhibition</term>
<term>Mechanism of action</term>
<term>Models</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Nucleotide sequence</term>
<term>Oligonucleotides, Antisense (chemistry)</term>
<term>Oligonucleotides, Antisense (pharmacology)</term>
<term>Specificity</term>
<term>Time Factors</term>
<term>Treatment</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cellules cultivées</term>
<term>Données de séquences moléculaires</term>
<term>Facteurs temps</term>
<term>Humains</term>
<term>Mutation</term>
<term>Oligonucléotides antisens ()</term>
<term>Oligonucléotides antisens (pharmacologie)</term>
<term>Réplication virale ()</term>
<term>Survie cellulaire ()</term>
<term>Séquence nucléotidique</term>
<term>Techniques in vitro</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (croissance et développement)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
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<term>Virus Replication</term>
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<term>Cells, Cultured</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Time Factors</term>
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<term>Données de séquences moléculaires</term>
<term>Facteurs temps</term>
<term>Humains</term>
<term>Mutation</term>
<term>Oligonucléotides antisens</term>
<term>Réplication virale</term>
<term>Survie cellulaire</term>
<term>Séquence nucléotidique</term>
<term>Techniques in vitro</term>
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<term>In vitro</term>
<term>Synthèse chimique</term>
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<front><div type="abstract" xml:lang="en">We have developed a culture system, simulating in vivo conditions of human immunodeficiency virus type 1 (HIV-1) injection, to evaluate the long-term efficacy of antisense oligonucleotide treatment. Five oligonucleotide phosphorothioates (28-mers), complementary to different regions of HIV-1 RNA, blocked replication of the virus in a sequence-specific manner at 1 μM concentration. Variations in antiviral activity were seen among the different oligonucleotides, invealing an effect of target selection</div>
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<name sortKey="Sun, D" sort="Sun, D" uniqKey="Sun D" first="D." last="Sun">D. Sun</name>
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