Current advancements and potential strategies in the development of MERS-CoV vaccines
Identifieur interne : 001C93 ( Main/Exploration ); précédent : 001C92; suivant : 001C94Current advancements and potential strategies in the development of MERS-CoV vaccines
Auteurs : Naru Zhang [États-Unis] ; Shibo Jiang [États-Unis, République populaire de Chine] ; Lanying Du [États-Unis]Source :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Adjuvants immunologiques (isolement et purification), Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Découverte de médicament (tendances), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Infections à coronavirus (), Modèles animaux de maladie humaine, Moyen Orient (épidémiologie), Vaccination (), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins antiviraux (isolement et purification), Vaccins sous-unitaires (génétique), Vaccins sous-unitaires (immunologie), Vaccins sous-unitaires (isolement et purification).
- MESH :
- administration et posologie : Adjuvants immunologiques.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux, Vaccins sous-unitaires.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux, Vaccins sous-unitaires.
- isolement et purification : Adjuvants immunologiques, Vaccins antiviraux, Vaccins sous-unitaires.
- tendances : Découverte de médicament.
- épidémiologie : Moyen Orient.
- Animaux, Humains, Infections à coronavirus, Modèles animaux de maladie humaine, Vaccination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adjuvants, Immunologic (isolation & purification), Animals, Coronavirus Infections (prevention & control), Disease Models, Animal, Drug Discovery (trends), Humans, Middle East (epidemiology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Vaccination (methods), Vaccines, Subunit (genetics), Vaccines, Subunit (immunology), Vaccines, Subunit (isolation & purification), Viral Vaccines (genetics), Viral Vaccines (immunology), Viral Vaccines (isolation & purification).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic.
- chemical , genetics : Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines.
- chemical , immunology : Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines.
- chemical , isolation & purification : Adjuvants, Immunologic, Vaccines, Subunit, Viral Vaccines.
- geographic , epidemiology : Middle East.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- methods : Vaccination.
- prevention & control : Coronavirus Infections.
- trends : Drug Discovery.
- Animals, Disease Models, Animal, Humans.
Abstract
Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the
Url:
DOI: 10.1586/14760584.2014.912134
PubMed: 24766432
PubMed Central: 4241375
Affiliations:
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Le document en format XML
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<term>Disease Models, Animal</term>
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β-coronavirus (β-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the <italic>in vivo</italic>
efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future.</p>
</div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
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<tree><country name="États-Unis"><noRegion><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name>
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<name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
<name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
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